LOCUS       NM_001201391             639 bp    mRNA    linear   ROD 13-JAN-2023
DEFINITION  Mus musculus hemoglobin, beta adult s chain (Hbb-bs), mRNA.
ACCESSION   NM_001201391 XM_003084713 XM_003084715
VERSION     NM_001201391.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 639)
  AUTHORS   Brown FC, Scott N, Rank G, Collinge JE, Vadolas J, Vickaryous N,
            Whitelaw N, Whitelaw E, Kile BT, Jane SM and Curtis DJ.
  TITLE     ENU mutagenesis identifies the first mouse mutants reproducing
            human beta-thalassemia at the genomic level
  JOURNAL   Blood Cells Mol Dis 50 (2), 86-92 (2013)
   PUBMED   23040355
  REMARK    GeneRIF: ENU mutagenesis generated mouse lines with dominant
            beta-thalassemia mutations resembling those in the human disease: a
            nonsense mutation at codon 40 in exon 2 and a mutation at the
            polyadenylation signal of the beta-major gene.
REFERENCE   2  (bases 1 to 639)
  AUTHORS   Runck AM, Moriyama H and Storz JF.
  TITLE     Evolution of duplicated beta-globin genes and the structural basis
            of hemoglobin isoform differentiation in Mus
  JOURNAL   Mol Biol Evol 26 (11), 2521-2532 (2009)
   PUBMED   19675095
REFERENCE   3  (bases 1 to 639)
  AUTHORS   Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M
            and Ley TJ.
  TITLE     Analysis of mice containing a targeted deletion of beta-globin
            locus control region 5' hypersensitive site 3
  JOURNAL   Mol Cell Biol 16 (6), 2906-2912 (1996)
   PUBMED   8649401
REFERENCE   4  (bases 1 to 639)
  AUTHORS   Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin
            DI, Enver T, Ley TJ and Groudine M.
  TITLE     Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals
            that it is not essential for proper regulation of the beta-globin
            locus
  JOURNAL   Genes Dev 9 (18), 2203-2213 (1995)
   PUBMED   7557375
REFERENCE   5  (bases 1 to 639)
  AUTHORS   Shehee WR, Loeb DD, Adey NB, Burton FH, Casavant NC, Cole P, Davies
            CJ, McGraw RA, Schichman SA, Severynse DM et al.
  TITLE     Nucleotide sequence of the BALB/c mouse beta-globin complex
  JOURNAL   J Mol Biol 205 (1), 41-62 (1989)
   PUBMED   2926808
REFERENCE   6  (bases 1 to 639)
  AUTHORS   Weaver,S., Comer,M.B., Jahn,C.L., Hutchison,C.A. 3rd and
            Edgell,M.H.
  TITLE     The adult beta-globin genes of the 'single' type mouse C57BL
  JOURNAL   Cell 24 (2), 403-411 (1981)
   PUBMED   7237554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131116.3.
            
            On or before Jan 17, 2011 this sequence version replaced
            XM_003084713.1, XM_003084715.1.
            
            Summary: This gene encodes a beta polypeptide chain found in adult
            hemoglobin, which consists of a tetramer of two alpha chains and
            two beta chains, and which functions in the transport of oxygen to
            various peripheral tissues. This gene is one of a cluster of
            beta-hemoglobin genes that are distally regulated by a locus
            control region, and which are organized along the chromosome in the
            order of their developmental expression. In mouse, two major
            strain-specific haplotypes of the beta-globin gene cluster are
            found - a 'single' haplotype found in C57BL/-type strains, which
            includes two highly similar adult beta-globin genes, beta s and
            beta t, and a 'diffuse' haplotype found in strains such as BALB/c
            and 129Sv, which includes two somewhat diverse adult beta-globin
            genes, beta-major and beta-minor. This gene represents the beta s
            adult gene found in the 'single' haplotype. Primary chromosome 7 of
            the mouse reference genome assembly, which is derived from C57BL/6
            strain mice, represents the 'single' haplotype, while the 'diffuse'
            haplotype is represented in the reference genome collection by the
            BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq,
            May 2013].
            
            CCDS Note: This gene represents the first of two adult-expressed
            beta-globin genes in the 'single' haplotype of the beta-globin
            cluster (PMID:7237554). The 'single' haplotype is found in
            C57BL/-type strains and includes two highly similar adult
            beta-globin genes, beta s and beta t, while the 'diffuse' haplotype
            is found in strains such as BALB/c and 129Sv, and includes two
            somewhat diverse adult beta-globin genes, beta-major and
            beta-minor. This CCDS is based on primary chromosome 7 of the mouse
            reference genome assembly, which represents the 'single' haplotype.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027903.1, AK011069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC131116.3         135939-136083       c
            146-368             AC131116.3         135603-135825       c
            369-639             AC131116.3         134678-134948       c
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..639
                     /gene="Hbb-bs"
                     /gene_synonym="Beta-s; Hbbt1; Hbbt2"
                     /note="hemoglobin, beta adult s chain"
                     /db_xref="GeneID:100503605"
                     /db_xref="MGI:MGI:5474852"
     exon            1..145
                     /gene="Hbb-bs"
                     /gene_synonym="Beta-s; Hbbt1; Hbbt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..497
                     /gene="Hbb-bs"
                     /gene_synonym="Beta-s; Hbbt1; Hbbt2"
                     /note="beta-single; beta-globin; hemoglobin subunit
                     beta-1-like; beta s"
                     /codon_start=1
                     /product="hemoglobin, beta adult s chain"
                     /protein_id="NP_001188320.1"
                     /db_xref="CCDS:CCDS52339.1"
                     /db_xref="GeneID:100503605"
                     /db_xref="MGI:MGI:5474852"
                     /translation="MVHLTDAEKAAVSGLWGKVNADEVGGEALGRLLVVYPWTQRYFD
                     SFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPE
                     NFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVAAALAHKYH"
     exon            146..368
                     /gene="Hbb-bs"
                     /gene_synonym="Beta-s; Hbbt1; Hbbt2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..639
                     /gene="Hbb-bs"
                     /gene_synonym="Beta-s; Hbbt1; Hbbt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatttgct tctgacatag ttgtgttgac tcacaacccc agaaacagac atcatggtgc
       61 acctgactga tgctgagaag gctgctgtct ctggcctgtg gggaaaggtg aacgccgatg
      121 aagttggtgg tgaggccctg ggcaggctgc tggttgtcta cccttggacc cagcggtact
      181 ttgatagctt tggagaccta tcctctgcct ctgctatcat gggtaatgcc aaagtgaagg
      241 cccatggcaa gaaagtgata actgccttta acgatggcct gaatcacttg gacagcctca
      301 agggcacctt tgccagcctc agtgagctcc actgtgacaa gctgcatgtg gatcctgaga
      361 acttcaggct cctgggcaat atgatcgtga ttgtgctggg ccaccacctg ggcaaggatt
      421 tcacccccgc tgcacaggct gccttccaga aggtggtggc tggagtggcc gctgccctgg
      481 ctcacaagta ccactaaacc ccctttcctg ctcttgcctg tgaacaatgg ttaattgttc
      541 ccaagagagc atctgtcagt tgttggcaaa atgataaaga catttgaaaa tctgtcttct
      601 gacaaataaa aagcatttat ttcactgcaa tgatgtttt
//
