LOCUS       NM_008228               2048 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus histone deacetylase 1 (Hdac1), mRNA.
ACCESSION   NM_008228 XM_485447
VERSION     NM_008228.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Penninger,P., Brezovec,H., Tsymala,I., Teufl,M., Phan-Canh,T.,
            Bitencourt,T., Brinkmann,M., Glaser,W., Ellmeier,W., Bonelli,M. and
            Kuchler,K.
  TITLE     HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue
            damage in fungal infections
  JOURNAL   Cell Rep 43 (12), 114993 (2024)
   PUBMED   39580799
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Zhu,Y., Huang,Y., Tang,T. and Xie,Y.
  TITLE     HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural
            progenitor transition during brain development
  JOURNAL   iScience 27 (9), 110600 (2024)
   PUBMED   39224519
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2048)
  AUTHORS   De Sa Fernandes,C., Novoszel,P., Gastaldi,T., Krauss,D., Lang,M.,
            Rica,R., Kutschat,A.P., Holcmann,M., Ellmeier,W., Seruggia,D.,
            Strobl,H. and Sibilia,M.
  TITLE     The histone deacetylase HDAC1 controls dendritic cell development
            and anti-tumor immunity
  JOURNAL   Cell Rep 43 (6), 114308 (2024)
   PUBMED   38829740
REFERENCE   5  (bases 1 to 2048)
  AUTHORS   Xiong,F., Wang,D., Xiong,W., Wang,X., Huang,W.H., Wu,G.H.,
            Liu,W.Z., Wang,Q., Chen,J.S., Kuai,Y.Y., Wang,B. and Chen,Y.J.
  TITLE     Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic
            target for HP1alpha-positive intrahepatic cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 152 (2024)
   PUBMED   38812060
  REMARK    GeneRIF: Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a
            therapeutic target for HP1alpha-positive intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Jul 5;43(1):186. doi:
            10.1186/s13046-024-03112-w. PMID: 38965576]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2048)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   7  (bases 1 to 2048)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   8  (bases 1 to 2048)
  AUTHORS   Bartl,S., Taplick,J., Lagger,G., Khier,H., Kuchler,K. and Seiser,C.
  TITLE     Identification of mouse histone deacetylase 1 as a growth
            factor-inducible gene
  JOURNAL   Mol Cell Biol 17 (9), 5033-5043 (1997)
   PUBMED   9271381
REFERENCE   9  (bases 1 to 2048)
  AUTHORS   Alland,L., Muhle,R., Hou,H. Jr., Potes,J., Chin,L.,
            Schreiber-Agus,N. and DePinho,R.A.
  TITLE     Role for N-CoR and histone deacetylase in Sin3-mediated
            transcriptional repression
  JOURNAL   Nature 387 (6628), 49-55 (1997)
   PUBMED   9139821
REFERENCE   10 (bases 1 to 2048)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606921.6.
            
            On Oct 12, 2022 this sequence version replaced NM_008228.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.5099.1,
                                           SRR13422589.146891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL606921.6         144197-144339       c
            144-256             AL606921.6         136230-136342       c
            257-374             AL606921.6         130543-130660       c
            375-449             AL606921.6         125862-125936       c
            450-588             AL606921.6         124579-124717       c
            589-730             AL606921.6         123979-124120       c
            731-823             AL606921.6         123034-123126       c
            824-932             AL606921.6         120668-120776       c
            933-1073            AL606921.6         120447-120587       c
            1074-1182           AL606921.6         119629-119737       c
            1183-1313           AL606921.6         119409-119539       c
            1314-1466           AL606921.6         118972-119124       c
            1467-1515           AL606921.6         118516-118564       c
            1516-2048           AL606921.6         117720-118252       c
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..2048
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /note="histone deacetylase 1"
                     /db_xref="GeneID:433759"
                     /db_xref="MGI:MGI:108086"
     exon            1..143
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1543
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /EC_number="3.5.1.98"
                     /note="protein deacetylase HDAC1; protein decrotonylase
                     HDAC1; protein deacylase HDAC1"
                     /codon_start=1
                     /product="histone deacetylase 1"
                     /protein_id="NP_032254.1"
                     /db_xref="CCDS:CCDS18696.1"
                     /db_xref="GeneID:433759"
                     /db_xref="MGI:MGI:108086"
                     /translation="MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLN
                     YGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV
                     FDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI
                     LELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGK
                     GKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNL
                     TIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYF
                     EYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEE
                     SGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKE
                     KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA"
     exon            144..256
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..374
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            375..449
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            450..588
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..730
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..823
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..932
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1073
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1182
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1313
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1466
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1515
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2048
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2022..2027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /note="hexamer: AATAAA"
     polyA_site      2048
                     /gene="Hdac1"
                     /gene_synonym="HD1; Hdac1-ps; MommeD5; RPD3"
                     /note="major polyA site"
ORIGIN      
        1 gcttcgaggc cggcccctcc ccctggtcgg acgccgtaag gagccgcggg cgggcgggcg
       61 gacagactga cgggagggcc gggcggcgag caagatggcg cagactcagg gcaccaagag
      121 gaaagtctgt tactactacg acggggatgt tggaaactac tattatggac aagggcaccc
      181 catgaagcct caccgaatcc gcatgactca caatttgctg ctcaactatg gtctctaccg
      241 aaaaatggag atctaccgtc ctcacaaagc caatgctgag gagatgacca agtaccacag
      301 tgatgactac attaaattcc tgcgttctat tcgcccagat aatatgtctg aatacagcaa
      361 gcagatgcag agattcaatg ttggtgagga ctgtccggtg tttgatggct tgtttgagtt
      421 ctgtcagttg tccacgggag gctctgtcgc aagtgctgtg aagcttaata agcagcagac
      481 ggacatcgct gtgaactggg ccgggggcct gcaccatgca aagaagtctg aagcttctgg
      541 cttctgttac gtcaatgaca tcgtcctggc catcctggaa ctgctaaagt accaccagag
      601 ggtgctctat attgacattg atattcacca tggcgatggc gtggaagagg ccttctatac
      661 tacagaccgg gtcatgactg tgtcctttca taaatacgga gagtacttcc caggaactgg
      721 ggacctacgg gacattgggg ctggcaaagg caagtactat gctgtgaact acccactgcg
      781 agacggcatt gacgacgaat cctatgaagc catctttaag ccagtcatgt ccaaagtaat
      841 ggagatgttc cagcctagtg cagtggtctt acagtgtggc tcagattccc tgtctgggga
      901 ccggttaggt tgcttcaatc tgaccatcaa aggacacgcc aagtgtgtgg agttcgtgaa
      961 gagtttcaac ttgcccatgc tgatgctggg aggaggtggc tacaccatcc ggaatgttgc
     1021 tcgctgctgg acttacgaaa cagcggtggc cctggacaca gagatcccta atgagctgcc
     1081 ctacaacgac tactttgaat actttggacc ggatttcaag cttcacatca gcccttccaa
     1141 catgaccaac cagaacacta acgagtacct ggagaagatc aagcagcgtc tctttgagaa
     1201 cttgaggatg ctgccccatg cccctggggt ccagatgcag gccatccctg aggatgccat
     1261 ccccgaagag agtggggatg aagatgagga ggaccctgac aaacgcatct ccatctgctc
     1321 ctctgacaaa cgcattgcct gtgaggaaga gttctcggac tcagatgagg agggagaagg
     1381 tggtcgcaag aactcttcta acttcaaaaa agccaaaaga gttaaaacag aggatgagaa
     1441 agagaaagat cctgaagaga aaaaagaagt cacagaagaa gagaaaacca aggaggagaa
     1501 gccagaagcc aaaggggtca aagaagaggt caagttggcc tgagcaaggt ctgcagcccc
     1561 atcttctccc caagttcctc acttctcaga ttttatattt tctattcctc tgtgtattta
     1621 tataaaatat attaactata acgtccccag ggaccagagc acagggcagt ggtgctagga
     1681 gggctcttcc cagagcgacc ttgtccatcc tgccaccccc ctccccccat ttgcgtggaa
     1741 agaaaacaac cagaagagaa aaatcctgaa ctgccaagtg cctgcttagg agctctgcta
     1801 agatgcccct gttaaacttt ttaggagggg tctgggtctc ctaggacccc ttttcaggct
     1861 tgggtaatag cagccatttt tagattggtt ctgtttatac cttcccaccc atcttgggca
     1921 aacaaaaaaa cttatattgc ctgtcttccc ccaattctgt aggtggaggt tgatagccta
     1981 gcttcctttt tgagatattt tcattttgtg aaactctttg taataaaaca gctcatttct
     2041 ataccctc
//
