LOCUS       NM_001410431            2737 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus holocytochrome c synthetase (Hccs), transcript variant
            4, mRNA.
ACCESSION   NM_001410431 XM_006528705
VERSION     NM_001410431.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Hennig,M., Ewering,L., Pyschny,S., Shimoyama,S., Olecka,M.,
            Ewald,D., Magarin,M., Uebing,A., Thierfelder,L., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Dietary protein restriction throughout intrauterine and postnatal
            life results in potentially beneficial myocardial tissue remodeling
            in the adult mouse heart
  JOURNAL   Sci Rep 9 (1), 15126 (2019)
   PUBMED   31641210
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Magarin,M., Pohl,T., Lill,A., Schulz,H., Blaschke,F., Heuser,A.,
            Thierfelder,L., Donath,S. and Drenckhahn,J.D.
  TITLE     Embryonic cardiomyocytes can orchestrate various cell protective
            mechanisms to survive mitochondrial stress
  JOURNAL   J Mol Cell Cardiol 97, 1-14 (2016)
   PUBMED   27106802
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   Drenckhahn,J.D., Strasen,J., Heinecke,K., Langner,P., Yin,K.V.,
            Skole,F., Hennig,M., Spallek,B., Fischer,R., Blaschke,F.,
            Heuser,A., Cox,T.C., Black,M.J. and Thierfelder,L.
  TITLE     Impaired myocardial development resulting in neonatal cardiac
            hypoplasia alters postnatal growth and stress response in the heart
  JOURNAL   Cardiovasc Res 106 (1), 43-54 (2015)
   PUBMED   25661081
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Schwarz,Q.P. and Cox,T.C.
  TITLE     Complementation of a yeast CYC3 deficiency identifies an X-linked
            mammalian activator of apocytochrome c
  JOURNAL   Genomics 79 (1), 51-57 (2002)
   PUBMED   11827457
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   8  (bases 1 to 2737)
  AUTHORS   Van den Veyver,I.B., Cormier,T.A., Jurecic,V., Baldini,A. and
            Zoghbi,H.Y.
  TITLE     Characterization and physical mapping in human and mouse of a novel
            RING finger gene in Xp22
  JOURNAL   Genomics 51 (2), 251-261 (1998)
   PUBMED   9722948
REFERENCE   9  (bases 1 to 2737)
  AUTHORS   Schaefer,L., Ballabio,A. and Zoghbi,H.Y.
  TITLE     Cloning and characterization of a putative human holocytochrome
            c-type synthetase gene (HCCS) isolated from the critical region for
            microphthalmia with linear skin defects (MLS)
  JOURNAL   Genomics 34 (2), 166-172 (1996)
   PUBMED   8661044
REFERENCE   10 (bases 1 to 2737)
  AUTHORS   Limbach,K.J. and Wu,R.
  TITLE     Characterization of a mouse somatic cytochrome c gene and three
            cytochrome c pseudogenes
  JOURNAL   Nucleic Acids Res 13 (2), 617-630 (1985)
   PUBMED   2987801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831750.8.
            
            On Aug 8, 2022 this sequence version replaced XM_006528705.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.183223.1,
                                           SRR13422601.1938219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AL831750.8         62796-63378         c
            584-736             AL831750.8         62451-62603         c
            737-888             AL831750.8         60009-60160         c
            889-1037            AL831750.8         59559-59707         c
            1038-1157           AL831750.8         58615-58734         c
            1158-1244           AL831750.8         56601-56687         c
            1245-2737           AL831750.8         54543-56035         c
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.98 cM"
     gene            1..2737
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="holocytochrome c synthetase"
                     /db_xref="GeneID:15159"
                     /db_xref="MGI:MGI:106911"
     exon            1..583
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            584..736
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     CDS             625..1443
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /EC_number="4.4.1.17"
                     /note="isoform 1 is encoded by transcript variant 4;
                     cytochrome c-type heme lyase; holocytochrome c-type
                     synthase"
                     /codon_start=1
                     /product="holocytochrome c-type synthase isoform 1"
                     /protein_id="NP_001397360.1"
                     /db_xref="GeneID:15159"
                     /db_xref="MGI:MGI:106911"
                     /translation="MGASASSPATAVNASNASDGQPASPPSGCPMHKGQRKGCPVTAA
                     TSDLTSESKAHTVPAHQDRAYDYVECPVTGARAKDKESLDPSNLMPPPNQTPSPDQPF
                     TLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWKWKDDDISQKDMYNIIRIHNQ
                     NNEQAWKEILKWEALHAHECPCGPSLVRFGGKAREYSPRARIRSWMGYELPFDRHDWI
                     INRCGTEVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKVAWWRWTS"
     exon            737..888
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1037
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1157
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1244
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..2737
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="hexamer: AATAAA"
     polyA_site      2737
                     /gene="Hccs"
                     /gene_synonym="CCHL"
                     /note="major polyA site"
ORIGIN      
        1 aacggcgccc gagaacgccg gctgtgaccg gacgttagcg gtgaccccgc gtgaggaaaa
       61 accgcgggtg cagccgagcg acttcggctg ggcggttcga cgcgctcgcg gccgcgccgc
      121 gcgggacaag tcggagcgga gacttggggg cagggcggcg cccgggttcg gctggagccg
      181 gcggctgccg agtgagttcg gctgggcagg ttgacgcgct cggggccgcg cggcgcggga
      241 cagtcggcga ggtgacttgg ggacaggacg gcgtccgggt ccggctggag ccggtgcact
      301 gtgcagaccg cggtgccggt gggacgcgca tagacgggaa ggcaacactg gtggcttcct
      361 gcccttcgcc gctccttgcc tcccgttttg gtgacttttt tttttttaac cttcctattt
      421 tccctgaggc gcctgcccta ctgggaacac gggttcgagg ctagttcagt gtattttccc
      481 ttggacccca ccatcaagac tacacccgtc ttcacgacgt ggttgcatct tacaagtttc
      541 cagactctgg cacgggtccc caaatggtgg cataggcttc aagctgggta ttttagattg
      601 ggagtgaccc ctgtgattcc agccatgggt gcctcagcat cttctcctgc tactgcagta
      661 aacgcctcga atgcttcaga tggtcagcca gcttcaccac cttcaggatg cccgatgcat
      721 aaagggcaaa ggaaaggctg tccagtgact gcagcaacat ctgacctgac cagtgagagc
      781 aaagcacaca ctgtgcctgc tcaccaagac cgggcctatg attatgtgga atgccctgtt
      841 actggtgcta gagctaagga taaggagagc ctcgatcctt caaacctgat gccaccacct
      901 aatcagacac catccccaga tcagccattt actttgtcta cctcaagaga ggagtcatca
      961 attccaagag ctgactctga gaaaaagtgg gtttaccctt ctgaacagat gttctggaat
     1021 gccatgttac ggaaagggtg gaagtggaaa gatgatgata ttagtcagaa agatatgtac
     1081 aatatcatta gaattcacaa tcagaataat gagcaagcgt ggaaggagat tttaaaatgg
     1141 gaagcccttc atgctcatga gtgtccttgt ggcccatcgt tggtccgatt tggaggtaaa
     1201 gcaagagagt attcaccaag agcaagaatt cgttcctgga tggggtatga attgcctttt
     1261 gaccgccatg actggatcat caatcgttgt ggcacagaag ttagatatgt gattgattac
     1321 tatgatggtg gtgaggtgaa caaggagtac cagttcacta tcctggatgt gcgtcctgcc
     1381 tttgattcat tctctgcagt atgggacaga atgaaggttg cttggtggcg ctggacttcg
     1441 taactgttat tttgtttgtt atgaaaaaag tgaaactttt ttcctgagaa agctgttaaa
     1501 actattttcc ccaaactaaa tgcactcata atgtcattga gggtactttt cgagtgagtg
     1561 atcatatttg atcttgtatt taacaaagat gccatgctcc tttaaatttt gaatcacatt
     1621 ttccattgca gatgataggt cagtttaatt tttttcccta tttggtataa gttccttagt
     1681 tttcccacta agtccagtat ttcatgttat tttctttaga catcttaaca atctctgaaa
     1741 aagaggtttt aaaagcataa aaagttgttt ttattcttac tgtttcctca ggagtatttg
     1801 agatataaaa cctgaaagtg tgtgatgctt ttacctgcca aataatttaa ctatattcat
     1861 tataaataag aagcacttgt tcttgtttta aaagtaacta atatttctaa aatccctttg
     1921 gtctgaacaa aatatacaag tatataccga atgaagtctg caagactgat atgtctatgt
     1981 ttaaatgtga tttcagattt gaccctgata gaaatttcaa cttgatacat aaaaatttca
     2041 aaatacttgt tttttcaatt ctgtcccaat atgtaactat caatgaaaag ctgatcacac
     2101 catccctaga agatgacaaa ttatcttatc tcatcccatt ccctcttcct acttggagct
     2161 tgccaccagt cgtgtaatgt aaaccttgag agccgggctc caatcacagt gccagaagtg
     2221 tttctttgac gaataagatt atatttggct aagtgttaga attcacaaga agtgcatttt
     2281 ttttcagata tgaaatgttt gcaccaattc accatcattt tgatgtttta agcatgtgct
     2341 gagtttgctg ttgaaaactg gttgttttgc tgggcagtag tagcacaagc ctttaacccc
     2401 agcattccat agatctctga gtttgagact agcctggtct acagagtgag ttccatgaca
     2461 gccagaaaaa tcctctctct aaaaaaacaa aagaaaaaga aaagaaaact ggttgttttt
     2521 attttaatta tagcaacacc ttagaaatag ctttttctta aatgttgata atatgaaaaa
     2581 tatttaattt atcttaaata ctgtaacatt tagtggacag aatttgtgtt tttgagttat
     2641 ttgacgtaga tttctttgtt gtatgatgct ttaaaaatct aacatgtgaa aatatttgta
     2701 ttttttaaat aaagctgaca gttaaaaggt tctgaaa
//
