LOCUS       NM_001271386            8195 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus histone deacetylase 9 (Hdac9), transcript variant 1,
            mRNA.
ACCESSION   NM_001271386
VERSION     NM_001271386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8195)
  AUTHORS   Huang,X., Chen,J., Li,H., Cai,Y., Liu,L., Dong,Q., Li,Y., Ren,Y.,
            Xiang,W. and He,X.
  TITLE     LncRNA SNHG12 suppresses adipocyte inflammation and insulin
            resistance by regulating the HDAC9/Nrf2 axis
  JOURNAL   FASEB J 38 (13), e23794 (2024)
   PUBMED   38967258
  REMARK    GeneRIF: LncRNA SNHG12 suppresses adipocyte inflammation and
            insulin resistance by regulating the HDAC9/Nrf2 axis.
REFERENCE   2  (bases 1 to 8195)
  AUTHORS   Veerapaneni,P., Goo,B., Ahmadieh,S., Shi,H., Kim,D.S., Ogbi,M.,
            Cave,S., Chouhaita,R., Cyriac,N., Fulton,D.J., Verin,A.D., Chen,W.,
            Lei,Y., Lu,X.Y., Kim,H.W. and Weintraub,N.L.
  TITLE     Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy,
            Insulin Resistance and Hepatic Steatosis in Aging Mice
  JOURNAL   Biomolecules 14 (4), 494 (2024)
   PUBMED   38672510
  REMARK    GeneRIF: Transgenic Overexpression of HDAC9 Promotes Adipocyte
            Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging
            Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8195)
  AUTHORS   Dang,Z., Li,H., Xue,S., Shao,B., Ning,Y., Su,G., Zhang,F., Yu,W.
            and Leng,S.
  TITLE     Histone deacetylase 9-mediated phenotypic transformation of
            vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection
  JOURNAL   Biomed Pharmacother 173, 116396 (2024)
   PUBMED   38460370
  REMARK    GeneRIF: Histone deacetylase 9-mediated phenotypic transformation
            of vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection.
REFERENCE   4  (bases 1 to 8195)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8195)
  AUTHORS   Chen,Z., Lin,B., Yao,X., Weng,J., Liu,J., He,Q., Song,K., Zhou,C.,
            Zuo,Z., Huang,X., Liu,Z., Huang,Q., Xu,Q. and Guo,X.
  TITLE     Endothelial beta-catenin upregulation and Y142 phosphorylation
            drive diabetic angiogenesis via upregulating KDR/HDAC9
  JOURNAL   Cell Commun Signal 22 (1), 182 (2024)
   PUBMED   38491522
  REMARK    GeneRIF: Endothelial beta-catenin upregulation and Y142
            phosphorylation drive diabetic angiogenesis via upregulating
            KDR/HDAC9.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8195)
  AUTHORS   Zhang,C.L., McKinsey,T.A. and Olson,E.N.
  TITLE     Association of class II histone deacetylases with heterochromatin
            protein 1: potential role for histone methylation in control of
            muscle differentiation
  JOURNAL   Mol Cell Biol 22 (20), 7302-7312 (2002)
   PUBMED   12242305
  REMARK    GeneRIF: MITR, HDAC4, and HDAC5 associate with heterochromatin
            protein 1 (HP1), an adaptor protein that recognizes methylated
            lysines within histone tails and mediates transcriptional
            repression by recruiting histone methyltransferase
REFERENCE   7  (bases 1 to 8195)
  AUTHORS   Zhang,C.L., McKinsey,T.A., Chang,S., Antos,C.L., Hill,J.A. and
            Olson,E.N.
  TITLE     Class II histone deacetylases act as signal-responsive repressors
            of cardiac hypertrophy
  JOURNAL   Cell 110 (4), 479-488 (2002)
   PUBMED   12202037
REFERENCE   8  (bases 1 to 8195)
  AUTHORS   Zhang,C.L., McKinsey,T.A. and Olson,E.N.
  TITLE     The transcriptional corepressor MITR is a signal-responsive
            inhibitor of myogenesis
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7354-7359 (2001)
   PUBMED   11390982
REFERENCE   9  (bases 1 to 8195)
  AUTHORS   Zhang,C.L., McKinsey,T.A., Lu,J.R. and Olson,E.N.
  TITLE     Association of COOH-terminal-binding protein (CtBP) and
            MEF2-interacting transcription repressor (MITR) contributes to
            transcriptional repression of the MEF2 transcription factor
  JOURNAL   J Biol Chem 276 (1), 35-39 (2001)
   PUBMED   11022042
REFERENCE   10 (bases 1 to 8195)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133334.1, AC113481.12, CR974575.8 and AC163669.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. This variant lacks full-length
            transcript support the exon combination is inferred from partial
            transcripts and orthologous alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849374, SAMN00849375
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1754              AK133334.1         1-1754
            1755-1997           AC113481.12        57864-58106
            1998-2175           CR974575.8         197411-197588       c
            2176-2309           CR974575.8         188050-188183       c
            2310-2430           CR974575.8         172332-172452       c
            2431-2480           CR974575.8         167524-167573       c
            2481-2588           CR974575.8         133200-133307       c
            2589-2644           CR974575.8         106081-106136       c
            2645-2732           CR974575.8         105749-105836       c
            2733-2852           CR974575.8         100298-100417       c
            2853-2950           CR974575.8         99888-99985         c
            2951-3069           CR974575.8         54872-54990         c
            3070-3203           AC163669.2         26178-26311
            3204-3288           AC163669.2         37499-37583
            3289-3436           AC163669.2         54906-55053
            3437-8195           AC163669.2         81189-85947
FEATURES             Location/Qualifiers
     source          1..8195
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.06 cM"
     gene            1..8195
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /note="histone deacetylase 9"
                     /db_xref="GeneID:79221"
                     /db_xref="MGI:MGI:1931221"
     exon            1..42
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            43..114
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            115..231
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3476
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone deacetylase 7B; histone deacetylase-related
                     protein; MEF2-interacting transcription repressor MITR"
                     /codon_start=1
                     /product="histone deacetylase 9 isoform 1"
                     /protein_id="NP_001258315.1"
                     /db_xref="GeneID:79221"
                     /db_xref="MGI:MGI:1931221"
                     /translation="MSSPVQPDGVAGREQLLAQQRMHSMISSVDVKSEVPMGLEPISP
                     LDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQA
                     QLQEHIKLQQELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRER
                     AVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSG
                     TSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVT
                     SFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHPEQLVPQQRIL
                     IHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQGVPLPSQY
                     GSSIAASSSHVHVAMEGKPTSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATK
                     ERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMN
                     KLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQVGA
                     VKVKEEPVDSDEDAQIQEMECGEQAAFMQQPPLLESSRARSLSVHQTLAAVGTDGLEK
                     HGLLSRTHSSPAASMSPHPAADCPRQPSSATGIAYDPLMLKHQCICGSSTTHPEHAGR
                     IQSIWSRLQETGLLSKCERIQGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLL
                     GDDSRKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAV
                     VRPPGHHAEESAAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYAD
                     PSILYISLHRYDEGNFFPGSGAPNEVGVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFR
                     TVVMPVAREFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLANGRVAL
                     ALEGGHDLTAICDASEACINALLGNEPGPLEEDALHQSVNTNAAASLQKTIDIQSKYW
                     KSIKMVAAARGGALPASQLQEETETVSALASLTVDVEQPFAQEDGRTAGEPMEEEPAL
                     "
     exon            232..294
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            295..536
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            537..687
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            688..814
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            815..936
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1068
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1184
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1307
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1518
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1736
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1997
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2175
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2309
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2430
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2480
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2588
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2644
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2732
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2852
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2950
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3069
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3203
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3288
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3436
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..8195
                     /gene="Hdac9"
                     /gene_synonym="D030072B18Rik; HD7B; HD9; Hdac7b; HDRP;
                     Mitr; mKIAA0744"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagctgctgc ttaccatgga tcttgttgca gcaataagga aaaggctggg aaaataatga
       61 attgaaaata tttgctggac tatggatgta gctcagaggt tgaaaactta caaggtttct
      121 tctctgccat tgccacgtga acaaccattt tcagctgaga gcaggctgtg actctacatc
      181 tgcaaccgtc agcccttctg attcccacaa tgagctcgcc ggtgcagcca gatggagtgg
      241 ccggacggga gcagctcttg gctcagcaaa gaatgcacag tatgatcagc tcagtggacg
      301 tgaaatcaga ggttcctatg ggcctggagc ccatctcacc tttagacctg aggacagatc
      361 tcaggatgat gatgcctgtg gtggatcctg tcgtccgcga gaagcaactg cagcaagagt
      421 tacttcttat tcagcagcag cagcagatcc agaagcagct cctcatagca gagtttcaga
      481 agcagcacga gaatttgaca aggcagcatc aagcacaact ccaggagcac atcaagttac
      541 aacaggaact tctagccata aaacaacagc aagaactcct agaaaaggag cagaaactgg
      601 agcagcagag gcaagaacag gaagtagaga ggcatcgcag agagcagcag cttcctcctc
      661 tcagaggcaa agatagagga cgagaaaggg cagtggcaag cacagaggtt aagcagaagc
      721 ttcaagaatt cctgttgagt aaatcagcaa caaaagacac tccaaccaat ggaaagaatc
      781 attccgtggg ccgccatccc aagctctggt acacggctgc ccaccacaca tcactggatc
      841 aaagctctcc acccctcagt ggaacgtctc catcctacaa gtacacatta ccaggagctc
      901 aagatagcaa ggatgatttc cccttgagaa aaactgcctc agagcccaac ttgaaggtgc
      961 ggtccaggtt aaaacagaaa gtggcagaga ggagaagcag tcccttactc aggcggaagg
     1021 atggaaatct tgtcacttca ttcaagaagc gagtgtttga ggtggcagaa tcctcggtca
     1081 gtagcagctc tccagggtca ggtcccagtt caccaaacaa tggccctgct gggaatgtga
     1141 ccgaaaatga ggcttcagct ctgcctccca cgcctcaccc cgagcaactg gttccacagc
     1201 agcgcatact aattcatgaa gattccatga acctgctaag tctctatacc tccccgtccc
     1261 tgcccaatat cactctggga cttccagcag tgccgtcccc actcaatgct tctaactcac
     1321 tcaaagacaa acagaagtgc gagacacaga tgctcagaca aggtgttcct ctgcccagtc
     1381 agtatggcag tagcattgca gcgtcctcca gccacgttca tgtagcaatg gaaggaaaac
     1441 ccaccagcag ccaccaggct ctcctgcagc acctactgct gaaggaacaa atgcgacagc
     1501 aaaagcttct cgtggctggt ggagttccat tacaccctca gtctcctttg gcaacaaaag
     1561 aaagaatttc accaggcatt agaggtaccc acaaattgcc ccgccaccga cccctgaatc
     1621 gaacccagtc tgcacctttg cctcagagca cgctggctca gctggtcatt cagcagcagc
     1681 accagcagtt cctggagaag cagaaacaat accagcagca gatccacatg aacaaactgc
     1741 tatcgaaatc tattgaacaa ctgaagcaac caggcagcca ccttgaagaa gcagaggagg
     1801 agcttcaggg ggaccaatcc atggaagaca gagcagcctc taaggacaac agtgctagga
     1861 gtgacagcag tgcttgtgtg gaggacacgc tgggacaagt tggggctgtg aaggtcaagg
     1921 aggaacccgt ggacagcgat gaagatgctc agatacagga aatggaatgt ggggagcagg
     1981 ctgcttttat gcaacagcct cccttgctgg agtcctcacg cgcgcgctca ctctccgtgc
     2041 accagactct ggctgcagtt ggcaccgatg gattagagaa acatggtctc ctctcccgga
     2101 cccattcttc tcctgcagcc tccatgtcac ctcacccagc agccgactgt ccccgccagc
     2161 cttcctctgc cactggaatt gcctatgacc ctctgatgct gaaacaccag tgcatctgtg
     2221 gcagctccac gacccaccct gagcacgccg ggcggataca gagcatctgg tcacggctgc
     2281 aagaaacggg gctgctaagt aaatgtgagc gaattcaagg tcgaaaagcc agcctggagg
     2341 aaatacagct tgttcattct gaacatcact cactattgta tggcaccagc cccctggatg
     2401 gacagaagct ggaccccagg acactcttag gtgatgattc tcggaaattc ttttcctcgt
     2461 tgccttgtgg tggactcggg gtggacagtg acaccatttg gaatgagctg cactcgtccg
     2521 gtgctgcacg catggctgtt ggctgtgtca ttgagctggc ttccaaagtg gcctcaggag
     2581 agctgaagaa tgggtttgcc gttgtgaggc ccccaggcca tcatgcggaa gagtctgcag
     2641 ccatggggtt ctgctttttt aattcagttg caattaccgc caaatacttg agagaccaac
     2701 taaatataag caagatattg attgtagatc tggatgttca ccatggaaac ggtacacagc
     2761 aggcctttta tgctgacccc agcatcctgt acatttcact ccatcgctat gatgaaggga
     2821 actttttccc tggcagtgga gccccgaatg aggttggagt aggtctggga gaaggctaca
     2881 atgtaaacat tgcctggaca ggtggcctcg acccccctat gggagatgtt gagtaccttg
     2941 aagcgttcag gactgtcgtg atgcctgtgg ccagagagtt tgatccagat atggtcctgg
     3001 tttctgctgg atttgatgca ttggaaggcc atacccctcc cctcgggggt tacaaagtga
     3061 cagcaaaatg ctttggtcat ttgacgaagc aactgatgac attggctaat ggacgtgtgg
     3121 cattggctct ggaaggagga catgatctga cagctatttg tgatgcatcg gaagcctgca
     3181 taaatgccct tctaggaaat gagcctggtc ctcttgagga agatgctctc caccagtccg
     3241 tgaatacgaa tgcagccgct tctttacaga agaccattga catccaaagc aagtattgga
     3301 agtcaatcaa gatggtggct gctgcaaggg gcggtgctct gcctgcttct cagctgcaag
     3361 aggagacaga gaccgtttct gcgctagcct ccctgacggt agatgtggaa cagccatttg
     3421 ctcaggaaga tggcagaact gctggtgagc ccatggaaga ggagccagcc ttgtgaagtg
     3481 ccaagtctcc cccgatattt cctgtgtgtg acatcattgt gtatcccccc acacacaacc
     3541 ccagcaccct cagacatgtc tgctgcctgg gtggcacagt ttgatggaac ataaacactg
     3601 ggcacaaaat tctgaacagc agcttccctg gttctctgga tgcacttgaa agggcattac
     3661 agattcccga aatgtaacca ctgtgtatct aaagttacag taaccaggat tggaagaaac
     3721 tgtttccagc atgcttttct gctgatgacc cactcccaga cacaaagtgt gagctagaaa
     3781 ccttcaatac agcattcgat attgttcatt tcagaagcta tgacagccag tgaaatttgg
     3841 ggcaaatcct gagacgtacc cattcctgac attctgacca gtgtcttatt gtgtagttta
     3901 ctgtcaagta gacttaaatt gtttacagga cttcttttca gctgtgagtc gctgggaatt
     3961 acagacagat tgctgtgggt tgtagggagt ttttttctct ttgttatact tttgttttgt
     4021 tttgaacttt ttgcctttgt tctaatacac ttcaatccct cctggcaaga agggacctgg
     4081 gataagacgt ttttcctttt tccctttttt ttttgggggg ggggtgcggt ggagccatgg
     4141 tttccctgtg tagccctggc tgttctggaa ctcatgctgt agaccaggct ggctctgaac
     4201 tcagagatcc ccctgcctct gttctaggat caaaggaatg caccaccagc acccagcaac
     4261 aatgaggctt tttttttcct cgatggaaaa aatattacag tgtatctgac agttcaaaag
     4321 gagtttgcac actacgcggg caatgtggca gtattttgtg tctactttta ctggaaattt
     4381 acatctgtct caggttctca ctcacagtat atgagcttgc agtcttgaca ggtaatgagg
     4441 tcgcaccacc ccccatgcag cgccaccttg aggacagtgg ctctggaagt gaatctcttg
     4501 ggagccatgc agcccttgca cagctcagaa cttctcaagg gtggtagcta gctccagctc
     4561 tatctggcgc tcattctctc ttctttcctt ctcagccttt cttgtcaccc ttttagaaaa
     4621 ctcaccccaa cttccccatt actcaggcga tttgagtatt ttatttattt tctttacttt
     4681 tcgggtgaac ccactcgtgt tatcttctgc tgtggaacta ctttagtggg tatagtttaa
     4741 gtgatgccac tgaattccca ggtcttagaa acatgtcaat gaagatgaca acggtctgaa
     4801 gtccttttga atggggctaa gctaagaatt gtgccttcac atgaaaacta acacagaact
     4861 taacctttgc acgggtagta tttccaacaa aggttcaaaa taaaggacat ttaattctga
     4921 gattaaaaac agcttactaa gtaaaatata aacaagttag cccctgcctc tgaaaattgt
     4981 atttcagtgt ataactcaaa acacctaaag acagtgagta gaataccttg catatttaat
     5041 atctgacagt gcttttgaac attgattttt aatgtatttt tcttaactca aaggatatat
     5101 taaagccata agtgaagatt gtcatgcttt tattccgaaa tctgaaagaa accttaatta
     5161 aaacaaggtt ttagggaagg ctaagatatg aaagacatgg aacaatgtgg tttgagttag
     5221 ggaggactcc aacctgtaaa tcaaagatga aagatctcac tcacgtagag tcacataact
     5281 cccctttgtt atacagtcag gccacatttt tcatgcattt ggttttttta ggattaccat
     5341 tttaatttgt aagactttta ttacagatac aaaaatggct tggttcttga tttaacatct
     5401 tagaaatctg agataccctt tgaaatagga aatctgaaat ggaatgtaac ttagtattag
     5461 gtaaaaattg cttacattgc ataagaatta agtcaatcta gatgcataat tgtaataaat
     5521 ttcttgtaaa ttccattttc ttgatatttt agagaaattc aattatattt gctctctctc
     5581 tctctctctc tctctctctc tctcatgtgt gtgtgtttat gtgtgtgtgt gtgtaattag
     5641 cgaagttact ttaaaaatac caaaggctta caaaagacct tttcctttta aagggggaaa
     5701 cgttatcata cttcggaagg tgtacacttg tgaagcttta aaatcagcta cagaaccaca
     5761 ggtccccatg cttgctcttc agtctttgca aatacatttt agaagttggg taatgaagca
     5821 aaacagcagg actatactac tctactgatg ccccagcaac ggcatggcct cagaggctga
     5881 catgtcactc ggacaaagcc aagtcactgg ggcatcttcg tggtagttta gatttaaaaa
     5941 atacatatga aagcattaat cgcacacttc cttcccacca tgtgacaaca gcctgactga
     6001 ctgcaatgca aagtatcaga accctgggag aggaacagat atggtgcctt cagttctcgc
     6061 tatgaccctc tgggcatagt ttcatttgtt taactaaaat cacagaggcc ttgaaaataa
     6121 ggcatctcct cccacaaaaa cttcaaatat tatgggactg gtctctccta atagttcaga
     6181 cttgttttat ttctagaggc caatcacaaa gctttctgag ttcactgggt atctttacag
     6241 actccatatg gggagtgaat atgagtgacc ccgagagtct cctggaagaa aagccttctc
     6301 cacttagcat gtttaagctt ttataaattt tattccatca cttacaatta aggcaattta
     6361 tgtaattggt ttttgttatt atttcccatt taagactttc ctctatttgt ctcagtggaa
     6421 gcatgtttta aaatctaata gtccaaaaga aacctgaaag tggatcattc tgaacttaaa
     6481 aacagccgtt ctgtcaaagt ggcacactgt ctgttctagt cttaacattc tttttctgcc
     6541 tttggaagtg aaataatgtg ctcactacga gagacagaga gagagagaga gagagagagc
     6601 gagagagaga gagagcgagc gagcaagaga gagagagagc gagagagaga gcgagagaga
     6661 gagaaatgac ataactgctt taccacttcc ataaagagag catttttacc accaaaacaa
     6721 aacaaaacac ctagaaaacc agattaaggc tcagaacaga ggcattccgt tgccttcgac
     6781 gctgctcatt acttgtggtg gtggtctcac tcagcattag cccttctctc ttccccaagg
     6841 acactgctat attttggtct ctagtagaaa tctaaactat ttactgccat gtagcagaac
     6901 ttatattgag gatttcatca acttccttaa caccatcact aaaatattta aatgtgtatg
     6961 atgtggctct gttagtcaga tgtatttcca ttggaaatca gagactttgt ctcccagagc
     7021 caacatcttg gttctgctct attgaatatt tcatgagtca ctgagtgact gtgtgtgacc
     7081 agaggattgt gtgtgtgtgt gtgtgtgtat gtatatgtat atatacacat ctccacatgt
     7141 gctaaataag gtcagttgct ttccagaata ctgggaccaa gggccattac atttactgct
     7201 gtacaccctg ctctttgatg gagatagcat tttgtaacag atgacaaggc tgttccagca
     7261 attgaggcct ttattaacct aacatttaat aaaaatgaaa aaaaacaaag gatttaaaag
     7321 ctttataacc tgaagagaaa ttttacttct ttgtgtatgc agagattttt taaagagaga
     7381 gaaagagggg gggggagaga gagaagtcag ttatctcttt ttaaattgta aggttctcaa
     7441 actctttctg gatgagtggc ctcagtgcag accttcactt cagtgcagaa gctgggtgag
     7501 atgagactgt ctttccagtg gtaactgggc ttagcaagtg taccatccaa aatgacagac
     7561 ctttgtgtag gatatgtgcc aggcagtctg tgtcattcaa aactaataac ctgacatttc
     7621 aaatcagttg gactcttcag gcaaatatgc aacaaaagcg tttattattt tgctgattaa
     7681 atgctacacc aggattgctg gagtgaatgc tgataacctg gagtttctgg ttcctgtaat
     7741 gtgaatgtgt cttttgtatc atggtcttgt atctgttaac gtaagaagat caattgattc
     7801 tcctctgtga acaagttgtt ttgcccttaa tttttttttt tttactttca tcaaaatctg
     7861 tcatccagaa cagaaaagta tgcattgcca aacatgaagt tgttctgcca gtggtgtgcg
     7921 cccagatgtg caagctagtg cctaataaag aatgaaaaac taataacagc accattgttg
     7981 cacacgcctt tggaatgttc acctcctttc cgcttccctc ctgttttgtt gtgttgtgtt
     8041 gtgttttgtt ttgtttgtat ttggaaacac ggtatcatgc tccaaagggt ggctgatgtt
     8101 gttagtgtca ccacgccttc agaagaacaa tgacgcccat tttgtgtttt ctactgattt
     8161 cctctagtcc catgtgaata aaagctattt gaaat
//
