LOCUS       NM_134250               2725 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus hepatitis A virus cellular receptor 2 (Havcr2), mRNA.
ACCESSION   NM_134250
VERSION     NM_134250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Kim,K.S., Lee,C., Kim,H.S., Gu,S.J., Yoon,H.J., Won,S.B., Lee,H.,
            Lee,Y.S., Kim,S.S., Kane,L.P. and Park,E.J.
  TITLE     TIM-3 on myeloid cells promotes pulmonary inflammation through
            increased production of galectin-3
  JOURNAL   Commun Biol 7 (1), 1090 (2024)
   PUBMED   39237613
  REMARK    GeneRIF: TIM-3 on myeloid cells promotes pulmonary inflammation
            through increased production of galectin-3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Wang,F., Zhou,F., Peng,J., Chen,H., Xie,J., Liu,C., Xiong,H.,
            Chen,S., Xue,G., Zhou,X. and Xie,Y.
  TITLE     Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced
            colitis by suppressing neutrophil necroptosis
  JOURNAL   Redox Biol 70, 103072 (2024)
   PUBMED   38330550
  REMARK    GeneRIF: Macrophage Tim-3 maintains intestinal homeostasis in
            DSS-induced colitis by suppressing neutrophil necroptosis.
REFERENCE   3  (bases 1 to 2725)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2725)
  AUTHORS   Manandhar,P., Szymczak-Workman,A.L. and Kane,L.P.
  TITLE     Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to
            Lymphocytic Choriomeningitis Virus
  JOURNAL   J Immunol 212 (3), 466-474 (2024)
   PUBMED   38108417
  REMARK    GeneRIF: Tim-3 Is Not Required for Establishment of CD8+ T Cell
            Memory to Lymphocytic Choriomeningitis Virus.
REFERENCE   5  (bases 1 to 2725)
  AUTHORS   Shi,Y., Abidan,A., Li,D., Zibigu,R., Wang,M., Zheng,X., Kang,X.,
            Wang,H., Li,J. and Zhang,C.
  TITLE     [Effect of Echinococcus multilocularis infection on Tim3 expression
            in spleen natural killer cells of mice]
  JOURNAL   Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 35 (4), 366-373 (2023)
   PUBMED   37926471
  REMARK    GeneRIF: [Effect of Echinococcus multilocularis infection on Tim3
            expression in spleen natural killer cells of mice].
REFERENCE   6  (bases 1 to 2725)
  AUTHORS   Brenner,O., Levanon,D., Negreanu,V., Golubkov,O., Fainaru,O.,
            Woolf,E. and Groner,Y.
  TITLE     Loss of Runx3 function in leukocytes is associated with
            spontaneously developed colitis and gastric mucosal hyperplasia
  JOURNAL   Proc Natl Acad Sci U S A 101 (45), 16016-16021 (2004)
   PUBMED   15514019
REFERENCE   7  (bases 1 to 2725)
  AUTHORS   Sabatos,C.A., Chakravarti,S., Cha,E., Schubart,A.,
            Sanchez-Fueyo,A., Zheng,X.X., Coyle,A.J., Strom,T.B., Freeman,G.J.
            and Kuchroo,V.K.
  TITLE     Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1
            responses and induction of peripheral tolerance
  JOURNAL   Nat Immunol 4 (11), 1102-1110 (2003)
   PUBMED   14556006
REFERENCE   8  (bases 1 to 2725)
  AUTHORS   Sanchez-Fueyo,A., Tian,J., Picarella,D., Domenig,C., Zheng,X.X.,
            Sabatos,C.A., Manlongat,N., Bender,O., Kamradt,T., Kuchroo,V.K.,
            Gutierrez-Ramos,J.C., Coyle,A.J. and Strom,T.B.
  TITLE     Tim-3 inhibits T helper type 1-mediated auto- and alloimmune
            responses and promotes immunological tolerance
  JOURNAL   Nat Immunol 4 (11), 1093-1101 (2003)
   PUBMED   14556005
REFERENCE   9  (bases 1 to 2725)
  AUTHORS   Monney,L., Sabatos,C.A., Gaglia,J.L., Ryu,A., Waldner,H.,
            Chernova,T., Manning,S., Greenfield,E.A., Coyle,A.J., Sobel,R.A.,
            Freeman,G.J. and Kuchroo,V.K.
  TITLE     Th1-specific cell surface protein Tim-3 regulates macrophage
            activation and severity of an autoimmune disease
  JOURNAL   Nature 415 (6871), 536-541 (2002)
   PUBMED   11823861
REFERENCE   10 (bases 1 to 2725)
  AUTHORS   McIntire,J.J., Umetsu,S.E., Akbari,O., Potter,M., Kuchroo,V.K.,
            Barsh,G.S., Freeman,G.J., Umetsu,D.T. and DeKruyff,R.H.
  TITLE     Identification of Tapr (an airway hyperreactivity regulatory locus)
            and the linked Tim gene family
  JOURNAL   Nat Immunol 2 (12), 1109-1116 (2001)
   PUBMED   11725301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148474.1 and AL669948.8.
            
            On Nov 15, 2007 this sequence version replaced NM_134250.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF450241.1, AK148474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AK148474.1         2-151
            151-151             AL669948.8         32168-32168
            152-1898            AK148474.1         153-1899
            1899-2725           AL669948.8         56319-57145
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.9 cM"
     gene            1..2725
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /note="hepatitis A virus cellular receptor 2"
                     /db_xref="GeneID:171285"
                     /db_xref="MGI:MGI:2159682"
     exon            1..128
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..916
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /note="hepatitis A virus cellular receptor 2 homolog;
                     T-cell immunoglobulin mucin receptor 3; TIMD-3; HAVcr-2;
                     T-cell membrane protein 3; T-cell immunoglobulin and mucin
                     domain-containing protein 3; T-cell immunoglobulin and
                     mucin domain containing 3"
                     /codon_start=1
                     /product="hepatitis A virus cellular receptor 2 homolog
                     precursor"
                     /protein_id="NP_599011.2"
                     /db_xref="CCDS:CCDS36135.1"
                     /db_xref="GeneID:171285"
                     /db_xref="MGI:MGI:2159682"
                     /translation="MFSGLTLNCVLLLLQLLLARSLENAYVFEVGKNAYLPCSYTLST
                     PGALVPMCWGKGFCPWSQCTNELLRTDERNVTYQKSSRYQLKGDLNKGDVSLIIKNVT
                     LDDHGTYCCRIQFPGLMNDKKLELKLDIKAAKVTPAQTAHGDSTTASPRTLTTERNGS
                     ETQTLVTLHNNNGTKISTWADEIKDSGETIRTAIHIGVGVSAGLTLALIIGVLILKWY
                     SCKKKKLSSLSLITLANLPPGGLANAGAVRIRSEENIYTIEENVYEVENSNEYYCYVN
                     SQQPS"
     exon            129..467
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..551
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..592
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..719
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..756
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2725
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /note="hexamer: AATAAA"
     polyA_site      2725
                     /gene="Havcr2"
                     /gene_synonym="TIM-3; Tim3; Timd3"
                     /note="major polyA site"
ORIGIN      
        1 accattttaa ccgaggagct aaagctatcc ctacacagag ctgtccttgg atttcccctg
       61 ccaagtactc atgttttcag gtcttaccct caactgtgtc ctgctgctgc tgcaactact
      121 acttgcaagg tcattggaaa atgcttatgt gtttgaggtt ggtaagaatg cctatctgcc
      181 ctgcagttac actctatcta cacctggggc acttgtgcct atgtgctggg gcaagggatt
      241 ctgtccttgg tcacagtgta ccaacgagtt gctcagaact gatgaaagaa atgtgacata
      301 tcagaaatcc agcagatacc agctaaaggg cgatctcaac aaaggagacg tgtctctgat
      361 cataaagaat gtgactctgg atgaccatgg gacctactgc tgcaggatac agttccctgg
      421 tcttatgaat gataaaaaat tagaactgaa attagacatc aaagcagcca aggtcactcc
      481 agctcagact gcccatgggg actctactac agcttctcca agaaccctaa ccacggagag
      541 aaatggttca gagacacaga cactggtgac cctccataat aacaatggaa caaaaatttc
      601 cacatgggct gatgaaatta aggactctgg agaaacgatc agaactgcta tccacattgg
      661 agtgggagtc tctgctgggt tgaccctggc acttatcatt ggtgtcttaa tccttaaatg
      721 gtattcctgt aagaaaaaga agttatcgag tttgagcctt attacactgg ccaacttgcc
      781 tccaggaggg ttggcaaatg caggagcagt caggattcgc tctgaggaaa atatctacac
      841 catcgaggag aacgtatatg aagtggagaa ttcaaatgag tactactgct acgtcaacag
      901 ccagcagcca tcctgaccgc ctctggactg ccacttttaa aggctcgcct tcatttctga
      961 ctttggtatt tccctttttg aaaactatgt gatatgtcac ttggcaacct cattggaggt
     1021 tctgaccaca gccactgaga aaagagttcc agttttctgg ggataattaa ctcacaaggg
     1081 gattcgactg taactcatgc tacattgaaa tgctccattt tatccctgag tttcagggat
     1141 cggatctccc actccagaga cttcaatcat gcgtgttgaa gctcactcgt gctttcatac
     1201 attaggaatg gttagtgtga tgtctttgag acatagaggt ttgtggtata tctgcaaagc
     1261 tcctgaacag gtagggggaa taaagggcta agataggaag gtgaggttct ttgttgatgt
     1321 tgaaaatcta aagaagttgg tagcttttct agagatttct gaccttgaaa gattaagaaa
     1381 aagccaggtg gcatatgctt aacactatat aacttgggaa ccttaggcag gagggtgata
     1441 agttcaaggt cagccagggc tatgctggta agactgtctc aaaatccaaa gacgaaaata
     1501 aacatagaga cagcaggagg ctggagatga ggctcggaca gtgaggtgca ttttgtacaa
     1561 gcacgaggaa tctatatttg atcgtagacc ccacatgaaa aagctaggcc tggtagagca
     1621 tgcttgtaga ctcaagagat ggagaggtaa aggcacaaca gatccccggg gcttgcgtgc
     1681 agtcagctta gcctaggtgc tgagttccaa gtccacaaga gtccctgtct caaagtaaga
     1741 tggactgagt atctggcgaa tgtccatggg ggttgtcctc tgctctcaga agagacatgc
     1801 acatgaacct gcacacacac acacacacac acacacacac acacacacac acacacacac
     1861 acacacatga aatgaaggtt ctctctgtgc ctgctacctc tctataacat gtatctctac
     1921 aggactctcc tctgcctctg ttaagacatg agtgggagca tggcagagca gtccagtaat
     1981 taattccagc actcagaagg ctggagcaga agcgtggaga gttcaggagc actgtgccca
     2041 acactgccag actcttctta cagaagaaaa aggttacccg caagcagcct gctgtctgta
     2101 aaaggaaacc ctgcgaaagg caaactttga ctgttgtgtg ctcaagggga actgactcag
     2161 acaacttctc cattcctgga ggaaactgga gctgtttctg acagaagaac aaccggtgac
     2221 tgggacatac gaaggcagag ctcttgcagc aatctatata gtcagcaaaa tattctttgg
     2281 gaggacagtc gtcaccaaat tgatttccaa gccggtggac ctcagtttca tctggcttac
     2341 agctgcctgc ccagtgccct tgatctgtgc tggctcccat ctataacaga atcaaattaa
     2401 atagaccccg agtgaaaata ttaagtgagc agaaaggtag ctttgttcaa agattttttt
     2461 gcattgggga gcaactgtgt acatcagagg acatctgtta gtgaggacac caaaacctgt
     2521 ggtaccgttt tttcatgtat gaattttgtt gtttaggttg cttctagcta gctgtggagg
     2581 tcctggcttt cttaggtggg tatggaaggg agaccatcta acaaaatcca ttagagataa
     2641 cagctctcat gcagaaggga aaactaatct caaatgtttt aaagtaataa aactgtactg
     2701 gcaaagtact ttgagcatat ttaaa
//
