LOCUS       NM_001416149            2378 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus histone deacetylase 10 (Hdac10), transcript variant 5,
            mRNA.
ACCESSION   NM_001416149 XM_006520537
VERSION     NM_001416149.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Xiang,Y., Zhong,Y., Lai,X., Fang,Z., Su,G., Lv,Y., Tang,X.,
            Ouyang,L., Gao,X., Zheng,H., He,L., Chen,J., Huang,J. and Lai,T.
  TITLE     Myeloid-specific Hdac10 deletion protects against LPS-induced acute
            lung injury via P62 acetylation at lysine 165
  JOURNAL   Respir Res 25 (1), 263 (2024)
   PUBMED   38956592
  REMARK    GeneRIF: Myeloid-specific Hdac10 deletion protects against
            LPS-induced acute lung injury via P62 acetylation at lysine 165.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Zhou,W., Wang,J., Wang,X., Wang,B., Zhao,Z., Fu,J., Wang,Y.,
            Zhang,X., Zhu,P., Jiang,M. and Cao,X.
  TITLE     Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral
            innate immune responses
  JOURNAL   Sci Signal 15 (765), eabo4356 (2022)
   PUBMED   36538592
  REMARK    GeneRIF: Degradation of HDAC10 by autophagy promotes IRF3-mediated
            antiviral innate immune responses.
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   Witt,O., Deubzer,H.E., Milde,T. and Oehme,I.
  TITLE     HDAC family: What are the cancer relevant targets?
  JOURNAL   Cancer Lett 277 (1), 8-21 (2009)
   PUBMED   18824292
  REMARK    Review article
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Liu,F., Levin,M.D., Petrenko,N.B., Lu,M.M., Wang,T., Yuan,L.J.,
            Stout,A.L., Epstein,J.A. and Patel,V.V.
  TITLE     Histone-deacetylase inhibition reverses atrial arrhythmia
            inducibility and fibrosis in cardiac hypertrophy independent of
            angiotensin
  JOURNAL   J Mol Cell Cardiol 45 (6), 715-723 (2008)
   PUBMED   18926829
REFERENCE   10 (bases 1 to 2378)
  AUTHORS   Kao,H.Y., Lee,C.H., Komarov,A., Han,C.C. and Evans,R.M.
  TITLE     Isolation and characterization of mammalian HDAC10, a novel histone
            deacetylase
  JOURNAL   J Biol Chem 277 (1), 187-193 (2002)
   PUBMED   11677242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113069.10.
            
            On Jan 19, 2023 this sequence version replaced XM_006520537.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.753953.1,
                                           SRR7345562.921676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC113069.10        149396-149667       c
            273-407             AC113069.10        149191-149325       c
            408-504             AC113069.10        148928-149024       c
            505-602             AC113069.10        148600-148697       c
            603-707             AC113069.10        148392-148496       c
            708-776             AC113069.10        148156-148224       c
            777-903             AC113069.10        147875-148001       c
            904-969             AC113069.10        147647-147712       c
            970-1029            AC113069.10        147384-147443       c
            1030-1119           AC113069.10        147218-147307       c
            1120-1226           AC113069.10        146981-147087       c
            1227-1291           AC113069.10        146832-146896       c
            1292-1544           AC113069.10        146503-146755       c
            1545-1629           AC113069.10        146318-146402       c
            1630-1721           AC113069.10        145719-145810       c
            1722-1778           AC113069.10        145538-145594       c
            1779-1860           AC113069.10        145181-145262       c
            1861-2043           AC113069.10        144825-145007       c
            2044-2203           AC113069.10        144571-144730       c
            2204-2378           AC113069.10        144311-144485       c
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.64 cM"
     gene            1..2378
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /note="histone deacetylase 10"
                     /db_xref="GeneID:170787"
                     /db_xref="MGI:MGI:2158340"
     exon            1..272
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2217
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /EC_number="3.5.1.48"
                     /EC_number="3.5.1.62"
                     /note="isoform 2 is encoded by transcript variant 5;
                     polyamine deacetylase HDAC10"
                     /codon_start=1
                     /product="polyamine deacetylase HDAC10 isoform 2"
                     /protein_id="NP_001403078.1"
                     /db_xref="GeneID:170787"
                     /db_xref="MGI:MGI:2158340"
                     /translation="MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLE
                     ERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYNAVYFHPDTFHC
                     ARLAAGAALQLVDAVLTGAVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQK
                     YGLQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQ
                     GQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQ
                     ATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPTPPLLGLMV
                     PCQSALESIQSVQTAQTPYWTSLQQNVAPVLSSSTHSPEERSLRLLGESPTCAVAEDS
                     LSPLLDQLCLRPAPPICTAVASTVPGAALCLPPGVLHQEGSVLREETEAWARLHKSRF
                     QDEDLATLGKILCLLDGIMDGQIRNAIATTTALATAATLDVLIQRCLARRAQRVLCVA
                     LGQLDRPLDLADDGRRILWLNIRGKDAAIQSMFHFSTPLPQTTGGFLSLILGLVLPLA
                     YGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILAVVEEESIRLLARSLAQAL
                     HGETPPSLGPFSKATPEEIQALMFLKARLEARWKLLQVAAPPP"
     exon            273..407
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            408..504
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            505..602
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            603..707
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            708..776
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            777..903
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            904..969
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1029
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1119
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1226
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1291
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1544
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1629
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1721
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1778
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1860
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2043
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2203
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2378
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /note="hexamer: AATAAA"
     polyA_site      2378
                     /gene="Hdac10"
                     /gene_synonym="Hd10"
                     /note="major polyA site"
ORIGIN      
        1 agtttccagc ggttctcttc tgacaatcgg gcgggcttga gcccggacct gggcctgggg
       61 tggtttcctc ttgcccaggt ccagcgtgca caacccagtt cgtcccgagt gaggattgtt
      121 tacgtgcata gttaggtgag accgggcagt gcaattacct gccggcagag ggcgtgttgc
      181 gttagagcgg atcaaagtga ccacggtgta gctatgggca cagcacttgt gtaccacgag
      241 gacatgacag ccactcgact gctctgggat gaccccgagt gcgaaattga gtgcccagag
      301 cgcctgacag ctgccctgga tggcctgcgg cagcgtggcc tggaagaaag gtgcctgtgt
      361 ttgtcagctt gtgaggcatc agaggaagag ttgggcttgg tgcacagccc ggaatatata
      421 gccctggtgc agaagaccca gaccctggat aaagaggagc tccacgcact gtctaagcag
      481 tacaatgctg tctactttca cccggacacc tttcactgtg cccggctggc agcgggggct
      541 gcactgcagc tggtcgatgc tgtgctaaca ggagctgtgc acaatgggct tgccctggtg
      601 aggcctccag ggcaccacag tcagagggca gctgccaatg gattctgtgt gttcaacaat
      661 gtggctctag cagccaaaca tgccaagcag aaatatgggc tgcagaggat tctcattgtc
      721 gactgggatg tccaccatgg ccagggcatc cagtatatct tcaacgatga ccccagtgtc
      781 ctttatttct cttggcaccg ctatgagcat ggaagcttct ggccgtttct cccagagtct
      841 gatgcagatg cagttggcca agggcagggc caaggtttca ctgtcaattt gccctggaac
      901 caggttggga tgggaaatgc cgactatttg gctgcctttc tgcatgtgct gctcccactg
      961 gccttcgagt ttgatcctga gttggtgctg gtgtcggctg gatttgactc tgctatcggg
     1021 gaccctgagg ggcagatgca ggccacccct gagtgctttg cccatctcac acagctgctg
     1081 caggtgctgg ctggtggccg gatttgtgct gtgttggagg gtggctacca cttggagtcc
     1141 ctagcacagt cagtgtgcat gatggtgcag acactgcttg gtgaccccac acctcccctt
     1201 cttgggctca tggtgccatg tcagagtgcc ctggagtcca tccagagtgt ccagacagcc
     1261 cagacccctt actggacaag cctccagcaa aatgtggccc cagttctgag ttccagcacc
     1321 cactctcctg aagagagatc tctgcgtctg cttggtgaga gccccacatg tgcagtagca
     1381 gaggattcac tgagccccct cctggaccaa ctgtgcctcc gccctgcacc tccaatctgc
     1441 acagcggtgg cctcgactgt accaggtgct gctctgtgct tacctcctgg agtgctccat
     1501 caagaagggt cagtcttgag ggaggagacc gaagcctggg ccaggcttca caaatcccgg
     1561 ttccaggatg aggatcttgc cacactgggg aagattctgt gtctcttaga tggaatcatg
     1621 gatgggcaga taagaaatgc catagcaacc acaactgccc tcgccacagc agcaacattg
     1681 gatgtactca ttcagcgatg cctagctcgc agagctcaga gggtgctctg tgtggccctg
     1741 ggacaactgg atcgacccct ggaccttgca gatgatggaa ggagaattct gtggctcaac
     1801 atccggggca aggatgcagc catccagtcc atgttccact tctccactcc actgccacag
     1861 acaactggag ggtttctgag cctcattctg ggtctggtac tgcccttggc ctatggtttc
     1921 cagcctgata tggtgttgat ggcactgggg cctgcccatg gcctgcagaa cgctcaagct
     1981 gctctcttgg ctgcaatgct tcggagccca gtagggggcc gaattctagc tgtagtggaa
     2041 gaggaatcca tacgcctgct tgcaaggagc ctggcgcagg cattgcatgg agaaacacct
     2101 cccagtctgg gtcctttctc gaaggccact ccagaggaga tccaggctct gatgtttcta
     2161 aaagctcggc tggaggctcg ctggaaattg ctgcaggtgg ctgctcctcc accataataa
     2221 cagtgattgc cagtcgcttg aaatcggtca aggtgggcga ttcacacgtg aaaaatagca
     2281 cactcgggcc ccagcgaacc atggcccgag acctacgtcc cgtctgcggc ccaggcgtcc
     2341 tctacctcca gaacaataaa catcggccaa acacaaca
//
