LOCUS       NM_008216               4262 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus hyaluronan synthase 2 (Has2), mRNA.
ACCESSION   NM_008216
VERSION     NM_008216.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Halimani,N., Nesterchuk,M., Tsitrina,A.A., Sabirov,M.,
            Andreichenko,I.N., Dashenkova,N.O., Petrova,E., Kulikov,A.M.,
            Zatsepin,T.S., Romanov,R.A., Mikaelyan,A.S. and Kotelevtsev,Y.V.
  TITLE     Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in
            mice via induction of transcriptomic changes similar to 4MU
            treatment
  JOURNAL   Sci Rep 14 (1), 2797 (2024)
   PUBMED   38307876
  REMARK    GeneRIF: Knockdown of Hyaluronan synthase 2 suppresses liver
            fibrosis in mice via induction of transcriptomic changes similar to
            4MU treatment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Eley,L., Richardson,R.V., Alqahtani,A., Chaudhry,B. and
            Henderson,D.J.
  TITLE     eNOS plays essential roles in the developing heart and aorta linked
            to disruption of Notch signalling
  JOURNAL   Dis Model Mech 17 (1) (2024)
   PUBMED   38111957
REFERENCE   6  (bases 1 to 4262)
  AUTHORS   Weigel,P.H., Hascall,V.C. and Tammi,M.
  TITLE     Hyaluronan synthases
  JOURNAL   J Biol Chem 272 (22), 13997-14000 (1997)
   PUBMED   9206724
  REMARK    Review article
REFERENCE   7  (bases 1 to 4262)
  AUTHORS   Spicer,A.P., Seldin,M.F., Olsen,A.S., Brown,N., Wells,D.E.,
            Doggett,N.A., Itano,N., Kimata,K., Inazawa,J. and McDonald,J.A.
  TITLE     Chromosomal localization of the human and mouse hyaluronan synthase
            genes
  JOURNAL   Genomics 41 (3), 493-497 (1997)
   PUBMED   9169154
REFERENCE   8  (bases 1 to 4262)
  AUTHORS   Fulop,C., Salustri,A. and Hascall,V.C.
  TITLE     Coding sequence of a hyaluronan synthase homologue expressed during
            expansion of the mouse cumulus-oocyte complex
  JOURNAL   Arch Biochem Biophys 337 (2), 261-266 (1997)
   PUBMED   9016821
REFERENCE   9  (bases 1 to 4262)
  AUTHORS   Spicer,A.P., Augustine,M.L. and McDonald,J.A.
  TITLE     Molecular cloning and characterization of a putative mouse
            hyaluronan synthase
  JOURNAL   J Biol Chem 271 (38), 23400-23406 (1996)
   PUBMED   8798545
REFERENCE   10 (bases 1 to 4262)
  AUTHORS   Semino,C.E., Specht,C.A., Raimondi,A. and Robbins,P.W.
  TITLE     Homologs of the Xenopus developmental gene DG42 are present in
            zebrafish and mouse and are involved in the synthesis of Nod-like
            chitin oligosaccharides during early embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4548-4553 (1996)
   PUBMED   8643441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY110777.1 and BC080281.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008216.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080281.1, U52524.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY110777.1         1-45
            46-4262             BC080281.1         1-4217
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 23.31 cM"
     gene            1..4262
                     /gene="Has2"
                     /note="hyaluronan synthase 2"
                     /db_xref="GeneID:15117"
                     /db_xref="MGI:MGI:107821"
     exon            1..553
                     /gene="Has2"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..2212
                     /gene="Has2"
                     /EC_number="2.4.1.212"
                     /note="HA synthase 2; hyaluronate synthase 2; hyaluronic
                     acid synthase 2; hyaluronan synthase homolog"
                     /codon_start=1
                     /product="hyaluronan synthase 2"
                     /protein_id="NP_032242.3"
                     /db_xref="CCDS:CCDS27480.1"
                     /db_xref="GeneID:15117"
                     /db_xref="MGI:MGI:107821"
                     /translation="MHCERFLCVLRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYF
                     SFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKC
                     LQSVKRLTYPGIKVVMVIDGNSDDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGET
                     EESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLD
                     PASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGC
                     VQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARS
                     KCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAVITGFFPFFLIA
                     TVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPA
                     KMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKKPFSESK
                     QTVLIVGTLIYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV"
     exon            554..1180
                     /gene="Has2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1282
                     /gene="Has2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..4244
                     /gene="Has2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Has2"
                     /note="hexamer: AATAAA"
     polyA_site      2983
                     /gene="Has2"
ORIGIN      
        1 ttgttaagac ccccttaagt tggaggaggc agaaaggcaa ccacagcgaa gaagaaggag
       61 aagtcaaggc gtctggaaag aattacccag tcctggcttc gagcagccca ttgaacgggg
      121 gacttgaacc agccaaagac ttcttcattc tgctcttgct agactctgct gagtcttgac
      181 ccggcttgta ggttgatgtg aaaagagatt ttgtgtcgtc ggagggaagg ggattggagc
      241 aaatagcaaa acagggggaa aagttaattt atttttaaag cacatttaac aaaaagaatt
      301 agaagactta agtgcagcgg aaataataaa agagaatatt agtgaaattt cttctcaaag
      361 aggggagaac caagcattta aggctccccc atcttttttt ttaaatgttg tttttaaatt
      421 tcttattttt tttggccggt cgtctcaaat tcatctgatt tcttattacc tcaattttgg
      481 aaacttcctt ccacgaccct ccgggaccac acagacaggc ggaggacgag tctatgagca
      541 ggagctgaac aagatgcatt gtgagaggtt tctatgtgtc ctgagaataa ttggaactac
      601 actttttgga gtgtctctcc tcctcggaat cacagctgct tatattgttg gctaccagtt
      661 tatccaaaca gataattact acttctcatt tggactgtac ggtgcctttt tagcctcgca
      721 tctcatcatc caaagcctct ttgccttttt ggaacaccgg aaaatgaaga agtcccttga
      781 aaccccgatt aaattgaaca aaacggtagc actctgcatc gctgcgtacc aagaggaccc
      841 tgactactta cggaaatgtt tgcaatctgt gaaaaggctg acctaccctg ggattaaagt
      901 cgtgatggtc atcgatggga actcagacga cgacctttac atgatggaca tattcagcga
      961 agttatgggc agggacaaat cggccacgta catctggaag aacaactttc atgaaaaggg
     1021 acctggtgag acagaagagt cccataaaga aagttcacaa catgtcaccc aattggtctt
     1081 gtctaacaaa agtatttgca tcatgcaaaa atggggtgga aagagagaag tcatgtacac
     1141 agccttcaga gcactggggc gaagcgtgga ttatgtacag gtgtgtgact cagatactat
     1201 gcttgaccct gcctcatctg tggagatggt gaaggtctta gaggaagacc ctatggttgg
     1261 aggtgttgga ggagatgtcc agattttaaa caagtatgat tcctggatct ccttcctcag
     1321 cagcgtgaga tactggatgg cttttaatat agaaagggcc tgccagtctt attttggctg
     1381 tgtccagtgc ataagcggtc ctctgggaat gtacagaaac tccttgctgc atgaatttgt
     1441 ggaagactgg tacaatcagg aattcatggg taaccaatgc agttttggtg acgacaggca
     1501 ccttaccaac agggtgttga gtctgggcta tgcaactaaa tacacggctc ggtccaagtg
     1561 ccttactgaa actcccatag aatatctgag atggctgaac cagcagaccc gttggagcaa
     1621 gtcctacttc cgagagtggc tgtacaatgc catgtggttt cacaagcatc acttgtggat
     1681 gacctatgaa gctgttatca ctggattctt tcctttcttt ctcattgcca cagtcatcca
     1741 gctcttctac aggggtaaaa tctggaacat cctcctcttc ctgttaactg tccagctagt
     1801 gggtctcatc aagtcatctt ttgccagctg ccttagagga aatatcgtca tggtattcat
     1861 gtctctgtat tcagtgttat acatgtcaag tctacttcct gccaagatgt ttgcaattgc
     1921 aaccataaac aaagctgggt ggggcacatc tggaaggaag accattgttg ttaatttcat
     1981 aggacttatt ccagtgtccg tgtggtttac aatccttcta ggtggtgtaa ttttcaccat
     2041 ttataaggaa tctaaaaagc cattttccga atccaaacag actgttctca tcgtgggaac
     2101 tttgatctat gcatgctact gggtcatgct tttgactctc tatgtggttc tcatcaataa
     2161 gtgtggcagg cggaagaagg gacaacagta tgacatggtg cttgatgtat gatgatgttt
     2221 gtagtcacac ctggagacac acacacacac acacatacac acacacacac accttagctc
     2281 ctcaaggggc tatacagtat tgtggcaccg caccctgcca ccacaggaga catatcactg
     2341 ctgctgggac ttgaacaaag acattcaatg ggggttggtt tcttttttat tctgccaaag
     2401 caaattgata catcagtgag aagaaagtcc gattaaatct gacagtttta ggacggtggg
     2461 atgatgtctt ggcttatgca cttttccctt actgtgcatc tgcctgacag tgtttgttct
     2521 aaatacctca cttgccatgc tttgtgtggg tgatcatgga agaaaaggat tctgaaaact
     2581 caagggaacg ttctttcaac ctacacatcc taacttatgg actcttttga tagctgatga
     2641 ttttctttct attttttgtt tttaaggaaa attgttcatc tttaccaaat gaaatgccaa
     2701 aggaaagttg gaaagccact ggctatgctg tattttgata taataattgt actgtgtttt
     2761 aaattttgta tccggatttt taaaaacaaa atttcacacc atagtctata ttttacttct
     2821 ctggcaaaat acacttttgt tcttttatat atatatatat atatatataa taaaataggt
     2881 tctaaaaaaa tccatactat aaaaaaaaat taacctgccc aaaatgtgaa acgtggttga
     2941 ctgatgttca tgaaagaata aaatgtttct ctctttctct acattttata attgaatagt
     3001 tatttctgtg aaaagaaatg taaagtttga atactctaac attttatttc ttttagaaag
     3061 ggtcgagata cctgtcaact tttaggtaaa aatacatact cacatgtgta caagagccaa
     3121 tcattaaagt tgaggccgaa agggtagaaa agtgcaattt ttgaaaatat atattttttt
     3181 caaaagggaa tcctagtctt tggaaaaagc aaaacaaaat gctgggctcc ttgtactgga
     3241 taaatgtgaa catccaagcc agatcatctg gagagatggt ggcagtcttt gcctaggcct
     3301 agacaaaatg gaaagctggt gagactttat ctgtgtgatt gggacaaata gaatgcaatt
     3361 cattaaaagt tttactctgt ggcctaaatg tggcagacct tctcacatgc acaatgagtg
     3421 tgtttcctcc agttagtgtc tgggttcgcc aagtcaccct gcctgttagt gatgtttaca
     3481 tgggcgaact gtaactgata cacaacacaa ttcagacctg gcacatttat gttcctagtg
     3541 gcttctttac ttctcaggaa gggtattttt tttctcaatt atacaggtaa tctctccatc
     3601 tcttccatac ttggccttcc taaaaatctc cacaagtaga aatgatgtca acctgtaatt
     3661 actattacta agaactggta aattaaaaaa agtgacgcac cagttcctcc aaacgtgtct
     3721 aattcagttg taacagggcc tcagttgtta atttgacttt tcacatgatt tatcttggct
     3781 ggtgctgtgt agggctgtga gacagacact cagaacacag gaatagctgc acagaagcct
     3841 tgtggcgaag caaaaagagc accaaggttc tgcttcctca ctgcgcagac taccacacca
     3901 cacacaactg tagcgagata ctgtctaagg gaaagctgca cactctacct tgtgagtaca
     3961 aagaggttcg ttcaagttct gaaaaactcc gactctcgcc gtatggagag ctagtgggaa
     4021 acaaacacac cctgacaata aatgaaacta aaacttgagt ttgccttttt aactatttat
     4081 gttctaagtt aagctttgat aacgttcaaa tgtcaaattt tttctcattc ttataaaaag
     4141 ttgaattaat tgccttgtat ttattttagc aattattcaa tgtatttcca ttataggatg
     4201 tatagtataa ttgattgttt ttgtaaataa aatatttttg ataaaaaaaa aaaaaaaaaa
     4261 aa
//
