LOCUS       NM_008214               1999 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus histidyl-tRNA synthetase 1 (Hars1), mRNA.
ACCESSION   NM_008214
VERSION     NM_008214.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Cui,Q., Bi,H., Lv,Z., Wu,Q., Hua,J., Gu,B., Huo,C., Tang,M.,
            Chen,Y., Chen,C., Chen,S., Zhang,X., Wu,Z., Lao,Z., Sheng,N.,
            Shen,C., Zhang,Y., Wu,Z.Y., Jin,Z., Yang,P., Liu,H., Li,J. and
            Bai,G.
  TITLE     Diverse CMT2 neuropathies are linked to aberrant G3BP interactions
            in stress granules
  JOURNAL   Cell 186 (4), 803-820 (2023)
   PUBMED   36738734
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Fernandez,I., Harlow,L., Zang,Y., Liu-Bryan,R., Ridgway,W.M.,
            Clemens,P.R. and Ascherman,D.P.
  TITLE     Functional redundancy of MyD88-dependent signaling pathways in a
            murine model of histidyl-transfer RNA synthetase-induced myositis
  JOURNAL   J Immunol 191 (4), 1865-1872 (2013)
   PUBMED   23842751
  REMARK    GeneRIF: AA 60-90 of HRS were absolutely required for in vitro as
            well as in vivo signaling via MyD88-dependent TLR pathways to case
            myositis.
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Blechynden,L.M., Lawson,C.M. and Garlepp,M.J.
  TITLE     Sequence and polymorphism analysis of the murine gene encoding
            histidyl-tRNA synthetase
  JOURNAL   Gene 178 (1-2), 151-156 (1996)
   PUBMED   8921907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA561201.1, AK166826.1 and AI849599.1.
            
            On Jul 8, 2009 this sequence version replaced NM_008214.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146922.1, AK011685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                CA561201.1         1-85
            86-1833             AK166826.1         2-1749
            1834-1999           AI849599.1         6-171               c
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..1999
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /note="histidyl-tRNA synthetase 1"
                     /db_xref="GeneID:15115"
                     /db_xref="MGI:MGI:108087"
     exon            1..195
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            196..285
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            286..405
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            406..501
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            502..627
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            628..735
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            736..834
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            835..928
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1056
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1299
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1416
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1563
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1989
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1969..1974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="Hars1"
                     /gene_synonym="Hars; MMHRS"
                     /note="major polyA site"
ORIGIN      
        1 ctctaggcac gaaagcgggg actcggtaac cggaagtcat ccgaacctag gctgagtcca
       61 ccaaggcggg ttttagacag ccgtcagttc ctgctggcag gcaggatggc agatcgtgct
      121 gctctggagg agctggtacg actccaggga gcgcatgtga ggggccttaa ggagcagaaa
      181 gcgtccgctg agcagatcga ggaggaggtg acgaaactcc taaaactgaa ggcacagctg
      241 ggccaggatg aaggcaaaca gaagtttgtg ctcaaaaccc ccaagggcac gagagactat
      301 agtccccggc agatggcggt ccgggaaaag gtgtttgatg tcatcatccg ctgtttcaaa
      361 cgccatggag cagaagtgat tgatacacct gtgtttgaac taaaggaaac actgactgga
      421 aagtacggag aagactcaaa gcttatctat gacttgaagg accagggtgg ggagctgctg
      481 tccctccgtt atgaccttac tgtccctttt gctcgctatc tggcaatgaa taaactgacc
      541 aacattaaac gctaccatat agcaaaggtg tatcgccggg acaacccagc tatgacccga
      601 ggccgttacc gtgaattcta tcaatgcgat tttgacattg ccggacagtt cgaccccatg
      661 attcctgatg cagagtgcct aaagattatg tgcgagatcc tgagttcact tcagatcggc
      721 aacttcctgg tcaaggtaaa cgacaggcgc atcctagatg ggatgtttgc tgtctgtggt
      781 gttcctgata gcaagttccg taccatctgc tcctcggtgg acaagctaga caaggtttcc
      841 tgggaggaag tgaagaatga gatggtggga gagaagggcc ttgcaccgga agtggctgat
      901 cgcatcgggg actatgtcca gcagcatggt ggggtttctc tggtggagca gttactgcag
      961 gatcctaaac tctcccaaaa caaacaggct gtagagggct tgggagacct aaagctgctc
     1021 tttgagtatc taatcctgtt tggcattgat gacaagatct cctttgacct gagccttgct
     1081 cgggggctag actactatac tggggtcatc tatgaggcag tgctgctaca gatgccaacc
     1141 caagctgggg aagagcccct gggtgtgggc agcatagctg ctggagggcg ctacgatggc
     1201 ctggttggca tgtttgaccc caaggggcgc aaggtgccat gcgttgggct cagtattgga
     1261 gtggagcgga tcttttccat tgtagagcaa agattagagg cttcagagga aaaggtacgg
     1321 accacagaga cgcaggtgct tgtggcatct gcacagaaga agctgctgga ggagagactg
     1381 aagcttgtct cagagttatg ggatgctggg atcaaggctg agctgctgta caagaagaac
     1441 ccgaagttac taaaccagtt gcagtactgt gaggaggcag gcatcccact ggtggccatc
     1501 attggtgagc aggaactcaa ggatggcgtc atcaagctcc gctcggtggc cagcagagag
     1561 gaggtggatg tccgaagaga agaccttgtg gaggaaatca gaagaagaac aaatcagccc
     1621 ctctccacct gctgagctga gcaaaccagt agaggaaaca ggattgatct taactgaacg
     1681 aaaacaaaac tgcatatgta cttaaacagt ctgcatattt gccatccagc agaagactga
     1741 agggtggtca gaacagaggc tttttgtttt ttgttttttt gtttttgttt ttattattat
     1801 gttatcagta atcactggca aaaaaaaaaa aaacaatggc caggtactac actgtcgggg
     1861 attataggtg gactaaccac gtctctgcct cctaaattcc tgtatggact tgagatggct
     1921 tcattgaaaa accacacggc agatgaacaa cctatggcca aaacgtccaa taaatgtctc
     1981 taccgctaaa aaaaaaaaa
//
