LOCUS       NM_010405                630 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus hemoglobin X, alpha-like embryonic chain in Hba
            complex (Hba-x), mRNA.
ACCESSION   NM_010405
VERSION     NM_010405.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 630)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 630)
  AUTHORS   Zhang,F., Zhang,B., Wang,Y., Jiang,R., Liu,J., Wei,Y., Gao,X.,
            Zhu,Y., Wang,X., Sun,M., Kang,J., Liu,Y., You,G., Wei,D., Xin,J.,
            Bao,J., Wang,M., Gu,Y., Wang,Z., Ye,J., Guo,S., Huang,H. and Sun,Q.
  TITLE     An extra-erythrocyte role of haemoglobin body in chondrocyte
            hypoxia adaption
  JOURNAL   Nature 622 (7984), 834-841 (2023)
   PUBMED   37794190
  REMARK    Erratum:[Nature. 2024 Oct;634(8034):E7. doi:
            10.1038/s41586-024-08057-w. PMID: 39322681]
REFERENCE   3  (bases 1 to 630)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 630)
  AUTHORS   Ueda,T., Yokota,T., Okuzaki,D., Uno,Y., Mashimo,T., Kubota,Y.,
            Sudo,T., Ishibashi,T., Shingai,Y., Doi,Y., Ozawa,T., Nakai,R.,
            Tanimura,A., Ichii,M., Ezoe,S., Shibayama,H., Oritani,K. and
            Kanakura,Y.
  TITLE     Endothelial Cell-Selective Adhesion Molecule Contributes to the
            Development of Definitive Hematopoiesis in the Fetal Liver
  JOURNAL   Stem Cell Reports 13 (6), 992-1005 (2019)
   PUBMED   31813828
REFERENCE   5  (bases 1 to 630)
  AUTHORS   Gudmundsdottir,B., Gudmundsson,K.O., Klarmann,K.D., Singh,S.K.,
            Sun,L., Singh,S., Du,Y., Coppola,V., Stockwin,L., Nguyen,N.,
            Tessarollo,L., Thorsteinsson,L., Sigurjonsson,O.E., Gudmundsson,S.,
            Rafnar,T., Tisdale,J.F. and Keller,J.R.
  TITLE     POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin
            and Human Fetal Hemoglobin Expression
  JOURNAL   Cell Rep 23 (11), 3236-3248 (2018)
   PUBMED   29898395
REFERENCE   6  (bases 1 to 630)
  AUTHORS   Leder,A., Kuo,A., Shen,M.M. and Leder,P.
  TITLE     In situ hybridization reveals co-expression of embryonic and adult
            alpha globin genes in the earliest murine erythrocyte progenitors
  JOURNAL   Development 116 (4), 1041-1049 (1992)
   PUBMED   1295728
REFERENCE   7  (bases 1 to 630)
  AUTHORS   Wilkinson,D.G., Bailes,J.A., Champion,J.E. and McMahon,A.P.
  TITLE     A molecular analysis of mouse development from 8 to 10 days post
            coitum detects changes only in embryonic globin expression
  JOURNAL   Development 99 (4), 493-500 (1987)
   PUBMED   2444404
REFERENCE   8  (bases 1 to 630)
  AUTHORS   Leder,A., Weir,L. and Leder,P.
  TITLE     Characterization, expression, and evolution of the mouse embryonic
            zeta-globin gene
  JOURNAL   Mol Cell Biol 5 (5), 1025-1033 (1985)
   PUBMED   4000117
REFERENCE   9  (bases 1 to 630)
  AUTHORS   Farace,M.G., Hill,A., Tripodi,M., Padgett,R.W., Raschella,G.,
            Gambari,R., Fantoni,A., Hutchison,C.A. 3rd and Edgell,M.H.
  TITLE     Molecular cloning and sequence analysis of a cDNA coding for the
            mouse alpha-like embryonic globin chain x
  JOURNAL   Gene 31 (1-3), 241-245 (1984)
   PUBMED   6084630
REFERENCE   10 (bases 1 to 630)
  AUTHORS   Leder,A., Swan,D., Ruddle,F., D'Eustachio,P. and Leder,P.
  TITLE     Dispersion of alpha-like globin genes of the mouse to three
            different chromosomes
  JOURNAL   Nature 293 (5829), 196-200 (1981)
   PUBMED   6168916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY111754.1 and BC051988.1.
            
            [WARNING] On Feb 3, 2025 this sequence was replaced by NM_010405.5.
            
            On Apr 16, 2009 this sequence version replaced NM_010405.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX567619.1, BQ748681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY111754.1         2-31
            31-630              BC051988.1         1-600
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.86 cM"
     gene            1..630
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /note="hemoglobin X, alpha-like embryonic chain in Hba
                     complex"
                     /db_xref="GeneID:15126"
                     /db_xref="MGI:MGI:96019"
     exon            1..159
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..493
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /note="hemaglobin zeta; zeta-globin; hemoglobin zeta
                     chain; alpha-like embryonic globin chain x"
                     /codon_start=1
                     /product="hemoglobin subunit zeta"
                     /protein_id="NP_034535.1"
                     /db_xref="CCDS:CCDS24522.1"
                     /db_xref="GeneID:15126"
                     /db_xref="MGI:MGI:96019"
                     /translation="MSLMKNERAIIMSMWEKMAAQAEPIGTETLERLFCSYPQTKTYF
                     PHFDLHHGSQQLRAHGFKIMTAVGDAVKSIDNLSSALTKLSELHAYILRVDPVNFKLL
                     SHCLLVTMAARFPADFTPEVHEAWDKFMSILSSILTEKYR"
     exon            160..364
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /inference="alignment:Splign:2.1.0"
     exon            365..601
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /note="hexamer: AATAAA"
     polyA_site      597
                     /gene="Hba-x"
                     /gene_synonym="Hbz"
                     /note="major polyA site"
ORIGIN      
        1 atcaggccag tcttgagtgc actcaactcc agcgcagcct ccaaccctca ccaccaccac
       61 caccatgtct ctgatgaaga atgagagagc tatcatcatg tccatgtggg agaagatggc
      121 tgctcaggcc gagcccattg gcactgagac tctagagagg ctcttctgca gctaccccca
      181 gacgaagacc tacttccccc acttcgacct gcaccatggg tctcagcagt tgcgggccca
      241 cggcttcaag atcatgaccg ccgtagggga tgcggttaag agcatcgaca acctctctag
      301 tgctttgact aagctgagcg agctgcatgc ctacatcctg cgtgtggatc cggtcaactt
      361 caagctcctg tcccactgtc tgctggtcac aatggccgca cgctttcccg ccgacttcac
      421 ccctgaggtc cacgaagcct gggacaagtt catgtctatc ctgtcttcta tcctgactga
      481 gaagtaccgc taagctccac cgccacgacc cccatgacca gctatgatcc ctctcctccc
      541 ctttattgaa ccctccctca ggtctttccc tgaatcccta ataaatggtt gaagaaggaa
      601 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
