LOCUS       NP_694878                526 aa            linear   ROD 27-APR-2025
DEFINITION  HMG box-containing protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_694878
VERSION     NP_694878.2
DBSOURCE    REFSEQ: accession NM_153198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Wen,L., Chen,W., Zhu,C., Li,J., Zhou,J., Zhang,M., Zhang,W. and
            Xue,Q.
  TITLE     Overexpression of macrophage migration inhibitory factor protects
            against pressure overload-induced cardiac hypertrophy through
            regulating the miR-29b-3p/HBP1 axis
  JOURNAL   Physiol Rep 12 (12), e16022 (2024)
   PUBMED   38924383
  REMARK    GeneRIF: Overexpression of macrophage migration inhibitory factor
            protects against pressure overload-induced cardiac hypertrophy
            through regulating the miR-29b-3p/HBP1 axis.
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Chu,K. and Gu,J.
  TITLE     microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic
            fatty liver disease by targeting HBP1
  JOURNAL   Immunopharmacol Immunotoxicol 44 (6), 993-1003 (2022)
   PUBMED   35848933
  REMARK    GeneRIF: microRNA-103a-3p promotes inflammation and fibrosis in
            nonalcoholic fatty liver disease by targeting HBP1.
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Cheng,Y., Yang,R., Zhou,Y., Wang,J., Zhang,T., Wang,S., Li,H.,
            Jiang,W. and Zhang,X.
  TITLE     HBP1 inhibits the development of type 2 diabetes mellitus through
            transcriptional activation of the IGFBP1 gene
  JOURNAL   Aging (Albany NY) 14 (21), 8763-8782 (2022)
   PUBMED   36326689
  REMARK    GeneRIF: HBP1 inhibits the development of type 2 diabetes mellitus
            through transcriptional activation of the IGFBP1 gene.
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Alqurashi,R.S., Yee,A.S., Malone,T., Alrubiaan,S., Tam,M.W.,
            Wang,K., Nandedwalla,R.R., Field,W., Alkhelb,D., Given,K.S.,
            Siddiqui,R., Baleja,J.D., Paulson,K.E. and Yee,A.S.
  TITLE     A Warburg-like metabolic program coordinates Wnt, AMPK, and mTOR
            signaling pathways in epileptogenesis
  JOURNAL   PLoS One 16 (8), e0252282 (2021)
   PUBMED   34358226
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 526)
  AUTHORS   de Chiara,C., Giannini,C., Adinolfi,S., de Boer,J., Guida,S.,
            Ramos,A., Jodice,C., Kioussis,D. and Pastore,A.
  TITLE     The AXH module: an independently folded domain common to ataxin-1
            and HBP1
  JOURNAL   FEBS Lett 551 (1-3), 107-112 (2003)
   PUBMED   12965213
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Shih,H.H., Xiu,M., Berasi,S.P., Sampson,E.M., Leiter,A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HMG box transcriptional repressor HBP1 maintains a proliferation
            barrier in differentiated liver tissue
  JOURNAL   Mol Cell Biol 21 (17), 5723-5732 (2001)
   PUBMED   11486012
  REMARK    Erratum:[Mol Cell Biol 2001 Nov;21(21):7535]
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Zhuma,T., Tyrrell,R., Sekkali,B., Skavdis,G., Saveliev,A.,
            Tolaini,M., Roderick,K., Norton,T., Smerdon,S., Sedgwick,S.,
            Festenstein,R. and Kioussis,D.
  TITLE     Human HMG box transcription factor HBP1: a role in hCD2 LCR
            function
  JOURNAL   EMBO J 18 (22), 6396-6406 (1999)
   PUBMED   10562551
REFERENCE   9  (residues 1 to 526)
  AUTHORS   Lavender,P., Vandel,L., Bannister,A.J. and Kouzarides,T.
  TITLE     The HMG-box transcription factor HBP1 is targeted by the pocket
            proteins and E1A
  JOURNAL   Oncogene 14 (22), 2721-2728 (1997)
   PUBMED   9178770
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Tevosian,S.G., Shih,H.H., Mendelson,K.G., Sheppard,K.A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HBP1: a HMG box transcriptional repressor that is targeted by the
            retinoblastoma family
  JOURNAL   Genes Dev 11 (3), 383-396 (1997)
   PUBMED   9030690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133127.1, AK132503.1 and CT010463.9.
            
            On Dec 3, 2009 this sequence version replaced NP_694878.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The upstream AUG also has a strong Kozak signal and an upstream
            in-frame stop codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132503.1, BC026853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.73 cM"
     Protein         1..526
                     /product="HMG box-containing protein 1 isoform 1"
                     /note="HMG box-containing protein 1; HMG box transcription
                     factor 1"
                     /calculated_mol_wt=58593
     Region          224..350
                     /region_name="AXH"
                     /note="domain in Ataxins and HMG containing proteins;
                     smart00536"
                     /db_xref="CDD:197779"
     Region          447..515
                     /region_name="HMG-box_HBP1"
                     /note="high mobility group (HMG)-box found in HMG
                     box-containing protein 1 (HBP1) and similar proteins;
                     cd21988"
                     /db_xref="CDD:438804"
     Site            order(447..448,450..454,457..458,465,477..478,481,
                     484..485,492,496,499,503,506)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438804"
     CDS             1..526
                     /gene="Hbp1"
                     /gene_synonym="1700058O05Rik; C330012F01Rik"
                     /coded_by="NM_153198.3:36..1616"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25867.2"
                     /db_xref="GeneID:73389"
                     /db_xref="MGI:MGI:894659"
ORIGIN      
        1 matglsehhn mvwevktnqm pnavqklllv mdkrapgmsd slellqcnen lpsspgynsc
       61 dehmelddlp elqavqsdpt qsaiyqlssd vshqeyprss wsqntsdipe nthredevdw
      121 ltelaniats pqsplmqcsf ynrsspvhii atskslhsya rpppvssssk sgpafphdhw
      181 keetpvrher ansesesgif cmsslsdddd lgwcnswpst iwhcflkgtr lcfhkesnke
      241 wqdvedfara ascdneeeiq mgthkgygsd glkllshees vsfgesvlkl tfdpgtvedg
      301 lltveckldh pfyvknkgws sfypsltvvq hgipcceihi gdvclppghp dainfddsgv
      361 fdtfksydft pmdssavyvl ssmarqrras lscgggpgtg qefsgsefsk scgspgssql
      421 sssslyakav kshssgtvsa tspnkckrpm nafmlfakky rveytqmypg kdnraisvil
      481 gdrwkkmkne errmytleak alaeeqkrln pdcwkrkrtn sgsqqh
//
