LOCUS       NM_008230               2415 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus histidine decarboxylase (Hdc), mRNA.
ACCESSION   NM_008230 NM_001282085
VERSION     NM_008230.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Minami-Ogawa,Y., Kiyokage,E., Yamanishi,H., Horie,S., Ichikawa,S.
            and Toida,K.
  TITLE     Structural Basis for Histaminergic Regulation of Neural Circuits in
            the Mouse Olfactory Bulb
  JOURNAL   J Comp Neurol 532 (10), e25671 (2024)
   PUBMED   39387358
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Warwick,R.A., Riccitelli,S., Heukamp,A.S., Yaakov,H., Swain,B.P.,
            Ankri,L., Mayzel,J., Gilead,N., Parness-Yossifon,R., Di Marco,S.
            and Rivlin-Etzion,M.
  TITLE     Top-down modulation of the retinal code via histaminergic neurons
            of the hypothalamus
  JOURNAL   Sci Adv 10 (35), eadk4062 (2024)
   PUBMED   39196935
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Yokoi,Y., Kubo,A., Nishimura,K., Takamura,Y., Morishita,Y.,
            Minami,M. and Nomura,H.
  TITLE     Chemogenetic activation of histamine neurons promotes retrieval of
            apparently lost memories
  JOURNAL   Mol Brain 17 (1), 38 (2024)
   PUBMED   38877480
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Jiang,Z., Waterbury,Q.T., Malagola,E., Fu,N., Kim,W., Ochiai,Y.,
            Wu,F., Guha,C., Shawber,C.J., Yan,K.S. and Wang,T.C.
  TITLE     Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes
            Intestinal Regeneration
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (3), 321-346 (2024)
   PUBMED   37898454
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Kim,K.H., Park,D., Cho,S.Y., Cho,Y., Lee,B., Jeong,H., Lee,Y.,
            Lee,Y. and Nam,K.T.
  TITLE     Role of histamine-mediated macrophage differentiation in clearance
            of metastatic bacterial infection
  JOURNAL   Front Immunol 14, 1290191 (2023)
   PUBMED   38035074
  REMARK    Erratum:[Front Immunol. 2023 Nov 28;14:1341818. doi:
            10.3389/fimmu.2023.1341818. PMID: 38090589]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2415)
  AUTHORS   Bruneau,G., Nguyen,V.C., Gros,F., Bernheim,A. and Thibault,J.
  TITLE     Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe
            by PCR and assignment of the human HDC gene to chromosome 15
  JOURNAL   Hum Genet 90 (3), 235-238 (1992)
   PUBMED   1487235
REFERENCE   7  (bases 1 to 2415)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   8  (bases 1 to 2415)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   9  (bases 1 to 2415)
  AUTHORS   Nelson,P.A., Lippke,J.A., Murcko,M.A., Rosborough,S.L. and
            Peattie,D.A.
  TITLE     cDNA encoding murine FK506-binding protein (FKBP): nucleotide and
            deduced amino acid sequence
  JOURNAL   Gene 109 (2), 255-258 (1991)
   PUBMED   1722474
REFERENCE   10 (bases 1 to 2415)
  AUTHORS   Adamson,M.C., Silver,J. and Kozak,C.A.
  TITLE     The mouse homolog of the Gibbon ape leukemia virus receptor:
            genetic mapping and a possible receptor function in rodents
  JOURNAL   Virology 183 (2), 778-781 (1991)
   PUBMED   1649508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133455.1, AV249910.1 and BQ176022.1.
            
            On or before Oct 19, 2013 this sequence version replaced
            NM_001282085.1, NM_008230.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052833.1, AK133455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2392              AK133455.1         2-2393
            2393-2394           AV249910.1         230-231
            2395-2415           BQ176022.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2415
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /note="histidine decarboxylase"
                     /db_xref="GeneID:15186"
                     /db_xref="MGI:MGI:96062"
     exon            1..161
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2098
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /EC_number="4.1.1.22"
                     /note="L-histidine decarboxylase"
                     /codon_start=1
                     /product="histidine decarboxylase"
                     /protein_id="NP_032256.3"
                     /db_xref="CCDS:CCDS16684.1"
                     /db_xref="GeneID:15186"
                     /db_xref="MGI:MGI:96062"
                     /translation="MMEPCEYREYREYYRARGKEMVDYISQYLSTVRERQVTPNVQPG
                     YLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPHMHAYYPALTSWPSLLGDML
                     ADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSSRGGGVLQSTVSES
                     TLIALLAARKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFL
                     PVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLW
                     LHVDAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQT
                     FSVNPIYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMA
                     KYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGQLFLIPATIQDK
                     LIIRFTVTSQFTTKEDILRDWHLIQEAANLVLSQHCTSQPSPRAKNVIPPPPGTRGLS
                     LESVSEGGDDPAQARKIIKQPGASLARREGGSDLETMPDPFDDCFSEEAPNTTKHKLS
                     SFLFSYLSVQNRRKTTRSLSCNSVPMSAQKSLPADASLKNGGSFRARIFSGFPEQMMM
                     MKKGAFKKLIKFYSVPSFPECSSQCARQLPCCPLEAMV"
     exon            162..334
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            335..448
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            449..571
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            572..706
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            707..850
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            851..917
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1080
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1171
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1270
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1372
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2400
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2373..2378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /note="hexamer: AATAAA"
     polyA_site      2396
                     /gene="Hdc"
                     /gene_synonym="Hdc-a; Hdc-c; Hdc-e; Hdc-s"
                     /note="major polyA site"
ORIGIN      
        1 actggctgcc agggagtgca cagcacagac aaaggcgacc aagaagccct gttgacagct
       61 gccttccagc ctcctctgtc tgtctgccag gaggagcaat ccaagggaga tgatggagcc
      121 ctgtgaatac cgtgaatacc gtgaatacta ccgagctaga gggaaagaga tggtggatta
      181 catctcccag tacctgagca ctgtgcggga gaggcaggtg actccaaatg tgcagcctgg
      241 atacctgcga gcccagctac ctgcgagtgc tcccgaggaa cccgacagct gggacagcat
      301 ctttggggac attgaacgag tcatcatgcc tggggtggtt cactggcaga gcccccacat
      361 gcacgcctac tatcctgctc ttacctcatg gccatccctg ctaggagaca tgctggccga
      421 tgccattaac tgcttaggat tcacgtgggc atctagccca gcttgcacag agctggagat
      481 gaacatcatg gactggctgg cgaagatgct ggggctcccg gagtacttcc tgcaccacca
      541 tcccagcagc cgagggggag gtgtcttaca gagcactgtc agcgaatcca ctttaattgc
      601 cctgctggca gcaagaaaga acaaaatcct agcaatgaaa gcatgcgagc ccgatgctaa
      661 tgagtcctcc ctgaacgctc ggctcgttgc ctacacctct gatcaggctc actcttcagt
      721 ggagaaggct ggcttgattt cccttgtgaa gatcagattt ctacctgtgg acgacaactt
      781 ctcactccga ggagaagctc tccagaaagc tattgaggaa gacaagcaac agggcttggt
      841 gcctgtgttt gtctgtgcaa cgttagggac tactggagtc tgtgcatttg acaggctgtc
      901 agaactgggg cccatctgtg ccagtgaggg actgtggctc cacgtcgatg ctgcttatgc
      961 aggcacggcc tttctgtgcc ctgagctccg ggggttcctg gagggcatcg agtacgctga
     1021 ctccttcacc tttaaccctt ccaagtggat gatggtacac tttgactgta ctggattctg
     1081 ggtcaaggac aagtacaagc tgcagcagac ctttagtgtg aaccccatct acctccgaca
     1141 tgccaactct ggtgcagcca cggacttcat gcattggcag atccccttga gccggcgctt
     1201 tcgctccatt aagctgtggt ttgtgattcg gtccttcggg gtgaagaatc ttcaagcaca
     1261 tgtcagacac ggcacagaaa tggctaaata ctttgaatct ctggtcagaa gcgacccttc
     1321 cttcgaaatt cctgctaaga ggcaccttgg tttggtggtt ttccgtctga agggtcctaa
     1381 ttgtctcaca gaaagtgtgt taaaggaaat agccaaagct ggccagctct ttctcatccc
     1441 ggctactatc caagacaagc tgatcatccg tttcactgtg acatcccagt ttaccaccaa
     1501 ggaggacatc ctgagagatt ggcacctcat ccaagaggct gctaaccttg tcctgagcca
     1561 gcactgcact tcccagccga gccctcgggc caagaacgtc atcccgccac cgccagggac
     1621 cagagggcta tccctggagt cagtcagcga gggaggagat gacccagcac aggcccggaa
     1681 gatcatcaag cagccaggag ccagtctggc gagaagggaa ggcggctctg atctggaaac
     1741 gatgccggat ccctttgatg attgcttctc ggaagaggcc cccaacacca ccaagcacaa
     1801 gctgtcgtcc tttctgttca gttacttgtc cgtccagaac aggaggaaga caacgcggtc
     1861 cctcagctgc aacagtgtgc ctatgagtgc ccagaagtca ctccccgcag acgcttcact
     1921 gaagaatggg ggctccttcc gggccagaat cttttccggg ttcccagaac aaatgatgat
     1981 gatgaagaaa ggtgccttca aaaagctgat caagttctac agcgtcccca gctttcctga
     2041 atgcagttct cagtgtgctc gccagctacc gtgctgcccc ctggaggcca tggtgtagag
     2101 tcctcaatca gaatgcaaga gtgcctgtgc ttcagggagt tggggaaccc ctcgaaattg
     2161 cgtgcagttt gtgtgcttat tatgtgtgtg tgcatcttga gggaagcaag cccattattt
     2221 tgatcataac ctcacagggt cttcgtgatc cacaacagat tgtaactggg aagtttaagc
     2281 gggcatgctc cagaggttgc aggcgcttgt gtgatagaag gggctgagac ggtggcgtgc
     2341 tgttgagctt gtaatgtgaa aaacaactta gaaataaatt gtgcttatat ctaaaataaa
     2401 aaaaaaaaaa aaaaa
//
