LOCUS       NM_008219                610 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hemoglobin Z, beta-like embryonic chain (Hbb-bh1),
            mRNA.
ACCESSION   NM_008219 XM_622773
VERSION     NM_008219.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 610)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 610)
  AUTHORS   Zhang,F., Zhang,B., Wang,Y., Jiang,R., Liu,J., Wei,Y., Gao,X.,
            Zhu,Y., Wang,X., Sun,M., Kang,J., Liu,Y., You,G., Wei,D., Xin,J.,
            Bao,J., Wang,M., Gu,Y., Wang,Z., Ye,J., Guo,S., Huang,H. and Sun,Q.
  TITLE     An extra-erythrocyte role of haemoglobin body in chondrocyte
            hypoxia adaption
  JOURNAL   Nature 622 (7984), 834-841 (2023)
   PUBMED   37794190
  REMARK    Erratum:[Nature. 2024 Oct;634(8034):E7. doi:
            10.1038/s41586-024-08057-w.. PMID: 39322681]
REFERENCE   3  (bases 1 to 610)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   4  (bases 1 to 610)
  AUTHORS   Sinha,T., Lammerts van Bueren,K., Dickel,D.E., Zlatanova,I.,
            Thomas,R., Lizama,C.O., Xu,S.M., Zovein,A.C., Ikegami,K.,
            Moskowitz,I.P., Pollard,K.S., Pennacchio,L.A. and Black,B.L.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   5  (bases 1 to 610)
  AUTHORS   Vinjamur,D.S., Yao,Q., Cole,M.A., McGuckin,C., Ren,C., Zeng,J.,
            Hossain,M., Luk,K., Wolfe,S.A., Pinello,L. and Bauer,D.E.
  TITLE     ZNF410 represses fetal globin by singular control of CHD4
  JOURNAL   Nat Genet 53 (5), 719-728 (2021)
   PUBMED   33859416
REFERENCE   6  (bases 1 to 610)
  AUTHORS   Strouboulis,J., Dillon,N. and Grosveld,F.
  TITLE     Developmental regulation of a complete 70-kb human beta-globin
            locus in transgenic mice
  JOURNAL   Genes Dev 6 (10), 1857-1864 (1992)
   PUBMED   1383089
REFERENCE   7  (bases 1 to 610)
  AUTHORS   Shehee,W.R., Loeb,D.D., Adey,N.B., Burton,F.H., Casavant,N.C.,
            Cole,P., Davies,C.J., McGraw,R.A., Schichman,S.A., Severynse,D.M.
            et al.
  TITLE     Nucleotide sequence of the BALB/c mouse beta-globin complex
  JOURNAL   J Mol Biol 205 (1), 41-62 (1989)
   PUBMED   2926808
REFERENCE   8  (bases 1 to 610)
  AUTHORS   Casavant,N.C., Hardies,S.C., Funk,F.D., Comer,M.B., Edgell,M.H. and
            Hutchison,C.A. 3rd.
  TITLE     Extensive movement of LINES ONE sequences in beta-globin loci of
            Mus caroli and Mus domesticus
  JOURNAL   Mol Cell Biol 8 (11), 4669-4674 (1988)
   PUBMED   2905421
REFERENCE   9  (bases 1 to 610)
  AUTHORS   Wilkinson,D.G., Bailes,J.A., Champion,J.E. and McMahon,A.P.
  TITLE     A molecular analysis of mouse development from 8 to 10 days post
            coitum detects changes only in embryonic globin expression
  JOURNAL   Development 99 (4), 493-500 (1987)
   PUBMED   2444404
REFERENCE   10 (bases 1 to 610)
  AUTHORS   Holdener-Kenny,B. and Weaver,S.
  TITLE     A naturally occurring deletion in the mouse Hbbs beta-globin gene
            cluster
  JOURNAL   Proc Natl Acad Sci U S A 83 (12), 4374-4378 (1986)
   PUBMED   3459181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012684.1.
            
            On Apr 19, 2007 this sequence version replaced NM_008219.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012684.1, AK011296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AK012684.1         2-611
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.85 cM"
     gene            1..610
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /note="hemoglobin Z, beta-like embryonic chain"
                     /db_xref="GeneID:15132"
                     /db_xref="MGI:MGI:96024"
     exon            1..144
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..496
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /note="minor beta-globin; protein Z; beta-H1-globin;
                     hemoglobin beta-H1 chain; beta Hl globin"
                     /codon_start=1
                     /product="hemoglobin subunit beta-H1"
                     /protein_id="NP_032245.1"
                     /db_xref="CCDS:CCDS21592.1"
                     /db_xref="GeneID:15132"
                     /db_xref="MGI:MGI:96024"
                     /translation="MVHFTAEEKAAITSIWDKVDLEKVGGETLGRLLIVYPWTQRFFD
                     KFGNLSSALAIMGNPRIRAHGKKVLTSLGLGVKNMDNLKETFAHLSELHCDKLHVDPE
                     NFKLLGNMLVIVLSTHFAKEFTPEVQAAWQKLVIGVANALSHKYH"
     exon            145..367
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..610
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /note="hexamer: AATAAA"
     polyA_site      607
                     /gene="Hbb-bh1"
                     /gene_synonym="betaH1"
                     /note="major polyA site"
ORIGIN      
        1 acacttgctt ttgcacactt gagatcatct ccaagcttct atacctcaca ccatggttca
       61 cttcacagct gaggagaagg cagctatcac aagcatctgg gataaagtgg acttggaaaa
      121 agttggagga gaaactctgg gaaggctcct gattgtttac ccatggactc agagattctt
      181 tgacaagttt ggaaacctct cttctgccct ggccatcatg ggaaaccccc ggattagagc
      241 ccatggcaag aaagtgctga catccttggg cttgggggtt aagaacatgg acaacctcaa
      301 ggagaccttt gctcatctca gtgagctgca ctgtgacaag cttcatgtgg atcctgagaa
      361 cttcaagctc ctgggcaaca tgttggtgat tgtcctttct actcattttg ccaaggaatt
      421 caccccagag gtgcaggctg cctggcagaa gctggtgatt ggagtggcca atgctctgtc
      481 ccacaagtac cattaaactc cattccagta cactggcaat cccatgtgtc tatgatgccc
      541 tctttgagtc catggggact gcattgagag cacaaatttt gtttaataaa attgattctt
      601 aataacattg
//
