LOCUS       NM_027168                718 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus HD domain containing 2 (Hddc2), transcript variant 1,
            mRNA.
ACCESSION   NM_027168 XM_125542
VERSION     NM_027168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Ihara,D., Watanabe,Y., Seya,D., Arai,Y., Isomoto,Y., Nakano,A.,
            Kubo,A., Ogura,T., Kawamura,T. and Nakagawa,O.
  TITLE     Expression of Hey2 transcription factor in the early embryonic
            ventricles is controlled through a distal enhancer by Tbx20 and
            Gata transcription factors
  JOURNAL   Dev Biol 461 (2), 124-131 (2020)
   PUBMED   32035085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104361.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027168.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104360.1, DV060756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-718               BC104361.1         1-718
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 17.34 cM"
     gene            1..718
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /note="HD domain containing 2"
                     /db_xref="GeneID:69692"
                     /db_xref="MGI:MGI:1916942"
     exon            1..79
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..610
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /EC_number="3.1.3.89"
                     /note="isoform 1 is encoded by transcript variant 1; HD
                     domain-containing protein 2; 5'-deoxynucleotidase HDDC2"
                     /codon_start=1
                     /product="5'-deoxynucleotidase HDDC2 isoform 1"
                     /protein_id="NP_081444.1"
                     /db_xref="CCDS:CCDS23767.1"
                     /db_xref="GeneID:69692"
                     /db_xref="MGI:MGI:1916942"
                     /translation="MALASSGSGAGLLRFLRLVGQLKRVPRTGWVYRNVEKPESVSDH
                     MYRMAVMAMVTRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMK
                     QITQLLPEDLRKELYELWEEYETQSSEEAKFVKQLDQCEMILQASEYEDLENKPGRLQ
                     DFYDSTAGKFSHPEIVQLVSELETERNASMATASAEPGS"
     exon            80..201
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            202..304
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..373
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            374..512
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            513..718
                     /gene="Hddc2"
                     /gene_synonym="2310057G13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttcagc atggctttgg cctcgtccgg ctctggagcc gggctgttgc gttttctgcg
       61 tctagttggg cagctcaaga gagttccacg gactggctgg gtatacagaa atgtcgaaaa
      121 gccagaaagc gtgtcagatc acatgtaccg gatggcagtt atggccatgg tgaccagaga
      181 tgaccgtctt aacaaggata gatgtatacg cctagccctg gttcacgata tggcagaatg
      241 catcgttggg gacatagcac ccgcagataa catccctaaa gaagagaaac acaggagaga
      301 agaggaggct atgaaacaga taacccagct gctgccagag gacctcagga aggagctata
      361 tgaactctgg gaagagtatg agactcagtc tagcgaagaa gccaaattcg tgaagcagct
      421 ggaccagtgt gaaatgatcc ttcaggcctc agaatatgaa gacctagaga ataagcctgg
      481 gagacttcaa gacttctatg attccacagc aggaaaattc agtcaccctg agatagtcca
      541 gcttgtttct gagctggaaa cagaaagaaa tgccagcatg gccacagcct cagcggagcc
      601 gggctcctga gatcgccttg ctgctccaca gtgctgcttt ctctgtttcc tggggttttc
      661 cccaagatga gagtctgttt tctgtgatct ggtcttgaac aagaaaggtg agataatc
//
