LOCUS       NM_008227               3297 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus hyperpolarization-activated, cyclic nucleotide-gated
            K+ 3 (Hcn3), transcript variant 1, mRNA.
ACCESSION   NM_008227
VERSION     NM_008227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3297)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3297)
  AUTHORS   Zhang,Y., Liu,X., Sun,K., Luo,Y., Yang,J., Li,A., Kiupel,M.,
            Fenske,S., Biel,M., Mi,Q.S., Wang,H. and Xiao,H.
  TITLE     Hyperpolarization-activated cyclic nucleotide-gated cation channel
            3 promotes HCC development in a female-biased manner
  JOURNAL   Cell Rep 42 (10), 113157 (2023)
   PUBMED   37733590
  REMARK    GeneRIF: Hyperpolarization-activated cyclic nucleotide-gated cation
            channel 3 promotes HCC development in a female-biased manner.
REFERENCE   3  (bases 1 to 3297)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   4  (bases 1 to 3297)
  AUTHORS   Schlusche,A.K., Vay,S.U., Kleinenkuhnen,N., Sandke,S.,
            Campos-Martin,R., Florio,M., Huttner,W., Tresch,A., Roeper,J.,
            Rueger,M.A., Jakovcevski,I., Stockebrand,M. and Isbrandt,D.
  TITLE     Developmental HCN channelopathy results in decreased neural
            progenitor proliferation and microcephaly in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34429357
REFERENCE   5  (bases 1 to 3297)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3297)
  AUTHORS   Mistrik,P., Mader,R., Michalakis,S., Weidinger,M., Pfeifer,A. and
            Biel,M.
  TITLE     The murine HCN3 gene encodes a hyperpolarization-activated cation
            channel with slow kinetics and unique response to cyclic
            nucleotides
  JOURNAL   J Biol Chem 280 (29), 27056-27061 (2005)
   PUBMED   15923185
  REMARK    GeneRIF: the distinct expression pattern in conjunction with the
            unusual biophysical properties implies that HCN3 may play an unique
            role in the body
REFERENCE   7  (bases 1 to 3297)
  AUTHORS   Santoro,B., Wainger,B.J. and Siegelbaum,S.A.
  TITLE     Regulation of HCN channel surface expression by a novel C-terminal
            protein-protein interaction
  JOURNAL   J Neurosci 24 (47), 10750-10762 (2004)
   PUBMED   15564593
REFERENCE   8  (bases 1 to 3297)
  AUTHORS   Ludwig,A., Zong,X., Jeglitsch,M., Hofmann,F. and Biel,M.
  TITLE     A family of hyperpolarization-activated mammalian cation channels
  JOURNAL   Nature 393 (6685), 587-591 (1998)
   PUBMED   9634236
REFERENCE   9  (bases 1 to 3297)
  AUTHORS   Santoro,B., Liu,D.T., Yao,H., Bartsch,D., Kandel,E.R.,
            Siegelbaum,S.A. and Tibbs,G.R.
  TITLE     Identification of a gene encoding a hyperpolarization-activated
            pacemaker channel of brain
  JOURNAL   Cell 93 (5), 717-729 (1998)
   PUBMED   9630217
REFERENCE   10 (bases 1 to 3297)
  AUTHORS   Santoro,B., Grant,S.G., Bartsch,D. and Kandel,E.R.
  TITLE     Interactive cloning with the SH3 domain of N-src identifies a new
            brain specific ion channel protein, with homology to eag and cyclic
            nucleotide-gated channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14815-14820 (1997)
   PUBMED   9405696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161600.6.
            
            On Jul 26, 2022 this sequence version replaced NM_008227.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ225124.1, BC039156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC161600.6         153577-153984       c
            409-838             AC161600.6         146423-146852       c
            839-1000            AC161600.6         145217-145378       c
            1001-1219           AC161600.6         144654-144872       c
            1220-1366           AC161600.6         144147-144293       c
            1367-1607           AC161600.6         143608-143848       c
            1608-1772           AC161600.6         142509-142673       c
            1773-3297           AC161600.6         140567-142091       c
FEATURES             Location/Qualifiers
     source          1..3297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..3297
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /note="hyperpolarization-activated, cyclic
                     nucleotide-gated K+ 3"
                     /db_xref="GeneID:15168"
                     /db_xref="MGI:MGI:1298211"
     exon            1..408
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            409..838
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1000
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1219
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1366
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1607
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1772
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..3297
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3297
                     /gene="Hcn3"
                     /gene_synonym="BCNG-4; Bcng4; HAC-3; Hac3; Hcn4"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcctgca cacgccccct gtgccccggg cgcacgcggg tcggagctcc cctgcctggg
       61 ctgctctccc agagacttgc gcgcccgcca tggccctgga ccggttgggg aggccctacg
      121 agtgagggca atcatggagg aggaggcgcg gccggcggcg ggggccggcg aagcggcgac
      181 ccctgcacgc gagacgcctc ctgcggctcc ggcccaggcc cgcgcggcct caggtggggt
      241 gccggagtct gcgcccgagc cgaagaggcg gcagctcggg acgctgctgc agccgacggt
      301 caacaagttc tctctccggg tcttcggcag ccacaaagca gtagaaatcg agcaggagag
      361 ggtgaagtcc gccggggcct ggatcatcca cccctacagc gacttccggt tttactggga
      421 tctcatcatg ctgctgctga tggtggggaa cctcatagtt ctgcctgtgg gtatcacttt
      481 cttcaaggag gagaactctc caccctggat cgtcttcaat gtcctctctg acactttctt
      541 cctgctggat ctggtgctca acttccgaac tggcatcgtg gtggaggaag gtgccgagat
      601 cctgctggcg ccaagggcca tccgaacgcg ttacctgcgc acctggttcc tggttgatct
      661 gatctcctcc atccctgtgg attatatctt cctagtggtg gagctggagc cacgactaga
      721 tgctgaggtc tacaaaacgg cacgggccct gcgcatcgtt agattcacca agatccttag
      781 cctgctgcgg ctgctccgcc tctcccgcct catccgctac atacaccagt gggaggagat
      841 ctttcacatg acctacgacc tggccagtgc agtggttcgc atcttcaacc tcattggaat
      901 gatgttgctg ctgtgtcact gggacggctg tctgcagttt ctggtcccta tgctgcagga
      961 cttcccgtcc gactgctggg tctccatgaa ccgcatggtg aaccactcgt ggggccgcca
     1021 gtattcccac gccctgttca aggccatgag tcacatgcta tgcattggct atgggcagca
     1081 ggcaccggta ggcatgcctg acgtctggct caccatgctc agtatgattg tgggcgccac
     1141 gtgttatgcc atgttcatcg gtcacgccac cgccctcatc cagtccctgg actcttcccg
     1201 gcgacagtac caggagaagt acaagcaggt ggagcagtac atgtccttcc acaagctgcc
     1261 cgctgacacc cggcagcgca tccacgagta ctacgagcat cgctaccagg gcaagatgtt
     1321 tgatgaagag agcatcctgg gggagctgag cgagccactt cgggaggaga ttattaactt
     1381 cacctgccgg ggcctggtgg cccacatgcc gctgtttgct catgctgacc ccagcttcgt
     1441 caccgcagtg ctcaccaagc tccgttttga ggtcttccaa ccaggggacc tggtggtgcg
     1501 tgagggctcc gtgggcagga agatgtactt catccagcac gggctgctga gtgtgctggc
     1561 acgtggcgcc cgcgacaccc gcctcactga tggatcctac tttggggaga tctgcctgct
     1621 gactcgaggt cggagaacag ccagtgtaag ggctgacacc tattgtcgcc tctactcgct
     1681 cagcgtggac cacttcaatg cggtgcttga ggagttccca atgatgcgca gggcttttga
     1741 gacggtggcc atggaccggc ttcggcgcat cggcaaaaag aattcgatac tgcagcggaa
     1801 acgctctgag ccgagtccag gcagcagcgg tggcgtcatg gagcagcatt tggtacaaca
     1861 cgacagagac atggctcgtg gtgttcgggg cctggctcct ggtacaggag ctcgactcag
     1921 tggaaagcca gtgctgtggg aaccactggt gcacgcccct ctgcaggcag ctgctgtgac
     1981 ctccaacgtg gccatagcct tgactcacca gcgaggccct ctgcccctct cccctgattc
     2041 tccagccacc ctcctagctc gatctgctag acgctcagca ggctccccag cctccccact
     2101 ggtgcctgtc cgagcaggtc ctctgctggc ccggggaccc tgggcgtcca cttctcgcct
     2161 gcctgctcca cctgcccgaa ccctccatgc cagcctatcc cggacagggc gttcccaggt
     2221 atctctgttg ggccctcccc caggaggagg tgctcggagg ctaggacctc ggggccgccc
     2281 actttctgcc tcgcaaccct ctctgcctca gcgagcaaca ggggatggct ctcctaggcg
     2341 taaaggctct ggaagtgagc gcctgccccc ctctgggctc ttggccaaac ctccagggac
     2401 agtccagcca cccaggtcat cagtgcctga gccagttacc cccagaggtc cccaaatttc
     2461 tgccaacatg tgaaatccta ggttacactg gccttagcta ttggcacgca ataacgtgtg
     2521 cccgagggta gacgcccctt gggggaaggc tgtgggggac ctaacatact gccctttatc
     2581 accacaaagc tattctctgt gtcctcagct caaagcagct gcagcctgct aatcctaatc
     2641 acatacccat ttgtcattgg taccccatgc ctaccatgtt caaggcactg tgctaggtac
     2701 tgtgtatcca ctgccaagta gaaataactc gaagcccttt aacaagggtg tccccaggcc
     2761 acggtcctgc caggcgcagg cctgggccca cagccctgcc tttattaagc acaagtactt
     2821 gctgcctcca tcactgccga gtaactagac ggctgtctcc ctgtcagtga ccctgcaggt
     2881 ggtgccagtg cgtcctctct tcccatctcc tttgtcgtag ctgggtaccg tcaattatct
     2941 agtacagcca acagatgtct agagccctgg gtgtgaacat cgaccctctg actggcacct
     3001 gtgggccctc cttgtccaca ccaagtgaga atccacgtct gcccactgta gtctgccctc
     3061 cgcagctcct gtgtggacgc actaccttta tgagctagaa gctgctcttc actgtgcccc
     3121 ctgcctcagt ggtgttgccc ctaaagctaa ggggcacgcg gcacctcctt acctactgtg
     3181 ccagcctagt tccccccagg tagggggcca ggggctgaat cctcatgtga ccttttatct
     3241 ttccctcttt gtcttattta tttggtcgtt tattaatttt atttattcat ttgctaa
//
