LOCUS       NM_001405232            5560 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus histone deacetylase 5 (Hdac5), transcript variant 7,
            mRNA.
ACCESSION   NM_001405232 XM_030245582
VERSION     NM_001405232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5560)
  AUTHORS   Li,N., Liu,T., Wang,Y.Y., Xu,T., Shi,H.J., Chang,L. and Zhu,L.J.
  TITLE     Hippocampal HDAC5-mediated histone acetylation underlies stress
            susceptibility in mice exposed to chronic social defeat stress
  JOURNAL   Neuroscience 557, 89-99 (2024)
   PUBMED   39127342
  REMARK    GeneRIF: Hippocampal HDAC5-mediated histone acetylation underlies
            stress susceptibility in mice exposed to chronic social defeat
            stress.
REFERENCE   2  (bases 1 to 5560)
  AUTHORS   Zhao,Y., Wang,H., Tang,Y., Wang,J., Wu,X., He,Z., He,Y. and Tang,Z.
  TITLE     SNHG16/miR-205/HDAC5 is involved in the progression of renal
            fibrosis
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23617 (2024)
   PUBMED   38079211
  REMARK    GeneRIF: SNHG16/miR-205/HDAC5 is involved in the progression of
            renal fibrosis.
REFERENCE   3  (bases 1 to 5560)
  AUTHORS   Zhu,C., Piao,Z. and Jin,L.
  TITLE     HDAC5 inhibition attenuates ventricular remodeling and cardiac
            dysfunction
  JOURNAL   Orphanet J Rare Dis 18 (1), 266 (2023)
   PUBMED   37667300
  REMARK    GeneRIF: HDAC5 inhibition attenuates ventricular remodeling and
            cardiac dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5560)
  AUTHORS   Kim,S.J., Hotta-Hirashima,N., Asano,F., Kitazono,T., Iwasaki,K.,
            Nakata,S., Komiya,H., Asama,N., Matsuoka,T., Fujiyama,T., Ikkyu,A.,
            Kakizaki,M., Kanno,S., Choi,J., Kumar,D., Tsukamoto,T.,
            Elhosainy,A., Mizuno,S., Miyazaki,S., Tsuneoka,Y., Sugiyama,F.,
            Takahashi,S., Hayashi,Y., Muratani,M., Liu,Q., Miyoshi,C.,
            Yanagisawa,M. and Funato,H.
  TITLE     Kinase signalling in excitatory neurons regulates sleep quantity
            and depth
  JOURNAL   Nature 612 (7940), 512-518 (2022)
   PUBMED   36477539
REFERENCE   5  (bases 1 to 5560)
  AUTHORS   Sharma,P., Karnam,K., Mahale,A., Sedmaki,K., Krishna Venuganti,V.
            and Kulkarni,O.P.
  TITLE     HDAC5 RNA interference ameliorates acute renal injury by
            upregulating KLF2 and inhibiting NALP3 expression in a mouse model
            of oxalate nephropathy
  JOURNAL   Int Immunopharmacol 112, 109264 (2022)
   PUBMED   36183679
  REMARK    GeneRIF: HDAC5 RNA interference ameliorates acute renal injury by
            upregulating KLF2 and inhibiting NALP3 expression in a mouse model
            of oxalate nephropathy.
REFERENCE   6  (bases 1 to 5560)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   7  (bases 1 to 5560)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
REFERENCE   8  (bases 1 to 5560)
  AUTHORS   Kao,H.Y., Downes,M., Ordentlich,P. and Evans,R.M.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
REFERENCE   9  (bases 1 to 5560)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   10 (bases 1 to 5560)
  AUTHORS   Verdel,A. and Khochbin,S.
  TITLE     Identification of a new family of higher eukaryotic histone
            deacetylases. Coordinate expression of differentiation-dependent
            chromatin modifiers
  JOURNAL   J Biol Chem 274 (4), 2440-2445 (1999)
   PUBMED   9891014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 21, 2022 this sequence version replaced XM_030245582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3049775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL954730.15        63571-63708         c
            139-360             AL954730.15        58300-58521         c
            361-898             AL954730.15        51982-52519         c
            899-1158            AL954730.15        40473-40732         c
            1159-1303           AL954730.15        40196-40340         c
            1304-1418           AL954730.15        39988-40102         c
            1419-1549           AL954730.15        39356-39486         c
            1550-1696           AL954730.15        39051-39197         c
            1697-1809           AL954730.15        38850-38962         c
            1810-1941           AL954730.15        38398-38529         c
            1942-2164           AL954730.15        37997-38219         c
            2165-2376           AL954730.15        36110-36321         c
            2377-2658           AL954730.15        35619-35900         c
            2659-2830           AL954730.15        34799-34970         c
            2831-2964           AL954730.15        33966-34099         c
            2965-3085           AL954730.15        33535-33655         c
            3086-3135           AL954730.15        33202-33251         c
            3136-3243           AL954730.15        32932-33039         c
            3244-3299           AL954730.15        32571-32626         c
            3300-3387           AL954730.15        32363-32450         c
            3388-3507           AL954730.15        31232-31351         c
            3508-3605           AL954730.15        30905-31002         c
            3606-3724           AL954730.15        30625-30743         c
            3725-3858           AL954730.15        30105-30238         c
            3859-3943           AL954730.15        29804-29888         c
            3944-4109           AL954730.15        29518-29683         c
            4110-5560           AL954730.15        27984-29434         c
FEATURES             Location/Qualifiers
     source          1..5560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.82 cM"
     gene            1..5560
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /note="histone deacetylase 5"
                     /db_xref="GeneID:15184"
                     /db_xref="MGI:MGI:1333784"
     exon            1..138
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            139..360
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            361..898
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     CDS             748..4149
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /EC_number="3.5.1.98"
                     /note="isoform 6 is encoded by transcript variant 7;
                     histone deacetylase mHDA1; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 5 isoform 6"
                     /protein_id="NP_001392161.1"
                     /db_xref="GeneID:15184"
                     /db_xref="MGI:MGI:1333784"
                     /translation="MLLVPKAQGLVEMLQTIYETESCFSADGMSGREPSLEILPRTPL
                     HSIPVAVEVKPVLPGAMPSSMGGGGGGSPSPVELRGALAGPMDPALREQQLQQELLVL
                     KQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKRQQELEQQRQREQQ
                     RQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLP
                     QHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSRDDFPLRKTASEPNLKVR
                     SRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSSVCNSAPGSGPSSPNS
                     SHSTIAENGFTGSVPNIPTEMIPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTV
                     TNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDTSPHG
                     HASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQS
                     SPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPEETEEEL
                     TEQQEALLGEGALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGESGPDE
                     GPDLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKSPT
                     DQPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCER
                     IRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVD
                     SDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFF
                     NSVAITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPG
                     SGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFSPDVVLVSA
                     GFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV
                     SALLSVELQPLDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFAAGLGCSLREAQT
                     GEKEEAETVSAMALLSVGAEQAQAVATQEHSPRPAEEPMEQEPAL"
     exon            899..1158
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1303
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1418
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1549
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1696
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1809
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1941
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2164
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2376
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2658
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2830
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2964
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3085
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3135
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3243
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3299
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3387
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3507
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3605
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3724
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3858
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..3943
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4109
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..5560
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4211..4216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /note="hexamer: AACAAA"
     polyA_site      4231
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /note="major polyA site"
     regulatory      5528..5533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /note="hexamer: AATAAA"
     polyA_site      5560
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
ORIGIN      
        1 gttgttgttg gtggcggcgg cgagcggagc cggaggagcc gccgcaaaga tggaggagcc
       61 gtcgaggagg cgctgccgct gctgttgccg ccgctgctgc cgccgccgcc cgcgaagccg
      121 gagctcgagc cgcagcgggg atgccgttct gagtgcctga ctgcctcgcc ccgccccgaa
      181 ggatggcctt ggatgggcat tagaggcact gcggccctgg gctcgggctc ctgtcccgtc
      241 cgtctgtctg ttatcgtctg tctctcttga catcacagca gctccgcccc ctcccgtccc
      301 agcccccaac gtcagcttcc tgcaggccca gagccggcat gaactctccc aacgagtcgg
      361 tctcctgcca gctgccggcg gctcattcgg ggaggaggag cagggagcca agcccagagc
      421 tgtcaccggt ggctctggga gggaacacag agagagcctg cctgcccact gagctcccct
      481 tcctgtcccc tgagcaccca gccatagccc aactcctgga acctttggac agactttggt
      541 ccacgctcct ggagcggaga gcaggccctt cagcctcatt agcctccctg cgtctgctgc
      601 ctccggagcg cgcccaggcc ggatgaggtg cctccttgcc tcgtgggtcc cagcggcagt
      661 ggcctgaggg agtccttgag cagccagctg gccccgctga ccaccttttc cctcaccggc
      721 ttccgcctcg ggcggcccct ccctggcatg ctgctggtgc ccaaggcaca ggggcttgtg
      781 gagatgctgc agaccatcta tgagaccgag tcctgtttct cagcagatgg catgtcaggc
      841 cgggaaccat ccttggaaat cctgccacgg actcctctgc acagcatccc tgtggcagtg
      901 gaggtgaagc cggtgctgcc aggagccatg cccagctcca tggggggtgg aggtggaggt
      961 agccccagcc ccgtggagct tcggggggct ctggcgggcc ccatggaccc tgcgctacgg
     1021 gagcagcaac tgcagcagga gctcctggtc ctcaagcagc agcagcagct ccagaagcag
     1081 ctcctgttcg ccgagttcca gaagcagcac gaccacttga cgcggcagca cgaggtccag
     1141 ctgcagaagc acctcaagca gcagcaggag atgctggcgg ctaagaggca gcaggagctg
     1201 gagcagcagc ggcagcggga gcagcagcgg caggaggagc tggagaaaca gcggctggag
     1261 cagcagctgc tcatcctgcg caacaaggag aagagcaaag agagtgccat cgccagcacc
     1321 gaggtaaagc tgaggctcca ggaattcctg ttgtccaagt caaaggagcc cacgccaggc
     1381 ggcctcaacc attccctccc acagcacccc aaatgctggg gagcccacca cgcttctttg
     1441 gaccagagtt cccctcccca gagcggccct cctgggacgc ctccctccta caaattgcct
     1501 ttgcttgggc cctatgacag ccgtgatgac tttcccctcc gtaaaacggc ctcggaaccc
     1561 aacttaaaag tacgttcgag gctaaaacag aaggtagccg agaggagaag cagtcccctc
     1621 ctgcgtcgaa aggatggcac tgttattagt acttttaaga agagagcagt tgagatcacc
     1681 ggcacggggc ctggggtgtc gtccgtgtgt aacagtgcgc ccggctctgg ccccagctct
     1741 cccaacagtt cccacagcac catcgctgag aacggcttta ctggctcagt ccccaacatc
     1801 cccactgaga tgatccccca gcaccgggcc ctccctctgg acagttcccc aaaccagttc
     1861 agcctctata cgtctccttc tctgcccaac atctccctag ggctgcaggc cactgtcact
     1921 gtcaccaact cgcacctcac cgcctccccg aagctgtcaa cacagcagga ggctgagagg
     1981 caggcccttc agtccctgcg gcagggcggc acactgaccg gcaagttcat gagcacatcc
     2041 tccatccctg gctgcctgtt gggagtggca ctggagggtg acacaagccc ccacgggcac
     2101 gcttccctgc tgcagcacgt tttgctcctg gagcaggccc ggcaacagag cacgctcata
     2161 gcagtgccgc tccatgggca gtccccactg gtgacgggtg aacgtgtggc caccagcatg
     2221 aggacggtgg gtaagctccc gaggcaccga cctctgagcc gcactcagtc ctccccgctg
     2281 ccgcagagtc cccaggccct gcagcagctg gtcatgcagc agcagcacca gcagttcctg
     2341 gagaagcaga agcagcagca gatgcagctg ggcaagatcc ttaccaaaac tggggagctg
     2401 tcaaggcagc ccaccactca cccggaggag acagaagagg agctgacgga gcagcaggag
     2461 gccttgctgg gagagggggc cctgaccatt ccccgggaag gctctacaga aagtgagagc
     2521 acccaggaag acctagaaga ggaggaggag gaggaggagg aggaagagga ggactgcatt
     2581 caggtcaagg atgaggatgg cgagagtggt cctgatgaag gccctgactt agaagagtcc
     2641 agtgctggtt acaaaaagtt gttcgcagat gcccagcagt tacagcccct ccaggtgtac
     2701 caggcacccc tcagcctggc cactgtgcct catcaggccc tgggccgcac ccagtcctca
     2761 cctgctgctc ctgggagcat gaagagcccc acagaccaac ccactgtggt gaagcacctc
     2821 ttcaccacag gtgtggtcta tgacacgttc atgctgaagc accagtgtat gtgcggaaac
     2881 acacacgtgc acccagagca cgccggccgc atccagagca tctggtcccg gctgcaggaa
     2941 actggtctgc tcggcaagtg tgagcggatc cggggtcgta aagccacact ggatgaaatc
     3001 cagaccgtgc actctgagta ccacaccctg ctctatggga ccagccccct taaccggcag
     3061 aagctggaca gcaagaagct gcttggcccc atcagccaga agatgtacgc catgctgccc
     3121 tgtgggggca ttggggtgga cagtgacacg gtgtggaatg agatgcactc ctcaagtgcc
     3181 gtgcgaatgg cagtgggctg cctggtggag ctggccttca aggtggctgc aggagagctc
     3241 aagaatggat ttgctatcat ccggccccca ggacaccatg ctgaggagtc cacagccatg
     3301 ggattctgct tcttcaactc cgtagccatc acagctaaac tcctgcagca gaagctgagc
     3361 gtgggcaagg tcctcatcgt ggactgggat attcaccatg gcaacggcac ccagcaagca
     3421 ttctacaacg atccctctgt gctctacatc tccctgcatc gctacgacaa cgggaacttc
     3481 tttccaggct ctggggctcc tgaagaggtt ggtggagggc caggtgtggg gtacaacgta
     3541 aatgtggcgt ggacaggagg tgtggatccc cccattggag atgtggaata cctgacagcc
     3601 ttcaggacag tggtgatgcc cattgcccag gagttctcac ctgacgtcgt cctagtctcc
     3661 gctgggtttg atgctgttga aggacatctg tctccactgg gtggctattc tgtcaccgcc
     3721 agatgttttg gccacttgac caggcagctc atgacactgg ctgggggccg ggtggtgctg
     3781 gccctggagg gaggccatga cttgaccgcc atctgtgatg cctctgaggc ctgtgtctcg
     3841 gctctgctca gcgtggagct gcagcccttg gatgaagcag tcttgcagca aaagcccagc
     3901 gtcaatgcgg ttgccacact agagaaagtc atcgagatcc agagcaaaca ctggagctgt
     3961 gtacagaggt ttgccgctgg tctgggctgc tcgctgcggg aggctcagac aggtgagaaa
     4021 gaggaggccg agactgtgag cgccatggcc ctgctttccg tgggggctga gcaggcccag
     4081 gctgttgcca ctcaagagca cagccccagg ccagcagagg agcccatgga gcaggagcct
     4141 gccctgtgac accctggccc ccatccctct gggcttcatc attgtgattt tgtttatttt
     4201 ttctattaaa aacaaaaagt cacacattca acaacgtgtg ccgtgtgggt ctctcagcct
     4261 cgcccgcctc caagctgttt cagaaccccc tcccactaca agggccctgg gtcagctttc
     4321 gaatccattc cttctatggg gcattgggtg cagtacccac tttgcccatg ttgtatccca
     4381 tacccaattc cccgtactct tctaccgtgg acagtgctcc aggcagtact gccaactctg
     4441 gagctgcctg agatgggaac agtgattggt gcctggactt cagttggctt ttggggaatg
     4501 ccttaatttg aaatctgccc ctctccaccc tcaggatgat gtactaccat ttaagatgca
     4561 gaatcgaggg aaggtaggcg tccaccccaa actttccctt cctctctatc tccctcacca
     4621 ttctgcagac tctcctcttt ggcctcagca ctgaagactc gtgcccagga tgtaggcctt
     4681 agacttgtgg ccaggcttct tgtctcttac tcctgagtat cccaggagct caaagggtac
     4741 cgggtggtgt gcagcggggt tagaaggggc caggaggacc tgcgtatgca ggcaggttct
     4801 ccactttttt tctattaaac tctccgtctt gtgctggacc agtataagga ggggagaagg
     4861 tagaccctgc atgggggctt caggttcatg caagcccctc tgatgttctg ggccagattt
     4921 tctccatcca tcagcctgct gcaagcagaa gggtcaagat ccagctccct tctggagcct
     4981 ttttgctttg aaacctgggg atcgtgaaag acagggtaga tatagttcta gaatagacag
     5041 ggccagaacc ctgtctagaa gccacccctg tcccccagag gtgttggggg ggggggagtc
     5101 cagctctcag caggaggttg ttaggagcta tccatctttt ccagtagcct tgtgtccaga
     5161 ggctggagcc cacagacttc cagtgaatgt ggtctagcct gtaggaaacc aaagatggga
     5221 aatggctcct aaggggccaa tttttcttcc cctataccac atccccaggg ctcagctatc
     5281 tgtttccata ttgtccgtat ggggcctgag cagggctgag ggagctgggg agtcccacca
     5341 ctattagttt tctgtgtgtt tgcgtgctgt ctgtatcatc cttgcactga accagaggct
     5401 gctcacctcc cactctctcc ccgtaggctg atcttatcct gtgccaaccc actcctgctt
     5461 tgtctccctg gacatggatt ttagttcagt agtttgtatc ccaacacatg gtttttgtct
     5521 tcgtgtaaat aaacttattt gtggcagtgc tttctgggaa
//
