LOCUS       NM_010353               2818 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus histone H3 associated protein kinase (Haspin), mRNA.
ACCESSION   NM_010353
VERSION     NM_010353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Li,Y., Wu,M., Liu,Y., Sun,L., Mu,P., Ma,B. and Xie,J.
  TITLE     Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in
            mouse embryonic stem cells
  JOURNAL   Protein Sci 33 (8), e5126 (2024)
   PUBMED   39073155
  REMARK    GeneRIF: Haspin mediates H3.3S31 phosphorylation downstream of
            Aurora B in mouse embryonic stem cells.
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   Berenguer,I., Lopez-Jimenez,P., Mena,I., Viera,A., Page,J.,
            Gonzalez-Martinez,J., Maestre,C., Malumbres,M., Suja,J.A. and
            Gomez,R.
  TITLE     Haspin participates in AURKB recruitment to centromeres and
            contributes to chromosome congression in male mouse meiosis
  JOURNAL   J Cell Sci 135 (13) (2022)
   PUBMED   35694956
  REMARK    GeneRIF: Haspin participates in AURKB recruitment to centromeres
            and contributes to chromosome congression in male mouse meiosis.
REFERENCE   3  (bases 1 to 2818)
  AUTHORS   Soupsana,K., Karanika,E., Kiosse,F., Christogianni,A., Sfikas,Y.,
            Topalis,P., Batistatou,A., Kanaki,Z., Klinakis,A., Politou,A.S. and
            Georgatos,S.
  TITLE     Distinct roles of haspin in stem cell division and male
            gametogenesis
  JOURNAL   Sci Rep 11 (1), 19901 (2021)
   PUBMED   34615946
  REMARK    GeneRIF: Distinct roles of haspin in stem cell division and male
            gametogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2818)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   5  (bases 1 to 2818)
  AUTHORS   Balboula,A.Z., Nguyen,A.L., Gentilello,A.S., Quartuccio,S.M.,
            Drutovic,D., Solc,P. and Schindler,K.
  TITLE     Haspin kinase regulates microtubule-organizing center clustering
            and stability through Aurora kinase C in mouse oocytes
  JOURNAL   J Cell Sci 129 (19), 3648-3660 (2016)
   PUBMED   27562071
  REMARK    GeneRIF: These data uncover a role for haspin as a regulator of
            bipolar spindle assembly by regulating AURKC function at
            acentriolar microtubule-organizing centers in oocytes.
REFERENCE   6  (bases 1 to 2818)
  AUTHORS   Szucsik,J.C., Witte,D.P., Li,H., Pixley,S.K., Small,K.M. and
            Potter,S.S.
  TITLE     Altered forebrain and hindbrain development in mice mutant for the
            Gsh-2 homeobox gene
  JOURNAL   Dev Biol 191 (2), 230-242 (1997)
   PUBMED   9398437
REFERENCE   7  (bases 1 to 2818)
  AUTHORS   Matsui,M., Ichihara,H., Kobayashi,S., Tanaka,H., Tsuchida,J.,
            Nozaki,M., Yoshimura,Y., Nojima,H., Rochelle,J.M., Nishimune,Y.,
            Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of six germ-cell-specific genes to mouse chromosomes
  JOURNAL   Mamm Genome 8 (11), 873-874 (1997)
   PUBMED   9337410
REFERENCE   8  (bases 1 to 2818)
  AUTHORS   Hsieh-Li,H.M., Witte,D.P., Szucsik,J.C., Weinstein,M., Li,H. and
            Potter,S.S.
  TITLE     Gsh-2, a murine homeobox gene expressed in the developing brain
  JOURNAL   Mech Dev 50 (2-3), 177-186 (1995)
   PUBMED   7619729
REFERENCE   9  (bases 1 to 2818)
  AUTHORS   Tanaka,H., Yoshimura,Y., Nishina,Y., Nozaki,M., Nojima,H. and
            Nishimune,Y.
  TITLE     Isolation and characterization of cDNA clones specifically
            expressed in testicular germ cells
  JOURNAL   FEBS Lett 355 (1), 4-10 (1994)
   PUBMED   7957958
REFERENCE   10 (bases 1 to 2818)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D87326.1, AV143145.2 and AI450094.1.
            
            On Jul 10, 2009 this sequence version replaced NM_010353.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: D87326.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2595              D87326.1           1-2595
            2596-2808           AV143145.2         348-560
            2809-2818           AI450094.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.25 cM"
     gene            1..2818
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /note="histone H3 associated protein kinase"
                     /db_xref="GeneID:14841"
                     /db_xref="MGI:MGI:1194498"
     exon            1..2811
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /note="major polyA site"
ORIGIN      
        1 gtttctgttt gaaacgccgg gcgggcgctc gctatggcac aggctcaccc gcggtcgggt
       61 acccggctct ttcgaacgta cgcggcgagg ggcgtccggg ggtcgcagcg gcagcctggc
      121 gggctggctg agcaatggtt ccagccgccg aacctgaagc gcgccttcag cagcagcctc
      181 agcgacagta acgagtcgcc ggctgtcgct tccgacgacc cggacgaccc cgacttcccc
      241 ggcagcctcg tgggccagcg gcggaggcgt cctcggggca gcggctcccg gaaccagcgg
      301 accctgacaa acactccaag agtccaaagg ctgcgacctc ggctcccgca gaagtgcagc
      361 accccgtgca gccggctgcg accgccacct ttccccaact gcagcccggg ctgcctcggg
      421 tcggaccaca gtgtgtgcat ccagtccagg gacagcaacg agctgggcac cagtgcctcc
      481 ctcttcagct ctccggcctc gcccggagcc cccgaccctt tgtatgctga ctctgcagtc
      541 cccgggagct tccacttgcc ggcagcctcc ctaagtgaac cgtctgtgcc ctgcccccag
      601 gtggcagcaa ccggtgacag gtacaccggg agggccctcc gagccgaagc cagcttcagg
      661 tcatctctct ttagccttgt gaactcaggg gccacagaag agaacaagtt tgggacagat
      721 ggggagaatg tgaaggaatc gtgttgtgaa agaagacagc agatgggaaa cagactaacg
      781 gaccctgatc tgacaagccc gggaaagaga aaggccgcgt gtaaaaaggt tgtgtcccaa
      841 ggagtcgacc agagagacta tgaggagtcc agtgcttgca aagaccttcg tgtaccaggg
      901 gaaatcagca ggcctaagag aactgggcca ctccggaaga ggaaacagca agaagcaacg
      961 ggaacccctc cccgccacta ccaccaatct aagaagaaaa ggaaagcgtc agtctcctta
     1021 tggaacttga atactagcca gagggattct tggaccaaaa ccagagcctc cttcggtttc
     1081 cacaagaaga aaattataac cagtgtgata gaggtatgca gttctgttgc cagttcttcc
     1141 tccaggtccc tcctgtctga atgttcgacc cctcctatca agaacagagc acaccttact
     1201 gtttcttctc gatgctcttc tgtgtatttg ctaagtccct taaagaccct gcatgtcaca
     1261 gaccaaaggc catcttatgc tgaaaaggtt tatggggagt gtaatcagga agggcccatc
     1321 ccctttagtg attgcctttc cacggaaaaa ctggaacggt gtgagaagat tggggaagga
     1381 gtgtttggag aagtgtttca gataattaac gaccaagcac ctgtagccct aaaaatcatt
     1441 gctattgaag ggttagattt agtcaatggg tcccaccaga aaacctttga ggaaatcctg
     1501 ccggagatca ttatctccaa agagctgagt ctcttgtcta gtgaggccta caaccgcaca
     1561 gaaggcttta ttgggctgaa ctcagtacac tgtgttcaag ggctttaccc tcccttgctg
     1621 ctgaaagcct gggatcacta taacacaacc aaaagatctg ccaatgaccg gcctgacttt
     1681 ttccaggaag accagctctt tattatcctg gaatttgagt ttggtggggt tgacttggag
     1741 cgaatgaaaa ccaagctgtc ctctgtggcg actgcaaaga gcattctcca ccagatcact
     1801 gcatctctgg ctgtggcaga agcatccctg cactttgagc accgggactt acactgggga
     1861 aatgtgctct taaagaaaac caacctcaaa gaactccgct acaccctcaa tgggaaaacg
     1921 agcaccattc ccacccatgg gctacaggtc aacatcattg actacaccct gtcccgcttg
     1981 gagcgggatg ggattgtggt tttctgtgat atctccgctg aagaggacct atttacaggt
     2041 gagggtgact accagtttga gatctacagg ctcatgagga aggagaacaa aaactgctgg
     2101 ggtgagtatc acccttacaa taatgtgctg tggctgcatt acctcacaga caagattctg
     2161 aataagatga aatttaagac taaatgccag agcgcagcca tgaagcaaat aaggaaaaac
     2221 ctgcaacatt tccacaggac tgtactgagt ttcagctctg ccacggacct gctctgccaa
     2281 cacagtctat ttaggtaagc caggaactta gactttcaga gcctctttaa gtacactttt
     2341 aggcctctgg tactaatctc tgccactaga gccagatgga ggtgaaagca catccttaag
     2401 agttcctgtc agcttcttaa aagagaactg tgtttttcaa aaggtaacca aaacatttgt
     2461 tgacatgatt aaacttgctt ttaacaaatg ttcctctttt ttaaaaaaaa aaataaacta
     2521 gacagaggac aagtggacac atctttaagt cctcgtcctg tcagcagagt ctacaagtct
     2581 gatgttgctg gtttttgagc cttgatactt ggtgtaggat gagcaaaacc aagcctcagc
     2641 tgtggtcctt actgctcttg atgctgttgt caagatgcag agcagagagc aagagactag
     2701 agagtcaaaa ccaagagaaa gtatggaaaa tgtttatccg gttcactccc caatcacagg
     2761 agcagaattt atagaatttc aacaggaaaa taaatgtctc tgtggctctc aaaaaaaa
//
