LOCUS       NM_001411234            8890 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus host cell factor C1 (Hcfc1), transcript variant 1,
            mRNA.
ACCESSION   NM_001411234 XM_006527836
VERSION     NM_001411234.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8890)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   2  (bases 1 to 8890)
  AUTHORS   Arbuckle,J.H., Vogel,J.L., Efstathiou,S. and Kristie,T.M.
  TITLE     Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs
            the Removal of Repressive Heterochromatin from Latent HSV Genomes
            and Suppresses the Initiation of Viral Reactivation
  JOURNAL   mBio 14 (1), e0354222 (2023)
   PUBMED   36692302
  REMARK    GeneRIF: Deletion of the Transcriptional Coactivator HCF-1 In Vivo
            Impairs the Removal of Repressive Heterochromatin from Latent HSV
            Genomes and Suppresses the Initiation of Viral Reactivation.
REFERENCE   3  (bases 1 to 8890)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    GeneRIF: Mutations in Hcfc1 and Ronin result in an inborn error of
            cobalamin metabolism and ribosomopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8890)
  AUTHORS   Popay,T.M., Wang,J., Adams,C.M., Howard,G.C., Codreanu,S.G.,
            Sherrod,S.D., McLean,J.A., Thomas,L.R., Lorey,S.L., Machida,Y.J.,
            Weissmiller,A.M., Eischen,C.M., Liu,Q. and Tansey,W.P.
  TITLE     MYC regulates ribosome biogenesis and mitochondrial gene expression
            programs through its interaction with host cell factor-1
  JOURNAL   Elife 10, e60191 (2021)
   PUBMED   33416496
  REMARK    GeneRIF: MYC regulates ribosome biogenesis and mitochondrial gene
            expression programs through its interaction with host cell
            factor-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8890)
  AUTHORS   Minocha,S. and Herr,W.
  TITLE     Cortical and Commissural Defects Upon HCF-1 Loss in Nkx2.1-Derived
            Embryonic Neurons and Glia
  JOURNAL   Dev Neurobiol 79 (6), 578-595 (2019)
   PUBMED   31207118
  REMARK    GeneRIF: In the brain, HCF-1 is important for organ development and
            cell proliferation.
REFERENCE   6  (bases 1 to 8890)
  AUTHORS   Kristie,T.M., Vogel,J.L. and Sears,A.E.
  TITLE     Nuclear localization of the C1 factor (host cell factor) in sensory
            neurons correlates with reactivation of herpes simplex virus from
            latency
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1229-1233 (1999)
   PUBMED   9990006
REFERENCE   7  (bases 1 to 8890)
  AUTHORS   Kristie,T.M.
  TITLE     The mouse homologue of the human transcription factor C1 (host cell
            factor). Conservation of forms and function
  JOURNAL   J Biol Chem 272 (42), 26749-26755 (1997)
   PUBMED   9334261
REFERENCE   8  (bases 1 to 8890)
  AUTHORS   Zoppe,M., Frattini,A., Faranda,S. and Vezzoni,P.
  TITLE     The complete sequence of the host cell factor 1 (HCFC1) gene and
            its promoter: a role for YY1 transcription factor in the regulation
            of its expression
  JOURNAL   Genomics 34 (1), 85-91 (1996)
   PUBMED   8661027
REFERENCE   9  (bases 1 to 8890)
  AUTHORS   Frattini,A., Chatterjee,A., Faranda,S., Sacco,M.G., Villa,A.,
            Herman,G.E. and Vezzoni,P.
  TITLE     The chromosome localization and the HCF repeats of the human host
            cell factor gene (HCFC1) are conserved in the mouse homologue
  JOURNAL   Genomics 32 (2), 277-280 (1996)
   PUBMED   8833156
REFERENCE   10 (bases 1 to 8890)
  AUTHORS   Frattini,A., Faranda,S., Redolfi,E., Zucchi,I., Villa,A.,
            Patrosso,M.C., Strina,D., Susani,L. and Vezzoni,P.
  TITLE     Genomic organization of the human VP16 accessory protein, a
            housekeeping gene (HCFC1) mapping to Xq28
  JOURNAL   Genomics 23 (1), 30-35 (1994)
   PUBMED   7829097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL672002.14.
            
            On Aug 23, 2022 this sequence version replaced XM_006527836.3.
            
            Summary: This gene encodes a transcription cofactor that regulates
            the progression of cell cycle and maintain the ability of embryonic
            stem cells to self-renew. The encoded protein is a large precursor
            that undergoes site-specific proteolytic cleavage to yield N- and
            C-terminal chains that form a non-covalent heterodimer. The encoded
            protein has been implicated in the regulation of expression of
            immediate early genes after herpes simplex virus infection and
            glucose-stimulated secretion of insulin by pancreatic beta cells.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995047.1694129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1170              AL672002.14        84152-85321         c
            1171-1319           AL672002.14        77925-78073         c
            1320-1480           AL672002.14        77464-77624         c
            1481-1689           AL672002.14        76593-76801         c
            1690-1774           AL672002.14        75728-75812         c
            1775-1881           AL672002.14        74908-75014         c
            1882-2061           AL672002.14        73796-73975         c
            2062-2421           AL672002.14        73355-73714         c
            2422-2582           AL672002.14        72923-73083         c
            2583-2780           AL672002.14        71666-71863         c
            2781-3005           AL672002.14        71167-71391         c
            3006-3110           AL672002.14        70903-71007         c
            3111-3330           AL672002.14        70514-70733         c
            3331-3473           AL672002.14        70267-70409         c
            3474-3612           AL672002.14        69995-70133         c
            3613-3833           AL672002.14        69584-69804         c
            3834-5337           AL672002.14        67539-69042         c
            5338-5501           AL672002.14        67243-67406         c
            5502-6078           AL672002.14        66183-66759         c
            6079-6402           AL672002.14        65532-65855         c
            6403-6518           AL672002.14        65276-65391         c
            6519-6656           AL672002.14        65051-65188         c
            6657-6842           AL672002.14        64465-64650         c
            6843-7143           AL672002.14        63474-63774         c
            7144-7207           AL672002.14        62987-63050         c
            7208-8890           AL672002.14        61136-62818         c
FEATURES             Location/Qualifiers
     source          1..8890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.52 cM"
     gene            1..8890
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /note="host cell factor C1"
                     /db_xref="GeneID:15161"
                     /db_xref="MGI:MGI:105942"
     exon            1..1170
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             978..7247
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /note="isoform 1 is encoded by transcript variant 1; host
                     cell factor 1; VP16 accessory protein"
                     /codon_start=1
                     /product="host cell factor 1 isoform 1"
                     /protein_id="NP_001398163.1"
                     /db_xref="GeneID:15161"
                     /db_xref="MGI:MGI:105942"
                     /translation="MASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKEL
                     IVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVE
                     YGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSE
                     DPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKL
                     VIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPL
                     VMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRL
                     YIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADS
                     YLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQ
                     AATAPPSTTTIQVLPTVPGSSISVPTAARTQGVPAVLKVTGPQATTGTPLVTMRPASQ
                     AGKAPVTVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPT
                     VLSVPAGTTIVKTVAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSA
                     ANTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGK
                     VMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQ
                     ASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSSPGIKSPITI
                     ITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVPMGGVRL
                     VTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLG
                     TIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQ
                     PVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTAT
                     TTVVANLGGHPQPTQVQFVCDRQETAASLVTSAVGQQNGNVVRVCSNPPCETHETGTT
                     NTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGTGQQRDTRRTTNTPTVVR
                     ITVAPGALERVQGTVKPQCQTQQTNMTTTTMTVQATGAPCSAGPLLRPSVALESGSHS
                     PAFVQLALPSVRVGLSGPSSKDMPTGRQPETYHTYTTNTPTTTRSIMVAGELGAARVV
                     PTSTYESLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAG
                     SAQRVCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPASGHPCETHQTTSTGTTM
                     SVSVGTLIPDATSSHGTLESGLEVVAVPTVTSQAGSTLLASFPTQRVCSNPPCETHET
                     GTTHTATTVTSNMSSNQDPPPAASDQGEVASTQGDSTNITSASAITTSVSSTLPRAVT
                     TVTQSTPVPGPSVPNISSLTETTPGALNSEVPIPATITVTIANTETSDMPFSAVDILQ
                     PPEELQVSPGPRQQLPPRQLLQSASTPLMGESTEVLSASQTPELQAAVDLSSTGDPSS
                     GQEPTTSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPEELAVT
                     AAAEAAAQAAATEEAQALAIQAVLQAAQQAVMGTGEPMDTSEAAAAVTQAELGHLSAE
                     GQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPADSLNDPSIE
                     SNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVASPAKMQAAATLTEVANGI
                     ESLGVKPDLPPPPSKAPVKKENQWFDVGVIKGTSVMVTHYFLPPDDAVQSDDDSGTVP
                     DYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKSPD
                     GAHLTWEPPSVTSGKIIEYSVYLAIQSSQASGEPKSSTPAQLAFMRVYCGPSPSCLVQ
                     SSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKRPMSS
                     PEMKSAPKKSKADGQ"
     exon            1171..1319
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1480
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1689
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1774
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1881
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2061
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2421
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2582
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2780
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..3005
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3110
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3330
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3473
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3612
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3833
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..5337
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5338..5501
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..6078
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6079..6402
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6403..6518
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6519..6656
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6657..6842
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6843..7143
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            7144..7207
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     exon            7208..8890
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8866..8871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /note="hexamer: ATTAAA"
     polyA_site      8890
                     /gene="Hcfc1"
                     /gene_synonym="HCF; HCF1"
                     /note="major polyA site"
ORIGIN      
        1 acacaagatg gcggctccca gggaggaggc atgatcgccc tgccgttacc gcttcttctg
       61 ccgtacaatt gtcacttcgg gtcttaactc ctgctctttc gagcggctcc tgtgggaagg
      121 agtcttaagg agggaagcga ggattggacg ctgccttgcg tttggtttgc tgtggaagaa
      181 ctgtccagga agaagaggat aggtggggtg ggggggggaa gagaagctag tctcaagatg
      241 gcggctccca gggcggccgc cacagcctga atagcagagg cggactcaag ggagaggtgc
      301 aaaacctctc gagccatacg ggtcggggct tcgagcagca actgagagtt ggagcccgtt
      361 ccgccagcct ctgacacgcc tttattactt aggaacgttg gggttctgcg atcggtggtt
      421 gtactaagtg ctgggtgggg aagcaggacg gtttcaagat ggcggcttcc acaattgtgg
      481 tctgactgtc ggcgaagttg agacaaccgc ggcatttgtg gctcttttcc acccgccccg
      541 gaagccagcc agtgctgggg acggggggtg tgggaaccgg gccggggctc cgccatttcc
      601 ggcgggggag ggctacgact gaggaaggga ggagagagag gcggctcaag atggcggctc
      661 ccagagcctc ctgctcgagg ttctaagcgg gaacacccag gcaaatagtt agagcgacgg
      721 cgctcagtgg cctccagctt ctcgggaata ggtgctctgc agttctgaga agcttttaag
      781 gatacgagct gagtgagaag ggggggaaga gccaaaggaa ggaggatagt taagatggcg
      841 gcctccatgg agtcgtccac cgctgtgtaa ggagccgctt cttcgtgaga gctgccttag
      901 acgaaagggg gtgtgtgaag aattaagggt atcctcccat tcagtgacct cttcccactg
      961 catccttaac cggaactatg gcttcggctg tgtctcccgc aaacttgcca gcggtgcttc
     1021 tgcagccccg ctggaaacgg gtggtgggct ggtcgggtcc cgtgccccga ccccgccacg
     1081 gccaccgtgc agtggctatc aaggagctta tagtggtgtt tggcggcggc aacgagggga
     1141 tagtggacga actacacgtg tacaacactg caaccaacca gtggttcatc ccagctgtga
     1201 gaggggatat ccctccaggg tgtgcagcct atggctttgt gtgtgatggt actcgcctat
     1261 tggtgtttgg tggaatggta gagtatggaa aatacagcaa cgacctctat gaactccagg
     1321 caagtcgttg ggaatggaag agactgaagg caaagacacc caaaaatggg cctcctccat
     1381 gtcctcggct tggacatagc ttctcccttg tgggcaacaa atgttacctg tttgggggtc
     1441 tggccaatga tagtgaggac cccaagaaca acattccgag gtacctgaat gacttatata
     1501 ttctcgaact acggccaggc tctggagtgg tagcttggga catccccatc acttacggtg
     1561 tcctgcctcc accccgggag tcacatactg ctgtggtcta cactgaaaaa gataacaaga
     1621 aatccaagct ggtgatctat ggagggatga gtggctgcag gctaggggac ctttggaccc
     1681 tggacattga gacactgaca tggaataagc ccagccttag tggggtggca ccccttcctc
     1741 gcagcctcca ctctgcaacc accataggaa acaaaatgta tgtatttggt ggctgggtgc
     1801 cccttgtcat ggacgatgtc aaagtggcca cacacgagaa ggagtggaag tgtaccaaca
     1861 cactggcttg tctcaacctg gataccatgg cctgggaaac catcctgatg gatacattgg
     1921 aggacaacat tcctcgagct cgagcaggcc actgtgctgt tgccatcaat actcgtctgt
     1981 atatttggag tggccgtgat ggctaccgca aggcctggaa caaccaggtc tgctgcaagg
     2041 acttgtggta tttggagaca gaaaagccac cacccccagc ccgagtacaa ctagtacgag
     2101 ccaacaccaa ctcactggag gttagctggg gtgcagtggc aacagctgac agttaccttc
     2161 tacaactcca gaaatatgac attcctgcca cagctgctac ggctacctcc cccactccca
     2221 atccagtccc gtctgtgcct gccaaccctc ccaagagccc tgcgccagca gcagctgcac
     2281 ctgctgtaca gccactgacc caagtaggca tcacacttgt gccccaggct gccactgcac
     2341 ccccaagcac aaccaccatc caggtcttgc cgacagtgcc aggcagctcc atttctgtgc
     2401 ccactgcagc caggactcaa ggtgtccctg ctgttctcaa agtgactggt cctcaagcta
     2461 caacaggaac accactggtt accatgagac ctgcaagcca ggctggaaaa gctcctgtca
     2521 ctgtgacttc cctgcctgcc agtgttcgaa tggttgtacc cacacagagt gcccagggga
     2581 cggtgatcgg cagcaaccca cagatgagtg ggatggccgc attggctgct gctgctgctg
     2641 ccacacagaa aatccctcca tcctcagcac ccacggtgct gagtgtccca gcagggacca
     2701 ccatcgtcaa gacagtggct gtgacacctg gcacgaccac tcttccagcc actgtgaagg
     2761 tggcctcctc ccctgtcatg gtgagcaacc cagccactcg aatgctaaag actgcagctg
     2821 cccaagtggg gacatctgtg tcctctgctg ccaacacatc tactcgccct atcatcacag
     2881 tacacaaatc aggaactgta acagtggccc agcaagccca ggtggtgacc acggtggtag
     2941 gtggagtcac caagaccatc accctagtga agagccccat ctctgtccca ggaggcagtg
     3001 ctctgatttc caatctggga aaagtgatgt cggtggtcca gaccaaacca gttcagacat
     3061 cagcagtgac aggccaagca tctacaggtc ctgtgactca gatcatccag accaaaggac
     3121 ccctgccagc ggggactatc ctgaagctgg tgacatcagc agatggcaag cccacaacca
     3181 tcattaccac cacacaggct agtggggcag ggaccaagcc cactatcctg ggcatcagta
     3241 gtgtttctcc cagcaccacc aaacctggca caactaccat tattaagacc attcctatgt
     3301 cggccattat cacccaggca ggtgccacag gtgttaccag cagtcctggc attaagtccc
     3361 caattacaat tatcaccacc aaagtgatga cttcaggaac aggagcgcct gctaaaatca
     3421 tcactgctgt ccccaagatt gctactggcc atgggcaaca aggagtgacc caggtggtgc
     3481 taaagggggc ccctggacaa ccaggcacca tcctccgtac tgtgcctatg ggcggcgttc
     3541 gcctggtcac ccctgtcacc gtctctgctg tcaagccagc tgtcaccaca ttggttgtga
     3601 agggtaccac aggtgttaca acgctaggca cagtgacagg cactgtctcc accagcctgg
     3661 ccggagctgg ggcacatagc accagtgctt ccctggctac acctatcact accttgggca
     3721 ctattgctac gctctcaagc caggtgatca accctactgc tatcacagtg tcagctgcac
     3781 agactacact aacagctgct ggtgggctta ccacacccac aatcacaatg cagcctgtct
     3841 cccagcctac ccaggtcact ctgattacag cacccagtgg ggttgaagca cagcctgtac
     3901 atgaccttcc tgtatccatt ttggcctcac ctactacaga gcagcccaca gcaacagtca
     3961 ccatcgctga ctcaggccag ggtgatgtgc agcccggcac tgtgacactg gtgtgttcca
     4021 acccaccctg tgaaacccat gaaacaggca ccaccaacac agctaccacc actgttgtgg
     4081 ctaaccttgg gggacatcct caacctaccc aggtgcagtt tgtttgtgac agacaggaga
     4141 cagctgcttc acttgtgacc tcagctgtag gacaacagaa tggtaatgtg gtccgtgtct
     4201 gttcaaaccc cccctgtgag acccatgaga cgggcactac caacactgcc acaacagcca
     4261 cctccaacat ggctgggcag catggctgct cgaacccccc ctgtgagact catgagacag
     4321 gcaccaccag cactgccact acagcaatgt ccagcatggg cactgggcag cagcgagaca
     4381 ctcgtcgtac cactaacacc cccactgtag tgcggatcac tgtggctcct ggggcattgg
     4441 agagagtcca gggtaccgtg aagcctcagt gccaaaccca gcagaccaac atgaccacca
     4501 ccaccatgac tgtgcaggcc actggagctc catgctcagc tggccccctg cttaggccaa
     4561 gtgtggcact ggagtctggg agccacagcc ctgcctttgt gcaactagcc cttccaagtg
     4621 tcagagttgg gctaagtggc cccagcagca aggacatgcc cacagggcgc caaccagaga
     4681 catatcatac ttacacaact aataccccaa ccacaacccg ctctatcatg gttgctgggg
     4741 agcttggtgc agctcgggtg gtccccacat ctacatatga gagcctccag gcaagctctc
     4801 ctagcagcac catgactatg acagccctag aggcactgct gtgcccttcg gctactgtca
     4861 cccaagtctg ctccaacccg ccatgtgaga cccatgagac gggtaccacc aacaccgcca
     4921 ctacctccaa tgcgggcagt gctcagcgag tatgctccaa cccgccttgt gagactcatg
     4981 agacgggcac cacacacaca gctaccactg ccacatcaaa tggaggtgca ggccagcctg
     5041 agggtggaca acagcctgcc agtggccatc cctgcgagac acaccagacc acttccactg
     5101 gcaccactat gtcagtcagt gtgggtaccc tgattcctga tgctacttcc tctcatggaa
     5161 ccctggagtc gggcttagag gtggtagcag tgcccactgt cacctcccag gctggttcca
     5221 cattgctggc ctctttccca acacagaggg tatgctccaa ccctccttgc gagacccacg
     5281 agacaggtac cacgcacaca gccaccactg tcacctctaa catgagctca aaccaagacc
     5341 ctccaccagc tgccagtgac caaggagagg tggcaagcac ccaaggtgac agcacaaata
     5401 tcaccagtgc cagtgctatc actacaagtg tgtcttctac attgccacga gcagtgacca
     5461 ctgtgacaca gtctacacca gtccctggtc cctctgtgcc gaacatctca tcattgactg
     5521 agactacccc aggggctctg aattccgaag tccccatccc agccacgata acagtgacca
     5581 tagccaacac agaaacttct gacatgccct tctctgctgt tgacatcctg cagcccccag
     5641 aggaactcca ggtctcacca gggcctcgcc agcagctgcc tccacggcaa ctcctgcagt
     5701 ctgcctccac acccctgatg ggggagtcta ctgaggtcct gtcagcctcc cagacccctg
     5761 agctccaggc cgccgtggat ctgagcagca ctggggaccc atcttcaggc caggagccta
     5821 ccacctctgc tgtcgtggcc actgtggtgg tccaaccacc cccacccaca cagtctgaag
     5881 tagaccagtt atcacttccc caagagctga tggctgaagc ccaggcgggc accacaaccc
     5941 ttatggtaac agggctcact ccagaggagc tggcagtgac tgctgctgct gaagcagctg
     6001 ctcaagctgc agccactgaa gaagcccaag ccttggccat ccaggctgtg ctccaggccg
     6061 cacagcaggc tgtcatgggc actggggagc ccatggatac atctgaagca gcagcagcag
     6121 tgacacaagc agaactgggt cacctttcag ctgaaggcca agagggtcag gctaccacca
     6181 tacccattgt gttgacacag caggagcttg cagccctggt gcagcagcag cagcagctcc
     6241 aggaggctca agctcaagcc cagcaacagc accatcttcc cactgaggct ctggccccag
     6301 ctgacagtct caatgaccca tccatcgaga gcaactgcct caacgagtta gctagtgctg
     6361 tcccaagcac cgtggctttg ctaccctcaa cagctaccga gagcctggct ccatctaaca
     6421 catttgtggc tccccagcct gttgtagcta gtccagcaaa gatgcaggct gcagctaccc
     6481 ttactgaagt ggccaatggc attgagtccc tgggtgtgaa accggacttg ccacccccac
     6541 ccagcaaagc ccctgtgaaa aaggagaacc agtggtttga tgtgggggtc attaagggta
     6601 ccagtgtaat ggtgacacac tattttctgc caccagatga tgctgttcag tcagatgatg
     6661 actcaggcac ggtcccagac tataaccagc taaagaagca ggagctacag ccaggcacgg
     6721 cttacaaatt tcgagttgct ggaatcaatg cttgtggccg gggacccttc agtgagatct
     6781 cagcctttaa gacttgtctg cctgggttcc caggggctcc ttgtgctatt aaaatcagca
     6841 agagcccaga tggtgctcac ctcacctggg agccaccgtc tgtgacctcc ggcaagatca
     6901 tcgagtactc tgtgtacctg gccatccaga gctcacaggc cagtggtgag ccaaagagct
     6961 ccaccccagc ccagctggcc ttcatgcgag tgtactgtgg gcctagccct tcctgcctag
     7021 tgcagtcctc cagcctctcc aacgcccaca ttgactatac tacaaagcct gccatcatct
     7081 tccgcattgc tgcccgcaat gaaaagggct acggccctgc cacacaagtg aggtggttgc
     7141 aagaaactag taaagacagc tctggcacca agccggccag caagcggccc atgtcgtctc
     7201 cagaaatgaa atctgctcca aagaagtcta aggctgatgg tcagtgagga agctggccag
     7261 caactggatc ctccagaccc ctctgcttca ggaaggccct atagggccca ccttcccgcc
     7321 ctgcccacct ggcctttgca cttcaccctc accagctact ggccaccatt cagtctcccc
     7381 cttttcctct gtttttacaa taaagaaagc acattttacc attgctattg ggaggaagca
     7441 gaaggcagat tggaaagaac agcgagtaag tgcaagttgt gctccttcct tttccctacc
     7501 tggtaccctc cctgggttga gtatgaatgg acagctcaga gactttggga agagaaatta
     7561 aaactgaaaa caaaggagat aacacccata cttaagcctg cacttgtttg tagttcatcg
     7621 cccttggcct gagaggcagc caaggactag agggggaagg atatccccca agttccctca
     7681 gaggcttttc ccagcaggta ccccattctg ggtatctgtc tggttctatt ttgttttgtt
     7741 attatccttg tatttccagc cacctcccat cccttcttca agcttagcca gatcctatct
     7801 cgcccagtga aatcacagga agtttaacgt atctcagagg cctttgagtt cccactcaat
     7861 acctctccct ctttacagaa gagaggggtg gggggagcct tggttggtct gagcagtggc
     7921 tgtgaaatcc tcccaatggg cacagaatgg cccccaggaa ccctggcctt ggcctacttt
     7981 tttgagcctg ggggccacat caccaactgc tgcatatgtt gtatttttta agttgaaatt
     8041 aatgaagtta acatttttat tgtaatttta gccttagcgt gtgggggttt atcccttttt
     8101 gttagctgtg tacagaatgt gtatcctatc tcctcccctc cttggctaat cattggcagg
     8161 ggtcttcctg gggaaaagct taaagagcag ctagggaagg agagaaacag tgtcctgggt
     8221 gagacttggt agatactgct ccaatatcct gttgctagcc cccacctcct tctggaacag
     8281 tgtgagacaa ttaaacttca ttccctgtgg gttagcactt aatatgtaga agcttgggct
     8341 tgaaggtgat gtccacctta atcagcatca cttgcagaga ctgaccctaa acaacacagc
     8401 aggggcaggg aacgggtagg acttgaccct cttgaaggca gcccaggatg ggagtagggt
     8461 atgccatatc ccacaggggc tatgagtagg taccagatac caactcagta attaattttg
     8521 tagcattgtc cccaagctct ggattttttt ctctccagga cccaagtttt aggcagtgag
     8581 taatgcttat aagcaaatta ctgaaggatt taaaaatgga cagccaatgt gttcagccgc
     8641 tctggcctgt accccctggg gcctctagtg tattgtatta tatttctgtg gaaagtcatg
     8701 tttagtcaaa ttggaatcca ctcacctgtt ccctttgttt tccctatccc ttctcctgag
     8761 caccctttga tttctgagga cagtactacc cattcatcta ttgtagagta acccttgtga
     8821 ctcaatatta ccatagtgcg atgttgtttt gtgctatttt gaacaattaa aaagactttt
     8881 tttgaaataa
//
