LOCUS       NM_198959               2202 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus hypocretin (orexin) receptor 1 (Hcrtr1), transcript
            variant 1, mRNA.
ACCESSION   NM_198959 XM_131679
VERSION     NM_198959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Fan JK, Wang MC, Yang HM, Zhang JN, Gu L and Zhang H.
  TITLE     alpha-Synuclein Induced the Occurrence of RBD via Interaction with
            OX1R and Modulated Its Degradation
  JOURNAL   Neuromolecular Med 25 (2), 286-300 (2023)
   PUBMED   36689149
  REMARK    GeneRIF: alpha-Synuclein Induced the Occurrence of RBD via
            Interaction with OX1R and Modulated Its Degradation.
REFERENCE   2  (bases 1 to 2202)
  AUTHORS   Raich I, Rebassa JB, Lillo J, Cordomi A, Rivas-Santisteban R, Lillo
            A, Reyes-Resina I, Franco R and Navarro G.
  TITLE     Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in
            Microglia from APPSw/Ind Mice Model
  JOURNAL   Int J Mol Sci 23 (21), 12801 (2022)
   PUBMED   36361598
  REMARK    GeneRIF: Antagonization of OX1 Receptor Potentiates CB2 Receptor
            Function in Microglia from APPSw/Ind Mice Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2202)
  AUTHORS   Cook C, Nunn N, Worth AA, Bechtold DA, Suter T, Gackeheimer S,
            Foltz L, Emmerson PJ, Statnick MA and Luckman SM.
  TITLE     The hypothalamic RFamide, QRFP, increases feeding and locomotor
            activity: The role of Gpr103 and orexin receptors
  JOURNAL   PLoS One 17 (10), e0275604 (2022)
   PUBMED   36251705
  REMARK    GeneRIF: The hypothalamic RFamide, QRFP, increases feeding and
            locomotor activity: The role of Gpr103 and orexin receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2202)
  AUTHORS   Kirjavainen A, Singh P, Lahti L, Seja P, Lelkes Z, Makkonen A,
            Kilpinen S, Ono Y, Salminen M, Aitta-Aho T, Stenberg T, Molchanova
            S, Achim K and Partanen J.
  TITLE     Gata2, Nkx2-2 and Skor2 form a transcription factor network
            regulating development of a midbrain GABAergic neuron subtype with
            characteristics of REM-sleep regulatory neurons
  JOURNAL   Development 149 (14) (2022)
   PUBMED   35815619
REFERENCE   5  (bases 1 to 2202)
  AUTHORS   Yaeger JDW, Krupp KT, Jacobs BM, Onserio BO, Meyerink BL, Cain JT,
            Ronan PJ, Renner KJ, DiLeone RJ and Summers CH.
  TITLE     Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the
            Balance From Pro- to Antistress Signaling and Behavior
  JOURNAL   Biol Psychiatry 91 (9), 841-852 (2022)
   PUBMED   35279280
  REMARK    GeneRIF: Orexin 1 Receptor Antagonism in the Basolateral Amygdala
            Shifts the Balance From Pro- to Antistress Signaling and Behavior.
REFERENCE   6  (bases 1 to 2202)
  AUTHORS   Chen J and Randeva HS.
  TITLE     Genomic organization of mouse orexin receptors: characterization of
            two novel tissue-specific splice variants
  JOURNAL   Mol Endocrinol 18 (11), 2790-2804 (2004)
   PUBMED   15256537
REFERENCE   7  (bases 1 to 2202)
  AUTHORS   Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT,
            Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE and
            Gaitanaris GA.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   8  (bases 1 to 2202)
  AUTHORS   Hungs M and Mignot E.
  TITLE     Hypocretin/orexin, sleep and narcolepsy
  JOURNAL   Bioessays 23 (5), 397-408 (2001)
   PUBMED   11340621
  REMARK    Review article
REFERENCE   9  (bases 1 to 2202)
  AUTHORS   Willie JT, Chemelli RM, Sinton CM and Yanagisawa M.
  TITLE     To eat or to sleep? Orexin in the regulation of feeding and
            wakefulness
  JOURNAL   Annu Rev Neurosci 24, 429-458 (2001)
   PUBMED   11283317
  REMARK    Review article
REFERENCE   10 (bases 1 to 2202)
  AUTHORS   Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H,
            Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR,
            Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS,
            Terrett JA, Elshourbagy NA, Bergsma DJ and Yanagisawa M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606925.16, AK140137.1 and AI852516.1.
            
            [WARNING] On Dec 5, 2023 this sequence was replaced by NM_198959.3.
            
            On Jul 8, 2009 this sequence version replaced NM_198959.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY336083.1, BC119583.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AL606925.16        104402-104556       c
            156-2184            AK140137.1         130-2158
            2185-2202           AI852516.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..2202
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /note="hypocretin (orexin) receptor 1"
                     /db_xref="GeneID:230777"
                     /db_xref="MGI:MGI:2385650"
     exon            1..155
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            156..273
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            274..511
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1563
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orexin receptor type 1; hypocretin receptor type 1;
                     orexin/Hypocretin receptor type 1"
                     /codon_start=1
                     /product="orexin/Hypocretin receptor type 1 isoform 1"
                     /protein_id="NP_945197.2"
                     /db_xref="CCDS:CCDS18707.1"
                     /db_xref="GeneID:230777"
                     /db_xref="MGI:MGI:2385650"
                     /translation="MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQ
                     YEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPA
                     SLLVDITESWLFGQALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR
                     ARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDEHWADELYPKIYHSC
                     FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEP
                     QPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE
                     AVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPGSSARHKSLS
                     LQSRCSVSKVSEHVVLTTVTTVLS"
     exon            512..690
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            691..934
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1050
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1277
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1399
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2187
                     /gene="Hcrtr1"
                     /gene_synonym="ox-1-R; ox1-R; Ox1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaccaga gccgggacca cgcagccact gagcggacag cgccgcctca ggagggggct
       61 accccgccgc gtctccagtt ccgcaccaag gcgaagtccc gcgagcaagg tccaggttcc
      121 agcaacggag gatgcccggg gccgggagcc aacagggctt gctaataatg ataccgaata
      181 ctgactggag ggccagcttc tgggtgtacc aggctctggg tgaagtagtt cccaaacctt
      241 agagctcaat actcttcatc gtggctctgg aagagcccag gactctcctc agctgaagtg
      301 gctcctaaac tcatggaacc ctcggccact cctggggccc agcctggagt ccccactagt
      361 agtggggaac ccttccatct gcctccagac tatgaggacg agttcctccg atacctgtgg
      421 cgcgattatc tctacccgaa gcagtacgag tgggttctca ttgcagccta cgtggctgtg
      481 ttcctcatag ccttggtggg caataccctg gtctgcctgg ctgtgtggcg gaaccaccac
      541 atgaggacag tcaccaacta cttcattgtc aacctgtccc tggcagatgt gctggtgact
      601 gccatctgcc tgcctgccag cctgttagtg gacatcaccg agtcgtggct cttcggccag
      661 gctttgtgca aggtcattcc ctatctccag gctgtgtcgg tgtcagtggc agtgctgact
      721 ctcagcttca tcgccctgga ccgctggtat gccatctgcc acccactgtt gttcaagagc
      781 acagctcgcc gtgcccgtgg ctccatcctg ggcatctggg ctgtgtcgct ggctgtcatg
      841 gtgccccagg ctgctgtcat ggagtgcagc agcgtgctgc ctgagctagc caatcgcacc
      901 cggctcttct ctgtctgtga tgagcactgg gcagatgaac tctaccccaa gatctatcac
      961 agctgctttt tcattgtcac ctacctggcc ccactgggcc tcatggctat ggcctatttc
     1021 cagatcttcc gcaagctctg gggccgccag atccctggta ccacatcagc cttggtgcgg
     1081 aactggaaac ggccctcgga acaactggag gctcagcacc agggcctctg tacagagccc
     1141 cagccccggg cccgagcctt cctggctgag gtgaagcaga tgcgagctcg gaggaagacg
     1201 gctaagatgc tgatggtagt cctgctggtt tttgcactct gttatctgcc catcagtgtc
     1261 ctcaatgtcc ttaagagagt gttcgggatg ttccgccaag ccagcgaccg ggaagccgtc
     1321 tacgcctgct tcaccttctc ccactggcta gtgtacgcca acagtgccgc caaccctatc
     1381 atctacaact tcctcagtgg caaattccgg gagcagttca aggctgcctt ctcctgctgc
     1441 ctgcctggtc tgggtcccgg ctcctctgcc agacacaagt ccttgtcctt gcagagccgc
     1501 tgctccgtct ccaaggtctc tgagcatgtc gtgctgacca ccgtcactac cgtgctgtcc
     1561 tgagtggggc cggcccaggc tctgggagac ctggtccttt gcctggggtc caccccagca
     1621 gtcacaggaa gactgctgcg gttcagtgag aggctgtgcg atgccagtcc tggttttctg
     1681 ccagagtcat cccctctctg aggttgtgtc ccctaagctg ggtggatagg ggcttaagct
     1741 gctcaagaaa gcagtgttgc aaaccgtcta gtgctgtggg cgtggttact gtcatccctg
     1801 tctcatatgg ctctacccta gagtgtcact tcaccctatc agagcttggc tttcctccca
     1861 aagacctgac tcctactcaa ttataggcct ttcctgcctg gagtctgctc caaaggtccc
     1921 cacagacata ttcacctggc ctgaagacca ctggaagccg ggactgcaca tggcctgttg
     1981 caccaatgtg tccctgtgaa ctaatttggg ctcagccctt ctcagtgagc tctgaagcac
     2041 ggtctaccct ctccaggtgt ggactgcatg ctgcacaggc tagagctcgt tggcattgtg
     2101 gaatgcttaa acactctcca tgtggccatt cgttcagcat ggaggccagc agcccggagc
     2161 agctgtaatt aaaagcctgg cactgaaaaa aaaaaaaaaa aa
//
