LOCUS       NM_010411               2005 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus histone deacetylase 3 (Hdac3), mRNA.
ACCESSION   NM_010411
VERSION     NM_010411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Li,J., Wang,C., Zhang,Y., Huang,Y., Shi,Z., Zhang,Y., Wang,Y.,
            Chen,S., Yuan,Y., Wang,H., Mao,L. and Gao,Y.
  TITLE     Orchestrating the frontline: HDAC3-miKO recruits macrophage
            reinforcements for accelerated myelin debris clearance after stroke
  JOURNAL   Theranostics 15 (2), 632-655 (2025)
   PUBMED   39744685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Chen,H., Qin,A., Xu,F., Guo,S., Zhang,G., Zhang,A., Li,W., Tian,F.
            and Zheng,Q.
  TITLE     HDAC3 inhibitors induce drug resistance by promoting IL-17 A
            production by T cells
  JOURNAL   Sci Rep 14 (1), 31937 (2024)
   PUBMED   39738540
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Yang,M., Zhu,H., Peng,L., Yin,T., Sun,S., Du,Y., Li,J., Liu,J. and
            Wang,S.
  TITLE     Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to
            participate in stroke injury and post-stroke anxiety like behavior
  JOURNAL   Exp Neurol 380, 114906 (2024)
   PUBMED   39079624
  REMARK    GeneRIF: Neuronal HIPK2-HDAC3 axis regulates mitochondrial
            fragmentation to participate in stroke injury and post-stroke
            anxiety like behavior.
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Zhang,J., Wang,G., Ma,J., Duan,Y., Sharma,S.A., Oladejo,S., Ma,X.,
            Arellano,G., Orchard,R.C., Reese,T.A. and Kuang,Z.
  TITLE     HDAC3 integrates TGF-beta and microbial cues to program tuft cell
            biogenesis and diurnal rhythms in mucosal immune surveillance
  JOURNAL   Sci Immunol 9 (99), eadk7387 (2024)
   PUBMED   39331726
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Shahror,R.A., Shosha,E., Morris,C., Wild,M., Mu,S., Csanyi,G.,
            Boerma,M., Rusch,N.J. and Fouda,A.Y.
  TITLE     Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate
            retinal ischemic injury
  JOURNAL   J Neuroinflammation 21 (1), 170 (2024)
   PUBMED   38997746
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Downes,M., Ordentlich,P., Kao,H.Y., Alvarez,J.G. and Evans,R.M.
  TITLE     Identification of a nuclear domain with deacetylase activity
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10330-10335 (2000)
   PUBMED   10984530
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Takami,Y. and Nakayama,T.
  TITLE     N-terminal region, C-terminal region, nuclear export signal, and
            deacetylation activity of histone deacetylase-3 are essential for
            the viability of the DT40 chicken B cell line
  JOURNAL   J Biol Chem 275 (21), 16191-16201 (2000)
   PUBMED   10748092
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Mahlknecht,U., Hoelzer,D., Bucala,R. and Verdin,E.
  TITLE     Cloning and characterization of the murine histone deacetylase
            (HDAC3)
  JOURNAL   Biochem Biophys Res Commun 263 (2), 482-490 (1999)
   PUBMED   10491319
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Dangond,F., Foerznler,D., Weremowicz,S., Morton,C.C., Beier,D.R.
            and Gullans,S.R.
  TITLE     Cloning and expression of a murine histone deacetylase 3 (mHdac3)
            cDNA and mapping to a region of conserved synteny between murine
            chromosome 18 and human chromosome 5
  JOURNAL   Mol Cell Biol Res Commun 2 (2), 91-96 (1999)
   PUBMED   10542131
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   Mahlknecht,U., Bucala,R. and Verdin,E.
  TITLE     Assignment of the histone deacetylase gene (Hdac3) to mouse
            chromosome 18B3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 192-193 (1999)
   PUBMED   10393429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166955.1, BQ932476.1, AF098295.1 and AK037478.1.
            
            On Mar 8, 2006 this sequence version replaced NM_010411.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145158.1, AF074881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               CJ166955.1         4-359
            357-685             BQ932476.1         369-697
            686-1292            AF098295.1         611-1217
            1293-2005           AK037478.1         1285-1997
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.81 cM"
     gene            1..2005
                     /gene="Hdac3"
                     /note="histone deacetylase 3"
                     /db_xref="GeneID:15183"
                     /db_xref="MGI:MGI:1343091"
     exon            1..130
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1362
                     /gene="Hdac3"
                     /EC_number="3.5.1.98"
                     /note="HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing
                     HDAC3beta; HDAC3 splicing HDAC3gamma; HDAC3 splicing
                     HDAC3delta; protein deacylase HDAC3; protein deacetylase
                     HDAC3"
                     /codon_start=1
                     /product="histone deacetylase 3"
                     /protein_id="NP_034541.2"
                     /db_xref="CCDS:CCDS37785.1"
                     /db_xref="GeneID:15183"
                     /db_xref="MGI:MGI:1343091"
                     /translation="MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKK
                     MIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFE
                     FCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKY
                     HPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYC
                     LNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGH
                     GECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAP
                     DFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE
                     ADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI"
     exon            131..213
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            214..356
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..438
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..495
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..551
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..685
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..766
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            767..840
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            841..905
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..995
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1054
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1134
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1292
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..2005
                     /gene="Hdac3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac3"
                     /note="hexamer: AATAAA"
     polyA_site      2005
                     /gene="Hdac3"
                     /note="major polyA site"
ORIGIN      
        1 acggcggggg tggggctgtc gtccggtggc gggcgggcgg gcagctgagg ctcggggcct
       61 ggtcccccca gcaccatggc caagaccgtg gcgtatttct acgaccccga tgtgggcaac
      121 ttccactatg gagctggaca cccaatgaaa cctcatcgcc tggcattgac tcatagccta
      181 gtcctgcatt atggtctcta taagaagatg atcgtcttca agccttacca ggcctcccag
      241 catgacatgt gccgcttcca ttctgaggac tacatcgact tcctgcagag agtcagcccc
      301 accaatatgc agggtttcac caagagcctt aatgccttca acgtgggtga tgactgccca
      361 gtgtttccag gacttttcga gttctgctcc cgttacacag gcgcatctct gcaaggagca
      421 acacagctaa acaacaagat ctgtgatatt gccatcaact gggccggtgg tctacatcat
      481 gccaagaaat ttgaggcctc tggcttctgc tatgtcaatg acatagtaat tggtatcctg
      541 gagctgctta agtaccaccc tcgggtgctc tacattgata tcgacatcca ccatggtgac
      601 ggggttcagg aagccttcta cctcactgac cgggtcatga ctgtgtcctt ccacaaatac
      661 ggaaattact tctttcctgg aacaggtgac atgtatgaag ttggagcaga gagtggccgc
      721 tactattgtc tcaatgtgcc cttacgagat ggcattgatg accagagtta caagcacctt
      781 ttccagccag tcatcagcca ggtggtggac ttctaccagc cgacgtgcat cgtgctccag
      841 tgtggcgctg actccctggg ctgtgatcga ttaggctgct tcaatctcag cattcgagga
      901 catggggaat gtgttgaata tgtcaagagt ttcaatatcc ctctcctggt actgggaggt
      961 ggtggctaca ctgtccgaaa tgttgcccgg tgttggacat atgaaacatc tctgctggta
     1021 gaagaggcca ttagtgagga acttccctat agtgaatact tcgagtactt tgccccagat
     1081 ttcacactcc atccagatgt cagcacccgc atcgagaatc agaactcacg ccagtatctg
     1141 gaccagatcc gccagacaat ctttgaaaac ttgaagatgc tgaaccatgc acccagtgtc
     1201 cagattcatg atgtcccggc agacctcctg acgtatgaca ggactgacga ggccgacgct
     1261 gaagagagag gtcccgagga gaactacagc aggccagaag cacccaatga gttctatgat
     1321 ggcgaccatg acaacgacaa ggaaagtgat gtggagattt agagcagcat ggatgctgtg
     1381 tccccaagag ttccttgtca cctctgtggt gggaaggaaa gtatggtttc cccaggtctg
     1441 aactgggtac ccccagggtg tttactaact ctggtgaagg gtttggaaac catatgtggt
     1501 tctagaatta actccccttt ccctcaaact ctcacggcct gatgattgtc cctctcaggg
     1561 atgagacatg gacaggtctc tggaacgtta tgggtaatga gccccagcaa ctgtcctcag
     1621 cccctcttcc cctcatttgt tccttctgtc cttccaacac agagactgtt agagatgaaa
     1681 gtttggacgg tactaaagtc acctctgact tccttctggg ttcccctact acagttcttg
     1741 cttccatgca aggtgaacct gaggggagga aggcgtggct ctctgaaacc ttaactgcag
     1801 atgaagtaca gtggcaagga ggagagggtg tgaagctcta actggcttta tgtccatttt
     1861 actgttttgg atctaataaa ccaattggtt tttttttttt ttttgtacct ttctgggatt
     1921 ttaattcttg ctagttaccg atgtatgatg tgaaaaggaa acagatgatg atgtgtataa
     1981 taaaattgtt accattcact cagta
//
