LOCUS       NM_010406               5421 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus hemolytic complement (Hc), mRNA.
ACCESSION   NM_010406
VERSION     NM_010406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5421)
  AUTHORS   Mitchell,J.S., Spanier,J.A., Dwyer,A.J., Knutson,T.P.,
            Alkhatib,M.H., Qian,G., Weno,M.E., Chen,Y., Shaheen,Z.R.,
            Tucker,C.G., Kangas,T.O., Morales,M.S., Silva,N., Kaisho,T.,
            Farrar,M.A. and Fife,B.T.
  TITLE     CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin
            A adopt a distinct effector fate and are pathogenic in autoimmune
            diabetes
  JOURNAL   Immunity 57 (10), 2399-2415 (2024)
   PUBMED   39214091
REFERENCE   2  (bases 1 to 5421)
  AUTHORS   Ballard,E., Sakurai,M., Yu,L., Liu,L., Oura,S., Huang,J. and Wu,J.
  TITLE     Incompatibility in cell adhesion constitutes a barrier to
            interspecies chimerism
  JOURNAL   Cell Stem Cell 31 (10), 1419-1426 (2024)
   PUBMED   39181131
REFERENCE   3  (bases 1 to 5421)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   4  (bases 1 to 5421)
  AUTHORS   Yang,Y., Valdes-Rives,S.A., Liu,Q., Gao,T., Burudpakdee,C., Li,Y.,
            Tan,J., Tan,Y., Koch,C.A., Rong,Y., Houser,S.R., Wei,S., Cai,K.Q.,
            Wu,J., Cheng,S.Y., Wechsler-Reya,R. and Yang,Z.J.
  TITLE     Thyroid hormone suppresses medulloblastoma progression through
            promoting terminal differentiation of tumor cells
  JOURNAL   Cancer Cell 42 (8), 1434-1449 (2024)
   PUBMED   39137728
REFERENCE   5  (bases 1 to 5421)
  AUTHORS   Leineweber,W.D., Rowell,M.Z., Ranamukhaarachchi,S.K., Walker,A.,
            Li,Y., Villazon,J., Mestre-Farrera,A., Hu,Z., Yang,J., Shi,L. and
            Fraley,S.I.
  TITLE     Divergent iron regulatory states contribute to heterogeneity in
            breast cancer aggressiveness
  JOURNAL   iScience 27 (9), 110661 (2024)
   PUBMED   39262774
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5421)
  AUTHORS   Merle,N.S., Church,S.E., Fremeaux-Bacchi,V. and Roumenina,L.T.
  TITLE     Complement System Part I - Molecular Mechanisms of Activation and
            Regulation
  JOURNAL   Front Immunol 6, 262 (2015)
   PUBMED   26082779
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5421)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
REFERENCE   8  (bases 1 to 5421)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   9  (bases 1 to 5421)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   10 (bases 1 to 5421)
  AUTHORS   Ooi,Y.M. and Colten,H.R.
  TITLE     Genetic defect in secretion of complement C5 in mice
  JOURNAL   Nature 282 (5735), 207-208 (1979)
   PUBMED   492335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080166.1, M35525.1 and AL845534.7.
            
            On Feb 11, 2019 this sequence version replaced NM_010406.2.
            
            Summary: This gene encodes a component of the complement system, a
            part of the innate immune system that plays an important role in
            inflammation, host homeostasis, and host defense against pathogens.
            The encoded preproprotein is proteolytically processed to generate
            multiple protein products, including the C5 alpha chain, C5 beta
            chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of
            the alpha and beta chains, which are linked by a disulfide bridge.
            Cleavage of the alpha chain by a convertase enzyme results in the
            formation of the C5a anaphylatoxin, which possesses potent
            spasmogenic and chemotactic activity, and the C5b macromolecular
            cleavage product, a subunit of the membrane attack complex (MAC).
            Mice with a homozygous mutation in this gene exhibit impaired bone
            fracture healing and an enhanced inflammatory response in an
            allergic lung disease model. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35525.1, M35526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2256              AK080166.1         29-2284
            2257-5419           M35525.1           2241-5403
            5420-5421           AL845534.7         16785-16786         c
FEATURES             Location/Qualifiers
     source          1..5421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.22 cM"
     gene            1..5421
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /note="hemolytic complement"
                     /db_xref="GeneID:15139"
                     /db_xref="MGI:MGI:96031"
     exon            1..94
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..5072
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /note="complement C5; hepatic fibrogenesis 2"
                     /codon_start=1
                     /product="complement C5 preproprotein"
                     /protein_id="NP_034536.3"
                     /db_xref="CCDS:CCDS15957.1"
                     /db_xref="GeneID:15139"
                     /db_xref="MGI:MGI:96031"
                     /translation="MGLWGILCLLIFLDKTWGQEQTYVISAPKILRVGSSENVVIQVH
                     GYTEAFDATLSLKSYPDKKVTFSSGYVNLSPENKFQNAALLTLQPNQVPREESPVSHV
                     YLEVVSKHFSKSKKIPITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETV
                     LTFIDPEGSEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFE
                     IKEYVLPRFSVSIELERTFIGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIK
                     DEEKQMMHKATQAAKLVDGVAQISFDSETAVKELSYNSLEDLNNKYLYIAVTVTESSG
                     GFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMA
                     QTVDVNQETSDLETKRSITHDTDGVAVFVLNLPSNVTVLKFEIRTDDPELPEENQASK
                     EYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTPKSPYIDKITHYNYLILSKGK
                     IVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEK
                     CGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGNAKRAMQRVF
                     QALDEKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKRNLHL
                     LRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIAN
                     KIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLWEIHRVPKRKQLQVTLPDSL
                     TTWEIQGIGISDNGICVADTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTSG
                     TKFCVKMSAVEGICTSGSSAASLHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSI
                     NFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLV
                     PKTKVERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLE
                     AGNHWNIFYPDTLSKRQSLEKKIKQGVVSVMSYRNADYSYSMWKGASASTWLTAFALR
                     VLGQVAKYVKQDENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTL
                     YLTAFSVIGIRKAVDICPTMKIHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDR
                     THPRFRLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVPSSGTAGMVETTAYALLAS
                     LKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVA
                     YKHEGDFHKYKVTEKHFLGRPVEVSLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEF
                     CSFYLKIDTQDIEASSHFRLSDSGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGI
                     GANEEDLRALVEGVDQLLTDYQIKDGHVILQLNSIPSRDFLCVRFRIFELFQVGFLNP
                     ATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAACTCVEADCAQLQAEVDLAISADSR
                     KEKACKPETAYAYKVRITSATEENVFVKYTATLLVTYKTGEAADENSEVTFIKKMSCT
                     NANLVKGKQYLIMGKEVLQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVENLN
                     NFAEDLFLNSCE"
     exon            95..287
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..450
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..521
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..613
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..696
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..787
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..902
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1029
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1145
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1331
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1535
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1745
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1895
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2028
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2100
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2298
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2389
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2463
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2603
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2831
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2892
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2982
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3195
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3271
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3431
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3527
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3699
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3905
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4058
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4121
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4203
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4261
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4364
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4439
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4545
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4546..4629
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4719
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4803
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4939
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5421
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5397..5402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /note="hexamer: CATAAA"
     polyA_site      5421
                     /gene="Hc"
                     /gene_synonym="C5; C5a; He; Hfib2"
                     /note="major polyA site"
ORIGIN      
        1 atgcccatgg gtttatgccg ctaccagcca tgggtctttg gggaatactt tgtcttttaa
       61 ttttcctgga caaaacttgg ggacaggaac aaacctacgt catttcagca cccaaaatcc
      121 tccgggtcgg ctcgtctgaa aatgtggtaa ttcaagtcca tggctacact gaagcatttg
      181 atgcaactct ttctctaaaa agctatcctg acaaaaaagt caccttctct tcaggctatg
      241 ttaatttgtc cccggaaaac aaattccaaa acgcggcact gttgacacta cagcccaatc
      301 aagttcctag agaagaaagc ccagtctctc acgtgtatct ggaagttgtg tcaaaacact
      361 tttcaaaatc aaagaaaata ccaattacct ataacaatgg aattctcttc atccatacag
      421 acaaacctgt ttacacgccg gaccagtcag taaagatcag agtctattct ctgggtgacg
      481 acttgaagcc agccaaacgg gagactgtct taactttcat agaccccgaa ggatcagaag
      541 ttgacattgt agaagaaaat gattacaccg gaattatctc ttttcctgac ttcaagattc
      601 catctaatcc caagtatggt gtttggacaa ttaaagctaa ctataagaag gattttacaa
      661 caactggaac tgcatacttt gaaattaaag aatatgtctt gccacgattc tctgtttcaa
      721 tagaactaga aagaaccttc attggctata aaaactttaa gaactttgaa atcactgtga
      781 aagcaagata tttttataat aaagtggtac ctgatgctga agtgtatgcc ttttttggat
      841 tgagagagga cataaaagat gaggagaagc agatgatgca caaagccaca caagccgcaa
      901 agttggttga cggagttgct cagatctctt ttgattctga aacagcagtt aaagagctgt
      961 cctacaacag tctagaagac ttaaacaaca agtaccttta tattgcagta acagtcacag
     1021 aatcttcagg tggattttca gaagaggcag aaatccctgg agtcaaatat gtcctctctc
     1081 cctacacact gaatttggtc gctactcctc ttttcgtgaa gcccgggatt ccattttcca
     1141 tcaaggcaca ggttaaagat tcactcgagc aggcggtagg aggggtccca gtaactctga
     1201 tggcacaaac agtcgatgtg aatcaagaga catctgactt ggaaacaaag aggagcatca
     1261 ctcatgacac tgatggagta gctgtgtttg tgctgaacct cccatcaaat gtgacggtgc
     1321 taaagtttga gatcagaact gatgacccag aacttcccga agaaaatcaa gccagcaaag
     1381 agtacgaagc agttgcgtac tcgtctctca gccaaagtta catttacatc gcttggactg
     1441 aaaactacaa gcccatgctt gtgggagaat acctgaatat tatggttacc cccaagagcc
     1501 catatatcga caaaataact cactataatt acttgatttt atccaaaggc aaaattgtac
     1561 agtacggcac aagagagaaa cttttctcct caacttatca aaatataaat attccagtga
     1621 cacagaacat ggttccttca gcacgactcc tggtctatta catagtcaca ggggagcaaa
     1681 cagcagaatt agtggctgac gcagtctgga taaatattga ggagaagtgt ggcaaccagc
     1741 tccaggtcca tctgtctcca gatgaatatg tgtattctcc aggccaaact gtgtcccttg
     1801 acatggtgac tgaagcagac tcatgggtag cactatcagc agtggacaga gctgtgtata
     1861 aagtccaggg aaacgccaaa agggccatgc aaagagtctt tcaagctttg gatgaaaaga
     1921 gtgacctggg ctgtggggca ggtggtggcc atgacaatgc agatgtattc catctagctg
     1981 ggctcacctt cctcaccaac gcaaacgcag atgactccca ttatcgtgat gactcttgta
     2041 aagaaattct caggtcaaag agaaacctgc atctcctaag gcagaaaata gaagaacaag
     2101 ctgctaagta caaacatagt gtgccaaaga aatgctgcta tgacggagcc cgagtgaact
     2161 tctacgaaac ctgtgaggag cgagtggccc gggttaccat aggccctctc tgcatcaggg
     2221 ccttcaacga gtgctgtact attgcgaaca agatccgaaa agaaagcccc cataaacctg
     2281 tccaactggg aaggatccac attaagaccc tgttaccagt gatgaaggca gatatccgaa
     2341 gctactttcc agagagctgg ctatgggaaa ttcatcgcgt tcccaaaaga aaacagctgc
     2401 aggtcacgct gcctgactca ctaacgactt gggaaattca aggcattggc atttcagaca
     2461 atggtatatg tgttgctgat acactcaagg caaaggtgtt caaagaagtc ttcctggaga
     2521 tgaacatacc atattctgtt gtgcgaggag aacagatcca attgaaagga actgtttaca
     2581 actatatgac ctcagggaca aagttctgtg ttaaaatgtc tgctgtggag gggatctgca
     2641 cttcaggaag ctcagctgct agccttcaca cctccaggcc ctccagatgt gtgttccaga
     2701 ggatagaggg ctcgtccagt cacttggtga ccttcaccct gcttcctctg gaaattggcc
     2761 ttcactccat aaacttctca ctagagacct catttgggaa agacatctta gtaaagacat
     2821 tacgggtagt gccagaagga gtcaagaggg aaagctatgc cggcgtgatt ctggacccta
     2881 agggaattcg tggtattgtt aacagacgaa aggaattccc atacaggatc ccattagatt
     2941 tggtccccaa gaccaaagtt gaaaggattt tgagtgtcaa aggactgctt gtaggggagt
     3001 tcttgtccac ggttctgagt aaggaaggca tcaacatcct aacccacctc cccaagggca
     3061 gtgcagaggc agagctcatg agcatagctc cggtgttcta tgttttccac tacctggaag
     3121 caggaaacca ttggaatatt ttctatcctg atacactgag taaaagacag agcctggaga
     3181 aaaaaataaa acaaggggtg gtgagcgtca tgtcctacag aaacgctgac tattcctaca
     3241 gcatgtggaa gggggcgagc gctagtacct ggctgacagc ttttgctctg agagtgcttg
     3301 gacaggtggc caagtatgta aaacaggatg aaaactcaat ttgtaactct ttgctatggc
     3361 tggttgagaa gtgtcagctg gaaaacggct ctttcaagga aaattcccaa tatctaccaa
     3421 taaaattaca gggtactttg cctgctgaag cccaagagaa aactttgtat cttacagcct
     3481 tttctgtgat tggaattaga aaggcagttg acatatgccc caccatgaaa atccacacag
     3541 cgctagataa agccgactcc ttcctgcttg aaaacaccct gccatccaag agcaccttca
     3601 cactggccat tgtagcctat gctctttccc taggagacag aacccacccg aggtttcgtc
     3661 taattgtgtc ggccctgagg aaggaagctt ttgttaaagg tgatccgccc atttaccgtt
     3721 actggagaga taccctcaaa cgtccagaca gctctgtgcc cagcagcggc acagcaggta
     3781 tggttgaaac cacagcctat gctttgctcg ccagcctgaa actgaaggat atgaattacg
     3841 ccaaccccat catcaagtgg ctatctgaag agcagaggta tggaggcggc ttttattcca
     3901 cccaggatac gattaatgcc atcgagggcc tgacagaata ttcactcctg ttaaaacaaa
     3961 ttcatttgga tatggacatc aatgtcgcct acaaacacga aggtgacttc cacaagtata
     4021 aggtgacaga gaagcatttc ctggggaggc cagtggaggt atctctcaat gatgaccttg
     4081 ttgtcagcac aggctacagc agtggcttgg ccacagtata tgtaaaaact gtggttcaca
     4141 aaattagtgt ctctgaggaa ttttgcagct tttacttgaa aattgatacc caagatattg
     4201 aagcatccag ccacttcagg ctcagtgact ctggattcaa gcgcataata gcatgtgcca
     4261 gctacaagcc cagcaaggag gagtcaacat ccgggtcctc ccatgcagta atggatatat
     4321 cactgccgac tggaatcgga gcaaacgagg aagatttacg ggctcttgtg gaaggagtgg
     4381 atcaactact aactgattac cagatcaaag atggccatgt cattctgcaa ctgaattcga
     4441 tcccctccag agatttcctc tgtgtccggt tccggatatt tgaacttttc caagttgggt
     4501 ttctgaatcc tgctaccttc acggtgtacg agtatcacag accagataag cagtgcacca
     4561 tgatttatag catttctgac accaggcttc agaaagtctg tgaaggagca gcttgcacat
     4621 gtgtggaagc tgactgtgcg caactgcagg cagaagtaga cctagccatc tctgcagact
     4681 ccagaaaaga gaaagcctgt aaaccagaga ctgcatatgc ttataaagtc aggatcacat
     4741 cagccactga agaaaatgtt tttgtcaagt acactgcgac tcttctggtc acttacaaaa
     4801 caggggaagc tgctgatgag aattcggagg tcaccttcat taaaaagatg agctgtacca
     4861 atgccaacct ggtgaaaggg aagcagtatt taatcatggg caaagaggtt ctgcagatca
     4921 aacacaattt cagtttcaag tatatatacc ctctagattc ctccacctgg attgaatatt
     4981 ggcccacaga cacaacgtgt ccatcctgtc aagcatttgt agagaatttg aataactttg
     5041 ctgaagacct ctttttaaac agctgtgaat gaaaagttct gctgcacgaa gattcctcct
     5101 gcggcggggg gattgctcct cctctggctt ggaaacctag cctagaatca gatacacttt
     5161 ctttagagta aagcacaagc tgatgagtta cgactttgtg aaatggatag ccttgagggg
     5221 aggcgaaaac aggtccccca aggctatcag atgtcagtgc caatagactg aaacaagtct
     5281 gtaaagttag cagtcagggg tgttggttgg ggccggaaga agagacccac tgaaactgta
     5341 gccccttatc aaaacatatc cttgcttgaa agaaaaatac caaggacaga aaatgccata
     5401 aaatcttgac tttgcactca a
//
