LOCUS       NM_001410042            1813 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus heparin binding growth factor (Hdgf), transcript
            variant 14, mRNA.
ACCESSION   NM_001410042
VERSION     NM_001410042.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Hu,T.H., Wu,J.C., Huang,S.T., Chu,T.H., Han,A.J., Shih,T.W.,
            Chang,Y.C., Yang,S.M., Ko,C.Y., Lin,Y.W., Kung,M.L. and Tai,M.H.
  TITLE     HDGF stimulates liver tumorigenesis by enhancing reactive oxygen
            species generation in mitochondria
  JOURNAL   J Biol Chem 299 (11), 105335 (2023)
   PUBMED   37827291
  REMARK    GeneRIF: HDGF stimulates liver tumorigenesis by enhancing reactive
            oxygen species generation in mitochondria.
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Voelkl,K., Gutierrez-Angel,S., Keeling,S., Koyuncu,S., da Silva
            Padilha,M., Feigenbutz,D., Arzberger,T., Vilchez,D., Klein,R. and
            Dudanova,I.
  TITLE     Neuroprotective effects of hepatoma-derived growth factor in models
            of Huntington's disease
  JOURNAL   Life Sci Alliance 6 (11), e202302018 (2023)
   PUBMED   37580082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Zheng,L., Chen,X., Yin,Q., Gu,J., Chen,J., Chen,M., Zhang,Y.,
            Dong,M., Jiang,H., Yin,N., Chen,H. and Li,X.
  TITLE     RNA-m6A modification of HDGF mediated by Mettl3 aggravates the
            progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming
  JOURNAL   Biochem Biophys Res Commun 635, 120-127 (2022)
   PUBMED   36265285
  REMARK    GeneRIF: RNA-m6A modification of HDGF mediated by Mettl3 aggravates
            the progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming.
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Hu,T.H., Huang,C.C., Liu,L.F., Lin,P.R., Liu,S.Y., Chang,H.W.,
            Changchien,C.S., Lee,C.M., Chuang,J.H. and Tai,M.H.
  TITLE     Expression of hepatoma-derived growth factor in hepatocellular
            carcinoma
  JOURNAL   Cancer 98 (7), 1444-1456 (2003)
   PUBMED   14508832
  REMARK    GeneRIF: Increased HDGF expression is correlated with disease
            progression of hepatocellular carcinoma and represent a specific
            prognostic factor in patient with liver cancer.
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Enomoto,H., Yoshida,K., Kishima,Y., Kinoshita,T., Yamamoto,M.,
            Everett,A.D., Miyajima,A. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor is highly expressed in developing
            liver and promotes fetal hepatocyte proliferation
  JOURNAL   Hepatology 36 (6), 1519-1527 (2002)
   PUBMED   12447878
  REMARK    GeneRIF: Hepatoma-derived growth factor helps regulate the
            hepatocyte proliferation in liver development.
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Kishima,Y., Yamamoto,H., Izumoto,Y., Yoshida,K., Enomoto,H.,
            Yamamoto,M., Kuroda,T., Ito,H., Yoshizaki,K. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor stimulates cell growth after
            translocation to the nucleus by nuclear localization signals
  JOURNAL   J Biol Chem 277 (12), 10315-10322 (2002)
   PUBMED   11751870
  REMARK    GeneRIF: Hepatoma-derived growth factor stimulates cell growth
            after translocation to the nucleus
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Everett,A.D.
  TITLE     Identification, cloning, and developmental expression of
            hepatoma-derived growth factor in the developing rat heart
  JOURNAL   Dev Dyn 222 (3), 450-458 (2001)
   PUBMED   11747079
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   Izumoto,Y., Kuroda,T., Harada,H., Kishimoto,T. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor belongs to a gene family in mice
            showing significant homology in the amino terminus
  JOURNAL   Biochem Biophys Res Commun 238 (1), 26-32 (1997)
   PUBMED   9299445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158233.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1876005.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC158233.2         74837-75014
            179-364             AC158233.2         82352-82537
            365-582             AC158233.2         82773-82990
            583-1813            AC158233.2         83202-84432
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..1813
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="heparin binding growth factor"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
     exon            1..178
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..589
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="isoform 8 is encoded by transcript variant 14;
                     hepatoma-derived growth factor"
                     /codon_start=1
                     /product="hepatoma-derived growth factor isoform 8"
                     /protein_id="NP_001396971.1"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
                     /translation="MSRSNRQKEYKCGDLVFAKMKGYPHWPARSSQKKSCAAEPEVEP
                     EAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGD
                     HEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVR
                     DHESL"
     exon            179..364
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            365..582
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1813
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1788..1793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="hexamer: AATAAA"
     polyA_site      1813
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagc ggcgccgcaa ccgccgcacg cgcaaacttg ggctcgcgct tcccggctcg
       61 gcgcggagcc cggggcgccc gcggccccgc catgtcgcga tccaaccggc agaaagagta
      121 caagtgcgga gacctggtgt ttgcgaagat gaaaggatac ccacactggc cggcccggtc
      181 ctcccagaaa aagagttgtg cggcagagcc cgaggtggag cccgaagccc atgagggtga
      241 cggtgataag aagggcagtg cagagggcag cagcgacgaa gaagggaaac tggtgatcga
      301 tgaaccagcc aaggagaaga acgaaaaggg cacgctgaag aggagagcag gggatgtgtt
      361 ggaggactcc cctaaacgtc ccaaggagtc aggagaccat gaggaggagg acaaggagat
      421 agctgccttg gagggtgaga ggcccctgcc tgtagaggtg gagaagaaca gcaccccctc
      481 tgagccagac tctggccagg gacctcctgc agaggaagaa gagggagagg aagaggctgc
      541 caaggaagag gctgaagccc agggcgtcag agatcatgag agcctgtagc caccaatgtt
      601 tcaagaggag cccctgcccc gttcctgctg ctgtctgggt gctactgggg aaactggcca
      661 tggcctgcaa actgggaacc ctttcccacc ctatttaccc tactccctca ctcactctct
      721 cctctaagcc cactcctgga gagtgtcttg gccctcacct ccagctccct tcctacatac
      781 accctgtgcc ccaggatgag atgaggcctt gtatctcttt acacttgttt cccagggttt
      841 ctgctggggt ctaggctgct gtttccacct cttgacacct ctgccctgct gcaggcattc
      901 tagacctttg gggtggatag tgggcaggag tggaggtgaa agaatataaa ggagtgtggg
      961 ttcatggatg gcatcgtcta cctgagctcc tgtctccagc ccccacactt attttcccat
     1021 ctgcctacat tcaagaaaca ggacactgtg ggagagaggc taccatccat ccataaatcc
     1081 ttgttgattt ttgggaacac ttatccccct gaccccaggg ttcaaggaat tgtagtttaa
     1141 catctagact ttggagtttc caagtttggg cctaggacct ggagggagct aagagctgaa
     1201 gaatcaactg atttgcattg aggaaatgtc tctttagatc tcagggcaga aatgataacc
     1261 tggggagacc tgctgccttc atctacttcc caatgcttga ggccagcctg tagtcagata
     1321 tttcacccag acataaagga aaagaccatt ttttttttag gaaatgtttt taataaaaga
     1381 aaattaccaa aaaagaaaaa aaaaacccaa cccacaaaag aagaaaaaaa ggaaaaaagt
     1441 tgccccgccc ctttgtgtgt tcctctctct gctcctttct ccccactgct gacccgtttt
     1501 ttgaggtgcg ctaggaggga ggctcgcctc tgaccgggtt ggctttctct ttggacatgg
     1561 ggctttgatg ttcttccaga gttggtctct ggtgttttct cacatccagt ttgtagccca
     1621 ctaagaatac agggaaaagt gtcctccagc ctcttctagt ggtttcttac atgcccctct
     1681 tccttgtctt ttactcccat ctctcctctg ggctctgaag aaaaattgct gactgtagct
     1741 ttggaagtgt agctctgaga ataatagaaa attttgagtt ctaggaaaat aaagccgctg
     1801 attactatcc tga
//
