LOCUS       NM_198962               3773 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus hypocretin (orexin) receptor 2 (Hcrtr2), transcript
            variant 1, mRNA.
ACCESSION   NM_198962
VERSION     NM_198962.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Sahoo,P., Sarkar,D., Sharma,S., Verma,A., Naik,S.K., Prashar,V.,
            Parkash,J. and Singh,S.K.
  TITLE     Knockdown of type 2 orexin receptor in adult mouse testis
            potentiates testosterone production and germ cell proliferation
  JOURNAL   Mol Cell Endocrinol 592, 112312 (2024)
   PUBMED   38866320
  REMARK    GeneRIF: Knockdown of type 2 orexin receptor in adult mouse testis
            potentiates testosterone production and germ cell proliferation.
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Tsuneoka,Y. and Funato,H.
  TITLE     Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized
            by Branched In Situ Hybridization Chain Reaction
  JOURNAL   eNeuro 11 (2) (2024)
   PUBMED   38199807
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Yadav,A., Singh,S.K. and Sarkar,D.
  TITLE     Localization and expression of Orexin B (OXB) and its type 2
            receptor (OX2R) in mouse testis during postnatal development
  JOURNAL   Peptides 164, 170979 (2023)
   PUBMED   36841281
  REMARK    GeneRIF: Localization and expression of Orexin B (OXB) and its type
            2 receptor (OX2R) in mouse testis during postnatal development.
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Mitsukawa,K. and Kimura,H.
  TITLE     Orexin 2 receptor (OX2R) protein distribution measured by
            autoradiography using radiolabeled OX2R-selective antagonist EMPA
            in rodent brain and peripheral tissues
  JOURNAL   Sci Rep 12 (1), 8473 (2022)
   PUBMED   35589803
  REMARK    GeneRIF: Orexin 2 receptor (OX2R) protein distribution measured by
            autoradiography using radiolabeled OX2R-selective antagonist EMPA
            in rodent brain and peripheral tissues.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Xiao,X., Yeghiazaryan,G., Hess,S., Klemm,P., Sieben,A.,
            Kleinridders,A., Morgan,D.A., Wunderlich,F.T., Rahmouni,K.,
            Kong,D., Scammell,T.E., Lowell,B.B., Kloppenburg,P., Bruning,J.C.
            and Hausen,A.C.
  TITLE     Orexin receptors 1 and 2 in serotonergic neurons differentially
            regulate peripheral glucose metabolism in obesity
  JOURNAL   Nat Commun 12 (1), 5249 (2021)
   PUBMED   34475397
  REMARK    GeneRIF: Orexin receptors 1 and 2 in serotonergic neurons
            differentially regulate peripheral glucose metabolism in obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Chen,J. and Randeva,H.S.
  TITLE     Genomic organization of mouse orexin receptors: characterization of
            two novel tissue-specific splice variants
  JOURNAL   Mol Endocrinol 18 (11), 2790-2804 (2004)
   PUBMED   15256537
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Willie,J.T., Chemelli,R.M., Sinton,C.M., Tokita,S., Williams,S.C.,
            Kisanuki,Y.Y., Marcus,J.N., Lee,C., Elmquist,J.K., Kohlmeier,K.A.,
            Leonard,C.S., Richardson,J.A., Hammer,R.E. and Yanagisawa,M.
  TITLE     Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null
            mice: molecular genetic dissection of Non-REM and REM sleep
            regulatory processes
  JOURNAL   Neuron 38 (5), 715-730 (2003)
   PUBMED   12797957
REFERENCE   8  (bases 1 to 3773)
  AUTHORS   Terao,A., Apte-Deshpande,A., Morairty,S., Freund,Y.R. and
            Kilduff,T.S.
  TITLE     Age-related decline in hypocretin (orexin) receptor 2 messenger RNA
            levels in the mouse brain
  JOURNAL   Neurosci Lett 332 (3), 190-194 (2002)
   PUBMED   12399012
  REMARK    GeneRIF: hypocretin receptor 2 mRNA levels declined with age in the
            hippocampus, thalamus, pons, and medulla (hypocretin receptor 2)
REFERENCE   9  (bases 1 to 3773)
  AUTHORS   Hungs,M. and Mignot,E.
  TITLE     Hypocretin/orexin, sleep and narcolepsy
  JOURNAL   Bioessays 23 (5), 397-408 (2001)
   PUBMED   11340621
  REMARK    Review article
REFERENCE   10 (bases 1 to 3773)
  AUTHORS   Willie,J.T., Chemelli,R.M., Sinton,C.M. and Yanagisawa,M.
  TITLE     To eat or to sleep? Orexin in the regulation of feeding and
            wakefulness
  JOURNAL   Annu Rev Neurosci 24, 429-458 (2001)
   PUBMED   11283317
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140311.2.
            
            On Jun 21, 2018 this sequence version replaced NM_198962.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038551.1, AK048781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC140311.2         155244-155585       c
            343-521             AC140311.2         91614-91792         c
            522-765             AC140311.2         86423-86666         c
            766-881             AC140311.2         78309-78424         c
            882-1102            AC140311.2         68131-68351         c
            1103-1224           AC140311.2         64862-64983         c
            1225-1447           AC140311.2         62466-62688         c
            1448-3773           AC140311.2         57842-60167         c
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.48 cM"
     gene            1..3773
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="hypocretin (orexin) receptor 2"
                     /db_xref="GeneID:387285"
                     /db_xref="MGI:MGI:2680765"
     exon            1..342
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1502
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orexin receptor type 2; hypocretin receptor type 2; orexin
                     receptor type-2a"
                     /codon_start=1
                     /product="orexin receptor type 2 isoform 1"
                     /protein_id="NP_945200.1"
                     /db_xref="CCDS:CCDS23350.1"
                     /db_xref="GeneID:387285"
                     /db_xref="MGI:MGI:2680765"
                     /translation="MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLW
                     REYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVL
                     VTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL
                     MFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEV
                     YPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPR
                     GSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFT
                     HTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHHRQGDR
                     LARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNWYLQQGVP
                     SSLLSTWLEV"
     exon            343..521
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..765
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..881
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1102
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1224
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1447
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..3773
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3062..3067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="hexamer: AGTAAA"
     polyA_site      3093
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="major polyA site"
     regulatory      3143..3148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="hexamer: CATAAA"
     polyA_site      3166
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="major polyA site"
     regulatory      3500..3505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="hexamer: ATTAAA"
     polyA_site      3518
                     /gene="Hcrtr2"
                     /gene_synonym="mOX2aR; mOX2bR; mOXR2; OX2aR; OX2bR; OX2R;
                     OXR2"
                     /note="major polyA site"
ORIGIN      
        1 attcccggct ccagagcccc tagtcgcggc ggcgcagcct ttcccaccgc ggatcctcag
       61 tgctcatggg gcaggcggag acaagcttgc agcactgagc cgaacgggac cagtccgtga
      121 tgtccagcac caaactggag gattccctct ctcgtcgcaa ctggtcatct gcttcagagc
      181 tgaatgaaac tcaagagccg tttttaaatc ccacggacta tgacgacgag gaattcctgc
      241 ggtacctgtg gagggaatac ctacacccga aagaatatga gtgggtcctg atcgcagggt
      301 atatcatcgt gttcgttgtg gctctcatcg ggaacgtcct ggtctgtgtg gcagtgtgga
      361 agaaccacca catgaggaca gtcaccaact acttcatagt caacctttcc ctagcagatg
      421 tgcttgtgac catcacctgc cttccagcta ccctcgttgt tgacatcact gagacttggt
      481 tctttggaca gtccctctgt aaggtcattc cttatttaca gactgtgtca gtgtctgtgt
      541 ctgttcttac gttgagctgc attgccttgg accgatggta cgccatttgt caccctttga
      601 tgttcaagag cacagccaaa cgggctcgaa acagcatcgt tgtcatctgg atcgtctcct
      661 gcatcataat gattcctcaa gccattgtca tggagtgcag cagcatgctc cctggcctag
      721 ccaataagac caccctcttt acagtatgtg atgaacactg gggcggtgaa gtttacccaa
      781 agatgtacca tatctgcttc tttctggtga catacatggc acctctgtgt cttatgatat
      841 tggcttatct ccaaatattc cgtaaactct ggtgccgaca gattcccgga acttcttctg
      901 tggttcagag aaaatggaag cagcagcagc cggtttctca gccccggggg tccggacagc
      961 agagcaaggc tcggattagc gctgttgctg ctgagataaa gcagatccga gcacgaagga
     1021 aaacagcccg gatgctcatg gttgtacttc tggtctttgc aatttgctat ctaccaatca
     1081 gcatcctcaa tgtgctaaag agagtatttg ggatgttcac acacacggaa gacagagaga
     1141 ctgtctatgc ttggttcact ttttctcatt ggcttgtata tgccaacagt gctgcaaacc
     1201 caattattta taattttctt agtggaaaat ttcgagagga atttaaagct gccttttctt
     1261 gttgtcttgg ggttcatcat cgccaaggag accgcctcgc caggggacgc acgagcacag
     1321 agagcaggaa gtccctgacc acacagatca gcaactttga caatgtatca aaactctcag
     1381 agcacgtggt gctcaccagc ataagcacac tcccagcagc caacggggca ggaccgcttc
     1441 aaaactggta tctacagcag ggagtaccat cttcactcct gtccacctgg ctggaggtct
     1501 gagagaagag gcccgagcat ccttatggaa tctcacccat gtctgctcaa agagataaca
     1561 gtttacaaaa caattgccac tgtgttctta gtatgatgtt aaagaagatg gactttaagg
     1621 cacgtatgcg ctttatacat gacccggatg acttgagttt tcatttacta aagtttccgt
     1681 tttgtggaag ccattcatgt tcaagaataa ttgttgcctg gaagaaaact gatgaataag
     1741 acacatgcat aaatgatgcg ggggatggaa tcatgaaccg tgtatatact tctcagcatt
     1801 agggcccggg aatcctgaga gatttgaatt aatgtggtga ccttcatagg acaaacggtt
     1861 aaaagatagg aggcccccaa acctagcaat ggtgttgggg tgcttaacta cttacttcat
     1921 tgtgtgctaa cgatgcaaat gagaagactt cataggaaag ttttgcttta gaactgagca
     1981 atgctgaaca ttggacattg acctaccttt atttcctttg tatttcaagc cttcgatgtg
     2041 agatgtcaac gtcattagtt ttgttgctaa taagacagtg taataatttt accaaatata
     2101 tttgagatga atgatttacg aatttttata atatcatgaa aaccttgata ttttgagttt
     2161 attcctttag ggttaaatat taacccaagt gtgtgagaga gaggtgaaaa aaatgagttc
     2221 tacattttcc acaatgtgga ataattaagt agttataaac tattgataag ttcagtgtaa
     2281 aagtgtcagg cacagtaata cctagtttca ctcgggtata cattaattca ggaagaataa
     2341 ttaactatgc ttttaagtga caatctgaat gtgtctagag ttgttactaa taataactga
     2401 aatgagggct attagcactt tgatacaatg taataatatc aggtttgcat tagctgtgag
     2461 tcataacagg aattaactgc atttcaagaa acatggctag tccttacaat tagaaaccct
     2521 tcagtgggac ttaactttca acagcttact cttctccttc aaaccacagg ccaaagcata
     2581 aattccatta gattattttc aaatagtttc cacattgctt gaagcaaaac aatggtattt
     2641 taaggtcatt atataagtag gaaagtattc atttataatc ctttctatta ctttatgcac
     2701 agaagaaaac aacataaaca tgaaaatcac tgttagttct caaagttcaa agggaatgct
     2761 tttctacact cttctgctat tgaaaagggg gacaaaagac tcccctacct tgccacgtat
     2821 ttctattctt ttagattttc tttatagact ttggagttag aaaatctagt ttttttcatg
     2881 aatatgtttt tattattgta tctatgtatg tatcagcatg acagttgctc aataattatt
     2941 tatttaaaat aattatatcc ttatgcttga ttgtactgtg tcttcatgaa aatctttttt
     3001 ttttgtataa aaaatgtgat tatatgtctc ccagtgtgaa ggttgaatta tgtaattttt
     3061 aagtaaaatg tcactgagaa gttcataatc acatccacat tgtcctgctg tcctatgtga
     3121 aaaatgatgt tgttgttcaa tacataaatt ggatatttgc tcataattat tgtcaaatct
     3181 ttgcagttaa ggattgaatt aaccctggtg cagtacttga tgaccaaaat atttttccaa
     3241 taagtttata taaccaggga taattatgat ataaaagatt tttaatatta tttctaagag
     3301 gaggtactat aataaaagtt aatattaaac acagagatat ttcataaaag ttatacaaaa
     3361 ccacacattt atagaagtaa aaatcaaagc ttttgtctga gtcagaattt tcctctgctt
     3421 gtgacttaga ataataaccc ccttagttta caaatgatta ttatagtctg aaaatgcatg
     3481 agttagcttt ctctaaaata ttaaactttt aaacgatacc tttagttgac tatttttttt
     3541 tgagccagat ggttatcaag gacttcaaac tatagtgtaa atgatttaaa tgattcttaa
     3601 aaccaattct tagtcagaac attttattct atttacaggg gtaagcattt gactcctaag
     3661 gtggaacacc atcatagaag aagggggagg gatgatggaa taggggtgtt ccggaggaga
     3721 aaccagaaaa ggggaaaaca tttgaaacgt aaacaaataa aaaatttaaa aac
//
