LOCUS       NM_008229               2004 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus histone deacetylase 2 (Hdac2), transcript variant 1,
            mRNA.
ACCESSION   NM_008229 XM_993761
VERSION     NM_008229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   Wang,Y., Chen,Y., Xiao,X., Deng,S., Kuang,J. and Li,Y.
  TITLE     HRD1-mediated ubiquitination of HDAC2 regulates PPARalpha-mediated
            autophagy and alleviates metabolic-associated fatty liver disease
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119765 (2024)
   PUBMED   38815686
  REMARK    GeneRIF: HRD1-mediated ubiquitination of HDAC2 regulates
            PPARalpha-mediated autophagy and alleviates metabolic-associated
            fatty liver disease.
REFERENCE   3  (bases 1 to 2004)
  AUTHORS   Zhu,Y., Huang,Y., Tang,T. and Xie,Y.
  TITLE     HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural
            progenitor transition during brain development
  JOURNAL   iScience 27 (9), 110600 (2024)
   PUBMED   39224519
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2004)
  AUTHORS   De Sa Fernandes,C., Novoszel,P., Gastaldi,T., Krauss,D., Lang,M.,
            Rica,R., Kutschat,A.P., Holcmann,M., Ellmeier,W., Seruggia,D.,
            Strobl,H. and Sibilia,M.
  TITLE     The histone deacetylase HDAC1 controls dendritic cell development
            and anti-tumor immunity
  JOURNAL   Cell Rep 43 (6), 114308 (2024)
   PUBMED   38829740
REFERENCE   5  (bases 1 to 2004)
  AUTHORS   Zhao,Y., Wu,X., Yang,Y., Zhang,L., Cai,X., Chen,S., Vera,A., Ji,J.,
            Bostrom,K.I. and Yao,Y.
  TITLE     Inhibition of endothelial histone deacetylase 2 shifts
            endothelial-mesenchymal transitions in cerebral arteriovenous
            malformation models
  JOURNAL   J Clin Invest 134 (15), e176758 (2024)
   PUBMED   38781032
  REMARK    GeneRIF: Inhibition of endothelial histone deacetylase 2 shifts
            endothelial-mesenchymal transitions in cerebral arteriovenous
            malformation models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2004)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2004)
  AUTHORS   Zeng,Y., Tang,C.M., Yao,Y.L., Yang,W.M. and Seto,E.
  TITLE     Cloning and characterization of the mouse histone deacetylase-2
            gene
  JOURNAL   J Biol Chem 273 (44), 28921-28930 (1998)
   PUBMED   9786895
REFERENCE   8  (bases 1 to 2004)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   9  (bases 1 to 2004)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (bases 1 to 2004)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165734.1, U31758.1 and AB221663.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_993761.1, NM_008229.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.142827.1, U31758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AK165734.1         2-242
            242-1073            U31758.1           202-1033
            1074-1675           AB221663.1         866-1467
            1676-1854           U31758.1           1636-1814
            1855-2004           U31758.1           1816-1965
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 19.44 cM"
     gene            1..2004
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /note="histone deacetylase 2"
                     /db_xref="GeneID:15182"
                     /db_xref="MGI:MGI:1097691"
     exon            1..260
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1675
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /EC_number="3.5.1.98"
                     /note="isoform a is encoded by transcript variant 1; HD2;
                     YY1 transcription factor-binding protein; protein
                     deacylase HDAC2"
                     /codon_start=1
                     /product="histone deacetylase 2 isoform a"
                     /protein_id="NP_032255.2"
                     /db_xref="CCDS:CCDS23783.1"
                     /db_xref="GeneID:15182"
                     /db_xref="MGI:MGI:1097691"
                     /translation="MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLL
                     NYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCP
                     VFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLA
                     ILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAG
                     KGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFN
                     LTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDY
                     FEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHE
                     DSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED
                     KKETEDKKTDVKEEDKSKDNSGEKTDPKGAKSEQLSNP"
     exon            261..373
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            374..491
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            492..566
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            567..705
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            706..847
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            848..940
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1049
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1190
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1299
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1430
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1586
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1644
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2004
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagtgtc gcgcgtcggc gccgctgcct atcccgctct gtgccctacg gccctcccgg
       61 cacccgccgc cgtcccgctc cgggctgccc ttgctccgag ggctgcagca ccggccgtcc
      121 ccgtcagccc tcttgtctgg ccgccgggcc gcggcgggcg ggagcagccg gaggaggagc
      181 cgcagccggg aggcggcggc ctgagcccat ggcgtacagt caaggaggcg gcaagaagaa
      241 agtgtgctac tactatgatg gtgatattgg caattattat tatggccagg gtcatcccat
      301 gaagcctcat agaatccgga tgactcataa cttgctgcta aattatggtt tataccgaaa
      361 aatggaaata tataggcctc ataaagccac tgctgaagaa atgactaaat accacagcga
      421 tgagtatatc aagtttctac gatcaataag accagataat atgtctgagt acagtaagca
      481 gatgcagaga tttaacgtcg gagaagattg tccggtgttt gatggactct ttgagttttg
      541 tcagctctcc acgggtggtt cagttgctgg ggctgtgaaa ttaaaccggc aacaaactga
      601 tatggctgtc aattgggctg gaggactaca tcatgccaag aagtcagaag catcagggtt
      661 ctgctatgtt aatgatattg tgcttgccat cctcgaatta cttaagtatc atcagagagt
      721 cttatatatt gacatagaca tccaccatgg tgatggtgtt gaggaagctt tttatacaac
      781 agatcgcgtg atgaccgtct cattccataa atatggggaa tactttcctg gaacaggaga
      841 cttgagggat attggtgctg gaaagggaaa atactatgct gtcaattttc ccatgagaga
      901 tggtatagat gatgaatcat atggacaaat ttttaagcct atcatctcaa aagtgatgga
      961 gatgtaccag cctagcgcgg tggtgctgca gtgtggcgca gactccctgt ctggggacag
     1021 gcttggttgt ttcaatctaa ctgtcaaagg tcatgctaaa tgtgtagaag tagtgaaaac
     1081 ttttaacttg ccattgctga tgctcggtgg aggaggctac acaatccgga atgttgcccg
     1141 atgttggaca tatgagactg cagttgccct tgattgtgaa attcccaatg agttgccata
     1201 taatgattac tttgagtatt ttggaccaga cttcaaactg catattagtc cttcaaacat
     1261 gacaaaccag aacactccag aatatatgga aaagataaaa cagcgtttat ttgaaaatct
     1321 acgtatgtta ccacatgcac ctggtgttca aatgcaagct attccagagg atgctgttca
     1381 tgaagacagt ggagatgagg atggagaaga cccggacaaa agaatttcca ttcgagcatc
     1441 agacaaacgg atagcttgcg atgaagagtt ttcagattct gaggatgaag gtgaaggagg
     1501 tcgtaggaat gttgctgatc ataagaaagg agcaaagaag gctaggattg aagaagacaa
     1561 gaaggagaca gaggacaaga agacagatgt taaggaagaa gacaaatcca aggacaatag
     1621 tggtgagaaa acagacccca aaggagccaa gtcagaacaa ctcagcaacc cttgaatttg
     1681 actctccaac tttaggaacc tcgaaaagtg agacgattct gggataagaa accttccctg
     1741 tttgaggaca ttggcttcat tttatactgt tttggcatgg actgtattta ttttcaaaat
     1801 ggcttgtttt tgtttttctt ggcaagtttt attgtgagtt tttctaatta tgaagcaaat
     1861 ttttttttcc accatgcttt atgtgattgt atttaaattg atgtgttatt atgtcaaaag
     1921 ccggatctat taaagaaaca attggccttt ctgagctgat ttttccatct tttgtaatta
     1981 tctttattaa aaaattgtac ttgg
//
