LOCUS       NM_153198               2651 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus high mobility group box transcription factor 1 (Hbp1),
            transcript variant 1, mRNA.
ACCESSION   NM_153198
VERSION     NM_153198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Wen,L., Chen,W., Zhu,C., Li,J., Zhou,J., Zhang,M., Zhang,W. and
            Xue,Q.
  TITLE     Overexpression of macrophage migration inhibitory factor protects
            against pressure overload-induced cardiac hypertrophy through
            regulating the miR-29b-3p/HBP1 axis
  JOURNAL   Physiol Rep 12 (12), e16022 (2024)
   PUBMED   38924383
  REMARK    GeneRIF: Overexpression of macrophage migration inhibitory factor
            protects against pressure overload-induced cardiac hypertrophy
            through regulating the miR-29b-3p/HBP1 axis.
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Chu,K. and Gu,J.
  TITLE     microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic
            fatty liver disease by targeting HBP1
  JOURNAL   Immunopharmacol Immunotoxicol 44 (6), 993-1003 (2022)
   PUBMED   35848933
  REMARK    GeneRIF: microRNA-103a-3p promotes inflammation and fibrosis in
            nonalcoholic fatty liver disease by targeting HBP1.
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Cheng,Y., Yang,R., Zhou,Y., Wang,J., Zhang,T., Wang,S., Li,H.,
            Jiang,W. and Zhang,X.
  TITLE     HBP1 inhibits the development of type 2 diabetes mellitus through
            transcriptional activation of the IGFBP1 gene
  JOURNAL   Aging (Albany NY) 14 (21), 8763-8782 (2022)
   PUBMED   36326689
  REMARK    GeneRIF: HBP1 inhibits the development of type 2 diabetes mellitus
            through transcriptional activation of the IGFBP1 gene.
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Alqurashi,R.S., Yee,A.S., Malone,T., Alrubiaan,S., Tam,M.W.,
            Wang,K., Nandedwalla,R.R., Field,W., Alkhelb,D., Given,K.S.,
            Siddiqui,R., Baleja,J.D., Paulson,K.E. and Yee,A.S.
  TITLE     A Warburg-like metabolic program coordinates Wnt, AMPK, and mTOR
            signaling pathways in epileptogenesis
  JOURNAL   PLoS One 16 (8), e0252282 (2021)
   PUBMED   34358226
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   de Chiara,C., Giannini,C., Adinolfi,S., de Boer,J., Guida,S.,
            Ramos,A., Jodice,C., Kioussis,D. and Pastore,A.
  TITLE     The AXH module: an independently folded domain common to ataxin-1
            and HBP1
  JOURNAL   FEBS Lett 551 (1-3), 107-112 (2003)
   PUBMED   12965213
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Shih,H.H., Xiu,M., Berasi,S.P., Sampson,E.M., Leiter,A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HMG box transcriptional repressor HBP1 maintains a proliferation
            barrier in differentiated liver tissue
  JOURNAL   Mol Cell Biol 21 (17), 5723-5732 (2001)
   PUBMED   11486012
  REMARK    Erratum:[Mol Cell Biol 2001 Nov;21(21):7535]
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Zhuma,T., Tyrrell,R., Sekkali,B., Skavdis,G., Saveliev,A.,
            Tolaini,M., Roderick,K., Norton,T., Smerdon,S., Sedgwick,S.,
            Festenstein,R. and Kioussis,D.
  TITLE     Human HMG box transcription factor HBP1: a role in hCD2 LCR
            function
  JOURNAL   EMBO J 18 (22), 6396-6406 (1999)
   PUBMED   10562551
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Lavender,P., Vandel,L., Bannister,A.J. and Kouzarides,T.
  TITLE     The HMG-box transcription factor HBP1 is targeted by the pocket
            proteins and E1A
  JOURNAL   Oncogene 14 (22), 2721-2728 (1997)
   PUBMED   9178770
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Tevosian,S.G., Shih,H.H., Mendelson,K.G., Sheppard,K.A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HBP1: a HMG box transcriptional repressor that is targeted by the
            retinoblastoma family
  JOURNAL   Genes Dev 11 (3), 383-396 (1997)
   PUBMED   9030690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133127.1, AK132503.1 and CT010463.9.
            
            On Mar 30, 2018 this sequence version replaced NM_153198.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The upstream AUG also has a strong Kozak signal and an upstream
            in-frame stop codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132503.1, BC026853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1747              AK133127.1         292-2038
            1748-1988           AK132503.1         1725-1965
            1989-1989           CT010463.9         60269-60269         c
            1990-2651           AK132503.1         1967-2628
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.73 cM"
     gene            1..2651
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /note="high mobility group box transcription factor 1"
                     /db_xref="GeneID:73389"
                     /db_xref="MGI:MGI:894659"
     exon            1..50
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            51..234
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            235..463
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..605
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..717
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..830
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            831..987
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1132
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1456
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1598
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..2651
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2630..2635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2650
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggaggggg aagacgaagc ttgaaagact tggtaatggc gacgggtttg tcggagcacc
       61 ataacatggt gtgggaagtg aagacaaatc agatgcctaa tgcagtacag aaactcctgc
      121 tggtgatgga caagagagca ccagggatga gtgactcgct ggagttgctg cagtgtaatg
      181 agaatttgcc atcctctcca ggatacaact cctgtgatga gcacatggag cttgatgacc
      241 ttcctgaact tcaggctgtt caaagtgacc ctacccaatc tgccatatac cagctaagtt
      301 cagatgtatc tcatcaagaa tatccaagat catcttggag ccagaatacc tcagatatac
      361 cggaaaatac tcaccgtgaa gatgaggtgg actggctaac agagttagca aatattgcca
      421 ctagtccaca aagtcccctg atgcagtgct cattttataa cagatcatct cctgtacaca
      481 tcatagctac tagcaaaagt ttacattcct atgcacgccc accaccagtg tcctcttctt
      541 caaaaagtgg gccagccttc cctcatgacc actggaagga agaaacacca gtaagacatg
      601 aaagggcaaa cagtgagtca gagtcaggca ttttctgtat gtcctccctg tcagatgatg
      661 atgatctggg ctggtgcaat tcctggccat ccaccatttg gcactgcttt ctgaaaggca
      721 cgcggctgtg cttccataag gaaagcaata aggaatggca agatgtggaa gactttgcta
      781 gagccgccag ctgtgataat gaggaagaga tccaaatggg cactcacaag ggctatgggt
      841 ctgatggtct aaagttgtta tcccatgaag agagtgtgtc attcggtgag tctgtactga
      901 agttgacatt tgatcctggt acagtagaag atggcttgct cactgtagag tgcaagctgg
      961 accacccttt ctatgttaaa aataaaggtt ggtcgtcatt ttatccaagc ttgactgtgg
     1021 tacagcatgg cattccatgt tgtgaaattc atattggtga cgtatgtcta cctcctggac
     1081 accctgatgc cattaatttc gatgattcag gtgtttttga tacatttaaa agctatgact
     1141 tcacacctat ggactcttct gcggtctatg ttttgagtag tatggctcgt cagcgccgtg
     1201 catctctgtc ttgtggagga ggacctggta ctggtcaaga gttttcggga tctgaattca
     1261 gtaaaagctg tggttcacct ggatcatcac agctctcttc tagttctttg tatgctaaag
     1321 ctgtcaaaag ccacagctca gggactgtga gtgccacttc tcctaataag tgcaaaagac
     1381 caatgaatgc cttcatgctt tttgccaaaa aatacagagt tgaatatact cagatgtatc
     1441 cagggaaaga taacagagcc ataagtgtga tccttggtga caggtggaaa aaaatgaaga
     1501 acgaagaaag gaggatgtac acattagaag caaaggcttt ggctgaagaa caaaagcgtt
     1561 taaatcctga ctgttggaaa aggaaaagaa ccaactcagg ctctcaacag cattaaacct
     1621 gatgcttgtg tttgtaagtc tgcatctgca taagtactga ctctggatgg aaaagcttgg
     1681 aagaccttgg tctcaccatt tgtctacatt tgtgtgacca taaaatgctg ggagcattga
     1741 gttttgtaat gatttaatgg gtgaggattg ctttctccat tagagcatta agctataact
     1801 atcaacattg taaaccaaat tgccttattt tccttccaaa cttcatatat ctatcaggta
     1861 atataggctt gaaaattgat atcctgtggt gctaaagtac agtagaaaga tgtgtatacg
     1921 ttttatttta aattgtacga aggggaattt aaaaatacgt aactgctgtt tatacatcag
     1981 ctccttactg cttattaatc tgtattgtac ccacgatatc aggagtgaag cagacgctgg
     2041 cctttccatg aatagccacc acatggccca gcatctctgc caaacacagt tgcttctagt
     2101 ctggccagtg ccaagagaca acataacatg gcaggtggat ggtgtcggtg tcattgtctc
     2161 agctcaaaga gccacctgct tcagatacca tgggcatgtg ctgagtggat gcaccagggg
     2221 gcagcacagc tccatgattc ccagtggggc ccaagccagg ccaaggtgca gtcagttaat
     2281 agcattggga cagtcattgt aatggtgctg ttaccagtcg acaccattgt gtttgaccgc
     2341 gttcctgtct cctcagccac ataccctcat ctgtgctgtc agtgtgtctc tggtggggca
     2401 gactttgcac ttactgcagt gcaccacttg cactttactc cctccggctt ctgagacaga
     2461 gcaagtactt cagcagtcct gctgctcttg ctctgagcta caatcatggc ttctcatgtt
     2521 acttaccaag tgagagtttt ggttagtaat cacagctgta aaattgattt acacttgtta
     2581 aacatattgc ccctcaattt tgcacactat attcttgtat attatttcaa ataaaaggaa
     2641 aaaaaaggtc t
//
