LOCUS       NM_010407               2107 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hemopoietic cell kinase (Hck), transcript variant 1,
            mRNA.
ACCESSION   NM_010407 XM_011251804
VERSION     NM_010407.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Chen,M., Menon,M.C., Wang,W., Fu,J., Yi,Z., Sun,Z., Liu,J., Li,Z.,
            Mou,L., Banu,K., Lee,S.W., Dai,Y., Anandakrishnan,N.,
            Azeloglu,E.U., Lee,K., Zhang,W., Das,B., He,J.C. and Wei,C.
  TITLE     HCK induces macrophage activation to promote renal inflammation and
            fibrosis via suppression of autophagy
  JOURNAL   Nat Commun 14 (1), 4297 (2023)
   PUBMED   37463911
  REMARK    GeneRIF: HCK induces macrophage activation to promote renal
            inflammation and fibrosis via suppression of autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Futosi,K., Bajza,B., Deli,D., Erdelyi,A., Tusnady,S. and Mocsai,A.
  TITLE     Analysis of intracellular tyrosine phosphorylation in circulating
            neutrophils as a rapid assay for the in vivo effect of oral
            tyrosine kinase inhibitors
  JOURNAL   Front Pharmacol 14, 1056154 (2023)
   PUBMED   37089957
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Lowell,C.A., Fumagalli,L. and Berton,G.
  TITLE     Deficiency of Src family kinases p59/61hck and p58c-fgr results in
            defective adhesion-dependent neutrophil functions
  JOURNAL   J Cell Biol 133 (4), 895-910 (1996)
   PUBMED   8666673
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Lowell,C.A., Niwa,M., Soriano,P. and Varmus,H.E.
  TITLE     Deficiency of the Hck and Src tyrosine kinases results in extreme
            levels of extramedullary hematopoiesis
  JOURNAL   Blood 87 (5), 1780-1792 (1996)
   PUBMED   8634424
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Jenkins,N.A., Mattei,M.G., Gilbert,D.J., Linard,C.G., Mbikay,M.,
            Chretien,M. and Copeland,N.G.
  TITLE     Assignment of secretogranin I locus to mouse chromosome 2 by in
            situ hybridization and interspecific backcross analysis
  JOURNAL   Genomics 11 (2), 479-480 (1991)
   PUBMED   1685143
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Lock,P., Ralph,S., Stanley,E., Boulet,I., Ramsay,R. and Dunn,A.R.
  TITLE     Two isoforms of murine hck, generated by utilization of alternative
            translational initiation codons, exhibit different patterns of
            subcellular localization
  JOURNAL   Mol Cell Biol 11 (9), 4363-4370 (1991)
   PUBMED   1875927
  REMARK    GeneRIF: Alternate protein isoforms arise through the use of a
            non-AUG (CUG), and a downstream in-frame AUG, translation
            initiation codons, in mouse and human.
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Lock,P., Stanley,E., Holtzman,D.A. and Dunn,A.R.
  TITLE     Functional analysis and nucleotide sequence of the promoter region
            of the murine hck gene
  JOURNAL   Mol Cell Biol 10 (9), 4603-4611 (1990)
   PUBMED   2388619
REFERENCE   9  (bases 1 to 2107)
  AUTHORS   Holtzman,D.A., Cook,W.D. and Dunn,A.R.
  TITLE     Isolation and sequence of a cDNA corresponding to a src-related
            gene expressed in murine hemopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 84 (23), 8325-8329 (1987)
   PUBMED   3317404
REFERENCE   10 (bases 1 to 2107)
  AUTHORS   Klemsz,M.J., McKercher,S.R. and Maki,R.A.
  TITLE     Nucleotide sequence of the mouse hck gene
  JOURNAL   Nucleic Acids Res 15 (22), 9600 (1987)
   PUBMED   3684607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY157889.1, AK150290.1 and
            AI849071.1.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251804.1, NM_010407.3.
            
            Summary: The protein encoded by this gene is a member of the Src
            family of tyrosine kinases. This protein is primarily hemopoietic,
            particularly in cells of the myeloid and B-lymphoid lineages. It
            may play a role in the innate immune response and the STAT5
            signaling pathway. Alternative translation initiation site usage,
            including a non-AUG (CUG) codon, results in the production of two
            different isoforms, that have different subcellular localization.
            [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This transcript (1) encodes multiple isoforms
            due to the use of alternative translation initiation codons, as
            demonstrated in PMID:1875927. The longer isoform (p59Hck) is
            derived from an upstream non-AUG (CUG) start codon, while the
            shorter isoform (p56Hck) is derived from a downstream AUG start
            codon. The longer isoform (p59Hck) is represented in this RefSeq.
            
            CCDS Note: This CCDS ID represents the longer mouse Hck isoform,
            known as p59Hck, as described in PMID:1875927. This isoform
            initiates translation from a non-AUG (CUG) start codon that is
            well-conserved and present in a strong Kozak signal context.
            Alternative translation initiation from a downstream AUG start
            codon produces an isoform that is 21 aa shorter at the N-terminus.
            The shorter isoform, which is known as p56Hck, is represented by
            CCDS 50756.1. These isoforms exhibit distinct subcellular
            localization, as indicated in PMID:1875927.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150709.1, AK150290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 1875927
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY157889.1         2-28
            28-2077             AK150290.1         2-2051
            2078-2107           AI849071.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..2107
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /note="hemopoietic cell kinase"
                     /db_xref="GeneID:15162"
                     /db_xref="MGI:MGI:96052"
     exon            1..287
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            288..405
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            406..448
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            449..548
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            549..647
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            648..751
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            752..901
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1054
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1234
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1311
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1465
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1597
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2092
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="Hck"
                     /gene_synonym="Bmk"
                     /note="major polyA site"
ORIGIN      
        1 atcacccagg gtgcggctaa ggcgcccaga tggccagtga gcgccactgg gttgcggctc
       61 ccagcttgca ctccccgcgg cggctctcag acgggtggga ggggaccaaa gtcgcccgtg
      121 aagggggctc tgacccgttc cgagcgccaa cgcagcctct gtagcccgca agtcttcgtc
      181 gcttgctccg ggctctgaag tccggggcca ccaggggccg cagcgctggg gggtcggtct
      241 agctgcgagg atccgggctg cccacgaagc gaagggcggg cgcccaggat gggatgcgtg
      301 aagtccaggt tcctccgaga tggaagcaag gcctcaaaaa cagagccaag tgccaatcag
      361 aagggccctg tgtatgtgcc ggatcccacg tcctccagca agctgggacc aaacaacagc
      421 aacagcatgc ccccagggtt tgtggagggc tctgaggata ccattgtggt cgcactgtac
      481 gactatgagg ctattcaccg tgaagacctc agcttccaga agggagacca gatggtggtt
      541 ctggaggagg ctggggagtg gtggaaggca cggtccctgg ctaccaagaa ggaaggctac
      601 atcccaagca actatgtggc tcgagttaac tctttggaga cagaagagtg gttcttcaag
      661 gggatcagcc ggaaggatgc agagcgccac ctcctggctc caggcaacat gctgggctcc
      721 ttcatgatcc gggacagtga gaccaccaaa gggagctact cgttgtctgt tcgagacttt
      781 gacccccagc acggagacac cgtgaagcac tataagatcc ggacgctgga cagtggaggc
      841 ttctacatct ctccaaggag caccttcagc agcctgcagg aactcgtgct ccactacaag
      901 aaggggaagg atgggctctg ccagaagctg tcagtgccct gtgtgtctcc caaaccccag
      961 aagccatggg agaaagatgc ttgggagatt cctcgagaat ccctccagat ggagaagaaa
     1021 cttggagctg ggcagtttgg agaagtgtgg atggccacct acaacaagca caccaaagtg
     1081 gcggtgaaga caatgaagcc agggagcatg tccgtggagg ccttcctggc tgaggccaac
     1141 ctgatgaagt cgctgcagca tgacaaactg gtgaagctac acgctgtggt ctctcaggag
     1201 cccatcttta ttgtcacgga gttcatggcc aaaggaagcc tgctggactt tctcaagagt
     1261 gaagaaggca gcaagcagcc actgccaaaa ctcattgact tctcagccca gatctcagaa
     1321 ggcatggcct tcattgagca gaggaactac atccaccgag acctgagggc tgccaacatc
     1381 ttagtctctg catcactggt gtgtaagatt gctgactttg gactggcacg aatcatcgag
     1441 gacaatgagt acacagctcg ggaaggagcc aagttcccca tcaagtggac agctcctgaa
     1501 gccatcaact ttggttcctt caccatcaag tcagatgtct ggtcctttgg tatcctgctg
     1561 atggaaattg tcacctatgg ccggatccct tacccaggta tgtcaaaccc agaggtgatt
     1621 cgggcactag agcatgggta ccgtatgcct cgaccagata actgtccaga agagctctac
     1681 aatatcatga tccgctgctg gaagaaccgc cccgaggaac ggcccacctt tgaatacatc
     1741 cagagtgtgc tggatgactt ctacacggcc actgagagcc agtatcagca gcagccttga
     1801 cagcagtaag gacatgagca gagccagaag ccccatcagt gccttgacac gcccaacttg
     1861 ctgggcccac tctcagacac cacaccacac acactgcagc tgttgagtgg gtgggaggac
     1921 ttcacaatct ctttctgact ctagtcatct gcaatccgcc actctcaggg cctccaagtt
     1981 ggtatgtctc atttgcctgg aatgactgaa ttcaatctat agctgtgatt taagtggaaa
     2041 ctgttagaat agtatttaaa taaaagatat gaatgtcaaa ggctttcccc aaaaaaaaaa
     2101 aaaaaaa
//
