LOCUS       NM_010410                584 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus hypocretin (Hcrt), mRNA.
ACCESSION   NM_010410
VERSION     NM_010410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 584)
  AUTHORS   Chen,B., Jin,K., Dong,J., Cheng,S., Kong,L., Hu,S., Chen,Z. and
            Lu,J.
  TITLE     Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and
            Cognitive Function through Hippocampal Lactate Homeostasis in
            Depressed Model
  JOURNAL   Adv Sci (Weinh) 11 (38), e2405354 (2024)
   PUBMED   39119889
  REMARK    GeneRIF: Hypocretin-1/Hypocretin Receptor 1 Regulates
            Neuroplasticity and Cognitive Function through Hippocampal Lactate
            Homeostasis in Depressed Model.
REFERENCE   2  (bases 1 to 584)
  AUTHORS   Braga,A., Chiacchiaretta,M., Pellerin,L., Kong,D. and Haydon,P.G.
  TITLE     Astrocytic metabolic control of orexinergic activity in the lateral
            hypothalamus regulates sleep and wake architecture
  JOURNAL   Nat Commun 15 (1), 5979 (2024)
   PUBMED   39013907
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 584)
  AUTHORS   Yang,D., Wang,Y., Qi,T., Zhang,X., Shen,L., Ma,J., Pang,Z.,
            Lal,N.K., McClatchy,D.B., Seradj,S.H., Leung,V.H., Wang,K., Xie,Y.,
            Polli,F.S., Maximov,A., Gonzalez,O.C., de Lecea,L., Cline,H.T.,
            Augustine,V., Yates,J.R. 3rd and Ye,L.
  TITLE     Phosphorylation of pyruvate dehydrogenase inversely associates with
            neuronal activity
  JOURNAL   Neuron 112 (6), 959-971 (2024)
   PUBMED   38266644
REFERENCE   4  (bases 1 to 584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 584)
  AUTHORS   Liao,Y., Wen,R., Fu,S., Cheng,X., Ren,S., Lu,M., Qian,L., Luo,F.,
            Wang,Y., Xiao,Q., Wang,X., Ye,H., Zhang,X., Jiang,C., Li,X., Li,S.,
            Dang,R., Liu,Y., Kang,J., Yao,Z., Yan,J., Xiong,J., Wang,Y., Wu,S.,
            Chen,X., Li,Y., Xia,J., Hu,Z. and He,C.
  TITLE     Spatial memory requires hypocretins to elevate medial entorhinal
            gamma oscillations
  JOURNAL   Neuron 112 (1), 155-173 (2024)
   PUBMED   37944520
REFERENCE   6  (bases 1 to 584)
  AUTHORS   Chemelli,R.M., Willie,J.T., Sinton,C.M., Elmquist,J.K.,
            Scammell,T., Lee,C., Richardson,J.A., Williams,S.C., Xiong,Y.,
            Kisanuki,Y., Fitch,T.E., Nakazato,M., Hammer,R.E., Saper,C.B. and
            Yanagisawa,M.
  TITLE     Narcolepsy in orexin knockout mice: molecular genetics of sleep
            regulation
  JOURNAL   Cell 98 (4), 437-451 (1999)
   PUBMED   10481909
REFERENCE   7  (bases 1 to 584)
  AUTHORS   Siegel,J.M.
  TITLE     Narcolepsy: a key role for hypocretins (orexins)
  JOURNAL   Cell 98 (4), 409-412 (1999)
   PUBMED   10481905
  REMARK    Review article
REFERENCE   8  (bases 1 to 584)
  AUTHORS   Yamamoto,Y., Ueta,Y., Date,Y., Nakazato,M., Hara,Y., Serino,R.,
            Nomura,M., Shibuya,I., Matsukura,S. and Yamashita,H.
  TITLE     Down regulation of the prepro-orexin gene expression in genetically
            obese mice
  JOURNAL   Brain Res Mol Brain Res 65 (1), 14-22 (1999)
   PUBMED   10036303
REFERENCE   9  (bases 1 to 584)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   10 (bases 1 to 584)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF019566.1.
            
            On Apr 5, 2007 this sequence version replaced NM_010410.1.
            
            Summary: This gene encodes a hypothalamic neuropeptide precursor
            protein that gives rise to two mature neuropeptides, orexin A and
            orexin B, by proteolytic processing. Orexin A and orexin B, which
            bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2,
            function in the regulation of sleep and arousal. This neuropeptide
            arrangement may also play a role in feeding behavior, metabolism,
            and homeostasis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF019566.1, CD769124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AF019566.1         2-585
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.6 cM"
     gene            1..584
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
                     /note="hypocretin"
                     /db_xref="GeneID:15171"
                     /db_xref="MGI:MGI:1202306"
     exon            1..111
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..483
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
                     /note="prepro-orexin; orexin A; orexin B;
                     preprohypocretin; hypocretin neuropeptide"
                     /codon_start=1
                     /product="hypocretin neuropeptide precursor precursor"
                     /protein_id="NP_034540.1"
                     /db_xref="CCDS:CCDS25436.1"
                     /db_xref="GeneID:15171"
                     /db_xref="MGI:MGI:1202306"
                     /translation="MNFPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTC
                     SCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGA
                     ELEPHPCSGRGCPTVTTTALAPRGGSGV"
     exon            112..584
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      556..561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
     polyA_site      575
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
ORIGIN      
        1 aagacgacgg cctcagactt cttgggtatt tggaccactg cactgaagag atcatctctc
       61 cagattactt tcccctgagc tccaggcacc atgaactttc cttctacaaa ggttccctgg
      121 gccgccgtga cgctgctgct gctgctactg ctgccgccgg cgctgctgtc gcttggggtg
      181 gacgcacagc ctctgcccga ctgctgtcgc cagaagacgt gttcctgccg tctctacgaa
      241 ctgttgcacg gagctggcaa ccacgctgcg ggtatcctga ctctgggaaa gcggcggcct
      301 ggacctccag gcctccaggg acggctgcag cgcctccttc aggccaacgg taaccacgca
      361 gctggcatcc tgaccatggg ccgccgcgca ggcgcagagc tagagccaca tccctgctct
      421 ggtcgcggct gtccgaccgt aactaccacc gctttagcac cccggggagg gtccggagtc
      481 tgaacccatc ttctatcctt gtcctgatcc aaacttcccc ctctgctcgc cgctgtcagt
      541 ctcttggtaa atggcaataa agacgattct ctgttggtgt gact
//
