LOCUS       NP_001392161            1133 aa            linear   ROD 01-MAY-2025
DEFINITION  histone deacetylase 5 isoform 6 [Mus musculus].
ACCESSION   NP_001392161 XP_030101442
VERSION     NP_001392161.1
DBSOURCE    REFSEQ: accession NM_001405232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1133)
  AUTHORS   Li,N., Liu,T., Wang,Y.Y., Xu,T., Shi,H.J., Chang,L. and Zhu,L.J.
  TITLE     Hippocampal HDAC5-mediated histone acetylation underlies stress
            susceptibility in mice exposed to chronic social defeat stress
  JOURNAL   Neuroscience 557, 89-99 (2024)
   PUBMED   39127342
  REMARK    GeneRIF: Hippocampal HDAC5-mediated histone acetylation underlies
            stress susceptibility in mice exposed to chronic social defeat
            stress.
REFERENCE   2  (residues 1 to 1133)
  AUTHORS   Zhao,Y., Wang,H., Tang,Y., Wang,J., Wu,X., He,Z., He,Y. and Tang,Z.
  TITLE     SNHG16/miR-205/HDAC5 is involved in the progression of renal
            fibrosis
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23617 (2024)
   PUBMED   38079211
  REMARK    GeneRIF: SNHG16/miR-205/HDAC5 is involved in the progression of
            renal fibrosis.
REFERENCE   3  (residues 1 to 1133)
  AUTHORS   Zhu,C., Piao,Z. and Jin,L.
  TITLE     HDAC5 inhibition attenuates ventricular remodeling and cardiac
            dysfunction
  JOURNAL   Orphanet J Rare Dis 18 (1), 266 (2023)
   PUBMED   37667300
  REMARK    GeneRIF: HDAC5 inhibition attenuates ventricular remodeling and
            cardiac dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1133)
  AUTHORS   Kim,S.J., Hotta-Hirashima,N., Asano,F., Kitazono,T., Iwasaki,K.,
            Nakata,S., Komiya,H., Asama,N., Matsuoka,T., Fujiyama,T., Ikkyu,A.,
            Kakizaki,M., Kanno,S., Choi,J., Kumar,D., Tsukamoto,T.,
            Elhosainy,A., Mizuno,S., Miyazaki,S., Tsuneoka,Y., Sugiyama,F.,
            Takahashi,S., Hayashi,Y., Muratani,M., Liu,Q., Miyoshi,C.,
            Yanagisawa,M. and Funato,H.
  TITLE     Kinase signalling in excitatory neurons regulates sleep quantity
            and depth
  JOURNAL   Nature 612 (7940), 512-518 (2022)
   PUBMED   36477539
REFERENCE   5  (residues 1 to 1133)
  AUTHORS   Sharma,P., Karnam,K., Mahale,A., Sedmaki,K., Krishna Venuganti,V.
            and Kulkarni,O.P.
  TITLE     HDAC5 RNA interference ameliorates acute renal injury by
            upregulating KLF2 and inhibiting NALP3 expression in a mouse model
            of oxalate nephropathy
  JOURNAL   Int Immunopharmacol 112, 109264 (2022)
   PUBMED   36183679
  REMARK    GeneRIF: HDAC5 RNA interference ameliorates acute renal injury by
            upregulating KLF2 and inhibiting NALP3 expression in a mouse model
            of oxalate nephropathy.
REFERENCE   6  (residues 1 to 1133)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   7  (residues 1 to 1133)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
REFERENCE   8  (residues 1 to 1133)
  AUTHORS   Kao,H.Y., Downes,M., Ordentlich,P. and Evans,R.M.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
REFERENCE   9  (residues 1 to 1133)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   10 (residues 1 to 1133)
  AUTHORS   Verdel,A. and Khochbin,S.
  TITLE     Identification of a new family of higher eukaryotic histone
            deacetylases. Coordinate expression of differentiation-dependent
            chromatin modifiers
  JOURNAL   J Biol Chem 274 (4), 2440-2445 (1999)
   PUBMED   9891014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Apr 21, 2022 this sequence version replaced XP_030101442.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3049775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.82 cM"
     Protein         1..1133
                     /product="histone deacetylase 5 isoform 6"
                     /EC_number="3.5.1.98"
                     /note="histone deacetylase mHDA1; histone deacetylase 4"
                     /calculated_mol_wt=123142
     Region          87..174
                     /region_name="ClassIIa_HDAC_Gln-rich-N"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     cl25407"
                     /db_xref="CDD:421006"
     Site            order(88..89,91..92,95,99,102..103,106..107,109..110,
                     113..114,116..117,120..122,124..126,128..129,142..143,
                     146..148)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:197385"
     Site            order(88..89,91..92,95,99,102,106,109,113..114,116..117,
                     120..121,124,128,142,146)
                     /site_type="other"
                     /note="dimer interface A, C [polypeptide binding]"
                     /db_xref="CDD:197385"
     Site            order(99,103,107,110,114,117,121..122,125..126,129)
                     /site_type="other"
                     /note="dimer interface A, D [polypeptide binding]"
                     /db_xref="CDD:197385"
     Region          690..1109
                     /region_name="HDAC5"
                     /note="Histone deacetylase 5; cd10007"
                     /db_xref="CDD:212531"
     Site            order(843..844,852..853,881,883,975,1015)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:212531"
     CDS             1..1133
                     /gene="Hdac5"
                     /gene_synonym="HD5; Hdac4; mHDA1; mKIAA0600"
                     /coded_by="NM_001405232.1:748..4149"
                     /note="isoform 6 is encoded by transcript variant 7"
                     /db_xref="GeneID:15184"
                     /db_xref="MGI:MGI:1333784"
ORIGIN      
        1 mllvpkaqgl vemlqtiyet escfsadgms grepsleilp rtplhsipva vevkpvlpga
       61 mpssmggggg gspspvelrg alagpmdpal reqqlqqell vlkqqqqlqk qllfaefqkq
      121 hdhltrqhev qlqkhlkqqq emlaakrqqe leqqrqreqq rqeelekqrl eqqllilrnk
      181 ekskesaias tevklrlqef llskskeptp gglnhslpqh pkcwgahhas ldqssppqsg
      241 ppgtppsykl pllgpydsrd dfplrktase pnlkvrsrlk qkvaerrssp llrrkdgtvi
      301 stfkkravei tgtgpgvssv cnsapgsgps spnsshstia engftgsvpn iptemipqhr
      361 alpldsspnq fslytspslp nislglqatv tvtnshltas pklstqqeae rqalqslrqg
      421 gtltgkfmst ssipgcllgv alegdtsphg hasllqhvll leqarqqstl iavplhgqsp
      481 lvtgervats mrtvgklprh rplsrtqssp lpqspqalqq lvmqqqhqqf lekqkqqqmq
      541 lgkiltktge lsrqptthpe eteeelteqq eallgegalt ipregstese stqedleeee
      601 eeeeeeeedc iqvkdedges gpdegpdlee ssagykklfa daqqlqplqv yqaplslatv
      661 phqalgrtqs spaapgsmks ptdqptvvkh lfttgvvydt fmlkhqcmcg nthvhpehag
      721 riqsiwsrlq etgllgkcer irgrkatlde iqtvhseyht llygtsplnr qkldskkllg
      781 pisqkmyaml pcggigvdsd tvwnemhsss avrmavgclv elafkvaage lkngfaiirp
      841 pghhaeesta mgfcffnsva itakllqqkl svgkvlivdw dihhgngtqq afyndpsvly
      901 islhrydngn ffpgsgapee vgggpgvgyn vnvawtggvd ppigdveylt afrtvvmpia
      961 qefspdvvlv sagfdavegh lsplggysvt arcfghltrq lmtlaggrvv lalegghdlt
     1021 aicdaseacv sallsvelqp ldeavlqqkp svnavatlek vieiqskhws cvqrfaaglg
     1081 cslreaqtge keeaetvsam allsvgaeqa qavatqehsp rpaeepmeqe pal
//
