LOCUS       NM_001081400            4074 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus HUWE1 associated protein modifying stress responses
            (Hapstr1), mRNA.
ACCESSION   NM_001081400 XM_978179
VERSION     NM_001081400.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4074)
  AUTHORS   Amici,D.R., Alhayek,S., Klein,A.T., Wang,Y.Z., Wilen,A.P., Song,W.,
            Zhu,P., Thakkar,A., King,M.A., Steffeck,A.W., Alasady,M.J.,
            Peek,C., Savas,J.N. and Mendillo,M.L.
  TITLE     Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for
            mammalian life
  JOURNAL   Life Sci Alliance 7 (5), e202302370 (2024)
   PUBMED   38453366
  REMARK    GeneRIF: Tight regulation of a nuclear HAPSTR1-HUWE1 pathway
            essential for mammalian life.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4074)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4074)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 4074)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4074)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156026.3, BC116780.1, AK032072.1, BG079300.2, AV335391.2 and
            CD539516.1.
            
            On Aug 20, 2008 this sequence version replaced NM_001081400.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.34927.1,
                                           SRR1660817.16575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC156026.3         128388-128404       c
            18-1226             BC116780.1         1-1209
            1227-2172           AC156026.3         101482-102427       c
            2173-3155           AK032072.1         582-1564
            3156-3498           BG079300.2         161-503
            3499-3971           AV335391.2         99-571
            3972-4074           CD539516.1         1-103               c
FEATURES             Location/Qualifiers
     source          1..4074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 4.37 cM"
     gene            1..4074
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="HUWE1 associated protein modifying stress
                     responses"
                     /db_xref="GeneID:69053"
                     /db_xref="MGI:MGI:1916303"
     exon            1..586
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1188
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="UPF0472 protein C16orf72 homolog; telomere
                     attrition and p53 response 1 protein"
                     /codon_start=1
                     /product="HUWE1-associated protein modifying stress
                     responses"
                     /protein_id="NP_001074869.1"
                     /db_xref="CCDS:CCDS49756.1"
                     /db_xref="GeneID:69053"
                     /db_xref="MGI:MGI:1916303"
                     /translation="MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLSPELQE
                     EAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYK
                     ESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAP
                     PRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSS
                     GPNASRRRNGLHDVDLNTFITEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRML"
     exon            587..667
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..943
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..4074
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="hexamer: AATACA"
     polyA_site      1851
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="major polyA site"
     regulatory      3330..3335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="hexamer: ATTAAA"
     polyA_site      3351
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="major polyA site"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
                     /note="hexamer: AATAAA"
     polyA_site      4071
                     /gene="Hapstr1"
                     /gene_synonym="1110017P05Rik; 1810013L24Rik;
                     3010002C02Rik; Gm19906; Tapr1"
ORIGIN      
        1 gaggcgtcga cgccgccgcc gtagacgacg ttcctcagtc ttcgaggtgg gctcggcggc
       61 gcaggccgga cagggaacgc cggttggaga gcggcggcgg tcggaccgag gccgcggggc
      121 cgtgggtggg cggtaaaggg gtgcgggcga ggctagggca gggtgcggca cctcggagcg
      181 gggttggtgg gcagaggact cgggctgtgc ggggtgggtg ccggctccgc gggcttgcac
      241 agaggcctgg gccggccgcc gggcccctcg ttcccgggcc tgtcgacgac gacgttcccg
      301 cggggaccgc gcttaaggag gacgcggcgg cggcggccag gccgcgggag gccgcggagg
      361 atggaggagc ggaaggagga gggcgaggcg gagatccagg agcacgggcc ggagcattgg
      421 ttctccaagt gggagcggca gtgcctggcc gaggccgagc aggacgagca gttgtctccc
      481 gagctgcagg aggaggcggc ggccgccgcg cagcccgagc acaagcaaca gaagctgtgg
      541 catctcttcc agaactcggc cacggccgtg gctcagctct acaaagaccg agtgtgtcag
      601 cagccaggac tttctctctg ggtccccttc caaaacgcag ccaccgccgt caccaacctc
      661 tataaagaaa gtgtggatac ccatcagcga agttttgata ttggaattca gattggctat
      721 cagcgacgca ataaggatgt gctggcctgg gtaaaaaagc gcagaagaac tattcgtaga
      781 gaagatttga tcagcttcct gtgtggaaag gttcctccac cacgaaactc tagagctccc
      841 ccaagactga ctgtagtgtc ccctaaccga gctacttcaa cggaaactag ctcatctgta
      901 gagactgatt tgcaaccctt ccgggaagcc atagctctgc atggtcttag tggtgcaatg
      961 gctagtataa gcgtgcgttc gagtacccca ggctctccta cacatgtaag cagtggaccg
     1021 aatgctagtc gaaggagaaa tggactccat gatgtcgatt tgaacacttt cataacagaa
     1081 gaaatggcac tccacttgga caatggtgga actagaaagc gtacctcagc ccagtgtggc
     1141 gatgtcatta cagactcacc aacccataaa cgcaacagaa tgctctaaac tgcagacatt
     1201 ttcacaccca ccatgctgct tgaaagccac tcgatcctca acatatacta ttattgcaaa
     1261 ggaaacatga ggccatcttc ccttgttcac tgtttaagaa aagtgaattc tctagtggtt
     1321 gccataaaag gaagttctag gtatttacag tagatgcctc ctgtaactat ggctttctca
     1381 aactataatc ctagcagagg acttgaacta ttgtagtcat tagcaagatc atcataggca
     1441 aacatatatc cgttccaagg cgaaaagtga ccttaactgt atttattctc aaagggaaag
     1501 gaaataacag atgtttattt ggttatagaa tgctttctta tttttatttt ttggtccatt
     1561 tcctgctgta ttgagtattt ttacttaaac agtattgcca ggttcctaca attgtctaaa
     1621 accttgatct ggcttgcaag ccagatcttc aggcttccat ttttgcagcc acactgaacc
     1681 acacatctgg tttccatagt gatagtgtgt aatttctgat tatcagatta tgcccagttt
     1741 tcagttttca aaacagtttt caaaactctg gtgattgtga gatgtaaaga ggtgctatgg
     1801 tggtcatgca agtaatacgt aatatgaatc aatacacaga actctatcgg attcactttg
     1861 tgtgtgttag tgctctgaaa atagcaatat taaactgtcc ccagaataac cctgtaggct
     1921 tcaactcagt tttaagacaa gtactacttc ctatgccagg tacttaactt atggttaaac
     1981 acagactgca ttcaaagtga cctgaaaaac aggtcatgat ctttgagagt gggcttcctt
     2041 tttggtttgg tagtagtgag aggaaatgga cggtgggagt agatatttat tgtttaggtt
     2101 ttttttgttg ttgttgttgg tttttttttt ttttgttttt ttgtttttgc atttttatgg
     2161 atgccctact gtgtgtagtt gtcatagtag gtggaagatg ataaatatgt tttatctgct
     2221 actaatgtga aagtaactta aatagcaaaa cccagctttt cctgtccctc catttctctc
     2281 agaaatgcag tttggacttt ccttctggaa atgatgagat cgcatggagg ttttctagat
     2341 gttaggtaga cccaaataaa agctctcaga gtcctctttg ggtaaatata agacctcttg
     2401 tagctacaac cttttagagc atgtttcatc tgcattttta ctactttgaa ctgaatggta
     2461 gtctttttta gaagactgat gtcagcctgc caggtactgt aattcattct atcctattat
     2521 attatatatc aagtaggaca gtgaaaaatg tttccttgca gacttgtagt ccagtttcag
     2581 tttcttctat ttttatcctt aataaccact gcaaatcagt gtaagggttt ttctggtaat
     2641 tacagcactt tgttaaaagt ttgcaatttt gtcagccatt aataatacct ttctgtgaag
     2701 aaaccttact aagttaacca ttactggctg agtgggatgt gaatggaatg ttagaaatgt
     2761 tgtgtgaatt gaagttctgt attcattata gatatagccc ttatttaaaa cagtgaagtc
     2821 catattcaga ctaggaatga aagtaaggta tttctcagtt tgtgcaaaag tggagcttta
     2881 ctttgtttat ttgaaaagca ggaaaaatta tagcaatctg tcattttacc ttaaatggac
     2941 aagcctgggc atcacaagta cttccaggct tccctgggat ataccaagac atggagttca
     3001 attttgcttt tctgtggttg tgagtataga tgctggaatt ggggtttgac ggtgtgatgg
     3061 ctgctgacaa gaagccagaa ctcccattcc tgagggactt gagactgagg accacgtttc
     3121 atctcccttc atgccgtgtt ctgtctcctc tgtccaagtt gactaaggat gttcttggtt
     3181 gtttggtttc agttggtgct ctgaagctga atctcagtgc cctttactcg cagttgtcaa
     3241 attttgataa aacgtgccat tttctttggt aagagaaagc aggtctaatg tctgccagaa
     3301 cacaatttat atgccgaatt attggctcca ttaaactttt taaaaacttt agcactggtt
     3361 acttttttcc attgcattca atatgtagca cctcctcacc tcatgagtag cgcttccttc
     3421 cctactgccg ctcctgtccc ttcctccctg gcctgccaga gtagaagaac tgagaccggc
     3481 ccatcagtac aaagggaggt ggtttttaat cttagcgtga gttagtctga tgaagttcag
     3541 aatcttttgg aagtttttat tagttaagat gcagaacatc aaagatgacc acatactagt
     3601 gtagtattag gcactgactt tgactttttt actttctttt tttttttttg gacaggtctt
     3661 tttgtgtagt tcatgctgac ttctagcatt cgatcctcct gtttcagttg cctaagtgct
     3721 atggtttact ggcatggtgc ttgcttggcc ttttcagccg atcaagaaca gaatgggctg
     3781 ctcttgaagc taagcacttg agtatgggag aacagagtct ttgtcatgag ccagagtctg
     3841 attcttaaca cagtgtatct ccttagttct gtcattaacc tgacgggggt aggccaggct
     3901 gagttctcca ctgcagtgtc ctgaacgtag ctgagaggct cacgaacttt tattacaatt
     3961 tttaatatct tttacagcaa atttcgagta tcatcaatgt agtttacctc attgaagtaa
     4021 tgacatacac cttaaaccat aatacaaata aatcattgaa aatgccaaaa agac
//
