LOCUS       NM_026115               1576 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus histone aminotransferase 1 (Hat1), mRNA.
ACCESSION   NM_026115
VERSION     NM_026115.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Guo,B., Zhang,S., Wang,S., Zhang,H., Fang,J., Kang,N., Zhen,X.,
            Zhang,Y., Zhou,J., Yan,G., Sun,H., Ding,L. and Liu,C.
  TITLE     Decreased HAT1 expression in granulosa cells disturbs oocyte
            meiosis during mouse ovarian aging
  JOURNAL   Reprod Biol Endocrinol 21 (1), 103 (2023)
   PUBMED   37907924
  REMARK    GeneRIF: Decreased HAT1 expression in granulosa cells disturbs
            oocyte meiosis during mouse ovarian aging.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Qi,Y., Yao,R., Zhang,W. and Cui,Q.
  TITLE     KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate
            the progression of diabetic retinopathy
  JOURNAL   Pharmacol Res 170, 105713 (2021)
   PUBMED   34098071
  REMARK    GeneRIF: KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to
            alleviate the progression of diabetic retinopathy.
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Agudelo Garcia,P.A., Lovejoy,C.M., Nagarajan,P., Park,D.,
            Popova,L.V., Freitas,M.A. and Parthun,M.R.
  TITLE     Histone acetyltransferase 1 is required for DNA replication fork
            function and stability
  JOURNAL   J Biol Chem 295 (25), 8363-8373 (2020)
   PUBMED   32366460
  REMARK    GeneRIF: Histone acetyltransferase 1 is required for DNA
            replication fork function and stability.
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Yang,G., Feng,J., Liu,Y., Zhao,M., Yuan,Y., Yuan,H., Yun,H.,
            Sun,M., Bu,Y., Liu,L., Liu,Z., Niu,J.Q., Yin,M., Song,X., Miao,Z.,
            Lin,Z. and Zhang,X.
  TITLE     HAT1 signaling confers to assembly and epigenetic regulation of HBV
            cccDNA minichromosome
  JOURNAL   Theranostics 9 (24), 7345-7358 (2019)
   PUBMED   31695772
  REMARK    GeneRIF: HAT1 signaling confers to assembly and epigenetic
            regulation of HBV cccDNA minichromosome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   Zhao,X.M., Ren,J.J., Du,W.H., Hao,H.S., Wang,D., Qin,T., Liu,Y. and
            Zhu,H.B.
  TITLE     Effect of vitrification on promoter CpG island methylation patterns
            and expression levels of DNA methyltransferase 1o, histone
            acetyltransferase 1, and deacetylase 1 in metaphase II mouse
            oocytes
  JOURNAL   Fertil Steril 100 (1), 256-261 (2013)
   PUBMED   23548937
  REMARK    GeneRIF: Expression levels of Hat1 promoter mRNA are not
            significantly different in vitrified oocyte promoter compared with
            fresh oocytes.
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Nagarajan,P., Ge,Z., Sirbu,B., Doughty,C., Agudelo Garcia,P.A.,
            Schlederer,M., Annunziato,A.T., Cortez,D., Kenner,L. and
            Parthun,M.R.
  TITLE     Histone acetyl transferase 1 is essential for mammalian
            development, genome stability, and the processing of newly
            synthesized histones H3 and H4
  JOURNAL   PLoS Genet 9 (6), e1003518 (2013)
   PUBMED   23754951
  REMARK    GeneRIF: Hat1 is not only responsible for the acetylation of newly
            synthesized histone H4 but is also required to maintain the
            acetylation of histone H3 on lysines 9, 18, and 27 during
            replication-coupled chromatin assembly.
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   9  (bases 1 to 1576)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1576)
  AUTHORS   Bulfield,G.
  TITLE     Genetic variation in the activity of the histidine catabolic
            enzymes between inbred strains of mice: a structural locus for a
            cytosol histidine aminotransferase isozyme (Hat-1)
  JOURNAL   Biochem Genet 16 (11-12), 1233-1241 (1978)
   PUBMED   751649
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK041700.1.
            
            On Oct 24, 2008 this sequence version replaced NM_026115.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041700.1, AK010715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1576              AK041700.1         5-1580
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.38 cM"
     gene            1..1576
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /note="histone aminotransferase 1"
                     /db_xref="GeneID:107435"
                     /db_xref="MGI:MGI:96013"
     exon            1..45
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1289
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /EC_number="2.3.1.48"
                     /note="histidine aminotransferase 1; histone
                     acetyltransferase 1"
                     /codon_start=1
                     /product="histone acetyltransferase type B catalytic
                     subunit"
                     /protein_id="NP_080391.2"
                     /db_xref="CCDS:CCDS16114.1"
                     /db_xref="GeneID:107435"
                     /db_xref="MGI:MGI:96013"
                     /translation="MAALEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLEND
                     IRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTLFRVEYSSKVDENFDCVEAD
                     DVEGKIRQIIPPGFCTNTNDFLSLLEKETNFKPFGTLLHTYTVPSQTGGETFTFQIHK
                     ADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGY
                     MTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYISFPTVLDITAEDPS
                     RSYLKLRDFVLVKFCQFLPSFSRERLLQGFSEDMAIQAQQMFKINKQHARRVYEILRL
                     LVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMKKCLRPEELTNQMNQIEISVQH
                     EQLEERFQELVEDYRRVIERLAQE"
     exon            46..141
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..217
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..338
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..518
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..640
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..745
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..852
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1004
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1121
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1576
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /note="hexamer: AATAAA"
     polyA_site      1469
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /note="major polyA site"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
                     /note="hexamer: AATAAA"
     polyA_site      1524
                     /gene="Hat1"
                     /gene_synonym="2410071B14Rik; Hat-1; KAT1"
ORIGIN      
        1 tttgtccttc ctcagctgcg ggcgctcgga gctcggaaat ggcggccttg gagaaatttc
       61 tggtggagta taagagtgcc gtggagaaga aactagcaga gtacaagtgt aacaccaaca
      121 cagcaatcga gctgaaacta gttcgttttc ctgaagatct tgagaatgac attagaactt
      181 tctttcctga atatacccat cagctctttg gggatgatga aactgctttc ggttacaagg
      241 gcctgaagat cttgctgtac tatattgctg gtagcctgtc aacactgttc cgtgttgaat
      301 attcatctaa agttgatgag aactttgatt gtgtggaggc agatgatgtt gaaggcaaaa
      361 tcagacaaat cattccacct gggttttgca caaacacaaa tgattttctt tccttgctgg
      421 aaaaggaaac taatttcaag ccttttggaa ccctcctcca tacatacaca gttcctagtc
      481 agacaggagg tgaaaccttt actttccaga tccacaaggc tgacatgaca tgtagaggct
      541 ttcgagaata tcatgaaagg cttcagacct ttttgatgtg gtttattgaa actgctagct
      601 ttattgacgt ggatgatgaa agatggcact actttctagt atttgagaag tataataagg
      661 atggagctac gctctttgcg accgtaggct acatgacagt ctataattac tatgtgtacc
      721 cagacaaaac ccggccacgt gtaagtcaga tgctgatact gactccattt caaggtcagg
      781 gccacggtgc tcaacttctt gaaacagttc atagatacta catttcattt cctacagttc
      841 ttgatattac agcggaagat ccgtccagaa gctatttgaa actaagagac tttgtgcttg
      901 tgaagttttg tcaatttttg cccagtttct cccgggaaag attactgcaa ggattcagtg
      961 aagatatggc aatacaggca cagcaaatgt tcaaaataaa taagcaacat gctagaaggg
     1021 tttatgaaat tcttcgactg ctggtgactg acatgagcga tgctgagcaa tacagaagct
     1081 acagactgga tattaaaaga agactaatta gcccttacaa gaaaaagcag agggatcttg
     1141 ccaagatgaa gaaatgcctg agaccagaag agctgacaaa tcagatgaac cagatagaaa
     1201 taagtgtgca gcatgagcag ctggaagaga gatttcagga gctggtggag gactaccggc
     1261 gtgtcattga gcgacttgct caagagtgaa gcccttgttc cccagaatac ctgcagattt
     1321 ctgtgcatcg tgctgtgaac ctctgatgac cctaaagtta tctatgttct ccttagtgga
     1381 atatttcctt ttgagagatt gtatatttta aaatactgtc tagagtttat gaacatatat
     1441 tgcattaata aaagatggct tgtgaaatac caccgcccac tgctttcttc ttaaacagta
     1501 aaataaatga ttggttgtag tatattaagt tataatgtgg tgcttaaggc tttaggataa
     1561 atattttgag ttacac
//
