LOCUS       NM_001282032             923 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus HCLS1 associated X-1 (Hax1), transcript variant 2,
            mRNA.
ACCESSION   NM_001282032
VERSION     NM_001282032.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Dong,Q., Li,D., Zhao,H., Zhang,X., Liu,Y., Hu,Y., Yao,Y., Zhu,L.,
            Wang,G.F., Liu,H., Gao,T., Niu,X., Zheng,T., Song,C., Wang,D.,
            Bai,Y., Jin,J., Liu,Z., Jin,Y., Li,P., Cao,C. and Liu,X.
  TITLE     Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl
            kinase-involved ROS clearance
  JOURNAL   Cell Death Dis 13 (4), 298 (2022)
   PUBMED   35379774
  REMARK    GeneRIF: Anti-apoptotic HAX-1 suppresses cell apoptosis by
            promoting c-Abl kinase-involved ROS clearance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Sui,X., Yoshioka,H., Fukumoto,Y., Kanemaru,K. and Kinouchi,H.
  TITLE     Neuroprotective roles of HAX-1 in ischemic neuronal injury
  JOURNAL   Exp Neurol 339, 113642 (2021)
   PUBMED   33600816
  REMARK    GeneRIF: Neuroprotective roles of HAX-1 in ischemic neuronal
            injury.
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Zhang,Y., Varela,L., Szigeti-Buck,K., Williams,A., Stoiljkovic,M.,
            Sestan-Pesa,M., Henao-Mejia,J., D'Acunzo,P., Levy,E., Flavell,R.A.,
            Horvath,T.L. and Kaczmarek,L.K.
  TITLE     Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1
            to regulate trafficking of the cell survival protein Hax-1
  JOURNAL   Nat Commun 12 (1), 1731 (2021)
   PUBMED   33741962
  REMARK    GeneRIF: Cerebellar Kv3.3 potassium channels activate TANK-binding
            kinase 1 to regulate trafficking of the cell survival protein
            Hax-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Alogaili,F., Chinnarasu,S., Jaeschke,A., Kranias,E.G. and Hui,D.Y.
  TITLE     Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing
            mitochondrial activity and bile salt export
  JOURNAL   J Biol Chem 295 (14), 4631-4646 (2020)
   PUBMED   32079675
  REMARK    GeneRIF: Hepatic HAX-1 inactivation prevents metabolic diseases by
            enhancing mitochondrial activity and bile salt export.
REFERENCE   6  (bases 1 to 923)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   7  (bases 1 to 923)
  AUTHORS   Gallagher,A.R., Cedzich,A., Gretz,N., Somlo,S. and Witzgall,R.
  TITLE     The polycystic kidney disease protein PKD2 interacts with Hax-1, a
            protein associated with the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4017-4022 (2000)
   PUBMED   10760273
REFERENCE   8  (bases 1 to 923)
  AUTHORS   Suzuki,Y., Demoliere,C., Kitamura,D., Takeshita,H., Deuschle,U. and
            Watanabe,T.
  TITLE     HAX-1, a novel intracellular protein, localized on mitochondria,
            directly associates with HS1, a substrate of Src family tyrosine
            kinases
  JOURNAL   J Immunol 158 (6), 2736-2744 (1997)
   PUBMED   9058808
REFERENCE   9  (bases 1 to 923)
  AUTHORS   Segade,F., Claudio,E., Wrobel,K., Ramos,S. and Lazo,P.S.
  TITLE     Isolation of nine gene sequences induced by silica in murine
            macrophages
  JOURNAL   J Immunol 154 (5), 2384-2392 (1995)
   PUBMED   7868905
REFERENCE   10 (bases 1 to 923)
  AUTHORS   Mixter,P.F., Russell,J.Q., Durie,F.H. and Budd,R.C.
  TITLE     Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking
            beta 2-microglobulin
  JOURNAL   J Immunol 154 (5), 2063-2074 (1995)
   PUBMED   7868883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163616.3, BY253818.1, AF465243.1, AK135138.1 and BM900159.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_001282032.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site and exon in the coding region, but maintains the
            reading frame compared to variant 1. This results in a shorter
            protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135138.1, AF465243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC163616.3         106642-106652       c
            12-136              BY253818.1         1-125
            137-628             AF465243.1         1-492
            629-896             AK135138.1         591-858
            897-923             BM900159.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.19 cM"
     gene            1..923
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /note="HCLS1 associated X-1"
                     /db_xref="GeneID:23897"
                     /db_xref="MGI:MGI:1346319"
     exon            1..189
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..727
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /note="isoform 2 is encoded by transcript variant 2; HS1
                     binding protein; HCLS1-associated protein X-1;
                     HS1-associating protein X-1; HS1-associated protein X-1"
                     /codon_start=1
                     /product="HCLS1-associated protein X-1 isoform 2"
                     /protein_id="NP_001268961.1"
                     /db_xref="CCDS:CCDS79957.1"
                     /db_xref="GeneID:23897"
                     /db_xref="MGI:MGI:1346319"
                     /translation="MSVFDLFRGFFGFPGPRSHRDPFFGGMTRDDDDDDDDDDEAEED
                     RGAWGRESYAFDGSQPPEEFGFSFSPRGGMRFHGNFGFDDLLDDTWPVSPHSRAKEDK
                     DLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKPDGTVEERRTVVDSEGRRETTVTHQ
                     EAHDSSRSDPDSQRSSALDDPFSILDLLLGRWFRSR"
     exon            190..391
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
     exon            392..443
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
     exon            551..641
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
     exon            642..906
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111;
                     Silg111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgccgcac cgtagggttg ctttccggca gcgaacgctg agccctggct atatccgaca
       61 gggtagcgta agctggtcgt ggtctcgtgt tgcccatggg ctgcagagct tcaaagtttc
      121 tagtgcccct actggaatga gcgtctttga tcttttccga ggctttttcg gctttcctgg
      181 acctcggagc cacagagatc ctttttttgg agggatgact cgagatgatg acgacgatga
      241 tgatgatgat gacgaagcgg aggaagacag aggcgcgtgg ggtcgagaga gctatgcgtt
      301 tgatggttct cagcctccag aggaattcgg tttcagcttc agccccaggg gagggatgcg
      361 attccacggc aactttggct ttgatgatct attggatgat acatggcctg tgagtcccca
      421 ttctagagcc aaagaggaca aagatcttga ctcccaggtt tcccaggaag gtctgggtcc
      481 acttcttcaa ccccagccca aatcgtattt caaaagtatc tctgtgacca agatcactaa
      541 gccagatggg acagtggagg aacgccgcac tgtggtagac agtgagggcc ggagggagac
      601 cacagtgacc catcaagaag cccatgacag ttccagaagt gatccagact ctcagagatc
      661 ttcagctttg gatgatccct tttccattct ggatttgcta ctaggacgtt ggtttcggtc
      721 ccgatagcgt tcttaaacag aggccttcag gtccttccca ctcccttcct gttgcccatt
      781 gccaataagc ttagctctgt ctgtcatccc agggtcttaa atgtgtgaaa caattaattg
      841 agcttatgcc agtctgtcat tcatccaaat tgaccaataa agcctttatt tatgctaaag
      901 gtcttaaaaa aaaaaaaaaa aaa
//
