LOCUS       NM_177981               3225 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus huntingtin-associated protein 1 (Hap1), transcript
            variant 2, mRNA.
ACCESSION   NM_177981
VERSION     NM_177981.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Chen,X., Sun,Y., Chen,L., Chen,X.S., Pan,M., Zhang,Y., Wang,Q.,
            Yang,W., Yin,P., He,D., Guo,X., Yang,S., Zeng,Y., Yan,S., Li,X.J.
            and Li,S.
  TITLE     Differential expression and roles of Huntingtin and
            Huntingtin-associated protein 1 in the mouse and primate brains
  JOURNAL   Cell Mol Life Sci 79 (11), 554 (2022)
   PUBMED   36251080
  REMARK    GeneRIF: Differential expression and roles of Huntingtin and
            Huntingtin-associated protein 1 in the mouse and primate brains.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Xin,N., Lu,J., Zhou,Y. and Cheng,Y.
  TITLE     Dexamethasone Protects Against Ischaemic Brain Injury via
            Inhibiting the pAkt Signalling Pathway Through Increasing Hap1
  JOURNAL   Neurotox Res 39 (2), 191-197 (2021)
   PUBMED   32876919
  REMARK    GeneRIF: Dexamethasone Protects Against Ischaemic Brain Injury via
            Inhibiting the pAkt Signalling Pathway Through Increasing Hap1.
REFERENCE   4  (bases 1 to 3225)
  AUTHORS   Gong,Y.J., Feng,Y., Cao,Y.Y., Zhao,J., Wu,W., Zheng,Y.Y., Wu,J.R.,
            Li,X., Yang,G.Z. and Zhou,X.
  TITLE     Huntingtin-associated protein 1 plays an essential role in the
            pathogenesis of type 2 diabetes by regulating the translocation of
            GLUT4 in mouse adipocytes
  JOURNAL   BMJ Open Diabetes Res Care 8 (1) (2020)
   PUBMED   33060070
  REMARK    GeneRIF: Huntingtin-associated protein 1 plays an essential role in
            the pathogenesis of type 2 diabetes by regulating the translocation
            of GLUT4 in mouse adipocytes.
REFERENCE   5  (bases 1 to 3225)
  AUTHORS   Liu,Q., Cheng,S., Yang,H., Zhu,L., Pan,Y., Jing,L., Tang,B., Li,S.
            and Li,X.J.
  TITLE     Loss of Hap1 selectively promotes striatal degeneration in
            Huntington disease mice
  JOURNAL   Proc Natl Acad Sci U S A 117 (33), 20265-20273 (2020)
   PUBMED   32747555
  REMARK    GeneRIF: Loss of Hap1 selectively promotes striatal degeneration in
            Huntington disease mice.
REFERENCE   6  (bases 1 to 3225)
  AUTHORS   Sheng,G., Xu,X., Lin,Y.F., Wang,C.E., Rong,J., Cheng,D., Peng,J.,
            Jiang,X., Li,S.H. and Li,X.J.
  TITLE     Huntingtin-associated protein 1 interacts with Ahi1 to regulate
            cerebellar and brainstem development in mice
  JOURNAL   J Clin Invest 118 (8), 2785-2795 (2008)
   PUBMED   18636121
  REMARK    GeneRIF: Hap1 interacts with Ahi1 to regulate cerebellar and
            brainstem development in mice.
REFERENCE   7  (bases 1 to 3225)
  AUTHORS   Martin,E.J., Kim,M., Velier,J., Sapp,E., Lee,H.S., Laforet,G.,
            Won,L., Chase,K., Bhide,P.G., Heller,A., Aronin,N. and Difiglia,M.
  TITLE     Analysis of Huntingtin-associated protein 1 in mouse brain and
            immortalized striatal neurons
  JOURNAL   J Comp Neurol 403 (4), 421-430 (1999)
   PUBMED   9888310
REFERENCE   8  (bases 1 to 3225)
  AUTHORS   Nasir,J., Duan,K., Nichol,K., Engelender,S., Ashworth,R.,
            Colomer,V., Thomas,S., Disteche,C.M., Hayden,M.R. and Ross,C.A.
  TITLE     Gene structure and map location of the murine homolog of the
            Huntington-associated protein, Hap1
  JOURNAL   Mamm Genome 9 (7), 565-570 (1998)
   PUBMED   9657855
REFERENCE   9  (bases 1 to 3225)
  AUTHORS   Bertaux,F., Sharp,A.H., Ross,C.A., Lehrach,H., Bates,G.P. and
            Wanker,E.
  TITLE     HAP1-huntingtin interactions do not contribute to the molecular
            pathology in Huntington's disease transgenic mice
  JOURNAL   FEBS Lett 426 (2), 229-232 (1998)
   PUBMED   9599014
REFERENCE   10 (bases 1 to 3225)
  AUTHORS   Dragatsis,I., Efstratiadis,A. and Zeitlin,S.
  TITLE     Mouse mutant embryos lacking huntingtin are rescued from lethality
            by wild-type extraembryonic tissues
  JOURNAL   Development 125 (8), 1529-1539 (1998)
   PUBMED   9502734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY288360.1 and BC053043.1.
            
            On Apr 16, 2009 this sequence version replaced NM_177981.1.
            
            Summary: The protein encoded by this gene was first identified as a
            neuronal protein that binds the HD protein huntingtin. The protein
            also interacts with kinesin light chain, 14-3-3 proteins, and
            Abelson helper integration site 1 protein. The protein is involved
            in intracellular trafficking of vesicles and organelles, and lack
            of the protein results in neuronal death resembling the
            hypothalamic degeneration that occurs in Huntington's disease.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (B).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053043.1, BC034089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 18636121
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY288360.1         2-14
            14-3225             BC053043.1         1-3212
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..3225
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /note="huntingtin-associated protein 1"
                     /db_xref="GeneID:15114"
                     /db_xref="MGI:MGI:1261831"
     exon            1..452
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..529
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..646
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..825
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..925
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..992
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1123
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1186
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1321
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1413
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1796
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2004
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..3157
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3155
                     /gene="Hap1"
                     /gene_synonym="HAP-1"
                     /note="major polyA site"
ORIGIN      
        1 agtggagccc gctccgagca caggttataa agccccggct gcggcagcgg actgcggagt
       61 caagatgcgc ccgaaagagc aggtgcagag cggtgcggga gacgggacag ggtcggggga
      121 cccagcagca ggcaccccca cgacccagcc tgcagttggt cccgctccgg agccctcggc
      181 ggagcccaaa cctgctccag cgcagggaac cgggtccgga caaaaatcag gatcccgaac
      241 caagacagga agcttttgtc ggtccatgat cattggtgat tcggacgcac catggacccg
      301 ctacgtattc caggggcctt acggtccccg ggccactggc ctgggcactg gaaaggccga
      361 gggaatctgg aagacaccag ccgcgtacat cggccggagg cccggcgtgt ccggccctga
      421 gcgtgcggcg tttattcgag agctgcagga agcgttgtgt cctaatccac cacccacgaa
      481 gaagatcacc gaagatgatg tcaaagtgat gttgtatttg ctggaagaga aagaacggga
      541 cctgaacaca gccgcccgga tcggccagtc cctggtgaaa cagaacagtg tcttgatgga
      601 ggagaataat aagctggaaa ccatgctggg ctcagccagg gaggagattt tacatctccg
      661 gaagcaggtg aacctgcgag atgaccttct tcagctctac tcagactctg atgacgatga
      721 tgatgaggaa gacgaggaag acgaggaaga gggcgaagag gaggaacgag aaggacagag
      781 ggatcaagac cagcagcacg accaccccta tggtgccccc aagccacacc ctaaggctga
      841 gacagcgcac cgctgcccac agctggaaac cctgcagcag aagctcaggc ttctggagga
      901 agagaacgac cacctgcgag aggaggcctc ccaccttgac aacctggagg acgaagagca
      961 gatgctcatt ctggaatgtg tggagcagtt ctctgaagcc agccagcaga tggcagagct
     1021 atcggaagtg ctggtgttga ggctggaagg ctatgagagg cagcagaaag agatcactca
     1081 gctgcaggcc gagatcacca agctacaaca gcgttgtcag tcttatgggg cccagacaga
     1141 gaaactgcag cagatgctgg cctcagagaa ggggatccac tcggagagcc tgcgagctgg
     1201 ctcctacatg caggattatg ggagcaggcc tcgtgaccgc caggaggatg ggaagagtca
     1261 tcgccagcgc tcctccatgc ccgcaggctc tgtcacccac tatggataca gtgtgcctct
     1321 ggatgcactt ccaagtttcc cagagacact ggctgaggag ctccgaacat ctctgaggaa
     1381 gttcatcact gaccctgcgt atttcatgga gagacgtgac actcactgca gggaggggcg
     1441 gaagaaggag cagagggcga tgccaccccc accggctcaa gatctcaagc cacctgaaga
     1501 ttttgaggct ccagaggagt tggttcctga ggaggagctg ggggccatcg aagaggtggg
     1561 gacagctgag gatgggcagg cagaagagaa cgagcaggcg tctgaggaga ccgaggcctg
     1621 ggaggaggtg gaaccggagg tggacgagac cacaaggatg aatgtggtgg tctccgccct
     1681 ggaggccagt ggcctgggcc cttcccacct ggacatgaag tatgtcctcc agcaactgtc
     1741 caactggcag gacgcccact ctaagcggca gcagaagcag aaggtggtcc caaaagactc
     1801 cccaaccccg cagcagcaaa caaacatggg gggcgggatc ctggagcagc agcccagagt
     1861 gccgacccag gactctcaga ggctggagga ggacagggcc actcactctc ccagtgccag
     1921 ggaggaagag gggccttctg gggccaccta ggcctggaac gaaggcctct gccagcaagg
     1981 gccacagttg gaccattccc ccggctcctt tcgtcttcat ggccctgtgg gtgggtacat
     2041 gtgattgtgc accatttatt agaagaggaa cccgaagttc agagatctga gatgacttgg
     2101 ccaaggtcat actaggagca gatctgagcc cgtgtctatg agttctgaac ccctggcctg
     2161 gtctcactgc tgtccgcacc tcctgctccc atctttgcgt tccacctgaa gttttggcag
     2221 cctccttcag tcgttctgat gcccccaccc ccgttttggg gtgcaccaat gggtggaaca
     2281 tccctggctg cggcacagta agatggcgca ggttgtaagc tgggtcagca cttccgtggc
     2341 tgaccacggg ggacctgagt gagggccagt ggtggttttc tgtcgtctcc tctgtcaggg
     2401 ccgactgggt ttgagggtgg tctggctcct gactcccatc cacccccttc tcttcccggg
     2461 cttgctgttt cccagcagcc ggaagaagcc ccacagacag cttgagaccc cctccttctg
     2521 ctgcctggcc aagtcccacc cttcctttct ttcctctgaa acaggaccct accccccgcc
     2581 ccccccatgt ctgccagaag ttctccctct cctgtcctgg tagacctgtc tcctcttgta
     2641 ggacaggctg aaagaacccc ggtccctcat tctgaaactg gggccaaagc tgtggctgct
     2701 ggaaccccag gggtggaagc aaactgggca gattggctgg ctaccagatc cagctctgag
     2761 atgggtgtga gtgggcgtgt ccctagggta ggcagttatt gggggggggg gggtcctctc
     2821 tatcccttga acctctcacg taaagggact tccccagtcc tggttggctt tttgaacctg
     2881 gtccttttcg ctctttttta cccttctccg tttctattac tgtgtgtgac gtaaagtgta
     2941 tctgcgtgag ggttgtgtcc ctctgcccag tgctgtctct gtgtcctgtg gcctgtgagt
     3001 ttccttctag agttctgcct tcctccacat ccgtgctcac acagagctgt ggcctcagcg
     3061 cctgccctgc ttctgcagcg cttcatagtc ttgtagctag tcagcctttg tattgatgta
     3121 tgtgccaatg tgggaaataa agaacttgtg agatatcaaa aaaaaaaaaa aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
