LOCUS       NM_010415               2392 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus heparin-binding EGF-like growth factor (Hbegf), mRNA.
ACCESSION   NM_010415
VERSION     NM_010415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2392)
  AUTHORS   Yang,Y., Xu,L., Atkins,C., Kuhlman,L., Zhao,J., Jeong,J.M., Wen,Y.,
            Moreno,N., Kim,K.H., An,Y.A., Wang,F., Bynon,S., Villani,V.,
            Gao,B., Brombacher,F., Harris,R., Eltzschig,H.K., Jacobsen,E. and
            Ju,C.
  TITLE     Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and
            macrophages controls liver regeneration after ischaemia and
            reperfusion injury
  JOURNAL   Gut 73 (9), 1543-1553 (2024)
   PUBMED   38724220
  REMARK    GeneRIF: Novel IL-4/HB-EGF-dependent crosstalk between eosinophils
            and macrophages controls liver regeneration after ischaemia and
            reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2392)
  AUTHORS   Linnerbauer,M., Losslein,L., Vandrey,O., Peter,A., Han,Y.,
            Tsaktanis,T., Wogram,E., Needhamsen,M., Kular,L., Nagel,L.,
            Zissler,J., Andert,M., Meszaros,L., Hanspach,J., Zuber,F.,
            Naumann,U.J., Diebold,M., Wheeler,M.A., Beyer,T., Nirschl,L.,
            Cirac,A., Laun,F.B., Gunther,C., Winkler,J., Bauerle,T.,
            Jagodic,M., Hemmer,B., Prinz,M., Quintana,F.J. and Rothhammer,V.
  TITLE     The astrocyte-produced growth factor HB-EGF limits autoimmune CNS
            pathology
  JOURNAL   Nat Immunol 25 (3), 432-447 (2024)
   PUBMED   38409259
  REMARK    GeneRIF: The astrocyte-produced growth factor HB-EGF limits
            autoimmune CNS pathology.
REFERENCE   3  (bases 1 to 2392)
  AUTHORS   Guild,J., Juul,N.H., Andalon,A., Taenaka,H., Coffey,R.J.,
            Matthay,M.A. and Desai,T.J.
  TITLE     Evidence for lung barrier regeneration by differentiation prior to
            binucleated and stem cell division
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37843535
REFERENCE   4  (bases 1 to 2392)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   5  (bases 1 to 2392)
  AUTHORS   Kim,Y.S., Yuan,J., Dewar,A., Borg,J.P., Threadgill,D.W., Sun,X. and
            Dey,S.K.
  TITLE     An unanticipated discourse of HB-EGF with VANGL2 signaling during
            embryo implantation
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2302937120 (2023)
   PUBMED   37155852
  REMARK    GeneRIF: An unanticipated discourse of HB-EGF with VANGL2 signaling
            during embryo implantation.
REFERENCE   6  (bases 1 to 2392)
  AUTHORS   Chen,X., Raab,G., Deutsch,U., Zhang,J., Ezzell,R.M. and
            Klagsbrun,M.
  TITLE     Induction of heparin-binding EGF-like growth factor expression
            during myogenesis. Activation of the gene by MyoD and localization
            of the transmembrane form of the protein on the myotube surface
  JOURNAL   J Biol Chem 270 (31), 18285-18294 (1995)
   PUBMED   7629148
REFERENCE   7  (bases 1 to 2392)
  AUTHORS   Pathak,B.G., Gilbert,D.J., Harrison,C.A., Luetteke,N.C., Chen,X.,
            Klagsbrun,M., Plowman,G.D., Copeland,N.G., Jenkins,N.A. and
            Lee,D.C.
  TITLE     Mouse chromosomal location of three EGF receptor ligands:
            amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF
            (Hegfl)
  JOURNAL   Genomics 28 (1), 116-118 (1995)
   PUBMED   7590736
REFERENCE   8  (bases 1 to 2392)
  AUTHORS   Serrano,J., Scavo,L., Roth,J., de la Rosa,E.J. and de Pablo,F.
  TITLE     A novel chicken homeobox-containing gene expressed in neurulating
            embryos
  JOURNAL   Biochem Biophys Res Commun 190 (1), 270-276 (1993)
   PUBMED   7678491
REFERENCE   9  (bases 1 to 2392)
  AUTHORS   Abraham,J.A., Damm,D., Bajardi,A., Miller,J., Klagsbrun,M. and
            Ezekowitz,R.A.
  TITLE     Heparin-binding EGF-like growth factor: characterization of rat and
            mouse cDNA clones, protein domain conservation across species, and
            transcript expression in tissues
  JOURNAL   Biochem Biophys Res Commun 190 (1), 125-133 (1993)
   PUBMED   7678488
REFERENCE   10 (bases 1 to 2392)
  AUTHORS   Higashiyama,S., Abraham,J.A., Miller,J., Fiddes,J.C. and
            Klagsbrun,M.
  TITLE     A heparin-binding growth factor secreted by macrophage-like cells
            that is related to EGF
  JOURNAL   Science 251 (4996), 936-939 (1991)
   PUBMED   1840698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164309.1, AK145548.1 and AW489543.1.
            
            On Sep 3, 2009 this sequence version replaced NM_010415.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145548.1, AK164309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1076              AK164309.1         2-1077
            1077-2368           AK145548.1         1046-2337
            2369-2392           AW489543.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..2392
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /note="heparin-binding EGF-like growth factor"
                     /db_xref="GeneID:15200"
                     /db_xref="MGI:MGI:96070"
     exon            1..338
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..919
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /note="diphtheria toxin receptor; proheparin-binding
                     EGF-like growth factor; heparin binding epidermal growth
                     factor-like growth factor"
                     /codon_start=1
                     /product="proheparin-binding EGF-like growth factor
                     precursor"
                     /protein_id="NP_034545.1"
                     /db_xref="CCDS:CCDS29153.1"
                     /db_xref="GeneID:15200"
                     /db_xref="MGI:MGI:96070"
                     /translation="MKLLPSVMLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPT
                     GSTNQLLPTGGDRAQGVQDLEGTDLNLFKVAFSSKPQGLATPSKERNGKKKKKGKGLG
                     KKRDPCLRKYKDYCIHGECRYLQEFRTPSCKCLPGYHGHRCHGLTLPVENPLYTYDHT
                     TVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGVASSH"
     exon            339..512
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            513..690
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            691..846
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            847..937
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     exon            938..2375
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="Hbegf"
                     /gene_synonym="Dtr; Dts; Hegfl"
                     /note="major polyA site"
ORIGIN      
        1 attcccggcc gcgcgctgcg agcgagagct cagtcggccc ggggagctgc acgcggctgg
       61 ctggtcggcc tgacagacct tcaagggctg gagtggacgc gcggaccgac tctgaacaga
      121 cagacgaacc gcggccgcaa ggttcccaga caggatctca cccagaggca ggcagcggac
      181 agtgccttag tggaacctcg ctgtcctcca ccgcctggcc ccggtgcagg cgtccagtgg
      241 ccgccgcatc caaagtgatc gctgcctccc cgtctccgcc aggctcggga ccatgaagct
      301 gctgccgtcg gtgatgctga agctctttct ggccgcagtg ttgtccgcgt tggtgaccgg
      361 tgagagtctg gagcggcttc ggagaggtct ggcggcagca accagcaacc ctgaccctcc
      421 cactggatcc acaaaccagc tgctacccac gggaggtgat cgtgctcagg gggtccagga
      481 cttggaaggg acagatctga accttttcaa agttgctttc tcctccaagc cacaaggcct
      541 ggccacccca agcaaagaaa ggaatgggaa aaagaagaag aaaggaaagg ggttagggaa
      601 gaagagagac ccatgcctca ggaaatacaa ggactactgc atccacgggg agtgcagata
      661 cctgcaggag ttccgtactc cctcttgcaa atgcctccct ggttaccacg gacacaggtg
      721 tcatgggctg actctaccag tggagaatcc cctatacaca tatgaccaca ctacagtctt
      781 ggctgtggtg gctgtagtac tgtcgtccgt ctgtcttctt gtcatcgtgg gacttctcat
      841 gtttaggtac cacaggagag gaggttatga cttggaaagt gaagagaaag tgaagttggg
      901 cgtggctagc tcccactgag gaggacctga gctataggaa ccttcagagg ctacttctga
      961 gacagtggtt cgttacacgt tctacataga ggagaaatat ttcaccagca gccatgaaaa
     1021 cgtcttcatt catttccagt tgctaccctg actgggcctc ctgtaattgc tctgttaaaa
     1081 gaaaaaaaaa aatctcagag cctctaagtg ccaaacagac catgcccgct gggatccgga
     1141 tcagaagaaa gcaggatcga gtgagccctt caggccttcc tggtcctcct ccattgaacc
     1201 cactggtttg tttaaacact tagcttctgg attagagtgt cagctagttt ccatatgctc
     1261 caggattttt gactggaaaa aaaaaaaaaa aaggagagga aggttaaatg gtttatggac
     1321 tggaagagag caacagagct gagaagctat gtgttcaagt agccgcaagg gatctgctgt
     1381 ttggaccctc cagcacgctg gatttgatga actaactgtg aaataccgca agctcgagaa
     1441 ctcttgagtt ttgggacttt tctacccaga gggggaaaat aacaagtatt ttgttgtttt
     1501 gttgtttttg tttgtttgtt tgtaaaatgc cttttaaatt atatatttat tttattctat
     1561 gtatgttaat atatttagtt tttaacaatc taacaataat atttcaagtg cctagactgt
     1621 tactttggca atgtcctggc ccacttctct gcgctccacc atctggctca atgccacgct
     1681 gggtcctatt tgctctgtaa cccatcggta gtaatttatt gtctgtctac atttcagaag
     1741 atgtccctgg agcagaatat cccagggtag gttgtgtatg gtcagagtgc agggatcggt
     1801 ttgggcggag ccactctgtg agttggactg cagtcttgcc taggtgattt ttgtctaccg
     1861 ttcgtgttcc gaaagcccaa ggtgctgatg ttagcgtgta atagatattg gtgtttgcct
     1921 gtgtcctctc cctgccaaat cccagaagag attgagcatc catgcctgca ggaagtccat
     1981 gggcttcctg gtcctctatc cccccacctc actccctttg tgtcaagaca tttcccttat
     2041 cctgctgttc ttcgggtgct acttcgtgca ggggttggca gagcacagga cagtttggag
     2101 aaggcattag taaaggaaaa ggctgaggaa gagcagggag ctttggagtt gactattctt
     2161 ggtcattgat acctatcaat tactataggg aaggttggtg ggagggaagg ttttgggtaa
     2221 ggagactacg gtctcaccaa gactataatg tatgctgtca cagtccccat ggaaggttct
     2281 agtgccatgt ctgaactgtt acaacttata tttccaaaac ctggttcata tttatacttt
     2341 gtgacccaaa taaagataac ccttactcca tccataaaaa aaaaaaaaaa aa
//
