LOCUS       NM_011827                452 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hematopoietic cell signal transducer (Hcst), mRNA.
ACCESSION   NM_011827
VERSION     NM_011827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Wang,S., Sudan,R., Peng,V., Zhou,Y., Du,S., Yuede,C.M., Lei,T.,
            Hou,J., Cai,Z., Cella,M., Nguyen,K., Poliani,P.L., Beatty,W.L.,
            Chen,Y., Cao,S., Lin,K., Rodrigues,C., Ellebedy,A.H., Gilfillan,S.,
            Brown,G.D., Holtzman,D.M., Brioschi,S. and Colonna,M.
  TITLE     TREM2 drives microglia response to amyloid-beta via SYK-dependent
            and -independent pathways
  JOURNAL   Cell 185 (22), 4153-4169 (2022)
   PUBMED   36306735
REFERENCE   3  (bases 1 to 452)
  AUTHORS   Ampudia-Mesias,E., Puerta-Martinez,F., Bridges,M., Zellmer,D.,
            Janeiro,A., Strokes,M., Sham,Y.Y., Taher,A., Castro,M.G.,
            Moertel,C.L., Pluhar,G.E. and Olin,M.R.
  TITLE     CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response
            Through the DAP10 Signaling Pathway
  JOURNAL   Neurotherapeutics 18 (3), 1980-1994 (2021)
   PUBMED   33829411
  REMARK    GeneRIF: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma
            Response Through the DAP10 Signaling Pathway.
            Erratum:[Neurotherapeutics. 2021 Jul;18(3):2131. doi:
            10.1007/s13311-021-01062-1.. PMID: 33929711]
REFERENCE   4  (bases 1 to 452)
  AUTHORS   Babic,M., Dimitropoulos,C., Hammer,Q., Stehle,C., Heinrich,F.,
            Sarsenbayeva,A., Eisele,A., Durek,P., Mashreghi,M.F., Lisnic,B.,
            Van Snick,J., Lohning,M., Fillatreau,S., Withers,D.R., Gagliani,N.,
            Huber,S., Flavell,R.A., Polic,B. and Romagnani,C.
  TITLE     NK cell receptor NKG2D enforces proinflammatory features and
            pathogenicity of Th1 and Th17 cells
  JOURNAL   J Exp Med 217 (8) (2020)
   PUBMED   32453422
REFERENCE   5  (bases 1 to 452)
  AUTHORS   Parikh,B.A., Bern,M.D., Piersma,S.J., Yang,L., Beckman,D.L.,
            Poursine-Laurent,J., Plougastel-Douglas,B. and Yokoyama,W.M.
  TITLE     Control of Viral Infection by Natural Killer Cell Inhibitory
            Receptors
  JOURNAL   Cell Rep 32 (4), 107969 (2020)
   PUBMED   32726632
REFERENCE   6  (bases 1 to 452)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   7  (bases 1 to 452)
  AUTHORS   Wilson,M.J., Haude,A. and Trowsdale,J.
  TITLE     The mouse Dap10 gene
  JOURNAL   Immunogenetics 53 (4), 347-350 (2001)
   PUBMED   11491539
REFERENCE   8  (bases 1 to 452)
  AUTHORS   Yim,D., Jie,H.B., Sotiriadis,J., Kim,Y.S., Kim,K.S.,
            Rothschild,M.F., Lanier,L.L. and Kim,Y.B.
  TITLE     Molecular cloning and characterization of pig immunoreceptor DAP10
            and NKG2D
  JOURNAL   Immunogenetics 53 (3), 243-249 (2001)
   PUBMED   11398969
REFERENCE   9  (bases 1 to 452)
  AUTHORS   Chang,C., Dietrich,J., Harpur,A.G., Lindquist,J.A., Haude,A.,
            Loke,Y.W., King,A., Colonna,M., Trowsdale,J. and Wilson,M.J.
  TITLE     Cutting edge: KAP10, a novel transmembrane adapter protein
            genetically linked to DAP12 but with unique signaling properties
  JOURNAL   J Immunol 163 (9), 4651-4654 (1999)
   PUBMED   10528161
REFERENCE   10 (bases 1 to 452)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF172930.1.
            
            On Aug 13, 2009 this sequence version replaced NM_011827.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF172930.1, W13188.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               AF172930.1         1-452
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.45 cM"
     gene            1..452
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /note="hematopoietic cell signal transducer"
                     /db_xref="GeneID:23900"
                     /db_xref="MGI:MGI:1344360"
     exon            1..151
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..348
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /note="membrane protein DAP10; DNAX-activation protein 10;
                     transmembrane adapter protein KAP10"
                     /codon_start=1
                     /product="hematopoietic cell signal transducer precursor"
                     /protein_id="NP_035957.2"
                     /db_xref="CCDS:CCDS39882.1"
                     /db_xref="GeneID:23900"
                     /db_xref="MGI:MGI:1344360"
                     /translation="MDPPGYLLFLLLLPVAASQTSAGSCSGCGTLSLPLLAGLVAADA
                     VMSLLIVGVVFVCMRPHGRPAQEDGRVYINMPGRG"
     exon            152..175
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            176..307
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /inference="alignment:Splign:2.1.0"
     exon            308..442
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      425..430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /note="hexamer: AATAAA"
     polyA_site      442
                     /gene="Hcst"
                     /gene_synonym="DAP10; KAP10"
                     /note="major polyA site"
ORIGIN      
        1 gtcaccatcg gggtgacatc cgtcctagct gcctctcttc tcctctactg ttctgaggac
       61 ttccctggac cacagttttg gccagatccc ttcaggtccc agcccagcat ggacccccca
      121 ggctacctcc tgttcctgct tctgctccca gtggctgcaa gtcagacatc ggcaggttcc
      181 tgctccggat gtgggactct gtctctgcca ctcctggcag gcctagtggc tgcagatgcg
      241 gtcatgtcac tcctaattgt aggggtggtg tttgtatgta tgcgcccaca cggcaggcct
      301 gcccaagaag atggtagagt ctacatcaac atgcctggca gaggctgacc acggcacctt
      361 ctgacccgct catcctggat cctgtgggtt tggggtgcgt gggaacgcac ttcttcagga
      421 caggaataaa gcgattcaaa taaaaaaaaa aa
//
