LOCUS       NM_008222               2405 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus holocytochrome c synthetase (Hccs), transcript variant
            2, mRNA.
ACCESSION   NM_008222
VERSION     NM_008222.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Hennig,M., Ewering,L., Pyschny,S., Shimoyama,S., Olecka,M.,
            Ewald,D., Magarin,M., Uebing,A., Thierfelder,L., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Dietary protein restriction throughout intrauterine and postnatal
            life results in potentially beneficial myocardial tissue remodeling
            in the adult mouse heart
  JOURNAL   Sci Rep 9 (1), 15126 (2019)
   PUBMED   31641210
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Magarin,M., Pohl,T., Lill,A., Schulz,H., Blaschke,F., Heuser,A.,
            Thierfelder,L., Donath,S. and Drenckhahn,J.D.
  TITLE     Embryonic cardiomyocytes can orchestrate various cell protective
            mechanisms to survive mitochondrial stress
  JOURNAL   J Mol Cell Cardiol 97, 1-14 (2016)
   PUBMED   27106802
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   Drenckhahn,J.D., Strasen,J., Heinecke,K., Langner,P., Yin,K.V.,
            Skole,F., Hennig,M., Spallek,B., Fischer,R., Blaschke,F.,
            Heuser,A., Cox,T.C., Black,M.J. and Thierfelder,L.
  TITLE     Impaired myocardial development resulting in neonatal cardiac
            hypoplasia alters postnatal growth and stress response in the heart
  JOURNAL   Cardiovasc Res 106 (1), 43-54 (2015)
   PUBMED   25661081
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Schwarz,Q.P. and Cox,T.C.
  TITLE     Complementation of a yeast CYC3 deficiency identifies an X-linked
            mammalian activator of apocytochrome c
  JOURNAL   Genomics 79 (1), 51-57 (2002)
   PUBMED   11827457
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   8  (bases 1 to 2405)
  AUTHORS   Van den Veyver,I.B., Cormier,T.A., Jurecic,V., Baldini,A. and
            Zoghbi,H.Y.
  TITLE     Characterization and physical mapping in human and mouse of a novel
            RING finger gene in Xp22
  JOURNAL   Genomics 51 (2), 251-261 (1998)
   PUBMED   9722948
REFERENCE   9  (bases 1 to 2405)
  AUTHORS   Schaefer,L., Ballabio,A. and Zoghbi,H.Y.
  TITLE     Cloning and characterization of a putative human holocytochrome
            c-type synthetase gene (HCCS) isolated from the critical region for
            microphthalmia with linear skin defects (MLS)
  JOURNAL   Genomics 34 (2), 166-172 (1996)
   PUBMED   8661044
REFERENCE   10 (bases 1 to 2405)
  AUTHORS   Limbach,K.J. and Wu,R.
  TITLE     Characterization of a mouse somatic cytochrome c gene and three
            cytochrome c pseudogenes
  JOURNAL   Nucleic Acids Res 13 (2), 617-630 (1985)
   PUBMED   2987801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831750.8.
            
            On Aug 8, 2022 this sequence version replaced NM_008222.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 all encode the same protein.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1291372.1, AK077566.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AL831750.8         63128-63378         c
            252-404             AL831750.8         62451-62603         c
            405-556             AL831750.8         60009-60160         c
            557-705             AL831750.8         59559-59707         c
            706-825             AL831750.8         58615-58734         c
            826-912             AL831750.8         56601-56687         c
            913-2405            AL831750.8         54543-56035         c
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.98 cM"
     gene            1..2405
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="holocytochrome c synthetase"
                     /db_xref="GeneID:15159"
                     /db_xref="MGI:MGI:106911"
     exon            1..251
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            252..404
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1111
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /EC_number="4.4.1.17"
                     /note="isoform 1 is encoded by transcript variant 2;
                     cytochrome c-type heme lyase; holocytochrome c-type
                     synthase"
                     /codon_start=1
                     /product="holocytochrome c-type synthase isoform 1"
                     /protein_id="NP_032248.3"
                     /db_xref="CCDS:CCDS30535.1"
                     /db_xref="GeneID:15159"
                     /db_xref="MGI:MGI:106911"
                     /translation="MGASASSPATAVNASNASDGQPASPPSGCPMHKGQRKGCPVTAA
                     TSDLTSESKAHTVPAHQDRAYDYVECPVTGARAKDKESLDPSNLMPPPNQTPSPDQPF
                     TLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWKWKDDDISQKDMYNIIRIHNQ
                     NNEQAWKEILKWEALHAHECPCGPSLVRFGGKAREYSPRARIRSWMGYELPFDRHDWI
                     INRCGTEVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKVAWWRWTS"
     exon            405..556
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            557..705
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            706..825
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            826..912
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            913..2405
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="major polyA site"
ORIGIN      
        1 aacggcgccc gagaacgccg gctgtgaccg gacgttagcg gtgaccccgc gtgaggaaaa
       61 accgcgggtg cagccgagcg acttcggctg ggcggttcga cgcgctcgcg gccgcgccgc
      121 gcgggacaag tcggagcgga gacttggggg cagggcggcg cccgggttcg gctggagccg
      181 gcggctgccg agtgagttcg gctgggcagg ttgacgcgct cggggccgcg cggcgcggga
      241 cagtcggcga gctgggtatt ttagattggg agtgacccct gtgattccag ccatgggtgc
      301 ctcagcatct tctcctgcta ctgcagtaaa cgcctcgaat gcttcagatg gtcagccagc
      361 ttcaccacct tcaggatgcc cgatgcataa agggcaaagg aaaggctgtc cagtgactgc
      421 agcaacatct gacctgacca gtgagagcaa agcacacact gtgcctgctc accaagaccg
      481 ggcctatgat tatgtggaat gccctgttac tggtgctaga gctaaggata aggagagcct
      541 cgatccttca aacctgatgc caccacctaa tcagacacca tccccagatc agccatttac
      601 tttgtctacc tcaagagagg agtcatcaat tccaagagct gactctgaga aaaagtgggt
      661 ttacccttct gaacagatgt tctggaatgc catgttacgg aaagggtgga agtggaaaga
      721 tgatgatatt agtcagaaag atatgtacaa tatcattaga attcacaatc agaataatga
      781 gcaagcgtgg aaggagattt taaaatggga agcccttcat gctcatgagt gtccttgtgg
      841 cccatcgttg gtccgatttg gaggtaaagc aagagagtat tcaccaagag caagaattcg
      901 ttcctggatg gggtatgaat tgccttttga ccgccatgac tggatcatca atcgttgtgg
      961 cacagaagtt agatatgtga ttgattacta tgatggtggt gaggtgaaca aggagtacca
     1021 gttcactatc ctggatgtgc gtcctgcctt tgattcattc tctgcagtat gggacagaat
     1081 gaaggttgct tggtggcgct ggacttcgta actgttattt tgtttgttat gaaaaaagtg
     1141 aaactttttt cctgagaaag ctgttaaaac tattttcccc aaactaaatg cactcataat
     1201 gtcattgagg gtacttttcg agtgagtgat catatttgat cttgtattta acaaagatgc
     1261 catgctcctt taaattttga atcacatttt ccattgcaga tgataggtca gtttaatttt
     1321 tttccctatt tggtataagt tccttagttt tcccactaag tccagtattt catgttattt
     1381 tctttagaca tcttaacaat ctctgaaaaa gaggttttaa aagcataaaa agttgttttt
     1441 attcttactg tttcctcagg agtatttgag atataaaacc tgaaagtgtg tgatgctttt
     1501 acctgccaaa taatttaact atattcatta taaataagaa gcacttgttc ttgttttaaa
     1561 agtaactaat atttctaaaa tccctttggt ctgaacaaaa tatacaagta tataccgaat
     1621 gaagtctgca agactgatat gtctatgttt aaatgtgatt tcagatttga ccctgataga
     1681 aatttcaact tgatacataa aaatttcaaa atacttgttt tttcaattct gtcccaatat
     1741 gtaactatca atgaaaagct gatcacacca tccctagaag atgacaaatt atcttatctc
     1801 atcccattcc ctcttcctac ttggagcttg ccaccagtcg tgtaatgtaa accttgagag
     1861 ccgggctcca atcacagtgc cagaagtgtt tctttgacga ataagattat atttggctaa
     1921 gtgttagaat tcacaagaag tgcatttttt ttcagatatg aaatgtttgc accaattcac
     1981 catcattttg atgttttaag catgtgctga gtttgctgtt gaaaactggt tgttttgctg
     2041 ggcagtagta gcacaagcct ttaaccccag cattccatag atctctgagt ttgagactag
     2101 cctggtctac agagtgagtt ccatgacagc cagaaaaatc ctctctctaa aaaaacaaaa
     2161 gaaaaagaaa agaaaactgg ttgtttttat tttaattata gcaacacctt agaaatagct
     2221 ttttcttaaa tgttgataat atgaaaaata tttaatttat cttaaatact gtaacattta
     2281 gtggacagaa tttgtgtttt tgagttattt gacgtagatt tctttgttgt atgatgcttt
     2341 aaaaatctaa catgtgaaaa tatttgtatt ttttaaataa agctgacagt taaaaggttc
     2401 tgaaa
//
