LOCUS       NM_144919               2494 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus histone deacetylase 11 (Hdac11), mRNA.
ACCESSION   NM_144919
VERSION     NM_144919.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2494)
  AUTHORS   Yang,H., Li,C., Che,M., Liang,J., Tian,X., Yang,G. and Sun,C.
  TITLE     HDAC11 deficiency resists obesity by converting adipose-derived
            stem cells into brown adipocyte-like cells
  JOURNAL   Int J Biol Macromol 258 (Pt 1), 128852 (2024)
   PUBMED   38110164
  REMARK    GeneRIF: HDAC11 deficiency resists obesity by converting
            adipose-derived stem cells into brown adipocyte-like cells.
REFERENCE   3  (bases 1 to 2494)
  AUTHORS   Baek,S.Y., Lee,J., Kim,T., Lee,H., Choi,H.S., Park,H., Koh,M.,
            Kim,E., Jung,M.E., Iliopoulos,D., Lee,J.Y., Kim,J. and Lee,S.
  TITLE     Development of a novel histone deacetylase inhibitor unveils the
            role of HDAC11 in alleviating depression by inhibition of
            microglial activation
  JOURNAL   Biomed Pharmacother 166, 115312 (2023)
   PUBMED   37567072
  REMARK    GeneRIF: Development of a novel histone deacetylase inhibitor
            unveils the role of HDAC11 in alleviating depression by inhibition
            of microglial activation.
REFERENCE   4  (bases 1 to 2494)
  AUTHORS   Wu,H., Yin,X., Zhao,X., Wu,Z., Xiao,Y., Di,Q., Sun,P., Tang,H.,
            Quan,J. and Chen,W.
  TITLE     HDAC11 negatively regulates antifungal immunity by inhibiting Nos2
            expression via binding with transcriptional repressor STAT3
  JOURNAL   Redox Biol 56, 102461 (2022)
   PUBMED   36087429
  REMARK    GeneRIF: HDAC11 negatively regulates antifungal immunity by
            inhibiting Nos2 expression via binding with transcriptional
            repressor STAT3.
REFERENCE   5  (bases 1 to 2494)
  AUTHORS   Bagchi,R.A., Robinson,E.L., Hu,T., Cao,J., Hong,J.Y., Tharp,C.A.,
            Qasim,H., Gavin,K.M., Pires da Silva,J., Major,J.L.,
            McConnell,B.K., Seto,E., Lin,H. and McKinsey,T.A.
  TITLE     Reversible lysine fatty acylation of an anchoring protein mediates
            adipocyte adrenergic signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35149557
REFERENCE   6  (bases 1 to 2494)
  AUTHORS   Liu,H., Hu,Q., Kaufman,A., D'Ercole,A.J. and Ye,P.
  TITLE     Developmental expression of histone deacetylase 11 in the murine
            brain
  JOURNAL   J Neurosci Res 86 (3), 537-543 (2008)
   PUBMED   17893925
  REMARK    GeneRIF: Role for HDAC11 in central nervous system histone
            deacetylation and the development of oligodendrocytes and neurons
            during postnatal development.
REFERENCE   7  (bases 1 to 2494)
  AUTHORS   Izzi,L., Silvestri,C., von Both,I., Labbe,E., Zakin,L., Wrana,J.L.
            and Attisano,L.
  TITLE     Foxh1 recruits Gsc to negatively regulate Mixl1 expression during
            early mouse development
  JOURNAL   EMBO J 26 (13), 3132-3143 (2007)
   PUBMED   17568773
REFERENCE   8  (bases 1 to 2494)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (bases 1 to 2494)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   10 (bases 1 to 2494)
  AUTHORS   Verdin,E., Dequiedt,F. and Kasler,H.G.
  TITLE     Class II histone deacetylases: versatile regulators
  JOURNAL   Trends Genet 19 (5), 286-293 (2003)
   PUBMED   12711221
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110256.12
            and AC131764.3.
            
            On Nov 17, 2006 this sequence version replaced NM_144919.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016208.1, AK045994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC110256.12        236181-236213
            34-182              AC110256.12        236763-236911
            183-283             AC110256.12        238527-238627
            284-400             AC131764.3         99369-99485         c
            401-443             AC131764.3         98761-98803         c
            444-520             AC131764.3         97166-97242         c
            521-583             AC131764.3         96175-96237         c
            584-680             AC131764.3         95555-95651         c
            681-859             AC131764.3         92703-92881         c
            860-2494            AC131764.3         90363-91997         c
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.38 cM"
     gene            1..2494
                     /gene="Hdac11"
                     /note="histone deacetylase 11"
                     /db_xref="GeneID:232232"
                     /db_xref="MGI:MGI:2385252"
     exon            1..33
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1075
                     /gene="Hdac11"
                     /EC_number="3.5.1.98"
                     /note="HD11"
                     /codon_start=1
                     /product="histone deacetylase 11"
                     /protein_id="NP_659168.1"
                     /db_xref="CCDS:CCDS20366.1"
                     /db_xref="GeneID:232232"
                     /db_xref="MGI:MGI:2385252"
                     /translation="MPHATQLYQHVPEKRWPIVYSPRYNITFMGLEKLHPFDAGKWGK
                     VINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLP
                     NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITL
                     AIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEA
                     IRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPA
                     GIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNLHDLGLIGPEFPCVSA
                     QNSGIPLLSCAVP"
     exon            34..182
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            183..283
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            284..400
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            401..443
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            444..520
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            521..583
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            584..680
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            681..859
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2494
                     /gene="Hdac11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtccaga gcaggcaggg ccggctgcgg gatgcctcac gcaacacagc tgtaccagca
       61 tgtaccagag aaacgctggc ccatcgtgta ctcaccacgt tacaacatca ccttcatggg
      121 cctggagaag ctgcacccct ttgatgctgg gaaatggggc aaggtgatca acttcctgaa
      181 agaagagaag ctgctgtccg atggcatgct ggtggaggct cgggaggcct cggaggagga
      241 cctgctggtg gtgcacacga ggcgctatct caacgagctg aagtggtcct ttgtggtggc
      301 taccatcact gagatccccc cggtcatctt tcttcccaac ttccttgtgc agaggaaggt
      361 gctgaggccc ctgcggaccc agactggagg caccatcatg gcagggaagc tggctgtgga
      421 gcgaggctgg gccatcaatg ttggtggtgg cttccaccac tgctccagtg accgtggtgg
      481 gggcttctgt gcctatgcag acatcacact ggctatcaag ttcctgtttg aacgcgtgga
      541 aggcatctcc agagccacca tcattgatct cgatgcccac cagggcaatg ggcatgagcg
      601 agacttcatg ggtgacaagc gagtatacat catggatgtt tacaaccgcc acatctaccc
      661 tggggatcgc tttgctaaag aggccatcag gcggaaggtg gaattggagt ggggcacaga
      721 agatgaggaa tatctggaga aggtggagag gaatgtcagg aggtccctcc aggagcacct
      781 gcctgacgtg gtggtgtaca acgctggcac ggacgtgctg gagggagacc gcctcggggg
      841 gctgtccatc agcccagcgg gcattgtgaa gagggatgaa gtggttttcc gcgtggtccg
      901 agcccatgat atacccatcc tcatggtgac ctcgggtggg taccagaagc gcacagcccg
      961 tattatcgcc gactccatcc tcaacttgca tgacctgggg ctcattgggc ctgagtttcc
     1021 ctgcgtctcg gcacagaact cgggcatccc cctgctttcc tgtgctgtgc cttgacggct
     1081 actcacagaa cattgtcata cctgcccccc caccccatcc acccgcccac ccgcctgtgt
     1141 ttgttgctgt gaagacagct gccagtgagt gtggaggggc aggaagagca ggagccagcc
     1201 ttgctggcca ctcctccact ccccaccagg tgcccaaggg tctctgggcc tttggggtgg
     1261 aagagctgag tcccagggag gagcccatgt gggaagcagg caggccatca agagtcaggg
     1321 aggacagctt agctccagcc acagggaggg gcctctggag tagagtcgtt tgctgttcat
     1381 atcagcagaa gaagggccct ccccgacctg gttggcttac ttcctcactt tagtctggag
     1441 aggtcccctc ctggacgttg gtgcctgtgg gtctgaggag tttccatagc cagcctccag
     1501 ggggcactgg gttctcagct aacaggtagt agtcctggta tggattggga ggcctaagga
     1561 agaaggaagc tgggattctc cagtttgggt tcccctcaat aagtcaaggt ccagacagac
     1621 ctgtttttcc aagctccccc tatgatgatg gggttgaaca ctgaggatgc ccaaggcccc
     1681 caacttatct cctctgttca gcatgaaaac acgtttggga tgagtgttta gctcaggagt
     1741 gaccctccaa actggagttt ttaaggggct gctgaccagg atggagagaa ggcaaggccc
     1801 tgcagataga aatgagatgg aggctggtgg ccaagctagt cctaggtggg gcttgctaga
     1861 gggagggcag cgaaggtaac atctaggtac agtggcccca cagaccttga gtgagctaca
     1921 atctccattg ggctcaccca aagtgcccaa ttttcatctt tgtctgtggc cccaaggtct
     1981 acctgccctc tggccatttg accctgaagg gacagccagg gccctccgtg acgtaggcag
     2041 gaaagcagcc acccctagcc agagattggc agcataacca agggcacagg ggtaagagga
     2101 tgtgggccag ctgggtttcc tcctgccctg gatctgctcc aactacagga ctcatattca
     2161 ttaccatgtg ggggtattcc cacagccttc atagtgtcct tcatactccc tctgctggag
     2221 tcgggaggat gccagagtca ccagttgtct aaaccactga cctggaccag accccacagt
     2281 actaatagtg cagcaccaca cccctctgtc atggcctctt tgcctctgac tggaggtacc
     2341 tcccaggaca ttggggagtg gtgacagcac agtttgtcat tgtggagttt gtctgagtgc
     2401 cattcaggct ccaggttgtt gctgtgtgtt ctgaggtaga cagacctgcc tcctgaggac
     2461 cactggaaat aaagattcaa aattcaccaa tcca
//
