LOCUS       NM_008215               2107 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus hyaluronan synthase 1 (Has1), mRNA.
ACCESSION   NM_008215
VERSION     NM_008215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Zhang,Y.H., Sun,X.T., Guo,R.F., Feng,G.Y., Gao,H.L., Zhong,M.L.,
            Tian,L.W., Qiu,Z.Y., Cui,Y.W., Li,J.Y. and Zhao,P.
  TITLE     AbetaPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and
            gene transcription in Alzheimer's disease
  JOURNAL   Matrix Biol 129, 29-43 (2024)
   PUBMED   38518923
  REMARK    GeneRIF: AbetaPP-tau-HAS1 axis trigger HAS1-related nuclear
            speckles and gene transcription in Alzheimer's disease.
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Cooley,A., Madhukaran,S., Stroebele,E., Colon Caraballo,M.,
            Wang,L., Akgul,Y., Hon,G.C. and Mahendroo,M.
  TITLE     Dynamic states of cervical epithelia during pregnancy and
            epithelial barrier disruption
  JOURNAL   iScience 26 (2), 105953 (2023)
   PUBMED   36718364
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Lin,X., Mekonnen,T., Verma,S., Zevallos-Delgado,C., Singh,M.,
            Aglyamov,S.R., Gesteira,T.F., Larin,K.V. and Coulson-Thomas,V.J.
  TITLE     Hyaluronan Modulates the Biomechanical Properties of the Cornea
  JOURNAL   Invest Ophthalmol Vis Sci 63 (13), 6 (2022)
   PUBMED   36478198
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Sun,Y., Ying,X., Li,R., Weng,M., Shi,J. and Chen,Z.
  TITLE     FGF9 Promotes Expression of HAS2 in Palatal Elevation via the
            Wnt/beta-Catenin/TCF7L2 Pathway
  JOURNAL   Biomolecules 12 (11), 1639 (2022)
   PUBMED   36358989
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Spicer,A.P., Seldin,M.F., Olsen,A.S., Brown,N., Wells,D.E.,
            Doggett,N.A., Itano,N., Kimata,K., Inazawa,J. and McDonald,J.A.
  TITLE     Chromosomal localization of the human and mouse hyaluronan synthase
            genes
  JOURNAL   Genomics 41 (3), 493-497 (1997)
   PUBMED   9169154
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Fulop,C., Salustri,A. and Hascall,V.C.
  TITLE     Coding sequence of a hyaluronan synthase homologue expressed during
            expansion of the mouse cumulus-oocyte complex
  JOURNAL   Arch Biochem Biophys 337 (2), 261-266 (1997)
   PUBMED   9016821
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Shyjan,A.M., Heldin,P., Butcher,E.C., Yoshino,T. and Briskin,M.J.
  TITLE     Functional cloning of the cDNA for a human hyaluronan synthase
  JOURNAL   J Biol Chem 271 (38), 23395-23399 (1996)
   PUBMED   8798544
REFERENCE   9  (bases 1 to 2107)
  AUTHORS   Itano,N. and Kimata,K.
  TITLE     Expression cloning and molecular characterization of HAS protein, a
            eukaryotic hyaluronan synthase
  JOURNAL   J Biol Chem 271 (17), 9875-9878 (1996)
   PUBMED   8626618
REFERENCE   10 (bases 1 to 2107)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino
            acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid
            oxidase (Hao-1) loci on chromosome 2
  JOURNAL   Biochem Genet 14 (11-12), 981-987 (1976)
   PUBMED   13782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D82964.1, AK138203.1 and AW488161.1.
            
            On Apr 18, 2009 this sequence version replaced NM_008215.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D82964.1, BC125424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1556              D82964.1           7-1562
            1557-2086           AK138203.1         843-1372
            2087-2107           AW488161.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 10.53 cM"
     gene            1..2107
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /note="hyaluronan synthase 1"
                     /db_xref="GeneID:15116"
                     /db_xref="MGI:MGI:106590"
     exon            1..51
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            52..759
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            760..985
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1118
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..2092
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="Has1"
                     /gene_synonym="HAS"
                     /note="major polyA site"
ORIGIN      
        1 agaacaagac ggagaagaga gaatccagga ggacccacag ccatgagaca ggacatgcca
       61 aagccctcag aggcagcgcg ttgctgctct ggcctggcca ggcgagcact cacgatcatc
      121 tttgccctgc tcatcctggg cctcatgacc tgggcctacg ccgcaggcgt tcctctggct
      181 tcagatcgct atggactcct ggcctttggc ctctatgggg cattcctcag cgcacaccta
      241 gtggcacaga gcctcttcgc ttacctggag caccgaaggg tggcagcggc tgcgcggcgc
      301 tccttggcga aggggcccct ggatgcggcc actgcacgca gcgtggcact caccatctca
      361 gcctaccaag aggatcccgc ttacctgcgc cagtgcttga cctccgcgcg cgccttgctg
      421 tacccgcaca cgaggttacg cgtgctcatg gtggtggacg gcaaccgcgc tgaggatctg
      481 tacatggtgg acatgttccg agaagtcttc gccgatgagg accccgccac ttatgtgtgg
      541 gatggcaact accatcagcc ctgggaacca gcggaggcta cgggcgctgt cggtgaaggt
      601 gcctaccggg aggtggaggc ggaggacccc gggcggttgg cggtggaggc gctggtgaga
      661 acacgcaggt gcgtgtgcgt ggctcagcgt tggggcggca aacgtgaggt catgtacaca
      721 gctttcaagg cactgggcga ctccgtggac tacgtgcagg tctgtgactc agacacaaga
      781 ctagacccca tggcactgct ggagcttgtg cgagtgttgg atgaagaccc ccgggtaggg
      841 gctgttggag gggatgtgag gatccttaac cctctggact cctgggtcag cttcttgagc
      901 agtcttcgat actgggtagc cttcaatgtg gaacgagctt gtcagagcta cttccactgt
      961 gtgtcctgca tcagtggtcc tctgggtcta tacagaaaca atctcctgca gcagttcttg
     1021 gaggcctggt acaaccaaaa gttcctgggc acccactgca catttgggga tgacaggcac
     1081 ctcaccaacc gaatgcttag catgggctat gctaccaagt atacctcgcg ctccagatgc
     1141 tactcggaga cgccctcctc cttccttcgt tggttgagcc aacagacccg ctggtccaaa
     1201 tcttacttcc gagagtggct atacaatgct ctgtggtggc atcgccacca cgcatggatg
     1261 acctatgaag cggtggtctc gggcctcttc cctttcttcg tggctgccac ggtgttgagg
     1321 ctcttctatg cagggcgccc gtgggctctg ctctgggtgc tgctctgtgt gcagggcgta
     1381 gcactggcaa aggcagcctt tgcagcctgg ctgcgtggct gcgtgcgcat ggtgctgctg
     1441 tcactctatg caccactcta catgtgcggc ctcctgcctg ccaaattcct agcgttggtt
     1501 accatgaatc aaagtggttg gggtacctcg ggccggaaga aactggctgc taactacgtc
     1561 cccgtgttgc ccctggcact ctgggctcta ctgctgcttg gaggcctggc ccgcagtgtg
     1621 gcccaggagg ccagagctga ctggagtggc ccatcccgag cagctgaagc ctaccacctt
     1681 gctgctgggg ctggtgccta tgtggcctac tgggtggtaa tgttaactat ctactgggta
     1741 ggtgtgagga ggctgtgcag acgtcggagc ggtggttacc gtgtccaagt atgagtctgg
     1801 acatgaagat gcagctgagg gctcttaaag gaggagtcct tgtgaggcac cccctggagt
     1861 catggctttc tggggactca gtttaccttc tctttgaaat gagggagtta tttaagattc
     1921 ttcaatatgg actgtattgg aactcagatc taggtctctg gggaggggta atttattgat
     1981 cagggagtgg gattgtagga ccagggccag aacgtctcca ttttctccct gttgctattt
     2041 aatgtttgta ctgtaagatt atataataaa ttttttattt attttcttcc aaaaaaaaaa
     2101 aaaaaaa
//
