LOCUS       NM_019702               2793 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus Hbs1-like (S. cerevisiae) (Hbs1l), transcript variant
            1, mRNA.
ACCESSION   NM_019702
VERSION     NM_019702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Terrey,M., Adamson,S.I., Chuang,J.H. and Ackerman,S.L.
  TITLE     Defects in translation-dependent quality control pathways lead to
            convergent molecular and neurodevelopmental pathology
  JOURNAL   Elife 10, e66904 (2021)
   PUBMED   33899734
  REMARK    GeneRIF: Defects in translation-dependent quality control pathways
            lead to convergent molecular and neurodevelopmental pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   O'Connell,A.E., Gerashchenko,M.V., O'Donohue,M.F., Rosen,S.M.,
            Huntzinger,E., Gleeson,D., Galli,A., Ryder,E., Cao,S., Murphy,Q.,
            Kazerounian,S., Morton,S.U., Schmitz-Abe,K., Gladyshev,V.N.,
            Gleizes,P.E., Seraphin,B. and Agrawal,P.B.
  TITLE     Mammalian Hbs1L deficiency causes congenital anomalies and
            developmental delay associated with Pelota depletion and 80S
            monosome accumulation
  JOURNAL   PLoS Genet 15 (2), e1007917 (2019)
   PUBMED   30707697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Liakath-Ali,K., Mills,E.W., Sequeira,I., Lichtenberger,B.M.,
            Pisco,A.O., Sipila,K.H., Mishra,A., Yoshikawa,H., Wu,C.C., Ly,T.,
            Lamond,A.I., Adham,I.M., Green,R. and Watt,F.M.
  TITLE     An evolutionarily conserved ribosome-rescue pathway maintains
            epidermal homeostasis
  JOURNAL   Nature 556 (7701), 376-380 (2018)
   PUBMED   29643507
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Ishimura,R., Nagy,G., Dotu,I., Zhou,H., Yang,X.L., Schimmel,P.,
            Senju,S., Nishimura,Y., Chuang,J.H. and Ackerman,S.L.
  TITLE     RNA function. Ribosome stalling induced by mutation of a
            CNS-specific tRNA causes neurodegeneration
  JOURNAL   Science 345 (6195), 455-459 (2014)
   PUBMED   25061210
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Wallrapp,C., Verrier,S.B., Zhouravleva,G., Philippe,H.,
            Philippe,M., Gress,T.M. and Jean-Jean,O.
  TITLE     The product of the mammalian orthologue of the Saccharomyces
            cerevisiae HBS1 gene is phylogenetically related to eukaryotic
            release factor 3 (eRF3) but does not carry eRF3-like activity
  JOURNAL   FEBS Lett 440 (3), 387-392 (1998)
   PUBMED   9872408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082265.1, AK173091.1 and BB016067.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_019702.3.
            
            On Jul 20, 2006 this sequence version replaced NM_019702.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173091.1, BC010251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CJ082265.1         1-54
            55-2787             AK173091.1         1-2733
            2788-2793           BB016067.1         220-225
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..2793
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /note="Hbs1-like (S. cerevisiae)"
                     /db_xref="GeneID:56422"
                     /db_xref="MGI:MGI:1891704"
     exon            1..198
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2204
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic release factor 3; HBS1-like protein"
                     /codon_start=1
                     /product="HBS1-like protein isoform 1"
                     /protein_id="NP_062676.2"
                     /db_xref="CCDS:CCDS35862.1"
                     /db_xref="GeneID:56422"
                     /db_xref="MGI:MGI:1891704"
                     /translation="MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSR
                     RDNPEEEYGYEDLRESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAIL
                     KHKFDVQKALSVVLEQDGVQPWKEKSERAVCAGQPSKGKSVISRSSQSESEIVPKVAK
                     MTVSGKKQTMGFEVPGLTSEENGLSVRAPHKGPPGDDVSVASPNIPETGTPKSALPPP
                     SLQTSEELGSTPTPVRKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMG
                     HMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETT
                     TKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVR
                     SLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENL
                     TARSQSSDLTTWYKGMCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIE
                     AGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVNLTLVGMDIIKINVGCIF
                     CGPKEPIKACTRFRARILVFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGE
                     VTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEIKE
                     "
     exon            199..264
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            265..378
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            379..573
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            574..682
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            683..948
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1114
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1232
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1379
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1454
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1572
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1641
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1746
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1837
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1946
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2047
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2192
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2793
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2669..2674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
     polyA_site      2691
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
     polyA_site      2789
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
     polyA_site      2793
                     /gene="Hbs1l"
                     /gene_synonym="2810035F15Rik; eRFS"
ORIGIN      
        1 gcaggtatga cgtcgcgcat gcgcggacgc tcggcgcaga ggcctggcgg aagacaagat
       61 ggcgcggcag aggtgttccg cccgcggtct gcgcctcgtc ggtttctgag ccgagttttt
      121 ctggaaggga cggcggcagg cgccgtctgt gcgcgatggc ccggcatcgg aacgtccggg
      181 gatataacta cgatgaagat tttgaagatg atgatctgta tgggcagtct gtggaggatg
      241 actactgtat ctcaccatca acagccgctc agttcattta ctcacgccgt gacaaccctg
      301 aagaagaata tggctatgaa gatctgagag agtcttctaa ttctcttttg aatcaccaat
      361 taagtgaaat tgaccaagct cgcctgtatt catgccttga tcacatgaga gaggtactgg
      421 gggacgctgt gcctgatgac atactgactg aggcaattct gaaacacaaa tttgatgtgc
      481 agaaggcttt gtccgtggtt ctggaacaag atggtgtgca gccttggaag gagaagagtg
      541 agcgagcagt gtgtgcagga cagccttcaa aaggaaaatc agttatatct cggtcatccc
      601 agagtgaatc tgaaattgtg ccaaaagttg ctaaaatgac tgtatccggg aagaagcaga
      661 ccatgggatt tgaagtgcct ggcttaactt ctgaggaaaa tggactcagt gtgcgcgctc
      721 ctcacaaagg gcctcctggt gatgatgtga gcgtagcttc tcctaacatt cctgagaccg
      781 gcactccaaa atctgccctc ccacctcctt cccttcaaac atcagaagag ctgggctcca
      841 ctccgacacc agtgagaaag tctggcaagc tgaggcagca gatagacgtg aaagcggaat
      901 tggaaaagcg gcagggcggg aagcagctcc tcaacttagt ggtcattggt catgttgatg
      961 ctgggaaaag tactctgatg ggccatatgc tttatcttct gggtaatgta aacaaaagaa
     1021 ctatgcataa gtatgagcaa gaatctaaaa aggctggcaa ggcttcattt gcatatgcgt
     1081 gggtcttgga tgaaactgga gaagaaaggg aaaggggagt aacaatggac gtcggaatga
     1141 cgaagtttga aaccacaacc aaagttatta ccttaatgga tgctccaggc cataaggatt
     1201 tcattccaaa catgatcaca ggagcagccc aggccgatgt cgctgtcctg gtcgttgatg
     1261 ccagcagagg agagtttgaa gctggatttg agacgggagg acagacccga gagcatggcc
     1321 ttttggtccg atctcttgga gtgacacagc ttgctgtggc tgtcaataag atggatcagg
     1381 taaattggca acaagaaaga tttcaagaga ttactggaaa actcgggcac tttcttaagc
     1441 aagcaggttt taaggagagt gatgtagctt ttatcccgac gagcggtctg agtggtgaga
     1501 atttaaccgc aaggtcacag tccagtgacc tcacgacgtg gtacaaaggg atgtgcttat
     1561 tggagcagat tgattccttc aagccccctc agcgctcgat tgacaaacct tttagattat
     1621 gtgtgtctga tgtcttcaaa gatcaaggat ctggcttttg tgtgactggt aaaattgaag
     1681 ctggttatat ccagactggt gaccgactgt tagccatgcc acccaatgaa acctgtactg
     1741 ctaaaggaat cactctgcac gatgagcctg tcgattgggc agcagcaggc gatcacgtaa
     1801 atcttacctt ggttgggatg gacatcatca aaatcaatgt cggctgcata ttttgtggcc
     1861 ccaaagaacc cattaaggct tgcacccgct tcagagcccg aatcctcgtc ttcaatattg
     1921 aagttccgat cactaaaggg tttcctgtgc tgttacacta ccaaaccgtc agtgagcctg
     1981 ctgttattaa gcgattgatt agtgtcctaa acaaaagtac tggtgaagtc acaaagaaga
     2041 agcccaagtt gctgaccaag ggccagaacg ccttggtaga gctgcagaca caaagaccag
     2101 tggctcttga gctctacaaa gacttcaagg agctggggcg gtttatgctg cgttatggtg
     2161 gctccacagt agctgccggt gttgtcactg agataaaaga gtgacggtcc ggtcctcatc
     2221 tcaccatgct tccagaggag cgagtcagcc cctggggcac tcagtggtgc agctaaggaa
     2281 acagcatgca gtcatgattg ttagatgaga gacactaaag tacagttagc tgccaacaag
     2341 tattaaggat tactctgcaa aacttcccag ttgccagctg ccagaggcca gcactgaact
     2401 gccatttctt ccctttcggg gtggcagtaa atatgtttgt tgtgctgaga cttgtgggag
     2461 gtatcacaag acacttaact cagtggactc gacttccagc caaaccaaat ccaaacgctg
     2521 ttctgtttcc attctcctgc tgtgtgtgtt ctaaggaagc cttgaacctt agtggggctt
     2581 ggagagtccg tctttgacct ggtgcttttt ttagttaaca ctaagaaaag atttactgaa
     2641 ggtaacagtg aagctgtttt gtgctgaaaa taaaaccgtc catcaagcct gccttctgga
     2701 gtgtaatgcg aagtgacaga aatctgttct taagtaacaa agatgctact taagttgaga
     2761 agccagctaa taaaatgcct tagtttgaat gta
//
