LOCUS       NM_030701               1947 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus hydroxycarboxylic acid receptor 2 (Hcar2), mRNA.
ACCESSION   NM_030701
VERSION     NM_030701.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1947)
  AUTHORS   Deng,G., Wen,B., Jia,L., Liu,J. and Yan,Q.
  TITLE     Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha and
            ameliorates acute pancreatitis-associated intestinal barrier injury
            in mice
  JOURNAL   Arch Microbiol 206 (6), 265 (2024)
   PUBMED   38761195
  REMARK    GeneRIF: Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha
            and ameliorates acute pancreatitis-associated intestinal barrier
            injury in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1947)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1947)
  AUTHORS   Sun,Y., Nie,Q., Zhang,S., He,H., Zuo,S., Chen,C., Yang,J., Chen,H.,
            Hu,J., Li,S., Cheng,J., Zhang,B., Zheng,Z., Pan,S., Huang,P.,
            Lian,L. and Nie,S.
  TITLE     Parabacteroides distasonis ameliorates insulin resistance via
            activation of intestinal GPR109a
  JOURNAL   Nat Commun 14 (1), 7740 (2023)
   PUBMED   38007572
  REMARK    GeneRIF: Parabacteroides distasonis ameliorates insulin resistance
            via activation of intestinal GPR109a.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1947)
  AUTHORS   Ni,D., Tan,J., Robert,R., Taitz,J., Ge,A., Potier-Villette,C.,
            Reyes,J.G.A., Spiteri,A., Wishart,C., Mackay,C., Piccio,L.,
            King,N.J.C. and Macia,L.
  TITLE     GPR109A expressed on medullary thymic epithelial cells affects
            thymic Treg development
  JOURNAL   Eur J Immunol 53 (11), e2350521 (2023)
   PUBMED   37595951
  REMARK    GeneRIF: GPR109A expressed on medullary thymic epithelial cells
            affects thymic Treg development.
REFERENCE   5  (bases 1 to 1947)
  AUTHORS   Zhao,C., Wang,H., Liu,Y., Cheng,L., Wang,B., Tian,X., Fu,H., Wu,C.,
            Li,Z., Shen,C., Yu,J., Yang,S., Hu,H., Fu,P., Ma,L., Wang,C.,
            Yan,W. and Shao,Z.
  TITLE     Biased allosteric activation of ketone body receptor HCAR2
            suppresses inflammation
  JOURNAL   Mol Cell 83 (17), 3171-3187 (2023)
   PUBMED   37597514
  REMARK    GeneRIF: Biased allosteric activation of ketone body receptor HCAR2
            suppresses inflammation.
REFERENCE   6  (bases 1 to 1947)
  AUTHORS   Benyo,Z., Gille,A., Kero,J., Csiky,M., Suchankova,M.C.,
            Nusing,R.M., Moers,A., Pfeffer,K. and Offermanns,S.
  TITLE     GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
  JOURNAL   J Clin Invest 115 (12), 3634-3640 (2005)
   PUBMED   16322797
  REMARK    GeneRIF: GPR109A mediates nicotinic acid-induced flushing, an
            effect which involves release of PGE(2) and PGD(2), most likely
            from immune cells of the skin
REFERENCE   7  (bases 1 to 1947)
  AUTHORS   Taggart,A.K., Kero,J., Gan,X., Cai,T.Q., Cheng,K., Ippolito,M.,
            Ren,N., Kaplan,R., Wu,K., Wu,T.J., Jin,L., Liaw,C., Chen,R.,
            Richman,J., Connolly,D., Offermanns,S., Wright,S.D. and Waters,M.G.
  TITLE     (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the
            nicotinic acid receptor PUMA-G
  JOURNAL   J Biol Chem 280 (29), 26649-26652 (2005)
   PUBMED   15929991
  REMARK    GeneRIF: (D)-beta-hydroxybutyrate ((D)-beta-OHB) specifically
            activates PUMA-G/HM74a at concentrations observed in serum during
            fasting; (D)-beta-OHB inhibits mouse adipocyte lipolysis in a
            PUMA-G-dependent manner
REFERENCE   8  (bases 1 to 1947)
  AUTHORS   Soga,T., Kamohara,M., Takasaki,J., Matsumoto,S., Saito,T.,
            Ohishi,T., Hiyama,H., Matsuo,A., Matsushime,H. and Furuichi,K.
  TITLE     Molecular identification of nicotinic acid receptor
  JOURNAL   Biochem Biophys Res Commun 303 (1), 364-369 (2003)
   PUBMED   12646212
REFERENCE   9  (bases 1 to 1947)
  AUTHORS   Tunaru,S., Kero,J., Schaub,A., Wufka,C., Blaukat,A., Pfeffer,K. and
            Offermanns,S.
  TITLE     PUMA-G and HM74 are receptors for nicotinic acid and mediate its
            anti-lipolytic effect
  JOURNAL   Nat Med 9 (3), 352-355 (2003)
   PUBMED   12563315
  REMARK    GeneRIF: PUMA-G is highly expressed in adipose tissue and is a
            nicotinic acid receptor
REFERENCE   10 (bases 1 to 1947)
  AUTHORS   Schaub,A., Futterer,A. and Pfeffer,K.
  TITLE     PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel
            member of the seven transmembrane spanning receptor superfamily
  JOURNAL   Eur J Immunol 31 (12), 3714-3725 (2001)
   PUBMED   11745392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129582.10, AK150795.1 and BY516126.1.
            
            On Mar 4, 2011 this sequence version replaced NM_030701.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK150795.1, AJ300198.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC129582.10        13893-13911
            20-1945             AK150795.1         2-1927
            1946-1947           BY516126.1         409-410
FEATURES             Location/Qualifiers
     source          1..1947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.24 cM"
     gene            1..1947
                     /gene="Hcar2"
                     /gene_synonym="Gpr109a; Gpr109b; HM74; mHM74b; Niacr1;
                     PUMA-G; Pumag"
                     /note="hydroxycarboxylic acid receptor 2"
                     /db_xref="GeneID:80885"
                     /db_xref="MGI:MGI:1933383"
     exon            1..1947
                     /gene="Hcar2"
                     /gene_synonym="Gpr109a; Gpr109b; HM74; mHM74b; Niacr1;
                     PUMA-G; Pumag"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1161
                     /gene="Hcar2"
                     /gene_synonym="Gpr109a; Gpr109b; HM74; mHM74b; Niacr1;
                     PUMA-G; Pumag"
                     /note="interferon-gamma inducible gene, Puma-g; G
                     protein-coupled receptor 109B; putative seven
                     transmembrane spanning receptor; nicotinic acid receptor;
                     G-protein coupled receptor 109; G-protein coupled receptor
                     HM74; G protein-coupled receptor 109A; niacin receptor 1"
                     /codon_start=1
                     /product="hydroxycarboxylic acid receptor 2"
                     /protein_id="NP_109626.1"
                     /db_xref="CCDS:CCDS19668.1"
                     /db_xref="GeneID:80885"
                     /db_xref="MGI:MGI:1933383"
                     /translation="MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGL
                     ALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLF
                     MLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLL
                     YTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMD
                     RHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTT
                     LSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPST
                     TRSIPGALMADPSEPGSPPYLASTSR"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hcar2"
                     /gene_synonym="Gpr109a; Gpr109b; HM74; mHM74b; Niacr1;
                     PUMA-G; Pumag"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="Hcar2"
                     /gene_synonym="Gpr109a; Gpr109b; HM74; mHM74b; Niacr1;
                     PUMA-G; Pumag"
                     /note="major polyA site"
ORIGIN      
        1 gttcaccaca cagacacaca ctcgccttga gccttcgcta ggtgaggcac tctgaagctg
       61 gactggccag atccactcat gagcaagtca gaccattttc tagtgataaa cggcaagaac
      121 tgctgtgtgt tccgagatga aaacatcgcc aaggtcttgc caccggtgtt ggggctggaa
      181 tttgtgttcg gactcctggg caatggcctt gccttgtgga ttttctgttt ccacctcaag
      241 tcctggaaat ccagccggat tttcttgttc aacttggccg tggctgactt tctcctgatc
      301 atctgcctgc cgttcctgac ggacaactat gtccataact gggactggag gttcggaggc
      361 atcccctgcc gtgtgatgct cttcatgttg gctatgaacc gacagggcag catcatcttc
      421 ctcaccgtgg tggctgtgga ccgctacttc cgggtggtcc atccacacca cttcttgaac
      481 aagatctcca accggacggc ggccatcatt tcttgcttct tgtggggtct caccatcggc
      541 ctgactgtcc acctcctcta tacaaacatg atgaccaaaa atggcgaggc atatctgtgt
      601 agcagcttca gcatctgtta caacttcagg tggcacgatg ctatgttcct cttggaattc
      661 ttcttgcccc tggccatcat cttgttctgc tcaggcagga tcatctggag cctgaggcag
      721 agacagatgg acagacatgc caagatcaag agggccatca acttcatcat ggtggtggct
      781 attgtattca tcatttgctt cctacccagt gtggctgtgc gcatccgcat cttctggctt
      841 ctctacaaat ataacgtacg caactgtgac atctactcct cggtggacct ggctttcttt
      901 accaccctta gctttaccta catgaacagc atgctggacc ctgtggtcta ctatttctcc
      961 agcccatctt tccccaactt cttctccacg tgtatcaacc gctgccttcg aaagaaaaca
     1021 ttgggtgaac ccgataataa ccgaagcact agtgtggagc tcacggggga ccccagcaca
     1081 accagaagta ttccaggggc gctaatggct gaccccagtg agccaggcag ccccccttat
     1141 ctggcttcca catctcgtta agttactatg acaagaaggg agattgccgc tcaggcctgt
     1201 gctctctgga gaggcgattt ggccgttcgt tgaacagggt aacatcttca gatttggctt
     1261 acgctttctt ggaacttcta gattcggaga atcgaattta gagaaacggc gtggtgcagt
     1321 gagcagtttt ggttgcgagg tgcagccata gaaaatctca gaggaacaga aagcagagtt
     1381 tccagacagt ggaaacttct cagccttcca agcttacagg actgaagaag acagagtcct
     1441 gcagagtttg agtcccagat gcacccagac acacctcagt tctgctcaaa gtcacggatg
     1501 gctcttcgtc ctagggtcct acctagcctg tccgtgggcc ccagtgagga caaggagatc
     1561 cacgaaactg gaggggatct ctacccagat gtcactgata agccagttgg tcacttgtgt
     1621 tcggtgggac cagtatacct ttcagccaga ctttagcaga aatgctaaag aggggaggag
     1681 atgcaaaaga tttgattgtt ctccaagtct ccaaaggtgg taagaggggg ttagccccag
     1741 gagggactga actcagtgct ggagagaaac aataacaaat tcagctgagc tttaaaaggc
     1801 tttggggaaa cagtggcttc cctcctctgt ctgcgtttct tagtaaaagg aattcaactg
     1861 tgtccatggt tggggggggg ggggcggttc attacttggg tttctgtact ttaacatcta
     1921 ccatttcaat aaatttcgac aggagac
//
