LOCUS       NM_001368720            5330 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus host cell factor C2 (Hcfc2), transcript variant 2,
            mRNA.
ACCESSION   NM_001368720 XM_006514013
VERSION     NM_001368720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Gresakova,V., Novosadova,V., Prochazkova,M., Prochazka,J. and
            Sedlacek,R.
  TITLE     Dual role of Fam208a during zygotic cleavage and early embryonic
            development
  JOURNAL   Exp Cell Res 406 (2), 112723 (2021)
   PUBMED   34216590
REFERENCE   2  (bases 1 to 5330)
  AUTHORS   Gudkova,D., Dergai,O., Praz,V. and Herr,W.
  TITLE     HCF-2 inhibits cell proliferation and activates
            differentiation-gene expression programs
  JOURNAL   Nucleic Acids Res 47 (11), 5792-5808 (2019)
   PUBMED   31049581
  REMARK    GeneRIF: HCF-2 is broadly present in human and mouse cells, and
            possesses activities distinct from HCF-1
REFERENCE   3  (bases 1 to 5330)
  AUTHORS   Sun,L., Jiang,Z., Acosta-Rodriguez,V.A., Berger,M., Du,X.,
            Choi,J.H., Wang,J., Wang,K.W., Kilaru,G.K., Mohawk,J.A., Quan,J.,
            Scott,L., Hildebrand,S., Li,X., Tang,M., Zhan,X., Murray,A.R., La
            Vine,D., Moresco,E.M.Y., Takahashi,J.S. and Beutler,B.
  TITLE     HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and
            for survival during viral infections
  JOURNAL   J Exp Med 214 (11), 3263-3277 (2017)
   PUBMED   28970238
  REMARK    GeneRIF: Data show that HCFC2 is a critical component of the IRF1
            and IRF2 transcriptional machinery that regulates Tlr3 gene
            expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152980.2 and AC155709.5.
            
            On Feb 20, 2019 this sequence version replaced XM_006514013.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.181667.1,
                                           SRR1660817.297822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC152980.2         11269-11461         c
            194-342             AC152980.2         9508-9656           c
            343-503             AC152980.2         7972-8132           c
            504-712             AC152980.2         1358-1566           c
            713-797             AC152980.2         527-611             c
            798-904             AC155709.5         127315-127421       c
            905-1093            AC155709.5         127018-127206       c
            1094-1261           AC155709.5         115470-115637       c
            1262-1314           AC155709.5         114860-114912       c
            1315-1489           AC155709.5         110829-111003       c
            1490-1563           AC155709.5         106580-106653       c
            1564-1695           AC155709.5         104775-104906       c
            1696-1881           AC155709.5         100792-100977       c
            1882-5330           AC155709.5         96828-100276        c
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.93 cM"
     gene            1..5330
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="host cell factor C2"
                     /db_xref="GeneID:67933"
                     /db_xref="MGI:MGI:1915183"
     exon            1..193
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            194..342
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            343..503
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            504..712
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            713..797
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            798..904
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1093
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1261
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1314
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1489
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1563
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1695
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1881
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..5330
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2350..2355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="hexamer: AATAAA"
     polyA_site      2380
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="major polyA site"
     regulatory      4275..4280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="hexamer: AATAAA"
     polyA_site      4294
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="major polyA site"
     regulatory      5303..5308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
                     /note="hexamer: AATAAA"
     polyA_site      5326
                     /gene="Hcfc2"
                     /gene_synonym="1700129L13Rik; fkls"
ORIGIN      
        1 attgtgggcc gaggggcggg ggttgggaag atggcggctc ccagcctcct caactggagg
       61 cgggtttcct cctttaccgg accggtgcct cgcgcccggc acggacaccg agccgtggcc
      121 atccgggagc tgatgatcat cttcggcggg ggcaacgagg gcatcgcgga cgagctgcac
      181 gtctacaata ccgttacaaa ccagtggttc ctaccagctg ttagaggaga catccctcca
      241 ggctgtgcag cccatggatt tgtctgtgat gggactagaa tcctagtgtt tgggggaatg
      301 gttgaatatg gaagatacag caatgagtta tatgagttac aagcaagtcg ttggttatgg
      361 aaaaaagtga aaccccagcc ccctccttct ggtttccctc cttgtccgcg gcttggacat
      421 agcttctctt tatatggtaa caaatgctat ttgtttggtg gtttggcaaa tgaaagtgaa
      481 gattcaaata ataatgtccc caggtattta aatgatttct atgagttgga gctacagcat
      541 ggttctggtg ttgtgggctg gagcatccca gccaccaaag gcgttgtgcc ttctccaaga
      601 gaatcccata ctgctattat ctattgtaaa aaagactctg cgagtcctaa gatgtatgtt
      661 tttggtggaa tgtgcggtgc tcgtctggat gacctatggc agcttgattt agaaactatg
      721 tcatggtcca aaccagaaac taaagggaca gtgccacttc cacgaagcct tcatacagcc
      781 agtgttatag gaaacaagat gtacattttt ggtggatggg ttccacataa aggtgaaaat
      841 cctgagactt ccccccatga ctgtgagtgg agatgcacca gctcgttttc ttacctaaac
      901 ctcgatacag cagagtggac tactctagta tcagattctc aggaagataa aaaaaattca
      961 aggccaagac caagagcagg acactgcgct gttgcaattg gcactcgact atacttttgg
     1021 agtggaagag atggctacaa aaaagcacta aatagtcagg tctgctgcaa ggacctttgg
     1081 tatcttgata ctgagaaacc tccagcacca tcacaagtgc agttaatcaa agctactacc
     1141 aactctttcc atgtcaagtg ggatgaagtg ccgacggttg agggctatct tttgcagttg
     1201 aatactgacc tgacgtacca agctacatcg tctgactctt cagcagcgcc aagtgtgcta
     1261 ggaggcagga tggaccctca cagacaaggc agtaatagca cccttcataa cagtgttagt
     1321 gatacagtaa acagtacaaa aactgaacac acggctgtga gaggaacttc actgagaagc
     1381 aagcctgact cgagagcagt tgactcgagt gccgctctgc attcaccatt ggcacccaac
     1441 acttccaata acagcagctg ggtgacggac atgctgcgca agaatgaagt tgatgaaata
     1501 tgtgctctgc ctgcaactaa gatcagccgt gtagaggtgc atgctgcagc aacgccattt
     1561 tctaaagaga caccttcaaa tccagtggcc attttgaaag cagagcagtg gtgtgatgtg
     1621 ggaattttta aaaacaacac agctttggtg agccagtttt atttgctacc aaaaggaaaa
     1681 caaagtatgt caaaggtagg aaatgcagac gtgcctgact acagtttgct taagaaacag
     1741 gatcttgttc caggaacagt atataagttc agggttgctg cgatcaatgg ctgtggaata
     1801 ggccctctca gtaaagtcag tgaatttaaa acgtgtactc ctggtttccc tggagcccca
     1861 tctacagtcc gcatctctaa gaatgttgac ggtatccacc tttcctggga gcctccaact
     1921 tcaccttctg gaaatatttt ggaatattca gcctacttgg ctatccgcac agcacagatg
     1981 caagataatc caagccaact tgtattcatg aggatctact gtggtcttaa aacctcatgt
     2041 acagtgactg ctgggcagct tgcaaatgca catattgatt acacatccag acccgccatt
     2101 gtgttcagaa tatccgcaaa gaatgaaaag ggctatggac cagccacaca agtccgatgg
     2161 cttcaaggta acagtaagaa agctcctttg agttgagttg ttttttatta aagctgttgt
     2221 gatagttatt tattagtaac tggttatgaa catctgttct ttgagagtat tctctgactg
     2281 tatttctagc agttatgaat ttgagtttgt aagttgttct taaaatgtat ttgctcactt
     2341 ctagatccaa ataaagatag aaagaagcaa agactgaaaa ttagtatatg gattcttcct
     2401 tacccatata gctgcttata aaggaaaaaa aaaatagcaa aatgaagata aaagccgtaa
     2461 ggtgtattgc cccttttctt ttactcagtc atcctgcggc tactgagatg agtttagtac
     2521 tggctggtgt acaccactgt ggtgggtgtt tcccatgttg taaatgccct ggctgagtac
     2581 ccgccggcct tattccagga gcaggggtct tctgtcagct atctctcagt gcagaggatc
     2641 ttcgattcta agtttagtag ccaccttact cccttatctt cagttatcac aagcttaagc
     2701 aattaaaaga gaaaggctag gtcagcaact ctgcttttga tttttaaaat tattttctga
     2761 gaatcccagc aaaatataaa aaggatagtg gacagtcttg atttgtgtct gaccaagata
     2821 cctgaatgta tctttagcta aagcacttag tctatctggc ccttgatctc ttcactggca
     2881 agtgaaggag ttaggagggt tttcctttaa agtccctttc agctccaaac gttcctattt
     2941 tccttgggag ctggctatat ccctgaacac tgtcacgtgt ctaataggac ctaggttttt
     3001 acagtgtttt aaacatttgt aagatctttg taaatgctct agatgtttta tttttgaatt
     3061 atttttacct caaaattgta taagcttttt tatatcggaa aaaaaagcac tagatggcca
     3121 cttcaggctc cttgccacct tagagatgca gaaggctccg agaccacttg gctacaggta
     3181 acttactttc caccatttga agtgtcataa tttggctggc tagtcagtta ggaagtgact
     3241 gcacacagaa cagactctgc agaggagacg tttcaggccg agggctgcag ttagcacaag
     3301 cacaggtccg cttctccagc gacatgatct catgccagtg taggacgact gagtagctgt
     3361 gccctccaac cttcgtgtga tgtgcccagt gtagatgaat atgattgtga agaattaata
     3421 gatatatata tgccagttac taacttaaag tgtatagaat attttaatat ataatttttt
     3481 gtaaagaact gggattttta tactacagta tttgtaatta atgtgtctca ctaattaaat
     3541 ttctcttgaa gaaaatatgc aaactattag acacatgagt ggcttttgaa ctctaaagat
     3601 aaaataaatg cactactctg gtgttgttag gatacctttt gggtacatga atcttcctaa
     3661 ttcaaagggt cctgtccaag cagtgtttac aaggaggcct ttggttccca cggggagagc
     3721 ttcactctgc cttcatttaa tttatgtgct ttgctttggc agcgcttgct ttttgcacta
     3781 gtagactttg aacttacctc attattatgt ttgtaatcat tgtgtagctt ccatgatgtg
     3841 tctgatagaa gctaaacatg tcttaaccaa agttacatgg gatgcagatt tgcacatatg
     3901 gactagtaag taggctttgc tgtatatgtg tgctcagcta agaagagtag ccagttttag
     3961 aaagtgtgtg ttttaagccc agttacttta gtagaaaact ttgggcttcc agtcctattc
     4021 tttgtattaa ttagcagttt gcatcttgaa accatttatc ttactattga ggcaaaggtt
     4081 gatgtcaagc agacgagaac gctgagtttg tgctcatttt acctatttag tatgcggttt
     4141 agttgatttt gcttaaaggc atcaccttct tttctattct agaccaggaa aaagatgtgg
     4201 gcccatggtt ctaatacccg atttgcttct ttgaagaaag ggtggccttt ctatactaag
     4261 cgatttgtta caataataaa cctttttacc tcaagaattg cccaaattgt attttttcca
     4321 ttggcattac ttccttagca taaatcatgt ttctgttatg ggactggtgg ctgaaagatc
     4381 cccttagcag atctgtgtgg ctttgctgtt agcaattcct atggtgctag agctgcatgt
     4441 ctgtgagagc agctgttctg ccaacatgca tagcgggggg cttctaagga ctgcacgtcg
     4501 tcagctgccg tcttcagcac gcagaccttg ggttttttgt ttgtttgtat gtgtgtgtgt
     4561 gtgtgtgtgt gtgtgtgtgt gtgtgtgcat gtgtgtgtgc gtgtgtgtgc acgctggaga
     4621 actggagatt gaccttgggg cctgggcacc taggctagtg ttctaatagc aagcaacacc
     4681 acagcccagg cagataactc ttccaagagg attttaccta agttaagttt ctttcttttg
     4741 tctccaagct gtatagctgt ctttgtgtca caagcctctt ccatgtgttc tggactttgg
     4801 ttcacataag taaaaatact gttgatactg catgctctta gaattatgtt tttttaaata
     4861 ctgtattggc cttattttat tttagcgcat tgttttaact agaaataagt tatatataaa
     4921 ctcagtctgt atttaagaac taagagaatc tgtttgcatg ggaggcacct ttgccccata
     4981 acccagttac atgttaagtc acctgcagag gagtgaagct gccactcagt atctcacagg
     5041 cttgcagacg agcaaaaatc gcttctgctt tagagtgtct gctctaacta aggggcttta
     5101 tttaaaacaa tagcatagta acgtaaagac atttgttatg ttctgtctgg agtgattggt
     5161 atctgggggt tactcctgta gtaagctgct cccaagtgga gagactgcga gtaggcttgg
     5221 tctttggcca tttgaagtaa ctgctgtgct tcccaagact ggttttaggc agttgtatgt
     5281 attgtgtacc aatgatatgt aaaataaaag ttcctttttc tataaacagt
//
