LOCUS       NM_207225               8100 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus histone deacetylase 4 (Hdac4), mRNA.
ACCESSION   NM_207225 XM_136806
VERSION     NM_207225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8100)
  AUTHORS   Cheung,K.L., Zhao,L., Sharma,R., Ghosh,A.A., Appiah,M., Sun,Y.,
            Jaganathan,A., Hu,Y., LeJeune,A., Xu,F., Han,X., Wang,X., Zhang,F.,
            Ren,C., Walsh,M.J., Xiong,H., Tsankov,A. and Zhou,M.M.
  TITLE     Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription
            in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2312111121 (2024)
   PUBMED   38657041
  REMARK    GeneRIF: Class IIa HDAC4 and HDAC7 cooperatively regulate gene
            transcription in Th17 cell differentiation.
REFERENCE   2  (bases 1 to 8100)
  AUTHORS   Schneider,S., Anderson,J.B., Bradley,R.P., Beigel,K., Wright,C.M.,
            Maguire,B.A., Yan,G., Taylor,D.M., Harbour,J.W. and Heuckeroth,R.O.
  TITLE     BAP1 is required prenatally for differentiation and maintenance of
            postnatal murine enteric nervous system
  JOURNAL   J Clin Invest 134 (9), e177771 (2024)
   PUBMED   38690732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8100)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8100)
  AUTHORS   Xu,W., Jin,Q., Li,X., Li,D., Fu,X., Chen,N., Lv,Q., Shi,Y., He,S.,
            Dong,L., Yang,Y., Yan,Y. and Shi,F.
  TITLE     Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis
  JOURNAL   Cell Death Dis 15 (2), 115 (2024)
   PUBMED   38326336
  REMARK    GeneRIF: Crosstalk of HDAC4, PP1, and GSDMD in controlling
            pyroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8100)
  AUTHORS   Li,Y., Chen,Y., Xiao,X., Deng,S., Kuang,J. and Wang,Y.
  TITLE     CX3CL1 represses autophagy via CX3CR1/ CaMKIIdelta/HDAC4/Rubicon
            axis and exacerbates chronic intermittent hypoxia induced Kupffer
            cell apoptosis
  JOURNAL   Cell Signal 111, 110873 (2023)
   PUBMED   37640194
  REMARK    GeneRIF: CX3CL1 represses autophagy via CX3CR1/
            CaMKIIdelta/HDAC4/Rubicon axis and exacerbates chronic intermittent
            hypoxia induced Kupffer cell apoptosis.
REFERENCE   6  (bases 1 to 8100)
  AUTHORS   Chang,S., McKinsey,T.A., Zhang,C.L., Richardson,J.A., Hill,J.A. and
            Olson,E.N.
  TITLE     Histone deacetylases 5 and 9 govern responsiveness of the heart to
            a subset of stress signals and play redundant roles in heart
            development
  JOURNAL   Mol Cell Biol 24 (19), 8467-8476 (2004)
   PUBMED   15367668
REFERENCE   7  (bases 1 to 8100)
  AUTHORS   Jeong,B.C., Hong,C.Y., Chattopadhyay,S., Park,J.H., Gong,E.Y.,
            Kim,H.J., Chun,S.Y. and Lee,K.
  TITLE     Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich
            protein that represses the transcriptional activity of androgen
            receptor through recruitment of histone deacetylase
  JOURNAL   Mol Endocrinol 18 (1), 13-25 (2004)
   PUBMED   14576337
REFERENCE   8  (bases 1 to 8100)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8100)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   10 (bases 1 to 8100)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163436.3, BY265337.1, BC066052.1 and AC109197.9.
            
            On Sep 1, 2015 this sequence version replaced NM_207225.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC163436.3         143785-143828       c
            45-185              BY265337.1         1-141
            186-4145            BC066052.1         1-3960
            4146-8100           AC109197.9         129406-133360
FEATURES             Location/Qualifiers
     source          1..8100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.24 cM"
     gene            1..8100
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:208727"
                     /db_xref="MGI:MGI:3036234"
     exon            1..84
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            85..323
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..3532
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /EC_number="3.5.1.98"
                     /codon_start=1
                     /product="histone deacetylase 4"
                     /protein_id="NP_997108.1"
                     /db_xref="CCDS:CCDS48324.1"
                     /db_xref="GeneID:208727"
                     /db_xref="MGI:MGI:3036234"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     TAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQ
                     HEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKG
                     KESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQS
                     GVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVA
                     TALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSAPAETSLAHRLVT
                     REGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRILFPGTHLT
                     PYLSTSPLERDGAAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHSQSLVGADRVSPS
                     IHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKIISK
                     PSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEEE
                     AEATRETEPGQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPL
                     SRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSI
                     WSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFVR
                     LPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEE
                     STPMGFCYFNSVAVAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHR
                     YDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTVVMPIANEF
                     APDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRLVLALEGGHDLTA
                     ICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMDIHSKYWRCLQRLSSTV
                     GHSLIEAQKCEKEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
     exon            324..395
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            396..637
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            638..788
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            789..909
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1031
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1163
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1276
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1393
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1589
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1813
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2068
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2255
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2389
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2495
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2542
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2650
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2706
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2794
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2914
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3012
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3131
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3265
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3350
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3492
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..8100
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8073..8078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /note="hexamer: AATAAA"
     polyA_site      8100
                     /gene="Hdac4"
                     /gene_synonym="4932408F19Rik; HD4"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggg cgcctgacgg gcgtagggcg cggcctatcc ccgcgcggct ctgcgctcga
       61 gggggagcag catcatggtt caacgttcat ctctgcaagg ccaggtgaca acgtttgctc
      121 ttctcgtgga ttacttggtt tacaagacgc tgccagtgag acttcaagtt tacgcagctg
      181 ggacccgggc ctcctcaatt ttgttcctgc atgtgctggt ggaaatttgg agtgtgttgg
      241 agccactgtt tacctggaca tcttgagcca ttttgaactt aaggcactga cgctgctagc
      301 aatgagctcc caaagccatc cagatggact ttctggccga gaccagcctg tggagctgct
      361 gaatcctgcc cgtgtgaacc acatgcccag cacggtggac gtggctacag cgctgcctct
      421 gcaagtggcc cctacagcag tacccatgga cctgcgcttg gaccaccagt tctcactgcc
      481 cttggaacct gcattgcggg agcagcaact gcagcaggaa ctcctagcac tgaaacagaa
      541 gcagcagatc cagcggcaga tactcattgc agagttccag cgtcaacatg agcagttgtc
      601 ccgacagcat gaggcacagt tgcatgaaca tatcaagcag cagcaggaga tgctggccat
      661 gaagcaccag caggagctgc tggagcacca gcggaaactg gagcggcacc ggcaagagca
      721 ggagctggag aagcagcacc gtgagcagaa gctgcagcag ctcaagaaca aggagaaggg
      781 caaagagagt gctgtggcga gcacagaggt gaagatgaag ctgcaggagt ttgttctcaa
      841 caagaagaag gctctagccc accggaacct gaaccactgc atttccagcg atccccgcta
      901 ctggtatggg aagacacagc acagctccct tgaccagagc tctccacccc agagtggggt
      961 gtcagcctcc tacaaccacc ccgtcttggg aatgtacgac gccaaagatg acttccctct
     1021 taggaaaaca gcttctgaac ctaacctgaa attacgctca aggcttaagc agaaagtagc
     1081 tgagagacgg agcagccccc tgttgcgcag gaaagatggc cctgtggcca ctgctctaaa
     1141 aaagcgaccc ctggatgtta cagactccgc atgcagcagc gcccctggct ccggtcccag
     1201 ctctccaaat agcagctctg gcaacgtcag cactgagaat ggcatcgcac ccactgtgcc
     1261 cagcgctcca gctgagacga gcttggcaca cagacttgtg actcgagaag gctcagtcgc
     1321 cccacttcct ctctacacgt caccatcctt acccaacatc accttgggac ttcctgccac
     1381 tggccctgcc gctggtgcgg caggtcagca ggatgctgag aggcttgctc tcccagctct
     1441 ccagcagcgg atcttgttcc ctgggaccca cctcaccccg tacctgagca cctcgcccct
     1501 ggagagggac ggtgcagcag ctcacaaccc cctcctgcag cacatggtcc tgctggagca
     1561 gccacccacc cagacacccc ttgtcacagg cctgggggcg ctgcccctcc actcacagtc
     1621 cctggttggt gcggacaggg tgtccccatc cattcacaag ctgcggcagc accgccctct
     1681 ggggcgcacg cagtcagcac ccctgccgca gaacgcacag gccctgcagc acctggtgat
     1741 ccagcagcag caccagcagt tcctggagaa gcacaagcaa cagttccagc agcagcagct
     1801 gcacctcagc aagataatct ccaaacctag tgagccacct cggcagcctg agagccaccc
     1861 agaggagaca gaggaggagc tccgtgagca ccaggccttg ctggatgagc cctacctaga
     1921 tcggctacct gggcagaagg agccctccct ggctggtgtg caggtgaagc aggagcccat
     1981 tgagagtgag gaggaagaag cggaggccac tcgagagaca gagcccggcc agcgcccagc
     2041 cactgagcag gagctgctct tcagacagca agccctccta ctggagcagc agaggatcca
     2101 ccagttaaga aactaccagg catctatgga ggctgctggc atccctgtgt catttggcag
     2161 ccacagacct ctgtctcggg cacagtcctc cccagcatct gccaccttcc ccatgtcagt
     2221 ccaggagccc cccaccaagc caaggttcac cacaggtctt gtgtatgaca cactgatgtt
     2281 gaagcatcag tgcacctgtg ggaacaccaa cagccacccg gagcatgctg ggaggatcca
     2341 gagcatctgg tcccgcctgc aggagactgg actccgtggc aagtgtgagt gcatccgtgg
     2401 acgcaaggcc acattggagg agctgcagac agtgcactcg gaggcccaca cactcctcta
     2461 cggcacaaat cctctcaaca gacagaaact ggacagctcg ctgacctcag tgttcgtcag
     2521 gcttccttgt ggtggtgttg gggtggatag cgacaccata tggaatgagg tgcactcgtc
     2581 tggggcagcc cgcctggctg taggctgtgt agtggagctg gtcttcaagg tggccacggg
     2641 agagctaaag aatggctttg ctgtggttcg tcccccagga caccatgccg aggagagcac
     2701 acccatgggt ttctgctact ttaactccgt ggcagttgca gccaaacttc tccagcagag
     2761 gctgaatgtg agcaagatcc tcattgtaga ctgggatgta catcatggga atgggaccca
     2821 gcaggccttc tacaatgacc ccaatgttct ctacatgtcc ctgcaccgct atgacgatgg
     2881 gaacttcttc ccaggaagtg gagcaccaga tgaggtgggc acagggccag gcgtgggttt
     2941 caatgtcaac atggctttca cgggtggcct cgaacccccc atgggagacg ctgagtactt
     3001 ggcagccttc agaacggtgg ttatgcctat cgcaaatgag tttgccccag atgtggtact
     3061 ggtgtcatcg ggcttcgatg ctgtggaggg ccaccccaca cctcttggag ggtacaatct
     3121 ctctgccaaa tgttttgggt acttgacaaa acagctgatg ggcttagctg gtggccggct
     3181 tgtgctggcc cttgagggag gccatgacct gacagccatc tgtgatgctt ctgaagcctg
     3241 cgtgtctgct ctgctgggaa acgagcttga gcctctgcca gaaaaggttc tacatcagag
     3301 acccaatgcc aatgctgtcc actccatgga gaaagtgatg gacatccaca gcaagtactg
     3361 gcgctgcctg cagcgtctgt cctccacggt ggggcactct ctgattgagg cgcaaaagtg
     3421 tgagaaggaa gaagctgaga cagtcaccgc catggcctcg ctgtctgtag gcgtcaaacc
     3481 tgctgagaag agatctgagg aggagcccat ggaggaggaa ccaccactgt agcccgaagc
     3541 tgctgttctc tcctttgttt gtctgtcttg aagctcagcc aagaaactta cccgtatcac
     3601 tcctgcgtcc tgccttggtg ctctcttgag tacaaaggga cagcaggcgt gcagcagcaa
     3661 cgggaagcct ttctgccgcc ctggaccaca ggtctggaga cgcacacgga acaccgggtg
     3721 tggcagatca catggaacac aggacagcgc gcaacacacg ggcacacaga catgtggaag
     3781 ccaagcacac gctggtggct ccccctcccc ctgggaagcc tcgaaggaag aagcttgtgg
     3841 caacttgggc agagttgctg aatcaagttg acatgaggaa aatgaaaatc aaagatctaa
     3901 taatacagaa caaacttgat taaaactggt gcttaacatt tgattcttac ccacaatccc
     3961 acagtctccg tgtaaaccac tcaactcatc ttgtagcttt tttttttttt taaacgaaaa
     4021 caaaaccatt ttctatggct ctggcctgcc ttgtgaacct tagtggggtg ctgtgggggt
     4081 tcacagctta gtgagggaca gagttggaag aaagtttaaa cgaaaaaaaa aaaaaaaaaa
     4141 aaaaaaactg gacagaacag aaatgtgagc ctgggaatca gctggagctt ctcgacgcca
     4201 ccggaagatg cgagtttgtg ccttttttat tgctctgatg gaagtttttg tggctgggtt
     4261 ttctgaagtc tgaggaacaa tgccttaaga aaaaaacaaa caaaaacaaa acaccactga
     4321 gaattggtgt gacagtgtcc tgtggctggc tgagcctggc attacaagag tgggcaccag
     4381 ccactgtccc cgagggccga agtacagcca gccttgcttg gtttgatcgc catttaagga
     4441 agatgaggta gttccaaaaa gcagcgaacg ccgccagcag ttttaaagtc taacacattt
     4501 taaacggatc caaagtcttc tttcctcatc cgtcacttag cagttgagca tctccattcg
     4561 gttgtgaagc atgtcgtagg cacactgcag tgttacgatc ggaatgcttt tcattaaaag
     4621 caggtagcat gaagtattgc ttaaatttta ggtataaata aatatatata tgtataatat
     4681 atattccact gtattccaag ctaagaaact tgattcttat gagatcttga taaaatattt
     4741 ataatgcatt tatagacaaa gtatatataa atatatataa taaatccaga ccgcagaggt
     4801 cctggcaggt gaaagacgtg tgttagctct gaggtgctga gggctggggt ctggattgaa
     4861 gcccaagggt ttttgagctc cagattggcc agcttccaga ttgccagcat gttcacccct
     4921 gggcaacttc cctaccagtt tgtactttaa ttttaattat tttctaacag aacctctgcc
     4981 ctcgccaaga ctccatgcac atatgtacct gatgagtttt tatagcaaaa gatataaact
     5041 tgctgttgat ttttgtatga atttttcaca aaaaagatcc tgaagaaaac attattttgt
     5101 gtattttaca tttttccctt accattcagc agttttctga aggtggtaat gtctgaaact
     5161 ttttctttct aaattcttac ttgtacattt tttttagctc tgaaggttat ttttatggtt
     5221 tgattttgtt tctttttgta cagcaagcag ggttctgctt tgagcaagag cgctgctatc
     5281 atgcttggtt tttttagagc aaacctctcg agattgggca gcaggtctgc gtggcaccct
     5341 ggtcttgtcc agctcacccg ggagcagcac agccaggggc ttctgccctg caacaccgct
     5401 agtattacag ggcgggcagg cctcgtgagc cgtgagggtg gttggcatta gtgaatgtgg
     5461 acttgtaacc actccatcag gatagaaccc cagctcgagt ttcccaaaga cctttgaggc
     5521 tctggccctg cacctgttca ggaatttcca ttgcggcctc ataacctgga ctctggctag
     5581 agccatagcc ctgggtttgt agcctgtggc cgctgaacca aggcctttgt ccttgtcctg
     5641 caggaataca cagggtcctg agggacagcc agtctttgtc tttgctcttt tttttttttt
     5701 ttcttatgac aactaacttt ttaactgcta acttcttttc tagcacttaa agccgccagt
     5761 ttctttccaa agtatgtgga gttcagactg gtgagaggaa gttgagatac tcagaaggga
     5821 catcaagcta agcttctgaa tttggtggca tttacagggt agatgggaac tgggtcaagc
     5881 ttttgacaga caggctgagc acacattctt ggacttttga tggctgggct gctgtgagtg
     5941 ctgagctaag acagagggtg gagaggtctt aggacgtcac tgactttgcc ctccctgtgg
     6001 ctgctctggc ccttggagaa ggagcagact tgagggagcc catgcaacct ctcccttgct
     6061 tgtcactgca tggcgacaga ggccagctag ctgctcttct ggccgccttg gcccatttac
     6121 tgcaaaccct gccacctgcc ctcttgtgcc agccacgact cgtgggaggt gcacctcatc
     6181 ttactttttc aggtgagggg taacaggcca ctcagtggcc agggtactgt gagagggact
     6241 cactttggtc ctattcagtc accctttgat gcaggggcct ggccagggag ccaactcact
     6301 ccagcttccc tgtgagctga aagcattacc taccatatag ccttttcttc cctttgaaga
     6361 cacatgtggc ccttccccac agtcatcacc cagggcagag ggcagaaggt cagccttgac
     6421 ctccagggca ggaccacagc actcccctgc ctggaccttg aaccttccac cttctccctt
     6481 cttttgcaga ggccttggtg ggtgctggga agggagctgg gagcaagcac tttacatccc
     6541 tttaagggaa gcccaaagca ccgtgtcctc aggatgccgg tgtccactca ccttgggtct
     6601 tccacctgca ccctgagagc ccacgctcca ccagcaggcg gccgttccaa ggccactacc
     6661 cactgggaca tcccagggct ctggcttgag ggccgcttta tcaaagtgtt tcagtttttc
     6721 tttactttcg aatctgtccc caagaggaag gaccatcctg cagtggtctc cacagcactg
     6781 gtgatagact tggttgtgtt tctttcctca gaacattcct tcttcactgg tcacagccac
     6841 gtgctcattc catccttctt tttgtagact ttgggcccat gtattttatg ggcattgata
     6901 catatataaa tatatagata taaatatata aatatatttt tttaagtttc ctacacctgg
     6961 aggttgcatg gacgtacgcc ggcatgtctt tatattgtat acagattttg cacgccaaac
     7021 tcggcagctt tggggaagga gaaacaatgc ctttctttcc cctctcatga tgtttgcaga
     7081 tgcagaattt tttctgtaaa acaaaacctt gaaggagaag aggggggagt ttgagtctta
     7141 ttgaacttat tcttaagaaa ctgtactttt tattgtaaga aaaaaggact acttacacac
     7201 ttgtcattaa gaaaagttta cctagcacct ttgacatacc gatagagagt cgattgtatc
     7261 catgtgcaag ccccacattc acaccctact gcctgtctgg caagctggct aggggcattt
     7321 tcttttgttt tgttggtttt ctccttttct ctccccacac agggccaggt gcaccctgcc
     7381 tgctgtcacc agcctctggt cgagaacctg aggttctggt gagtccccgt ctcagcacaa
     7441 ctgtgctgat gggttccttc cttcaggaag acacgggcgg gggctgggtt tccgagttgg
     7501 gcagtccagg cctttgtgag ccctaggtct cagcgacact tggcactgga ggaaactatt
     7561 tctccctctc aaggatccgg gcgtgctctg cacccggcct tggtggcctc accggcctca
     7621 cgttgatcag agtctcctat ggaagagaag aatgcagaca ggcttgttca gggttgtgca
     7681 ctccactgag gagatgccat ttcccaatct gtaagaatgt taaacatgct gtttccatat
     7741 atgcgcagga ggctgacctc attcagcaag agctcactac agaagtgtgg tcaaagccgc
     7801 caccggagcg ctgtgacatg aagctgtgtg tgctccacag ccacgaccgc cttcactctg
     7861 taacagcctg ttttctcttt gattgtctgg acctcccctc cgcggcgctt tctcctcttg
     7921 gcggggttgg gagtcatgtt tggttttctc attcttgttt ttgttttgtg tggtgggttc
     7981 actgaccggc ggtgtcctct ggcggtcacc tctttccacc tcccgggtcc agtgtttgta
     8041 ccacatcaca cacttgtcgc tctcgtggtg taaataaaga ctgcgttaat tgccctccca
//
