LOCUS       NM_001411604            4056 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus histone deacetylase 6 (Hdac6), transcript variant 3,
            mRNA.
ACCESSION   NM_001411604
VERSION     NM_001411604.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4056)
  AUTHORS   Deng,M., Tan,X., Peng,X., Zheng,W., Fu,R. and Tao,S.
  TITLE     HDAC6 promotes inflammation in lupus nephritis mice by regulating
            transcription factors MAFF and KLF5 in renal fibrosis
  JOURNAL   Ren Fail 46 (2), 2415517 (2024)
   PUBMED   39412062
  REMARK    GeneRIF: HDAC6 promotes inflammation in lupus nephritis mice by
            regulating transcription factors MAFF and KLF5 in renal fibrosis.
REFERENCE   2  (bases 1 to 4056)
  AUTHORS   Liu,Y., Wang,X., Wang,J., Jin,Q., Cai,W., Pan,C., Nivar,J., Tao,Y.,
            Cao,H. and Li,J.
  TITLE     ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway
  JOURNAL   Exp Neurol 380, 114922 (2024)
   PUBMED   39142371
  REMARK    GeneRIF: ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway.
REFERENCE   3  (bases 1 to 4056)
  AUTHORS   Fang,J., Shu,S., Dong,H., Yue,X., Piao,J., Li,S., Hong,L. and
            Cheng,X.W.
  TITLE     Histone deacetylase 6 controls cardiac fibrosis and remodelling
            through the modulation of TGF-beta1/Smad2/3 signalling in
            post-infarction mice
  JOURNAL   J Cell Mol Med 28 (17), e70063 (2024)
   PUBMED   39232846
  REMARK    GeneRIF: Histone deacetylase 6 controls cardiac fibrosis and
            remodelling through the modulation of TGF-beta1/Smad2/3 signalling
            in post-infarction mice.
REFERENCE   4  (bases 1 to 4056)
  AUTHORS   Zhou,H., Wu,R. and Li,H.
  TITLE     Downregulation of HDAC6 mitigates lung ischemia/reperfusion injury
            depending on activation of Nrf2/HO-1 signaling pathway and
            inactivation of ERK/NF-kappaB signaling pathway
  JOURNAL   Tissue Cell 89, 102446 (2024)
   PUBMED   38936199
  REMARK    GeneRIF: Downregulation of HDAC6 mitigates lung
            ischemia/reperfusion injury depending on activation of Nrf2/HO-1
            signaling pathway and inactivation of ERK/NF-kappaB signaling
            pathway.
REFERENCE   5  (bases 1 to 4056)
  AUTHORS   Wang,B., Liu,S., Hao,K., Wang,Y., Li,Z., Lou,Y., Chang,Y. and Qi,W.
  TITLE     HDAC6 modulates the cognitive behavioral function and hippocampal
            tissue pathological changes of APP/PS1 transgenic mice through
            HSP90-HSF1 pathway
  JOURNAL   Exp Brain Res 242 (8), 1983-1998 (2024)
   PUBMED   38935089
  REMARK    GeneRIF: HDAC6 modulates the cognitive behavioral function and
            hippocampal tissue pathological changes of APP/PS1 transgenic mice
            through HSP90-HSF1 pathway.
REFERENCE   6  (bases 1 to 4056)
  AUTHORS   Verdel,A., Curtet,S., Brocard,M.P., Rousseaux,S., Lemercier,C.,
            Yoshida,M. and Khochbin,S.
  TITLE     Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the
            cytoplasm
  JOURNAL   Curr Biol 10 (12), 747-749 (2000)
   PUBMED   10873806
REFERENCE   7  (bases 1 to 4056)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   8  (bases 1 to 4056)
  AUTHORS   Derry,J.M., Gormally,E., Means,G.D., Zhao,W., Meindl,A.,
            Kelley,R.I., Boyd,Y. and Herman,G.E.
  TITLE     Mutations in a delta 8-delta 7 sterol isomerase in the tattered
            mouse and X-linked dominant chondrodysplasia punctata.
            jderry@immunex.com
  JOURNAL   Nat Genet 22 (3), 286-290 (1999)
   PUBMED   10391218
REFERENCE   9  (bases 1 to 4056)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   10 (bases 1 to 4056)
  AUTHORS   Verdel,A. and Khochbin,S.
  TITLE     Identification of a new family of higher eukaryotic histone
            deacetylases. Coordinate expression of differentiation-dependent
            chromatin modifiers
  JOURNAL   J Biol Chem 274 (4), 2440-2445 (1999)
   PUBMED   9891014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670169.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1955959.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL670169.9         49650-49872         c
            224-343             AL670169.9         49200-49319         c
            344-472             AL670169.9         48978-49106         c
            473-561             AL670169.9         48738-48826         c
            562-646             AL670169.9         46789-46873         c
            647-687             AL670169.9         46649-46689         c
            688-784             AL670169.9         45716-45812         c
            785-882             AL670169.9         45462-45559         c
            883-987             AL670169.9         44108-44212         c
            988-1056            AL670169.9         43919-43987         c
            1057-1183           AL670169.9         41993-42119         c
            1184-1249           AL670169.9         41835-41900         c
            1250-1309           AL670169.9         41681-41740         c
            1310-1399           AL670169.9         41518-41607         c
            1400-1506           AL670169.9         40461-40567         c
            1507-1574           AL670169.9         40301-40368         c
            1575-1743           AL670169.9         39918-40086         c
            1744-1872           AL670169.9         39702-39830         c
            1873-2041           AL670169.9         39379-39547         c
            2042-2175           AL670169.9         39017-39150         c
            2176-2244           AL670169.9         38457-38525         c
            2245-2437           AL670169.9         38145-38337         c
            2438-2587           AL670169.9         36247-36396         c
            2588-2762           AL670169.9         34138-34312         c
            2763-3256           AL670169.9         33541-34034         c
            3257-3358           AL670169.9         33355-33456         c
            3359-3505           AL670169.9         33084-33230         c
            3506-3638           AL670169.9         32855-32987         c
            3639-4056           AL670169.9         32195-32612         c
FEATURES             Location/Qualifiers
     source          1..4056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.58 cM"
     gene            1..4056
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /note="histone deacetylase 6"
                     /db_xref="GeneID:15185"
                     /db_xref="MGI:MGI:1333752"
     exon            1..223
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            224..343
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            344..472
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            473..561
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            562..646
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            647..687
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            688..784
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..882
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            883..987
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1056
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1183
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1249
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1309
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1399
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1506
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1574
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1743
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1872
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2041
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2175
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2244
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2437
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2587
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2762
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..3256
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3358
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3505
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3638
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..4056
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4027..4032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /note="hexamer: AATAAA"
     polyA_site      4056
                     /gene="Hdac6"
                     /gene_synonym="Hd6; Hdac5; mHDA2; Sfc6"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcgga gcagcggggc acggggaaag ctcggggcga gatctgcgcg agtggaaggc
       61 gctggttcgg ccctgcagga ggtggagttg agtgagtctt taaaggtgct gccgaggccg
      121 cggcagcccg gtctggcgga ctagaaaggt gggtgatttt tctggggaaa taggctgaag
      181 cgggcaggtt gcagaagcca agcgttccgg gcgcagatta gagagccttt ccaggagctg
      241 aggctcttca gccatgacct ccaccggcca agattcttct actagacagc gaaagagtag
      301 gcacaatccc cagtcacccc ttcaggaatc cagcgccacc ttgaagcgtg gtggaaagaa
      361 gtgtgctgta ccccactcca gccccaatct agcggaggta aagaagaaag gcaaaatgaa
      421 gaagctgagc caaccagctg aagaggacct agttgtgggg cttcaagggc tggatctgaa
      481 ccctgagaca agagtgccag ttggtactgg attggtgttt gatgaacaac taaatgactt
      541 ccattgcctt tgggatgaca gcttccctga aagccctgag cggctccatg ccatcagaga
      601 gcaactgatc ctggagggcc tcctgggccg ctgtgtgtcc tttcaggccc ggttcgctga
      661 gaaggaggag ctgatgttgg ttcacagcct ggaatacatt gatctgatgg agacaaccca
      721 gtacatgaat gaaggggagc ttcgagtact ggcagaaacc tatgattcag tgtatctgca
      781 tccgaactca tattcctgtg cctgcctggc tacaggctct gtcctccggc tggtagatgc
      841 actcatgggg gctgagattc ggaatggcat ggccgtcatc aggcctcctg gacaccatgc
      901 tcagcacaat cttatggatg ggtattgcat gttcaaccat ctggctgtgg ctgcccgcta
      961 tgcgcaaaag aagcaccgca ttcagagggt tctcatcgtg gactgggatg tgcaccatgg
     1021 tcaaggaaca cagttcatct tcgaccagga ccccagtgtc ctttatttct ccatccaccg
     1081 atatgaacat ggtcgcttct ggccccacct taaggcttct aactggtcca ctataggttt
     1141 tggccaaggc caaggatata ccatcaatgt accttggaac cagacgggca tgcgggacgc
     1201 tgactacatt gctgctttcc tgcacatcct gctgccagtt gcctcggagt ttcagcctca
     1261 actggtcttg gtggccgctg gatttgatgc cctccacgga gaccccaagg gagagatggc
     1321 tgccacgcca gcaggatttg cccacctaac ccatttgctc atgggtttgg caggaggcaa
     1381 gttgattctg tccctggagg gtggctataa cctccgtgcc ctggctaagg gagtcagtgc
     1441 ttcactccac acccttcttg gagacccttg ccccatgctg gagtcctgtg ttgtaccttg
     1501 tgcaagcgcc cagacttcca tctactgcac tctagaagcc cttgaaccct tctgggaggt
     1561 cctggagaga tcagttgaga cccaggagga agatgaagtg gaagaagccg tgctagaaga
     1621 ggaggaggag gaaggtggct gggaggccac tgcactgccc atggatacat ggccactgct
     1681 ccagaaccgc actgggctgg tctatgatga gaagatgatg agtcactgca acctctggga
     1741 caatcatcac cctgagacac ctcagcgcat cttacgcatc atgtgtcacc tggaggaggt
     1801 gggccttgcg gctcgctgtc tcatcctacc tgctcggcct gccctggact ctgagctcct
     1861 tacctgccac agtgctgagt acgtggagca tctccgcacc acagaaaaga tgaaaacccg
     1921 ggatctgcac cgtgaaggtg ccaactttga ctccatctac atctgcccca gcacctttgc
     1981 ctgcgcaaag cttgccacag gcgctgcctg ccgcctggtg gaagctgtgc tctcgggaga
     2041 ggttctaaat ggcattgcag tagtgcgccc tccaggacac cacgcggagc caaatgctgc
     2101 ctgtggtttc tgctttttca actcagtagc tgtagctgct cgccatgccc agatcattgc
     2161 tggacgtgcc ctgcggatcc taatcgtgga ttgggatgtt catcatggta atggaactca
     2221 gcacatattt gaggatgacc ctagtgtatt atacgtgtcc ctgcaccggt atgaccgtgg
     2281 cactttcttc cccatggggg atgagggtgc cagtagccaa gtaggccgag atgcaggtat
     2341 aggcttcact gtcaatgtgc cctggaatgg gccccgcatg ggtgatgctg attacctggc
     2401 tgcatggcat cgtctggtac ttcccatcgc ctatgagttt aacccagaac tggtgctgat
     2461 ctcagctggc tttgatgctg cacaagggga tccgctgggg ggctgccaag taacaccgga
     2521 gggttatgcc cacctcaccc acctactgat gggccttgct ggtggccgta ttattcttat
     2581 tctagagggt ggatacaatt tggcatctat ctctgagtct atggctgcct gcacccattc
     2641 cctccttgga gacccaccac cccagcttac tttgctgcga ccgccacagt caggagccct
     2701 ggtttcaatc agtgaggtca tccaagtcca tcgcaaatac tggcgcagtt tgcggttgat
     2761 gaaaatggaa gacaaggaag aatgctctag ttctaggctt gtcatcaaga agttgccccc
     2821 aacagccagt cctgtatcag ctaaggaaat gaccacaccg aaaggaaagg ttcctgaaga
     2881 aagcgtgagg aagaccatag cagcactacc tgggaaagag tctactctag gccaggctaa
     2941 atcaaagatg gctaaggctg tgcttgctca gggccagtcc tcagaacaag ctgctaaggg
     3001 aactacactg gatctggcta cctcaaagga gactgtggga ggagccacga cggacctgtg
     3061 ggcctcagca gctgctcctg aaaacttccc taaccagacc acctctgtgg aggctttggg
     3121 agaaactgag ccaacgcctc cagcctcgca tacaaacaag cagaccacag gggcttcacc
     3181 tctgcaggga gtcacggctc agcagtccct acagcttggg gttctcagca ctttggagct
     3241 aagcagagaa gcagaggaag cccatgattc tgaggagggc ctgctagggg aagccgctgg
     3301 aggtcaggac atgaacagct tgatgctgac acaaggattt ggggacttta atacccagga
     3361 tgtattttat gctgtgaccc cactatcctg gtgtccccat ttgatggcag tatgccccat
     3421 tcctgcagca ggcctagatg tgtcccaacc ttgtaagacc tgtggaacag tccaggagaa
     3481 ctgggtgtgt ctgacttgct atcaggtgta ctgcagtcgc tatgtcaatg cccatatggt
     3541 ctgccaccat gaagcctctg aacacccgct ggtcctcagc tgtgttgacc tgtctacctg
     3601 gtgttatgtc tgtcaggctt atgtccacca cgaggtgaga tctccaagat gtgaagaacg
     3661 ctgcccacca gaacaagttt ggggaggaca tgccccactc acactaaatc ccagaccaca
     3721 ctgcctgttt cccttctgag gccacaggca gggcagctta gttcaccgca gtccgtacct
     3781 tggataaggg gcctcacttg aacccatctt gaataccctt tgccaggtgc ttatttaagt
     3841 acaaatcctt ttcaaaggac tctagtgttc agttgttgat gtgcccctgc ccactgcctg
     3901 ctcgaggaat acctctgttc tacccagaag gagggaggga cagcttagta gccctaggaa
     3961 ggagctgaga tcacaaggat gacattgaag gagacaacgg ggcagtggca gcaggtcagc
     4021 atatttaata aagttggagt tgctacaaaa cctgaa
//
