LOCUS       NM_175000                604 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hemoglobin, theta 1A (Hbq1a), mRNA.
ACCESSION   NM_175000
VERSION     NM_175000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 604)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 604)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 604)
  AUTHORS   Lynch,M.D., Smith,A.J., De Gobbi,M., Flenley,M., Hughes,J.R.,
            Vernimmen,D., Ayyub,H., Sharpe,J.A., Sloane-Stanley,J.A.,
            Sutherland,L., Meek,S., Burdon,T., Gibbons,R.J., Garrick,D. and
            Higgs,D.R.
  TITLE     An interspecies analysis reveals a key role for unmethylated CpG
            dinucleotides in vertebrate Polycomb complex recruitment
  JOURNAL   EMBO J 31 (2), 317-329 (2012)
   PUBMED   22056776
REFERENCE   5  (bases 1 to 604)
  AUTHORS   Storz,J.F., Hoffmann,F.G., Opazo,J.C. and Moriyama,H.
  TITLE     Adaptive functional divergence among triplicated alpha-globin genes
            in rodents
  JOURNAL   Genetics 178 (3), 1623-1638 (2008)
   PUBMED   18245844
REFERENCE   6  (bases 1 to 604)
  AUTHORS   Wallace,H.A., Marques-Kranc,F., Richardson,M., Luna-Crespo,F.,
            Sharpe,J.A., Hughes,J., Wood,W.G., Higgs,D.R. and Smith,A.J.
  TITLE     Manipulating the mouse genome to engineer precise functional
            syntenic replacements with human sequence
  JOURNAL   Cell 128 (1), 197-209 (2007)
   PUBMED   17218265
REFERENCE   7  (bases 1 to 604)
  AUTHORS   Anguita,E., Hughes,J., Heyworth,C., Blobel,G.A., Wood,W.G. and
            Higgs,D.R.
  TITLE     Globin gene activation during haemopoiesis is driven by protein
            complexes nucleated by GATA-1 and GATA-2
  JOURNAL   EMBO J 23 (14), 2841-2852 (2004)
   PUBMED   15215894
REFERENCE   8  (bases 1 to 604)
  AUTHORS   Flint,J., Tufarelli,C., Peden,J., Clark,K., Daniels,R.J.,
            Hardison,R., Miller,W., Philipsen,S., Tan-Un,K.C., McMorrow,T.,
            Frampton,J., Alter,B.P., Frischauf,A.M. and Higgs,D.R.
  TITLE     Comparative genome analysis delimits a chromosomal domain and
            identifies key regulatory elements in the alpha globin cluster
  JOURNAL   Hum Mol Genet 10 (4), 371-382 (2001)
   PUBMED   11157800
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK039049.1.
            
            On Apr 5, 2007 this sequence version replaced NM_175000.1.
            
            Summary: This gene is one of two mouse theta-globin genes found in
            the alpha-globin gene cluster on chromosome 11. This gene
            represents the T2 (or 3') theta-globin gene described in PMIDs
            18245844 and 11157800, respectively. [provided by RefSeq, Apr
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039049.1, BB632867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               AK039049.1         2-605
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.87 cM"
     gene            1..604
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /note="hemoglobin, theta 1A"
                     /db_xref="GeneID:216635"
                     /db_xref="MGI:MGI:2685722"
     exon            1..144
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..487
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /note="hemoglobin, theta 1; Hbq1 3'-theta"
                     /codon_start=1
                     /product="hemoglobin, theta T2"
                     /protein_id="NP_778165.1"
                     /db_xref="CCDS:CCDS24525.1"
                     /db_xref="GeneID:216635"
                     /db_xref="MGI:MGI:2685722"
                     /translation="MARSQDDQWLVLALWKKMGSNVGIYTTEALERTFVAFPSTKTYF
                     PHLDLRPGSSQVKAHAQKVADALTLATQHLDDLPASLSALSDLHAHKLCVDPANFQFF
                     SCCLLVTLARHYPGDFSGEKDACLLGHVSGSCDFCTGLQVMLN"
     exon            145..349
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..604
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
                     /note="hexamer: AGTAAA"
     polyA_site      564
                     /gene="Hbq1a"
                     /gene_synonym="A230090E05Rik; Gm876; Hbq1; Hbqt2"
ORIGIN      
        1 atctttgagc tcagccaggg ggcagagcgc aaggctcagt tcattgaaga tggctcggtc
       61 ccaggatgat cagtggctgg tccttgcgct ctggaagaag atgggcagca atgtcggaat
      121 ctacacgacc gaggccttgg agaggacctt cgtggctttc ccctccacca aaacctactt
      181 cccacacttg gacctgaggc caggctctag ccaggttaaa gcccatgccc aaaaggtggc
      241 cgatgcactg actctcgcta cccagcacct ggacgacctg cctgcttctc tgtctgctct
      301 cagtgatcta catgcgcaca agctctgtgt ggaccctgct aacttccagt tcttcagctg
      361 ctgtctgctg gtgactctcg ccaggcacta tcctggagac ttcagcggcg aaaaagatgc
      421 atgtctcctt ggacacgtgt ctgggtcatg tgacttttgc actggacttc aagtaatgct
      481 gaattgagga agcagggcag cttattctcc agtcatgccc ttcctaaagc ttacaatgtt
      541 tgagtaaact tccccagggc tgcattgcct ctgtgcatgt gtgcctggtg tgtgatgctg
      601 ctgt
//
