LOCUS       NM_001083955             587 bp    mRNA    linear   ROD 09-APR-2020
DEFINITION  Mus musculus hemoglobin alpha, adult chain 2 (Hba-a2), mRNA.
ACCESSION   NM_001083955
VERSION     NM_001083955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 587)
  AUTHORS   Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M,
            Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B,
            Reina M, Soriano FX, Hastie ND, Martinez FO and Martinez-Estrada
            OM.
  TITLE     Epicardial cell shape and maturation are regulated by Wt1 via
            transcriptional control of Bmp4
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31624071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 587)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 587)
  AUTHORS   Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso
            WV, Ai X and Lu J.
  TITLE     Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA
            function is required for development of yolk sac endoderm
  JOURNAL   J. Biol. Chem. 287 (8), 5979-5987 (2012)
   PUBMED   22187428
REFERENCE   4  (bases 1 to 587)
  AUTHORS   Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M,
            Lopez-Jones M, Eussen B, de Klein A, Singer RH and de Laat W.
  TITLE     Variegated gene expression caused by cell-specific long-range DNA
            interactions
  JOURNAL   Nat. Cell Biol. 13 (8), 944-951 (2011)
   PUBMED   21706023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 587)
  AUTHORS   Elorza A, Hyde B, Mikkola HK, Collins S and Shirihai OS.
  TITLE     UCP2 modulates cell proliferation through the MAPK/ERK pathway
            during erythropoiesis and has no effect on heme biosynthesis
  JOURNAL   J. Biol. Chem. 283 (45), 30461-30470 (2008)
   PUBMED   18687678
REFERENCE   6  (bases 1 to 587)
  AUTHORS   Wilkinson DG, Bailes JA, Champion JE and McMahon AP.
  TITLE     A molecular analysis of mouse development from 8 to 10 days post
            coitum detects changes only in embryonic globin expression
  JOURNAL   Development 99 (4), 493-500 (1987)
   PUBMED   2444404
REFERENCE   7  (bases 1 to 587)
  AUTHORS   Erhart,M.A., Piller,K. and Weaver,S.
  TITLE     Polymorphism and gene conversion in mouse alpha-globin haplotypes
  JOURNAL   Genetics 115 (3), 511-519 (1987)
   PUBMED   3032738
REFERENCE   8  (bases 1 to 587)
  AUTHORS   Popp,R.A., Lalley,P.A., Whitney,J.B. 3rd and Anderson,W.F.
  TITLE     Mouse alpha-globin genes and alpha-globin-like pseudogenes are not
            syntenic
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78 (10), 6362-6366 (1981)
   PUBMED   6947235
REFERENCE   9  (bases 1 to 587)
  AUTHORS   Curtis,P.J., Mantei,N. and Weissmann,C.
  TITLE     Characterization and kinetics of synthesis of 15S beta-globin RNA,
            a putative precursor of beta-globin mRNA
  JOURNAL   Cold Spring Harb. Symp. Quant. Biol. 42 Pt 2, 971-984 (1978)
   PUBMED   277329
REFERENCE   10 (bases 1 to 587)
  AUTHORS   Russell,E.S. and McFarland,E.C.
  TITLE     Genetics of mouse hemoglobins
  JOURNAL   Ann. N. Y. Acad. Sci. 241 (0), 25-38 (1974)
   PUBMED   4611305
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005434.1 and CF740193.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF740193.1, BU525656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               AK005434.1         2-552
            552-587             CF740193.1         539-574
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.87 cM"
     gene            1..587
                     /gene="Hba-a2"
                     /note="hemoglobin alpha, adult chain 2"
                     /db_xref="GeneID:110257"
                     /db_xref="MGI:MGI:96016"
     exon            1..127
                     /gene="Hba-a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..461
                     /gene="Hba-a2"
                     /note="alpha 2 globin"
                     /codon_start=1
                     /product="hemoglobin alpha, adult chain 2"
                     /protein_id="NP_001077424.1"
                     /db_xref="CCDS:CCDS48766.1"
                     /db_xref="GeneID:110257"
                     /db_xref="MGI:MGI:96016"
                     /translation="MVLSGEDKSNIKAAWGKIGGHGAEYGAEALERMFASFPTTKTYF
                     PHFDVSHGSAQVKGHGKKVADALANAAGHLDDLPGALSALSDLHAHKLRVDPVNFKLL
                     SHCLLVTLASHHPADFTPAVHASLDKFLASVSTVLTSKYR"
     exon            128..332
                     /gene="Hba-a2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..563
                     /gene="Hba-a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      535..540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hba-a2"
                     /note="putative"
     polyA_site      551
                     /gene="Hba-a2"
                     /note="putative"
ORIGIN      
        1 acttctgatt ctgacagact caggaagaaa ccatggtgct ctctggggaa gacaaaagca
       61 acatcaaggc tgcctggggg aagattggtg gccatggtgc tgaatatgga gctgaagccc
      121 tggaaaggat gtttgctagc ttccccacca ccaagaccta cttccctcac tttgatgtaa
      181 gccacggctc tgcccaggtc aagggtcacg gcaagaaggt cgccgatgct ctggccaatg
      241 ctgcaggcca cctcgatgac ctgcccggtg ccctgtctgc tctgagcgac ctgcatgccc
      301 acaagctgcg tgtggatccc gtcaacttca agctcctgag ccactgcctg ctggtgacct
      361 tggctagcca ccaccctgcc gatttcaccc ccgcggtgca tgcctctctg gataaattcc
      421 ttgcctctgt gagcaccgtg ctgacctcca agtaccgtta agctgccttc tgcggggctt
      481 gccttctggc catgcccttc ttctctccct tgcacctgta cctcttggtc tttgaataaa
      541 gcctgagtag gaagaagcct gcaaaaaaaa aaaaaaaaaa aaaaaaa
//
