LOCUS       NM_001418919            1915 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus HD domain containing 3 (Hddc3), transcript variant 7,
            mRNA.
ACCESSION   NM_001418919 XM_036153404
VERSION     NM_001418919.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Huang,R., Liu,J., Chen,X., Zhi,Y., Ding,S., Ming,J., Li,Y., Wang,Y.
            and Na,J.
  TITLE     A long non-coding RNA LncSync regulates mouse cardiomyocyte
            homeostasis and cardiac hypertrophy through coordination of miRNA
            actions
  JOURNAL   Protein Cell 14 (2), 153-157 (2023)
   PUBMED   36929003
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Kim,Y.J., Khoshkhoo,S., Frankowski,J.C., Zhu,B., Abbasi,S., Lee,S.,
            Wu,Y.E. and Hunt,R.F.
  TITLE     Chd2 Is Necessary for Neural Circuit Development and Long-Term
            Memory
  JOURNAL   Neuron 100 (5), 1180-1193 (2018)
   PUBMED   30344048
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136740.10.
            
            On Mar 24, 2023 this sequence version replaced XM_036153404.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422592.149535.1,
                                           SRR13422600.771801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC136740.10        118147-118280
            135-190             AC136740.10        118570-118625
            191-431             AC136740.10        118747-118987
            432-1915            AC136740.10        119645-121128
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..1915
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /note="HD domain containing 3"
                     /db_xref="GeneID:68695"
                     /db_xref="MGI:MGI:1915945"
     exon            1..134
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..760
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /EC_number="3.1.7.2"
                     /note="isoform 7 is encoded by transcript variant 7; HD
                     domain-containing protein 3;
                     guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
                     MESH1; (ppGpp)ase; penta-phosphate
                     guanosine-3'-pyrophosphohydrolase; metazoan SpoT homolog
                     1"
                     /codon_start=1
                     /product="guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase MESH1 isoform 7"
                     /protein_id="NP_001405848.1"
                     /db_xref="GeneID:68695"
                     /db_xref="MGI:MGI:1915945"
                     /translation="MGSEAAQLLEAADFAAHKHRQQRRKDPEGTPYINHPIGVARILT
                     HEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKR
                     QQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPTGSRCLYPTAAAALGGHLMVLASPK
                     HCMTPSVLGLQLQLRLHLHQWPSMASHSTEPQLLCVTPSCLQNQYHLGDPYILPSPTA
                     AGVHPWPSLEHCLFVLSENTSQKMSPQ"
     exon            135..190
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..431
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1915
                     /gene="Hddc3"
                     /gene_synonym="1110033O09Rik; MESH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctcgc gccaccagcg caatgggctc ggaggcagct cagctgctgg aggctgctga
       61 cttcgccgct cacaaacacc gacagcagcg acgaaaagat cctgaaggga ctccctacat
      121 taatcacccc atcggtgtag cccggatcct aacccatgag gctggaatca ctgatattgt
      181 ggtgttacag gccgccctgc tccatgacac agtagaagac acagatacta ccctggatga
      241 ggtagagctg cactttggag cacaggttcg acgcttggtg gaggaggtaa cagatgacaa
      301 gactctgccc aaactggaaa gaaagcggca acaggtggag caggcaccac acagcagccc
      361 aggggccaaa ctggtgaagc tggcagacaa gctatacaat ctgagggacc tgaatcgctg
      421 cacccctaca ggctccagat gcctgtaccc cactgctgct gctgctcttg gtggtcatct
      481 catggtactg gcatctccaa aacactgcat gaccccttca gtcctgggcc ttcaattgca
      541 actgaggctg caccttcacc aatggccttc catggcctct cacagtaccg aacctcagct
      601 gctttgcgtg accccttcat gccttcaaaa ccagtaccac ctgggtgacc cttacatatt
      661 accaagtccc actgcagcag gagtacatcc ttggccatct ctggaacact gcctctttgt
      721 gctttcagaa aacacttccc agaagatgtc acctcaatga tgctggtctc ttcttaatca
      781 ccgctaattt cttagctcca gctaaccagc atcaatagtc ccagtaatgc aaagtttttg
      841 cttggtagtt ctggtatctt gttaatcaca gctgattctt cagccccagc taaccagaac
      901 tacagaatct tcacaaacaa aacagcaatg gccctgaaaa gagtctttaa ttttccctct
      961 gaaatttcac aaaccagagc tccatcttct gcagtgttct caacattatc ttccaagctc
     1021 ctacatgaca tccgacagag ctcttaacaa cggatggatc ttcaagccca aagttccaaa
     1081 gtccttccac agtcctcccc aaaacatggt cagattgtca caggaatacc ccactcctgg
     1141 taccaatttg tcttagtcag ggtttctatt cctgcacaaa catcatgacc aagaagcaag
     1201 ttggatctca tggaggcatt tcctcaacag aagctccttt ctccgtgata actccagctg
     1261 tgtcaagttg acacaaaatt agccagtaca acctcctaga atagtcttct tccctaaggt
     1321 gggaacagag ttgctgggtc atggagaagt tgtcagatca tgccatcgca actcacggcc
     1381 ttgtaccaaa gcctgccagg aaacaggcaa aagccgatgc tgcccttgac accacacaag
     1441 caggtttctg tccactctgg tgcaggatgg tcagaacacc gagtccagga gtacttcgag
     1501 tgggcagccc aggtggtaaa agggcttcaa gggacaaacc agcaactgga agaggcacta
     1561 aagcagctgt tcgaggagcg agggctgacg ctctgagccg ttctctgtgc catcctgcag
     1621 catggctcca gcaaggtcca ggaaagatgg gattcttact gcagcgttcc agagcctcct
     1681 catttcccac attccatcac tcaaccctga catcacaggc taaaaacgtc tgtgtttttt
     1741 cactaaggtg ggcccggaat atggaaagca gatatgcccc tccatccagg cactaacagc
     1801 ctttctttaa gtcttgggtc tgtttgcatg gtgagacctc tggcccctca gggacctaag
     1861 attggaataa gcgtccgtgg tttagtcgtg gaaaataaag cacttaggta aaggc
//
