LOCUS       NM_027382               1736 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus histone deacetylase 8 (Hdac8), transcript variant 1,
            mRNA.
ACCESSION   NM_027382 XM_135999
VERSION     NM_027382.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1736)
  AUTHORS   Nelson,H.A., Mullins,N.A. and Abell,A.N.
  TITLE     MAP3K4 signaling regulates HDAC6 and TRAF4 coexpression and
            stabilization in trophoblast stem cells
  JOURNAL   J Biol Chem 301 (2), 108116 (2024)
   PUBMED   39710325
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1736)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1736)
  AUTHORS   Fukuda,M., Fujita,Y., Hino,Y., Nakao,M., Shirahige,K. and
            Yamashita,T.
  TITLE     Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem
            Cells in the Subventricular Zone
  JOURNAL   Int J Mol Sci 25 (5), 2540 (2024)
   PUBMED   38473789
  REMARK    GeneRIF: Inhibition of HDAC8 Reduces the Proliferation of Adult
            Neural Stem Cells in the Subventricular Zone.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1736)
  AUTHORS   Xu,Y., Zhu,Y., Wu,Z., Li,S., Shao,M., Tao,Q., Xu,Q., Chen,Y.,
            Shu,Y., Chen,M., Zhou,Y. and Shi,Y.
  TITLE     Hepatocyte-specific HDAC3 ablation promotes hepatocellular
            carcinoma in females by suppressing Foxa1/2
  JOURNAL   BMC Cancer 23 (1), 906 (2023)
   PUBMED   37752418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1736)
  AUTHORS   Zhou,X., Chen,H., Shi,Y., Li,J., Ma,X., Du,L., Hu,Y., Tao,M.,
            Zhong,Q., Yan,D., Zhuang,S. and Liu,N.
  TITLE     Histone deacetylase 8 inhibition prevents the progression of
            peritoneal fibrosis by counteracting the epithelial-mesenchymal
            transition and blockade of M2 macrophage polarization
  JOURNAL   Front Immunol 14, 1137332 (2023)
   PUBMED   36911746
  REMARK    GeneRIF: Histone deacetylase 8 inhibition prevents the progression
            of peritoneal fibrosis by counteracting the epithelial-mesenchymal
            transition and blockade of M2 macrophage polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1736)
  AUTHORS   Chang,S., Young,B.D., Li,S., Qi,X., Richardson,J.A. and Olson,E.N.
  TITLE     Histone deacetylase 7 maintains vascular integrity by repressing
            matrix metalloproteinase 10
  JOURNAL   Cell 126 (2), 321-334 (2006)
   PUBMED   16873063
REFERENCE   7  (bases 1 to 1736)
  AUTHORS   Vega,R.B., Matsuda,K., Oh,J., Barbosa,A.C., Yang,X., Meadows,E.,
            McAnally,J., Pomajzl,C., Shelton,J.M., Richardson,J.A., Karsenty,G.
            and Olson,E.N.
  TITLE     Histone deacetylase 4 controls chondrocyte hypertrophy during
            skeletogenesis
  JOURNAL   Cell 119 (4), 555-566 (2004)
   PUBMED   15537544
REFERENCE   8  (bases 1 to 1736)
  AUTHORS   Chang,S., McKinsey,T.A., Zhang,C.L., Richardson,J.A., Hill,J.A. and
            Olson,E.N.
  TITLE     Histone deacetylases 5 and 9 govern responsiveness of the heart to
            a subset of stress signals and play redundant roles in heart
            development
  JOURNAL   Mol Cell Biol 24 (19), 8467-8476 (2004)
   PUBMED   15367668
REFERENCE   9  (bases 1 to 1736)
  AUTHORS   Ajamian,F., Suuronen,T., Salminen,A. and Reeben,M.
  TITLE     Upregulation of class II histone deacetylases mRNA during neural
            differentiation of cultured rat hippocampal progenitor cells
  JOURNAL   Neurosci Lett 346 (1-2), 57-60 (2003)
   PUBMED   12850547
REFERENCE   10 (bases 1 to 1736)
  AUTHORS   Verdin,E., Dequiedt,F. and Kasler,H.G.
  TITLE     Class II histone deacetylases: versatile regulators
  JOURNAL   Trends Genet 19 (5), 286-293 (2003)
   PUBMED   12711221
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131998.1 and AL954850.12.
            
            On Sep 1, 2015 this sequence version replaced NM_027382.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131998.1, AK011332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1545              AK131998.1         204-1748
            1546-1736           AL954850.12        104318-104508       c
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 45.28 cM"
     gene            1..1736
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /note="histone deacetylase 8"
                     /db_xref="GeneID:70315"
                     /db_xref="MGI:MGI:1917565"
     exon            1..205
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1228
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1; HD8;
                     protein deacetylase HDAC8; protein decrotonylase HDAC8"
                     /codon_start=1
                     /product="histone deacetylase 8 isoform 1"
                     /protein_id="NP_081658.1"
                     /db_xref="CCDS:CCDS41084.1"
                     /db_xref="GeneID:70315"
                     /db_xref="MGI:MGI:1917565"
                     /translation="MEMPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSL
                     IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDC
                     PATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVL
                     GILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVG
                     LGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCS
                     FNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDH
                     EFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV"
     exon            206..258
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            259..389
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..531
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..644
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..722
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..831
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1004
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1099
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1205
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1736
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1736
                     /gene="Hdac8"
                     /gene_synonym="2610007D20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctggggctga acagaggagc aggaactgga gctcaggctg agtctgaaaa ctgttggctc
       61 cagactttgg ctcgcggacg gttggaagtg ggagatggag atgccagagg aacccgccaa
      121 cagtgggcat tcactacccc cggtttatat ttacagtccc gagtatgtca gcatctgcga
      181 ctcccttgtg aaggtcccca aacgggccag tatggtccac tctctgatcg aagcctatgc
      241 cctgcataaa caaatgagga tagtgaagcc caaagtggcc tccatggagg agatggccac
      301 cttccacact gatgcctatc tgcaacatct ccagaaagtc agccaagaag gtgatgagga
      361 ccatccagac tccatagaat atggactagg ttatgactgc ccagccacag aagggatatt
      421 tgactatgca gcagctatag gaggaggtac aatcacagct gcccagtgcc tgattgacgg
      481 gaagtgtaaa gtagccatca actggtctgg agggtggcat catgcaaaga aagatgaagc
      541 atctggtttc tgttatctca atgatgctgt cctgggaata ttacgattgc gacggaaatt
      601 tgaccgtatt ctctacgtgg atttggatct acaccatgga gatggtgtag aagatgcctt
      661 cagttttaca tcgaaggtta tgactgtgtc cctgcacaag ttctccccag gatttttccc
      721 aggaacaggt gacatgtctg atgttggcct ggggaaagga cggtactaca gtgtcaatgt
      781 gcccattcag gatggcatcc aggatgagaa gtactatcac atctgtgaaa gtgtactaaa
      841 agaagtgtac caggccttca atccgaaggc agtggtttta cagctgggag cagatactat
      901 tgccggagat ccaatgtgtt cctttaatat gacaccagtg gggatcggca agtgtctgaa
      961 gtatgtccta cagtggcagc tggcaactct gattttagga ggaggaggct ataaccttgc
     1021 caacacggct cgttgctgga catacttgac cggggtcatc ctagggaaaa cgctatcctc
     1081 tgagatccca gatcatgagt ttttcacagc atatggtcct gattatgtgc tggaaatcac
     1141 gccaagctgc cggccagacc gcaatgagcc ccaccgaatc cagcaaatcc tcaactacat
     1201 caaagggaat ctgaagcatg tggtctagtt gacaaaaaga gatcaggttc ccagagctgg
     1261 gcagcagtgc ctataatgaa gacagtgtgt tgatgcaagc ggtttgtgga atttgtgact
     1321 gcaggggaaa tttggaagaa attacttcct gaaaatttcc aaggggcacc aagtggcagc
     1381 tggcctcctg gggtgaggag ccaggcaccc cggagccagg cctaagggga agaagaagat
     1441 agccagtgtt taaagtgttt attttaaaac acaaatgcag tttttaatgg ttcaaaatta
     1501 tttttaagca agttgggggg aagaatttta tcttcataaa ggggacaagt caggagctgc
     1561 agaagagtgg ggttgggtag gggggtcagc agatgggcag gttcggccct cggggccatt
     1621 tagatagaga cctgtggggg aggggtatca gcagactggg aggtaaggag gagtctacca
     1681 cttttgtttt agtatgatgc actccagttg ttcttaataa aagttttgaa aatgta
//
