LOCUS       NM_001304784            2322 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus HDGF like 2 (Hdgfl2), transcript variant 1, mRNA.
ACCESSION   NM_001304784 XM_006523706
VERSION     NM_001304784.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Van Belle S, El Ashkar S, Cermakova K, Matthijssens F, Goossens S,
            Canella A, Hodges CH, Christ F, De Rijck J, Van Vlierberghe P,
            Veverka V and Debyser Z.
  TITLE     Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R
            Leukemogenesis but Important for Leukemic Cell Survival
  JOURNAL   Cells 10 (1), 192 (2021)
   PUBMED   33477970
  REMARK    GeneRIF: Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for
            MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Zhu X, Lan B, Yi X, He C, Dang L, Zhou X, Lu Y, Sun Y, Liu Z, Bai
            X, Zhang K, Li B, Li MJ, Chen Y and Zhang L.
  TITLE     HRP2-DPF3a-BAF complex coordinates histone modification and
            chromatin remodeling to regulate myogenic gene transcription
  JOURNAL   Nucleic Acids Res 48 (12), 6563-6582 (2020)
   PUBMED   32459350
  REMARK    GeneRIF: HRP2-DPF3a-BAF complex coordinates histone modification
            and chromatin remodeling to regulate myogenic gene transcription.
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Wang H, Shun MC, Dickson AK and Engelman AN.
  TITLE     Embryonic Lethality Due to Arrested Cardiac Development in
            Psip1/Hdgfrp2 Double-Deficient Mice
  JOURNAL   PLoS One 10 (9), e0137797 (2015)
   PUBMED   26367869
  REMARK    GeneRIF: The role of HRP2 protein in cardiac development
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2322)
  AUTHORS   Gao K, Xu C, Jin X, Wumaier R, Ma J, Peng J, Wang Y, Tang Y, Yu L
            and Zhang P.
  TITLE     HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell
            growth in hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 458 (4), 849-855 (2015)
   PUBMED   25689719
  REMARK    GeneRIF: HRP-2 can promote hepatocellular carcinoma cells growth in
            vitro and xenograft tumors in vivo.
REFERENCE   5  (bases 1 to 2322)
  AUTHORS   Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel
            PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH and Engelman
            A.
  TITLE     HRP2 determines the efficiency and specificity of HIV-1 integration
            in LEDGF/p75 knockout cells but does not contribute to the
            antiviral activity of a potent LEDGF/p75-binding site integrase
            inhibitor
  JOURNAL   Nucleic Acids Res 40 (22), 11518-11530 (2012)
   PUBMED   23042676
  REMARK    GeneRIF: The results show that HRP2 plays a role in HIV-1
            integration when LEDGF/p75 is absent.
REFERENCE   6  (bases 1 to 2322)
  AUTHORS   Thakar K, Votteler I, Kelkar D, Shidore T, Gupta S, Kelm S and
            Dietz F.
  TITLE     Interaction of HRP-2 isoforms with HDGF: chromatin binding of a
            specific heteromer
  JOURNAL   FEBS J 279 (5), 737-751 (2012)
   PUBMED   22212508
REFERENCE   7  (bases 1 to 2322)
  AUTHORS   Izumoto Y, Kuroda T, Harada H, Kishimoto T and Nakamura H.
  TITLE     Hepatoma-derived growth factor belongs to a gene family in mice
            showing significant homology in the amino terminus
  JOURNAL   Biochem Biophys Res Commun 238 (1), 26-32 (1997)
   PUBMED   9299445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009719.10, AK146813.1 and BF466128.1.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_001304784.3.
            
            On Sep 5, 2016 this sequence version replaced NM_001304784.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003741.1, AK146813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CT009719.10        123819-123886
            69-2302             AK146813.1         2-2235
            2303-2309           BF466128.1         14-20               c
            2310-2310           CT009719.10        144790-144790
            2311-2322           BF466128.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.15 cM"
     gene            1..2322
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /note="HDGF like 2"
                     /db_xref="GeneID:15193"
                     /db_xref="MGI:MGI:1194492"
     exon            1..196
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2161
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatoma-derived growth factor, related protein 2"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein 2
                     isoform 1"
                     /protein_id="NP_001291713.1"
                     /db_xref="CCDS:CCDS89122.1"
                     /db_xref="GeneID:15193"
                     /db_xref="MGI:MGI:1194492"
                     /translation="MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFF
                     FGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSD
                     SEAPEADLGCGSDVDKDKESRRVMTVTAVTTTATSDRMESDSDSDKSSDHSGLKRKTP
                     VLKVSVSKRARRASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTAARPPRRGP
                     LGGRKKKHPTGYACPQKVPSASDSDSKADSDGAKEEPVVTAQPSPSSSSSSSSSSSSD
                     SDVSVKKPPRGRKPAEKPPPKPRGRRPKPERPPSTSSSDSDSDSGEVDRISEWKRRDE
                     ERRRELEARRRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRK
                     ARGRGTPSSSDSEPEGELGKEGKKLAKKSQLPGSESARKPGQKEKRGRPDEKPRARPV
                     KVERTRKRSEGLSLERKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRKCLSALEEL
                     GTLQVTSQILQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKV
                     NKAGAEKERADNEKLEEQPGEQAPRELAEDEPSTDRSAPVNGEATSQKGENMEDRAQE
                     DGQDSEDGPRGGSSEELHDSPRDNSDPAKPGNERQDHERTRLASESANDDNEDS"
     exon            197..273
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..412
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..613
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..727
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..799
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..995
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1071
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1363
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1467
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1541
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1612
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1714
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1925
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2052
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2313
                     /gene="Hdgfl2"
                     /gene_synonym="Hdgfrp2; HRP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aataagtaga cgccggccgg cggcccgtgc ggacgcctcc gcccctcagg cgtccgactc
       61 ccgcctctga cttcgcctct caccgccgtt gctgcttccc gcggcctggg cctccgccga
      121 cagcatgccg cacgccttca agcccgggga cttggtgttt gccaagatga agggctaccc
      181 gcactggccg gcccggattg atgacattgc tgatggtgcc gtgaagcccc cacccaacaa
      241 ataccccatc ttcttctttg gaacgcatga aacggccttc ctgggaccca aggacctgtt
      301 cccctatgat aagtgcaagg acaagtacgg aaagcccaac aagaggaaag gcttcaatga
      361 ggggctctgg gagatccaga acaaccccca tgccagctac agtgcgcctc cgccggtgag
      421 ctcctctgac agtgaggccc ctgaagccga cctgggttgt ggcagcgacg tggacaagga
      481 caaagaatcc cggagggtca tgactgtgac agctgtgacc accacagcca ccagtgacag
      541 gatggagagc gattctgact ctgacaagag cagtgatcac agtggcctga agcggaagac
      601 accagtcttg aaggtgtcag tctctaaacg agctagaaga gcttccagtg acctggatca
      661 ggccagtgtg tccccatcag aagaggactc tgagagccca tctgagtcgg agaagaccag
      721 tgaccaggat tttaccccag agaagaagac agcggcccgg ccgccacggc gaggtcctct
      781 gggaggacgc aagaagaagc accccactgg ctatgcctgt ccccagaagg tgccatcagc
      841 ctcggattca gactccaaag ccgactcaga tggggccaag gaggagcctg tggttacagc
      901 acagccgtct ccatcctcct cgtcgtcgtc ctcatcatca tcctcctcag actcagatgt
      961 gtctgtcaag aaaccccctc gaggtagaaa gccagctgag aagccacccc caaaaccccg
     1021 agggcggaga ccaaagccag aacgaccacc ttccacctcc agcagtgaca gtgacagtga
     1081 cagtggtgaa gtagaccgca tcagtgaatg gaagagacgt gatgaagagc gaaggcgtga
     1141 gctggaggct cggaggcgac gggagcagga ggaagagctc cggagacttc gagaacagga
     1201 gagggaggag aaggagcggc gcaaggagcg ggcagagcgt gggggcagca gtggagagga
     1261 gctggaggac gaggagcctg tgaagaagcg tagccgaaag gctcgaggcc gaggcacacc
     1321 atcctcctct gactcagaac ctgaggggga gcttgggaaa gaggggaaga agttggccaa
     1381 gaagtcccaa ctgccaggct cagagtctgc aaggaagcct gggcaaaagg agaagagagg
     1441 gcggccagat gagaagccac gagccaggcc tgtgaaggtg gagcggacgc ggaagcggtc
     1501 agagggtctc tcactggaaa ggaaggggga gaagaagaaa gaaccctccg tagaggagag
     1561 actgcaaaag ctgcacagcg agatcaaatt tgcactgaag gttgacaacc cagatgtgag
     1621 gaagtgtctg agtgcactgg aagaactggg gactctgcag gtaacctctc agattcttca
     1681 gaagaacaca gatgtggtag caacgctgaa gaagattcgc cggtacaagg ccaacaagga
     1741 tgtgatggcg aaggcagcag aggtctacac ccggctcaag tcacgggtcc tggggccgaa
     1801 agttgaggct ctccagaagg tgaacaaggc tggagccgag aaggaacggg ccgataacga
     1861 gaagctagag gagcagccgg gggagcaggc tcccagagag ctggcagagg atgagcccag
     1921 caccgatcgg tcagcacctg tgaatggtga ggccacatcc cagaaggggg agaacatgga
     1981 agacagagca caggaagacg ggcaggactc tgaagatggc cccaggggtg gctcctcaga
     2041 agagctgcat gacagcccac gcgacaactc ggacccagcc aagcctggaa atgagcgtca
     2101 ggaccatgag aggacacggc tggcctctga gtctgccaat gatgacaatg aggacagctg
     2161 agctccagcc actgtggcca tggtgccatg tccatcccca gcctcccagg gaagtgctgc
     2221 gctgtttgta tttgtggtct gggcttttct gcctagttct gtgatttcaa ttgacatgaa
     2281 atggctataa agaattttgt aatgaaaaag aaaaaaaaaa aa
//
