LOCUS       NM_001081192            6581 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus hyperpolarization-activated, cyclic nucleotide-gated
            K+ 4 (Hcn4), mRNA.
ACCESSION   NM_001081192 XM_287905
VERSION     NM_001081192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6581)
  AUTHORS   Abassah-Oppong,S., Zoia,M., Mannion,B.J., Rouco,R., Tissieres,V.,
            Spurrell,C.H., Roland,V., Darbellay,F., Itum,A., Gamart,J.,
            Festa-Daroux,T.A., Sullivan,C.S., Kosicki,M.,
            Rodriguez-Carballo,E., Fukuda-Yuzawa,Y., Hunter,R.D., Novak,C.S.,
            Plajzer-Frick,I., Tran,S., Akiyama,J.A., Dickel,D.E.,
            Lopez-Rios,J., Barozzi,I., Andrey,G., Visel,A., Pennacchio,L.A.,
            Cobb,J. and Osterwalder,M.
  TITLE     A gene desert required for regulatory control of pleiotropic Shox2
            expression and embryonic survival
  JOURNAL   Nat Commun 15 (1), 8793 (2024)
   PUBMED   39389973
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6581)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6581)
  AUTHORS   Liang,D., Zhou,L., Zhou,H., Zhang,F., Fang,G., Leng,J., Wu,Y.,
            Zhang,Y., Yang,A., Liu,Y. and Chen,Y.H.
  TITLE     A GABAergic system in atrioventricular node pacemaker cells
            controls electrical conduction between the atria and ventricles
  JOURNAL   Cell Res 34 (8), 556-571 (2024)
   PUBMED   38849501
REFERENCE   4  (bases 1 to 6581)
  AUTHORS   Li,H., Tang,Q., Yang,T., Wang,Z., Li,D., Wang,L., Li,L., Chen,Y.,
            Huang,H., Zhang,Y. and Chen,Y.
  TITLE     Segregation of morphogenetic regulatory function of Shox2 from its
            cell fate guardian role in sinoatrial node development
  JOURNAL   Commun Biol 7 (1), 385 (2024)
   PUBMED   38553636
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6581)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 6581)
  AUTHORS   Stieber,J., Herrmann,S., Feil,S., Loster,J., Feil,R., Biel,M.,
            Hofmann,F. and Ludwig,A.
  TITLE     The hyperpolarization-activated channel HCN4 is required for the
            generation of pacemaker action potentials in the embryonic heart
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15235-15240 (2003)
   PUBMED   14657344
  REMARK    GeneRIF: HCN4 channels are essential for the proper generation of
            pacemaker potentials in the emerging sinoatrial node
REFERENCE   7  (bases 1 to 6581)
  AUTHORS   Kuwahara,K., Saito,Y., Takano,M., Arai,Y., Yasuno,S., Nakagawa,Y.,
            Takahashi,N., Adachi,Y., Takemura,G., Horie,M., Miyamoto,Y.,
            Morisaki,T., Kuratomi,S., Noma,A., Fujiwara,H., Yoshimasa,Y.,
            Kinoshita,H., Kawakami,R., Kishimoto,I., Nakanishi,M., Usami,S.,
            Saito,Y., Harada,M. and Nakao,K.
  TITLE     NRSF regulates the fetal cardiac gene program and maintains normal
            cardiac structure and function
  JOURNAL   EMBO J 22 (23), 6310-6321 (2003)
   PUBMED   14633990
REFERENCE   8  (bases 1 to 6581)
  AUTHORS   Garcia-Frigola,C., Shi,Y. and Evans,S.M.
  TITLE     Expression of the hyperpolarization-activated cyclic
            nucleotide-gated cation channel HCN4 during mouse heart development
  JOURNAL   Gene Expr Patterns 3 (6), 777-783 (2003)
   PUBMED   14643687
  REMARK    GeneRIF: Gene expression of HCN4 during mouse heart development.
REFERENCE   9  (bases 1 to 6581)
  AUTHORS   Santoro,B., Liu,D.T., Yao,H., Bartsch,D., Kandel,E.R.,
            Siegelbaum,S.A. and Tibbs,G.R.
  TITLE     Identification of a gene encoding a hyperpolarization-activated
            pacemaker channel of brain
  JOURNAL   Cell 93 (5), 717-729 (1998)
   PUBMED   9630217
REFERENCE   10 (bases 1 to 6581)
  AUTHORS   Santoro,B., Grant,S.G., Bartsch,D. and Kandel,E.R.
  TITLE     Interactive cloning with the SH3 domain of N-src identifies a new
            brain specific ion channel protein, with homology to eag and cyclic
            nucleotide-gated channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14815-14820 (1997)
   PUBMED   9405696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110530.10.
            
            On Jun 18, 2019 this sequence version replaced NM_001081192.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158106.1, SRR7652917.772197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1348              AC110530.10        151869-153216       c
            1349-1772           AC110530.10        131864-132287       c
            1773-1934           AC110530.10        122621-122782       c
            1935-2153           AC110530.10        120422-120640       c
            2154-2300           AC110530.10        118302-118448       c
            2301-2541           AC110530.10        117951-118191       c
            2542-2706           AC110530.10        116972-117136       c
            2707-6581           AC110530.10        112990-116864       c
FEATURES             Location/Qualifiers
     source          1..6581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.8 cM"
     gene            1..6581
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /note="hyperpolarization-activated, cyclic
                     nucleotide-gated K+ 4"
                     /db_xref="GeneID:330953"
                     /db_xref="MGI:MGI:1298209"
     exon            1..1348
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             564..4169
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /note="brain cyclic nucleotide-gated channel 3;
                     hyperpolarization-activated, cyclic nucleotide-gated K+ 3"
                     /codon_start=1
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 4"
                     /protein_id="NP_001074661.1"
                     /db_xref="CCDS:CCDS52815.1"
                     /db_xref="GeneID:330953"
                     /db_xref="MGI:MGI:1298209"
                     /translation="MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGRQDPS
                     RRSIRLRPLPSPSPSVAAGCSESRGAALGATESEGPGRSAGKSSTNGDCRRFRGSLAS
                     LGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPATAA
                     QPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQF
                     GAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN
                     LIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIK
                     MKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLS
                     RLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCW
                     VSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAM
                     FIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDE
                     ESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIR
                     EGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLY
                     SLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENE
                     IIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHH
                     PRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSS
                     FHIQQLAGFSAPPGLSPLLPSSSSSPPPGACGSPPAPTPSTSTAAAASTTGFGHFHKA
                     LGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSS
                     PGQLGQPPGELSLGLAAGPSSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGH
                     SPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISA
                     SQPALPQDGAQTLRRASPHSSGESVAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQH
                     VTLPRKTSSGSLPPPLSLFGARAASSGGPPLTTAAPQREPGARSEPVRSKLPSNL"
     exon            1349..1772
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1934
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2153
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2300
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2541
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2706
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..6581
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6561..6566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /note="hexamer: AATAAA"
     polyA_site      6581
                     /gene="Hcn4"
                     /gene_synonym="Bcng3; Hcn3"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggag gctgatgtaa gcccggcggg ccgctgggct ccgctccgct gcggcgggag
       61 tccccaggac tcggccggct gggctcagct agaggaggca aagcgagaac ccgggtgacc
      121 agctgcaaag cccgggcggt cacacgcgct gacagcccca gacacccgcc ggacgcactc
      181 ccgggaaccg cgcgggcagt gcgctctgcg ctcgggagcg gttcccggag cgcggtggcc
      241 gcagcgccgc cgctgcccgc gcccattgtt ccccgcgggg gcggggcgcc tggagccggg
      301 ccgcgcgccg cgcccctgat cgcaggaggg agggaaaaga gggagggagc gtggggtccc
      361 cgcgcccaag ccgggcccgg gaggaggtgc agcgcggcga acccggggac ctgcagccgg
      421 actaggagcc tcccctcggc gcgcagcccg cgcgatcatg ggctcgtgag gcagcgaagg
      481 acgcgtcctc actggcaggc gcacctggag cgggtccccc gtgccgcacc cgcaccgctg
      541 cccccggccc aatccctggc accatggaca agctgccgcc gtccatgcgc aagcggctct
      601 acagccttcc gcagcaggtg ggggccaagg cgtggatcat ggacgaggaa gaggatggtg
      661 aggaagaagg ggccgggggc cgccaggacc ccagccgaag gagcatccgg ctgcggccgc
      721 tgccctcgcc ctctccctcg gtggctgcgg gctgctcgga gtcccggggt gcggccctcg
      781 gggcgacaga gagcgagggg ccgggccgca gcgccggcaa gtccagcacc aacggtgact
      841 gcaggcgctt ccgcgggagt ctggcctcgc tgggcagccg gggcggcggc agtggtggag
      901 cagggggcgg cagcagtctc gggcacctgc atgactccgc ggaggaacgg cggctcatcg
      961 ccgctgaggg cgatgcgtcc cccggcgagg acaggacgcc cccgggcctg gcgaccgaac
     1021 ccgagcgccc ggccaccgcg gcacaacccg cagcctcgcc gccgccccag cagccgccgc
     1081 agccggcctc tgcctcctgc gagcagccct cggcggacac cgctatcaaa gtggagggag
     1141 gcgcggccgc cagcgaccag atcctccccg aggccgaggt gcgcctgggc cagagcggct
     1201 tcatgcagcg ccagttcggt gccatgctgc aacctggggt caacaaattc tccctaagga
     1261 tgttcggcag ccagaaagcg gtggagcgcg agcaggagag ggttaagtca gcagggtttt
     1321 ggattatcca cccctacagt gacttcagat tttactggga cctgacgatg ctgttgctga
     1381 tggtggggaa tctgatcatc atacccgtgg gcatcacctt cttcaaggat gagaacacca
     1441 caccctggat cgtcttcaat gtggtgtcag acacattctt cctcattgac ttggtcctca
     1501 acttccgcac ggggatcgtg gtggaggaca acacagaaat catccttgac ccgcagagga
     1561 tcaagatgaa gtacctgaaa agctggtttg tggtagattt catctcctcc atccctgtcg
     1621 actacatctt ccttatagtg gagactcgca ttgactcgga ggtctacaaa accgctaggg
     1681 ctctgcgcat tgtccgtttc actaagatcc tcagcctcct gcgcctcttg aggctttccc
     1741 gcctcattcg atacattcat cagtgggaag agatcttcca catgacctat gacctggcca
     1801 gcgccgtggt acgcatcgtg aacctcattg gcatgatgct tctgctgtgt cactgggatg
     1861 gctgcctgca gttcctagtg cccatgctgc aggacttccc ccatgactgc tgggtgtcca
     1921 tcaatggcat ggtgaataac tcctggggga agcagtattc ctacgccctc ttcaaggcca
     1981 tgagccacat gctgtgcatt gggtatggac ggcaggcacc cgtaggcatg tctgacgtct
     2041 ggctcaccat gctcagcatg atcgtggggg ccacctgcta tgccatgttc atcggccacg
     2101 ccactgccct catccagtcg ctagactcct cccggcgcca gtaccaggag aagtataaac
     2161 aggtggagca gtacatgtcc ttccacaagc tcccgcctga cacccgacag cgcatccatg
     2221 actactatga acaccgctac caaggcaaga tgtttgatga ggaaagcatc ctgggtgagc
     2281 tgagtgagcc acttcgagag gagatcatca actttaactg ccgaaagctg gtggcatcca
     2341 tgccactgtt tgccaacgca gatcccaact ttgtgacatc catgctgacc aagttgcgtt
     2401 tcgaggtctt ccagcctggg gattacatca tccgcgaagg caccatcggc aagaagatgt
     2461 actttatcca gcacggcgtg gtcagcgtgc tcactaaggg caacaaagag accaagctgg
     2521 ctgatggctc ctattttgga gagatctgct tgctgacccg gggtcggcgc acagccagcg
     2581 tcagagcgga tacttattgc cgcctctact cactgagcgt ggacaacttc aatgaggtgc
     2641 tggaggagta tcccatgatg cggagggcct tcgagacggt tgcgctggac cgcctggacc
     2701 gcataggcaa gaagaactcc atcctcctcc acaaggtgca gcacgacctc aactcaggcg
     2761 tcttcaacta ccaagagaac gagatcatcc agcagatcgt gcggcatgac cgtgagatgg
     2821 cccactgtgc tcaccgcgtc caggctgccg cctcagccac cccaaccccc acgcctgtta
     2881 tatggacccc gctgatccag gcgccactgc aggctgctgc tgctactact tcggtggcca
     2941 tagccctcac acaccacccc cgcctgcccg ccgccatctt ccggccccct cccggacctg
     3001 ggctgggcaa ccttggggct ggacagacac cgaggcaccc aaggaggctg cagtccttga
     3061 tcccttcagc tctgggctct gcttcacccg ccagcagccc ctcacaggtg gacacaccgt
     3121 cttcatcctc cttccacatc caacagctgg ctggattctc tgcacctcct ggattgagcc
     3181 ctctcctgcc ctcctctagc tcttccccac ctccaggagc ctgcggttcc ccaccagccc
     3241 ccacaccctc cacctccact gccgccgccg cctccaccac tgggttcggc cactttcaca
     3301 aggcgctggg tggctccctg tcatcctctg actccccgct gctcacccca ctgcaaccag
     3361 gcgctcgctc tccacaggct gcccagccac cacccccact gcctggggcc cgaggaggtc
     3421 tgggactcct ggagcacttc ttgccgcccc caccctcctc caggtcacca tcatccagcc
     3481 ctgggcagct gggccagcct cctggagagt tgtccctagg tctggcagct ggtccatcaa
     3541 gtacaccaga gacaccccca cggcctgagc gaccatcctt catggcaggg gcctctggag
     3601 gggcttctcc tgtagccttt accccccgag gaggcctcag tcctccgggc cacagcccgg
     3661 ggcccccaag aactttcccg agtgccccac cccgggcctc tggctcccat ggttccctgc
     3721 tcctgccacc tgcatccagc cctccacctc cccaggtccc acagcgcagg ggcacaccac
     3781 ccctcacccc tggccgcctc acacaggacc tgaagctcat ctcagcctct cagccagccc
     3841 tcccccagga tggggcacag actctccgca gggcctcgcc tcactcctca ggggagtcgg
     3901 tggctgcctt ctcactctac cccagagctg ggggtggcag tgggagtagt gggggccttg
     3961 ggcctcctgg aaggccatat ggtgccatcc caggccaaca tgtcactttg cctcggaaga
     4021 catcctcagg ttctttgcca cccccacttt ctttgtttgg ggcaagagcc gcctcttctg
     4081 gagggccccc tctgactact gctgcacccc agagggaacc tggcgctagg tctgagccag
     4141 tacgctccaa actgccgtct aatttatgag ctgggccctc cctccctctt ctttttcttg
     4201 ctcctttctt ccttcaggtt taactgtgat taggagatat accaacaaca ataataacca
     4261 taaaaaaaca taccccagaa aaacaaaaag acagcagaaa ataaccaggt attcttagag
     4321 ctatagattt ttggtcactt gcttttatag actattttaa tactcagcac tagagggaga
     4381 gagggaggga gggagggagg ggggagcaga caaggcccaa aggcaacagc caaaggaaga
     4441 caggcggggt ctctggggac agggcagggg tggggtgacc cgtgtttggg tcctagcata
     4501 gacctgtcat tgtattgttc tgtagagcaa gagctaccta ccatcaatca gttccttggc
     4561 tgtgaacttg gagcccactc tgctgggggc tgccctggag tgtgttccca ggagcctcct
     4621 gcgcccaagt tccttgggac acacagggcc cttgagggcc ttgctttttt tttttctact
     4681 gtaaacgtag caagatatgt atatgaatat gtatatgtat gtaagatgtg tctatgtata
     4741 gctatgtagt gctctgtaga gccgtgtaga tatcagcttc catgtgtgca cattcgtgtg
     4801 cagtctagtt taatcccatg ttgccaggac acccaggtca ccttacatcc agcaatctgc
     4861 tgtggcccgc aggctgggca ctgcaggctc tgggggaagt tctctctccc agccctcagg
     4921 gaaggggacc cctggaacct tgcagcagac cctctttccc catctctggg ctgcaaccca
     4981 gttctagccc aacctctagt cccatggaag gggaagactc caggccgagc ctttcacctc
     5041 ccagggcttc aagcacacct gtcacctctg tggcccgaag tttctccagc tgtacaacgg
     5101 gaggggaggg gaacgtctat ttattgagtc tgttctgtgc caagcactgg ttatacatac
     5161 tcacagactg gggggtgagg attatggttt ctcccatttc acaggtgagg aaactgaggg
     5221 ttgattagaa tcacataacc aggagtggca gagctggtct ggtctgagct gcaaatcaac
     5281 ctccctaagg ttaaagcctg tattcctccc atcagaaaac tgtgtttggt acagccctag
     5341 cttttggtcc ctaggcaaag tacaggagga agagatggga gcttggtagc agtcagactt
     5401 cagttcaaat cccagttctg ccacttctta gctgtgtggc cttgggcaag ttatctgacc
     5461 tttctgttcc ctcattagta aaataagaac tatggaactg cctcacaatg accagtgaga
     5521 accagataag aaaaagatgt gaaacgccca gcccagtgcc tggcacacag catagtaggt
     5581 gctcaataaa tcatgtttct tcaccacccc cccccctcat aaacttagcc cattgctcca
     5641 gtgaactatg atgagagccc aggggatttt agctgagggc tccaagactt aaaactctca
     5701 ggactcagga ggtggctggg cctccatcat ggctggagga aggtgcgtgg ccagtggtgg
     5761 gcttgagtca ggccttggga tatgggaagt gtgggtaaag aaaggaatta gaggagagag
     5821 tgcataggag aggttactgc agtgatgttg agatgtgggg cagggcctct gggggagaca
     5881 tagaggatgg ggacctcgga tgagaggcta agctgatctg tggctttggc cctgaattag
     5941 aagcagatgt caggaccctg gaggaggcac agccaacagc ttccctatcc atgggtcgga
     6001 gcaggtagga ctgatgcccg tgcagtgagg gggctggttc taccatgcct gtcatcccca
     6061 tgcagcagcc agaagggtgg catgagcagg tttggccctg gggtgccaca gggaatcctt
     6121 tgtgggtggc ttgcagggaa agagagggtg aagtccctgg tgccctagaa aatctgcagg
     6181 agccctaggt tatacagggc tgggagaagc ctcccagact gagagtcttc ggacctgtgt
     6241 tctgtccccc aaggaaggga gcttagggag ccagctggac gccacagaac ctgcagtcca
     6301 cccttgagga ataggagagg agctggggtc tgggataagg agtgaggggt ctcttgtcaa
     6361 caggcctggc ctagccaccc ttctctactg atacatgcat tttataaaca ccgacacact
     6421 ggcaaactcc ttggtgacta tggagaggcc aggtccagtc cataggacct tctaccccac
     6481 aacctctaca agcaattttc aaatcttcca cttttaaaac agaaaaacgg tcaaacacac
     6541 cgtcttgtat attttattta aataaaaaaa attacagcaa a
//
