LOCUS       NM_001410034            1960 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus heparin binding growth factor (Hdgf), transcript
            variant 6, mRNA.
ACCESSION   NM_001410034
VERSION     NM_001410034.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Hu,T.H., Wu,J.C., Huang,S.T., Chu,T.H., Han,A.J., Shih,T.W.,
            Chang,Y.C., Yang,S.M., Ko,C.Y., Lin,Y.W., Kung,M.L. and Tai,M.H.
  TITLE     HDGF stimulates liver tumorigenesis by enhancing reactive oxygen
            species generation in mitochondria
  JOURNAL   J Biol Chem 299 (11), 105335 (2023)
   PUBMED   37827291
  REMARK    GeneRIF: HDGF stimulates liver tumorigenesis by enhancing reactive
            oxygen species generation in mitochondria.
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Voelkl,K., Gutierrez-Angel,S., Keeling,S., Koyuncu,S., da Silva
            Padilha,M., Feigenbutz,D., Arzberger,T., Vilchez,D., Klein,R. and
            Dudanova,I.
  TITLE     Neuroprotective effects of hepatoma-derived growth factor in models
            of Huntington's disease
  JOURNAL   Life Sci Alliance 6 (11), e202302018 (2023)
   PUBMED   37580082
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Zheng,L., Chen,X., Yin,Q., Gu,J., Chen,J., Chen,M., Zhang,Y.,
            Dong,M., Jiang,H., Yin,N., Chen,H. and Li,X.
  TITLE     RNA-m6A modification of HDGF mediated by Mettl3 aggravates the
            progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming
  JOURNAL   Biochem Biophys Res Commun 635, 120-127 (2022)
   PUBMED   36265285
  REMARK    GeneRIF: RNA-m6A modification of HDGF mediated by Mettl3 aggravates
            the progression of atherosclerosis by regulating macrophages
            polarization via energy metabolism reprogramming.
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1960)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   6  (bases 1 to 1960)
  AUTHORS   Hu,T.H., Huang,C.C., Liu,L.F., Lin,P.R., Liu,S.Y., Chang,H.W.,
            Changchien,C.S., Lee,C.M., Chuang,J.H. and Tai,M.H.
  TITLE     Expression of hepatoma-derived growth factor in hepatocellular
            carcinoma
  JOURNAL   Cancer 98 (7), 1444-1456 (2003)
   PUBMED   14508832
  REMARK    GeneRIF: Increased HDGF expression is correlated with disease
            progression of hepatocellular carcinoma and represent a specific
            prognostic factor in patient with liver cancer.
REFERENCE   7  (bases 1 to 1960)
  AUTHORS   Enomoto,H., Yoshida,K., Kishima,Y., Kinoshita,T., Yamamoto,M.,
            Everett,A.D., Miyajima,A. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor is highly expressed in developing
            liver and promotes fetal hepatocyte proliferation
  JOURNAL   Hepatology 36 (6), 1519-1527 (2002)
   PUBMED   12447878
  REMARK    GeneRIF: Hepatoma-derived growth factor helps regulate the
            hepatocyte proliferation in liver development.
REFERENCE   8  (bases 1 to 1960)
  AUTHORS   Kishima,Y., Yamamoto,H., Izumoto,Y., Yoshida,K., Enomoto,H.,
            Yamamoto,M., Kuroda,T., Ito,H., Yoshizaki,K. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor stimulates cell growth after
            translocation to the nucleus by nuclear localization signals
  JOURNAL   J Biol Chem 277 (12), 10315-10322 (2002)
   PUBMED   11751870
  REMARK    GeneRIF: Hepatoma-derived growth factor stimulates cell growth
            after translocation to the nucleus
REFERENCE   9  (bases 1 to 1960)
  AUTHORS   Everett,A.D.
  TITLE     Identification, cloning, and developmental expression of
            hepatoma-derived growth factor in the developing rat heart
  JOURNAL   Dev Dyn 222 (3), 450-458 (2001)
   PUBMED   11747079
REFERENCE   10 (bases 1 to 1960)
  AUTHORS   Izumoto,Y., Kuroda,T., Harada,H., Kishimoto,T. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor belongs to a gene family in mice
            showing significant homology in the amino terminus
  JOURNAL   Biochem Biophys Res Commun 238 (1), 26-32 (1997)
   PUBMED   9299445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158233.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.887459.1,
                                           SRR13422597.1347204.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC158233.2         74837-75014
            179-255             AC158233.2         81391-81467
            256-325             AC158233.2         82141-82210
            326-511             AC158233.2         82352-82537
            512-729             AC158233.2         82773-82990
            730-1960            AC158233.2         83202-84432
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..1960
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="heparin binding growth factor"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
     exon            1..178
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..736
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="isoform 6 is encoded by transcript variant 6;
                     hepatoma-derived growth factor"
                     /codon_start=1
                     /product="hepatoma-derived growth factor isoform 6"
                     /protein_id="NP_001396963.1"
                     /db_xref="GeneID:15191"
                     /db_xref="MGI:MGI:1194494"
                     /translation="MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANK
                     YQVFFFGTHETPPPSCTEPCLPGLWVNPRANPTESSQKKSCAAEPEVEPEAHEGDGDK
                     KGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIA
                     ALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL"
     exon            179..255
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            256..325
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            326..511
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            512..729
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1960
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="Hdgf"
                     /gene_synonym="D3Ertd299e"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagc ggcgccgcaa ccgccgcacg cgcaaacttg ggctcgcgct tcccggctcg
       61 gcgcggagcc cggggcgccc gcggccccgc catgtcgcga tccaaccggc agaaagagta
      121 caagtgcgga gacctggtgt ttgcgaagat gaaaggatac ccacactggc cggcccggat
      181 tgatgagatg cctgaggctg cagtgaagtc aacagccaac aaataccaag tctttttttt
      241 tgggacccat gagacccctc ccccctcctg cacagagccc tgcctgcccg gcctgtgggt
      301 taaccccagg gctaatccaa cagagtcctc ccagaaaaag agttgtgcgg cagagcccga
      361 ggtggagccc gaagcccatg agggtgacgg tgataagaag ggcagtgcag agggcagcag
      421 cgacgaagaa gggaaactgg tgatcgatga accagccaag gagaagaacg aaaagggcac
      481 gctgaagagg agagcagggg atgtgttgga ggactcccct aaacgtccca aggagtcagg
      541 agaccatgag gaggaggaca aggagatagc tgccttggag ggtgagaggc ccctgcctgt
      601 agaggtggag aagaacagca ccccctctga gccagactct ggccagggac ctcctgcaga
      661 ggaagaagag ggagaggaag aggctgccaa ggaagaggct gaagcccagg gcgtcagaga
      721 tcatgagagc ctgtagccac caatgtttca agaggagccc ctgccccgtt cctgctgctg
      781 tctgggtgct actggggaaa ctggccatgg cctgcaaact gggaaccctt tcccacccta
      841 tttaccctac tccctcactc actctctcct ctaagcccac tcctggagag tgtcttggcc
      901 ctcacctcca gctcccttcc tacatacacc ctgtgcccca ggatgagatg aggccttgta
      961 tctctttaca cttgtttccc agggtttctg ctggggtcta ggctgctgtt tccacctctt
     1021 gacacctctg ccctgctgca ggcattctag acctttgggg tggatagtgg gcaggagtgg
     1081 aggtgaaaga atataaagga gtgtgggttc atggatggca tcgtctacct gagctcctgt
     1141 ctccagcccc cacacttatt ttcccatctg cctacattca agaaacagga cactgtggga
     1201 gagaggctac catccatcca taaatccttg ttgatttttg ggaacactta tccccctgac
     1261 cccagggttc aaggaattgt agtttaacat ctagactttg gagtttccaa gtttgggcct
     1321 aggacctgga gggagctaag agctgaagaa tcaactgatt tgcattgagg aaatgtctct
     1381 ttagatctca gggcagaaat gataacctgg ggagacctgc tgccttcatc tacttcccaa
     1441 tgcttgaggc cagcctgtag tcagatattt cacccagaca taaaggaaaa gaccattttt
     1501 tttttaggaa atgtttttaa taaaagaaaa ttaccaaaaa agaaaaaaaa aacccaaccc
     1561 acaaaagaag aaaaaaagga aaaaagttgc cccgcccctt tgtgtgttcc tctctctgct
     1621 cctttctccc cactgctgac ccgttttttg aggtgcgcta ggagggaggc tcgcctctga
     1681 ccgggttggc tttctctttg gacatggggc tttgatgttc ttccagagtt ggtctctggt
     1741 gttttctcac atccagtttg tagcccacta agaatacagg gaaaagtgtc ctccagcctc
     1801 ttctagtggt ttcttacatg cccctcttcc ttgtctttta ctcccatctc tcctctgggc
     1861 tctgaagaaa aattgctgac tgtagctttg gaagtgtagc tctgagaata atagaaaatt
     1921 ttgagttcta ggaaaataaa gccgctgatt actatcctga
//
