LOCUS       NM_008231               2029 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus heparin binding growth factor (Hdgf), transcript
            variant 1, mRNA.
ACCESSION   NM_008231
VERSION     NM_008231.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Hu,T.H., Wu,J.C., Huang,S.T., Chu,T.H., Han,A.J., Shih,T.W.,
            Chang,Y.C., Yang,S.M., Ko,C.Y., Lin,Y.W., Kung,M.L. and Tai,M.H.
  TITLE     HDGF stimulates liver tumorigenesis by enhancing reactive oxygen
            species generation in mitochondria
  JOURNAL   J Biol Chem 299 (11), 105335 (2023)
   PUBMED   37827291
  REMARK    GeneRIF: HDGF stimulates liver tumorigenesis by enhancing reactive
            oxygen species generation in mitochondria.
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Voelkl,K., Gutierrez-Angel,S., Keeling,S., Koyuncu,S., da Silva
            Padilha,M., Feigenbutz,D., Arzberger,T., Vilchez,D., Klein,R. and
            Dudanova,I.
  TITLE     Neuroprotective effects of hepatoma-derived growth factor in models
            of Huntington's disease
  JOURNAL   Life Sci Alliance 6 (11), e202302018 (2023)
   PUBMED   37580082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Zheng,L., Chen,X., Yin,Q., Gu,J., Chen,J., Chen,M., Zhang,Y.,
            Dong,M., Jiang,H., Yin,N., Chen,H. and Li,X.
  TITLE     RNA-m6A modification of HDGF mediated by Mettl3 aggravates the
            progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming
  JOURNAL   Biochem Biophys Res Commun 635, 120-127 (2022)
   PUBMED   36265285
  REMARK    GeneRIF: RNA-m6A modification of HDGF mediated by Mettl3 aggravates
            the progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming.
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2029)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   6  (bases 1 to 2029)
  AUTHORS   Hu,T.H., Huang,C.C., Liu,L.F., Lin,P.R., Liu,S.Y., Chang,H.W.,
            Changchien,C.S., Lee,C.M., Chuang,J.H. and Tai,M.H.
  TITLE     Expression of hepatoma-derived growth factor in hepatocellular
            carcinoma
  JOURNAL   Cancer 98 (7), 1444-1456 (2003)
   PUBMED   14508832
  REMARK    GeneRIF: Increased HDGF expression is correlated with disease
            progression of hepatocellular carcinoma and represent a specific
            prognostic factor in patient with liver cancer.
REFERENCE   7  (bases 1 to 2029)
  AUTHORS   Enomoto,H., Yoshida,K., Kishima,Y., Kinoshita,T., Yamamoto,M.,
            Everett,A.D., Miyajima,A. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor is highly expressed in developing
            liver and promotes fetal hepatocyte proliferation
  JOURNAL   Hepatology 36 (6), 1519-1527 (2002)
   PUBMED   12447878
  REMARK    GeneRIF: Hepatoma-derived growth factor helps regulate the
            hepatocyte proliferation in liver development.
REFERENCE   8  (bases 1 to 2029)
  AUTHORS   Kishima,Y., Yamamoto,H., Izumoto,Y., Yoshida,K., Enomoto,H.,
            Yamamoto,M., Kuroda,T., Ito,H., Yoshizaki,K. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor stimulates cell growth after
            translocation to the nucleus by nuclear localization signals
  JOURNAL   J Biol Chem 277 (12), 10315-10322 (2002)
   PUBMED   11751870
  REMARK    GeneRIF: Hepatoma-derived growth factor stimulates cell growth
            after translocation to the nucleus
REFERENCE   9  (bases 1 to 2029)
  AUTHORS   Everett,A.D.
  TITLE     Identification, cloning, and developmental expression of
            hepatoma-derived growth factor in the developing rat heart
  JOURNAL   Dev Dyn 222 (3), 450-458 (2001)
   PUBMED   11747079
REFERENCE   10 (bases 1 to 2029)
  AUTHORS   Izumoto,Y., Kuroda,T., Harada,H., Kishimoto,T. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor belongs to a gene family in mice
            showing significant homology in the amino terminus
  JOURNAL   Biochem Biophys Res Commun 238 (1), 26-32 (1997)
   PUBMED   9299445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158233.2.
            
            On Jul 26, 2022 this sequence version replaced NM_008231.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017863.1, AK029475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC158233.2         74837-75014
            179-255             AC158233.2         81391-81467
            256-394             AC158233.2         81613-81751
            395-580             AC158233.2         82352-82537
            581-798             AC158233.2         82773-82990
            799-2029            AC158233.2         83202-84432
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..2029
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="heparin binding growth factor"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
     exon            1..178
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..805
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatoma-derived growth factor"
                     /codon_start=1
                     /product="hepatoma-derived growth factor isoform 1"
                     /protein_id="NP_032257.3"
                     /db_xref="CCDS:CCDS17457.1"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
                     /translation="MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANK
                     YQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQS
                     SQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGD
                     VLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGE
                     EEAAKEEAEAQGVRDHESL"
     exon            179..255
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            256..394
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            395..580
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            581..798
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            799..2029
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagc ggcgccgcaa ccgccgcacg cgcaaacttg ggctcgcgct tcccggctcg
       61 gcgcggagcc cggggcgccc gcggccccgc catgtcgcga tccaaccggc agaaagagta
      121 caagtgcgga gacctggtgt ttgcgaagat gaaaggatac ccacactggc cggcccggat
      181 tgatgagatg cctgaggctg cagtgaagtc aacagccaac aaataccaag tctttttttt
      241 tgggacccat gagacggcat tcctgggccc caaagacctc ttcccttatg aggaatccaa
      301 ggagaagttt ggcaagccca acaagaggaa agggttcagc gaggggctgt gggagatcga
      361 gaacaaccct acagtcaagg cctctggcta ccagtcctcc cagaaaaaga gttgtgcggc
      421 agagcccgag gtggagcccg aagcccatga gggtgacggt gataagaagg gcagtgcaga
      481 gggcagcagc gacgaagaag ggaaactggt gatcgatgaa ccagccaagg agaagaacga
      541 aaagggcacg ctgaagagga gagcagggga tgtgttggag gactccccta aacgtcccaa
      601 ggagtcagga gaccatgagg aggaggacaa ggagatagct gccttggagg gtgagaggcc
      661 cctgcctgta gaggtggaga agaacagcac cccctctgag ccagactctg gccagggacc
      721 tcctgcagag gaagaagagg gagaggaaga ggctgccaag gaagaggctg aagcccaggg
      781 cgtcagagat catgagagcc tgtagccacc aatgtttcaa gaggagcccc tgccccgttc
      841 ctgctgctgt ctgggtgcta ctggggaaac tggccatggc ctgcaaactg ggaacccttt
      901 cccaccctat ttaccctact ccctcactca ctctctcctc taagcccact cctggagagt
      961 gtcttggccc tcacctccag ctcccttcct acatacaccc tgtgccccag gatgagatga
     1021 ggccttgtat ctctttacac ttgtttccca gggtttctgc tggggtctag gctgctgttt
     1081 ccacctcttg acacctctgc cctgctgcag gcattctaga cctttggggt ggatagtggg
     1141 caggagtgga ggtgaaagaa tataaaggag tgtgggttca tggatggcat cgtctacctg
     1201 agctcctgtc tccagccccc acacttattt tcccatctgc ctacattcaa gaaacaggac
     1261 actgtgggag agaggctacc atccatccat aaatccttgt tgatttttgg gaacacttat
     1321 ccccctgacc ccagggttca aggaattgta gtttaacatc tagactttgg agtttccaag
     1381 tttgggccta ggacctggag ggagctaaga gctgaagaat caactgattt gcattgagga
     1441 aatgtctctt tagatctcag ggcagaaatg ataacctggg gagacctgct gccttcatct
     1501 acttcccaat gcttgaggcc agcctgtagt cagatatttc acccagacat aaaggaaaag
     1561 accatttttt ttttaggaaa tgtttttaat aaaagaaaat taccaaaaaa gaaaaaaaaa
     1621 acccaaccca caaaagaaga aaaaaaggaa aaaagttgcc ccgccccttt gtgtgttcct
     1681 ctctctgctc ctttctcccc actgctgacc cgttttttga ggtgcgctag gagggaggct
     1741 cgcctctgac cgggttggct ttctctttgg acatggggct ttgatgttct tccagagttg
     1801 gtctctggtg ttttctcaca tccagtttgt agcccactaa gaatacaggg aaaagtgtcc
     1861 tccagcctct tctagtggtt tcttacatgc ccctcttcct tgtcttttac tcccatctct
     1921 cctctgggct ctgaagaaaa attgctgact gtagctttgg aagtgtagct ctgagaataa
     1981 tagaaaattt tgagttctag gaaaataaag ccgctgatta ctatcctga
//
