LOCUS       NM_008218                569 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus hemoglobin alpha, adult chain 1 (Hba-a1), mRNA.
ACCESSION   NM_008218
VERSION     NM_008218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 569)
  AUTHORS   Reed,E.C., Silva,V.A., Giebel,K.R., Natour,T., Lauten,T.H.,
            Jojo,C.N., Schlieker,A.E. and Case,A.J.
  TITLE     Hemoglobin alpha is a redox-sensitive mitochondrial-related protein
            in T-lymphocytes
  JOURNAL   Free Radic Biol Med 227, 1-11 (2025)
   PUBMED   39586383
REFERENCE   2  (bases 1 to 569)
  AUTHORS   Sveeggen,T.M., Isakson,B.E., Straub,A.C. and Bagher,P.
  TITLE     Bedding as a variable affecting fasting blood glucose and vascular
            physiology in mice
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (2), H338-H345 (2023)
   PUBMED   37389954
REFERENCE   3  (bases 1 to 569)
  AUTHORS   Keller,T.C.S. 4th, Lechauve,C., Keller,A.S., Broseghini-Filho,G.B.,
            Butcher,J.T., Askew Page,H.R., Islam,A., Tan,Z.Y., DeLalio,L.J.,
            Brooks,S., Sharma,P., Hong,K., Xu,W., Padilha,A.S., Ruddiman,C.A.,
            Best,A.K., Macal,E., Kim-Shapiro,D.B., Christ,G., Yan,Z.,
            Cortese-Krott,M.M., Ricart,K., Patel,R., Bender,T.P.,
            Sonkusare,S.K., Weiss,M.J., Ackerman,H., Columbus,L. and
            Isakson,B.E.
  TITLE     Endothelial alpha globin is a nitrite reductase
  JOURNAL   Nat Commun 13 (1), 6405 (2022)
   PUBMED   36302779
  REMARK    GeneRIF: Endothelial alpha globin is a nitrite reductase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 569)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 569)
  AUTHORS   Sundaresan,S.S., Ramesh,P., Shobana,N., Vinuchakkaravarthy,T.,
            Yasien,S. and Ponnuswamy,M.N.G.
  TITLE     Crystal structure of hemoglobin from mouse (Mus musculus) compared
            with those from other small animals and humans
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 4), 113-120 (2021)
   PUBMED   33830076
REFERENCE   6  (bases 1 to 569)
  AUTHORS   Wilkinson,D.G., Bailes,J.A., Champion,J.E. and McMahon,A.P.
  TITLE     A molecular analysis of mouse development from 8 to 10 days post
            coitum detects changes only in embryonic globin expression
  JOURNAL   Development 99 (4), 493-500 (1987)
   PUBMED   2444404
REFERENCE   7  (bases 1 to 569)
  AUTHORS   Erhart,M.A., Piller,K. and Weaver,S.
  TITLE     Polymorphism and gene conversion in mouse alpha-globin haplotypes
  JOURNAL   Genetics 115 (3), 511-519 (1987)
   PUBMED   3032738
REFERENCE   8  (bases 1 to 569)
  AUTHORS   Nishioka,Y. and Leder,P.
  TITLE     The complete sequence of a chromosomal mouse alpha--globin gene
            reveals elements conserved throughout vertebrate evolution
  JOURNAL   Cell 18 (3), 875-882 (1979)
   PUBMED   519760
REFERENCE   9  (bases 1 to 569)
  AUTHORS   Leder,A., Miller,H.I., Hamer,D.H., Seidman,J.G., Norman,B.,
            Sullivan,M. and Leder,P.
  TITLE     Comparison of cloned mouse alpha- and beta-globin genes:
            conservation of intervening sequence locations and extragenic
            homology
  JOURNAL   Proc Natl Acad Sci U S A 75 (12), 6187-6191 (1978)
   PUBMED   282635
REFERENCE   10 (bases 1 to 569)
  AUTHORS   Curtis,P.J., Mantei,N. and Weissmann,C.
  TITLE     Characterization and kinetics of synthesis of 15S beta-globin RNA,
            a putative precursor of beta-globin mRNA
  JOURNAL   Cold Spring Harb Symp Quant Biol 42 Pt 2, 971-984 (1978)
   PUBMED   277329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011055.1 and BC043020.1.
            
            On Apr 17, 2007 this sequence version replaced NM_008218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY710426.1, CA460448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AK011055.1         2-558
            558-569             BC043020.1         538-549
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.86 cM"
     gene            1..569
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /note="hemoglobin alpha, adult chain 1"
                     /db_xref="GeneID:15122"
                     /db_xref="MGI:MGI:96015"
     exon            1..130
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..464
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /note="alpha globin 1; haemaglobin alpha 1; alpha-globin;
                     hemoglobin alpha chain; alpha 1 globin"
                     /codon_start=1
                     /product="hemoglobin subunit alpha"
                     /protein_id="NP_032244.2"
                     /db_xref="CCDS:CCDS24523.1"
                     /db_xref="GeneID:15122"
                     /db_xref="MGI:MGI:96015"
                     /translation="MVLSGEDKSNIKAAWGKIGGHGAEYGAEALERMFASFPTTKTYF
                     PHFDVSHGSAQVKGHGKKVADALANAAGHLDDLPGALSALSDLHAHKLRVDPVNFKLL
                     SHCLLVTLASHHPADFTPAVHASLDKFLASVSTVLTSKYR"
     exon            131..335
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..559
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      538..543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /note="putative"
     polyA_site      557
                     /gene="Hba-a1"
                     /gene_synonym="Hba; Hba1; Hbat1"
                     /note="putative"
ORIGIN      
        1 gacacttctg attctgacag actcaggaag aaaccatggt gctctctggg gaagacaaaa
       61 gcaacatcaa ggctgcctgg gggaagattg gtggccatgg tgctgaatat ggagctgaag
      121 ccctggaaag gatgtttgct agcttcccca ccaccaagac ctacttccct cactttgatg
      181 taagccacgg ctctgcccag gtcaagggtc acggcaagaa ggtcgccgat gctctggcca
      241 atgctgcagg ccacctcgat gacctgcccg gtgccctgtc tgctctgagc gacctgcatg
      301 cccacaagct gcgtgtggat cccgtcaact tcaagctcct gagccactgc ctgctggtga
      361 ccttggctag ccaccaccct gccgatttca cccccgcggt gcatgcctct ctggacaaat
      421 tccttgcctc tgtgagcacc gtgctgacct ccaagtaccg ttaagctgcc ttctgcgggg
      481 cttgccttct ggccatgccc ttcttctctc ccttgcacct gtacctcttg gtctttgaat
      541 aaagcctgag taggaagaaa aaaaaaaaa
//
